PCED1B-AS1

Summary

PCED1B-AS1 (PCED1B antisense RNA 1, HGNC:44166) is a long non-coding RNA gene on chromosome 12q13.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44166
Approved symbol	PCED1B-AS1
Name	PCED1B antisense RNA 1
Location	12q13.11
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000247774
Ensembl biotype	lncRNA
Entrez	100233209
RNAcentral	URS000075C4C6 — lncRNA, 2502 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 132 — 128 lncRNA, 4 retained_intron

ENST00000500365, ENST00000547600, ENST00000547626, ENST00000547851, ENST00000548222, ENST00000548463, ENST00000550426, ENST00000551432, ENST00000551898, ENST00000552269, ENST00000552975, ENST00000552990, ENST00000663937, ENST00000685510, ENST00000686014, ENST00000686695, ENST00000687553, ENST00000687664, ENST00000688105, ENST00000688546, ENST00000689367, ENST00000690122, ENST00000690309, ENST00000690380, ENST00000690606, ENST00000690728, ENST00000691079, ENST00000691550, ENST00000693221, ENST00000693727, ENST00000697429, ENST00000697430, ENST00000697431, ENST00000697432, ENST00000697433, ENST00000697434, ENST00000697435, ENST00000697436, ENST00000697437, ENST00000702158, ENST00000702204, ENST00000702214, ENST00000702358, ENST00000702414, ENST00000702437, ENST00000702442, ENST00000702461, ENST00000702472, ENST00000702479, ENST00000702481, ENST00000702575, ENST00000702581, ENST00000702595, ENST00000702640, ENST00000702659, ENST00000702665, ENST00000702672, ENST00000702679, ENST00000702685, ENST00000702697, ENST00000702733, ENST00000702740, ENST00000702774, ENST00000702779, ENST00000703411, ENST00000789367, ENST00000789368, ENST00000789369, ENST00000789370, ENST00000789371, ENST00000789372, ENST00000789373, ENST00000789374, ENST00000789375, ENST00000789376, ENST00000789377, ENST00000789378, ENST00000789379, ENST00000789380, ENST00000789381, ENST00000789382, ENST00000789383, ENST00000789384, ENST00000789385, ENST00000789386, ENST00000789387, ENST00000789388, ENST00000789389, ENST00000789390, ENST00000789391, ENST00000789392, ENST00000789393, ENST00000789394, ENST00000789395, ENST00000789396, ENST00000789397, ENST00000789398, ENST00000789399, ENST00000789400, ENST00000789401, ENST00000789402, ENST00000789403, ENST00000789404, ENST00000789405, ENST00000789406, ENST00000789407, ENST00000789408, ENST00000789409, ENST00000789410, ENST00000789411, ENST00000789412, ENST00000789413, ENST00000789414, ENST00000789415, ENST00000789416, ENST00000789417, ENST00000789418, ENST00000789419, ENST00000789420, ENST00000789421, ENST00000789422, ENST00000789423, ENST00000789424, ENST00000789425, ENST00000789426, ENST00000789427, ENST00000789428, ENST00000789429, ENST00000789430, ENST00000789431, ENST00000789432, ENST00000789433

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500365 — 3 exons

Exon	Start	End
ENSE00001964315	47208420	47210761
ENSE00003986109	47216165	47216264
ENSE00004168656	47216384	47216435

Expression profiles

Bgee: expression breadth ubiquitous, 136 present calls, max score 99.06.

FANTOM5 (CAGE): breadth broad, TPM avg 23.7127 / max 1396.6839, expressed in 524 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
130661	15.3602	221
130663	7.7361	467
130662	0.5637	106
130660	0.0527	25

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	99.06	gold quality
lymph node	UBERON:0000029	98.14	gold quality
blood	UBERON:0000178	96.53	gold quality
bone marrow cell	CL:0002092	95.78	gold quality
vermiform appendix	UBERON:0001154	95.75	gold quality
spleen	UBERON:0002106	95.46	gold quality
bone marrow	UBERON:0002371	93.18	gold quality
thymus	UBERON:0002370	88.93	gold quality
tonsil	UBERON:0002372	87.38	gold quality
colonic epithelium	UBERON:0000397	86.47	gold quality
upper lobe of left lung	UBERON:0008952	85.52	gold quality
right lung	UBERON:0002167	85.44	gold quality
leukocyte	CL:0000738	84.92	gold quality
placenta	UBERON:0001987	84.48	gold quality
spinal cord	UBERON:0002240	84.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.41	gold quality
small intestine Peyer’s patch	UBERON:0003454	84.34	gold quality
lung	UBERON:0002048	83.71	gold quality
monocyte	CL:0000576	83.55	gold quality
mucosa of transverse colon	UBERON:0004991	83.22	gold quality
gall bladder	UBERON:0002110	83.14	gold quality
small intestine	UBERON:0002108	83.13	gold quality
rectum	UBERON:0001052	82.34	gold quality
right coronary artery	UBERON:0001625	82.00	gold quality
substantia nigra	UBERON:0002038	80.97	gold quality
omental fat pad	UBERON:0010414	80.43	gold quality
right adrenal gland cortex	UBERON:0035827	79.63	gold quality
right adrenal gland	UBERON:0001233	78.94	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.87	gold quality
left coronary artery	UBERON:0001626	78.50	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-10287	yes	31.88
E-ANND-3	yes	22.83

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• LncRNA PCED1B-AS1 activates the proliferation and restricts the apoptosis of glioma through cooperating with miR-194-5p/PCED1B axis. (PMID:31680313)
• Long noncoding RNA PCED1BAS1 promotes pancreatic ductal adenocarcinoma progression by regulating the miR4113p/HIF1alpha axis. (PMID:34036383)
• Long non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p / C-X-C motif chemokine receptor 1 axis. (PMID:34516330)
• LncRNA PCED1B-AS1 Upregulation in Hepatocellular Carcinoma and Regulation of the miR-10a/BCL6 Axis to Promote Cell Proliferation. (PMID:35997114)
• LncRNA PCED1B-AS1 knockdown inhibits osteosarcoma via methylation-mediated miR-10a downregulation. (PMID:36274134)
• Upregulation of PCED1B-AS1 in proliferative diabetic retinopathy and its involvement in retinal vascular endothelial cell proliferation. (PMID:36418980)
• Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis. (PMID:38748366)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.