PCGEM1

Summary

PCGEM1 (PCGEM1 prostate-specific transcript, HGNC:30145) is a long non-coding RNA gene on chromosome 2q32.3.

This gene produces a long non-coding RNA that is overexpressed in prostate cancer and may act a marker for tumor progression. This RNA may act a negative regulator of apoptosis, and may promote activity of androgen receptor and Myc.

Source: NCBI Gene 64002 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30145
Approved symbol	PCGEM1
Name	PCGEM1 prostate-specific transcript
Location	2q32.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00071, LINC00071, PCAT9
Ensembl gene	ENSG00000227418
Ensembl biotype	lncRNA
OMIM	605443
Entrez	64002
RNAcentral	URS00007479E9 — lncRNA, 1603 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000454040, ENST00000606314, ENST00000826526, ENST00000826527

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000454040 — 3 exons

Exon	Start	End
ENSE00001626296	192750789	192750872
ENSE00001696544	192775578	192776899
ENSE00001741814	192749845	192750028

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 65.05.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	65.05	gold quality
prostate gland	UBERON:0002367	64.20	gold quality
colonic epithelium	UBERON:0000397	60.29	silver quality
prefrontal cortex	UBERON:0000451	56.26	gold quality
monocyte	CL:0000576	49.76	silver quality
frontal cortex	UBERON:0001870	48.85	silver quality
amygdala	UBERON:0001876	48.74	gold quality
islet of Langerhans	UBERON:0000006	48.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	48.24	gold quality
primary visual cortex	UBERON:0002436	47.91	silver quality
muscle of leg	UBERON:0001383	46.82	silver quality
multicellular organism	UBERON:0000468	46.20	gold quality
adult mammalian kidney	UBERON:0000082	46.11	gold quality
gastrocnemius	UBERON:0001388	46.09	silver quality
blood	UBERON:0000178	45.79	silver quality
thoracic mammary gland	UBERON:0005200	45.65	gold quality
body of pancreas	UBERON:0001150	44.81	silver quality
kidney	UBERON:0002113	44.68	gold quality
tibial artery	UBERON:0007610	44.06	silver quality
heart left ventricle	UBERON:0002084	43.50	silver quality
vermiform appendix	UBERON:0001154	43.37	silver quality
cerebellar hemisphere	UBERON:0002245	43.37	silver quality
left ovary	UBERON:0002119	42.98	silver quality
body of stomach	UBERON:0001161	42.94	silver quality
subcutaneous adipose tissue	UBERON:0002190	42.87	silver quality
vagina	UBERON:0000996	42.69	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	42.48	silver quality
right hemisphere of cerebellum	UBERON:0014890	42.12	silver quality
lower esophagus muscularis layer	UBERON:0035833	42.02	silver quality
thoracic aorta	UBERON:0001515	41.96	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 30)

• cell proliferation/colony formation-promoting functions of PCGEM1 and the association of its increased expression with high-risk CaP patients suggest the potential roles of PCGEM1 in CaP onset/progression, especially in these high-risk groups (PMID:14724589)
• Apoptosis is regulated by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. (PMID:16569192)
• We demonstrated for the first time that cholesterols upregulated the expression of PCGEM1 even in androgen-insensitive prostate cancer cell lines (PMID:19186008)
• PCGEM1 polymorphisms may contribute to prostate cancer risk. (PMID:23459097)
• PRNCR1 and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells (PMID:23945587)
• we conclusively demonstrate that PCGEM1 and PRNCR1 are not prognostic lncRNAs in prostate cancer and we refute suggestions that these lncRNAs interact in androgen receptor signaling. (PMID:24727738)
• We demonstrate a reciprocal negative control relationship between PCGEM1 and miR-145 that regulates both LNCaP cell proliferation and nu/nu PCa tumor growth. (PMID:25200485)
• By being a coactivator for both c-Myc and AR, PCGEM1 reprograms the androgen network and the central metabolism in a tumor-specific way, making it a promising target for therapeutic intervention. (PMID:25512540)
• PCGEM1 was uniformly distributed in PCa cell nucleus and cytoplasm which remained unaltered upon AR transcriptional activation. (PMID:25744782)
• overexpression of PCGEM1 in synoviocytes suppressed miR-770 by direct binding (PMID:26340084)
• we demonstrate an androgen deprivation-mediated AR3 expression involving PCGEM1 and splicing factors in prostate cancer (PMID:26848868)
• PCGME1 silencing by small interfering RNA significantly induced early cell apoptosis but this effect was reduced by a miR148a inhibitor. In conclusion, the present study demonstrated a positive regulatory association between MEF2 and PCGEM1, and a reciprocal negative regulatory association between PCGEM1 and miR148a that controls cell apoptosis. (PMID:29749452)
• PCGEM1 may be an inducer in epithelial ovarian cancer tumorigenesis and progression by upregulating RhoA and the subsequent expression of YAP, P70S6K, MMP2, and Bcl-xL. (PMID:29949791)
• ROC curve showed that the area values under the curve of exosomal lncRNA PCGEM1 were 0.879, 0.757, and 0.593, respectively (PMID:30128669)
• we confirmed that PCGEM1 could upregulate the expression of STAT3 by acting as a competing endogenous RNA for miR-129-5p, thereby affecting the occurrence and development of endometrial carcinoma (PMID:30257404)
• High expression of PCGEM1 is associated with invasion and metastasis of gastric cancer. (PMID:30690667)
• LncRNA PCGEM1 promotes renal carcinoma progression by targeting miR-433-3p to regulate FGF2 expression. (PMID:31958075)
• Exosome-transmitted lncRNA PCGEM1 promotes invasive and metastasis in gastric cancer by maintaining the stability of SNAI1. (PMID:32519176)
• LncRNA PCGEM1 enhances metastasis and gastric cancer invasion through targeting of miR-129-5p to regulate P4HA2 expression. (PMID:32622013)
• LncRNA PCGEM1 accelerates non-small cell lung cancer progression via sponging miR-433-3p to upregulate WTAP. (PMID:32787827)
• [Mechanism of long-chain noncoding RNA PCGEM1 in the regulation of the invasion and metastasis of oral squamous carcinoma cells via transforming growth factor beta2/Smad2 signaling pathway]. (PMID:33085241)
• Down-regulation of lncRNA PCGEM1 inhibits cervical carcinoma by modulating the miR-642a-5p/LGMN axis. (PMID:33121976)
• LncRNA PCGEM1 contributes to malignant behaviors of glioma by regulating miR-539-5p/CDK6 axis. (PMID:33589577)
• Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1beta-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes. (PMID:34160339)
• PCGEM1 promotes proliferation, migration and invasion in prostate cancer by sponging miR-506 to upregulate TRIAP1. (PMID:35109849)
• Long non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression. (PMID:35412947)
• LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis. (PMID:35872368)
• lncRNA PCGEM1 Regulates the Progress of Colorectal Cancer through Targeting miR-129-5p/SOX4. (PMID:36193492)
• A review on the role of PCGEM1 lncRNA in cancer. (PMID:36403313)
• Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1. (PMID:36782343)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.