PCGF3

Summary

PCGF3 (polycomb group ring finger 3, HGNC:10066) is a protein-coding gene on chromosome 4p16.3, encoding Polycomb group RING finger protein 3 (Q3KNV8). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.

The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined.

Source: NCBI Gene 10336 — RefSeq curated summary.

At a glance

• GWAS associations: 25
• Clinical variants (ClinVar): 41 total
• MANE Select transcript: NM_006315

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10066
Approved symbol	PCGF3
Name	polycomb group ring finger 3
Location	4p16.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ36550, DONG1, RNF3A, MGC40413
Ensembl gene	ENSG00000185619
Ensembl biotype	protein_coding
OMIM	617543
Entrez	10336

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 22 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000362003, ENST00000400151, ENST00000419774, ENST00000427463, ENST00000430644, ENST00000433814, ENST00000440452, ENST00000470161, ENST00000475288, ENST00000482726, ENST00000484141, ENST00000488032, ENST00000620529, ENST00000870362, ENST00000870363, ENST00000870364, ENST00000917776, ENST00000917777, ENST00000954672, ENST00000954673, ENST00000954674, ENST00000954675, ENST00000954676, ENST00000954677, ENST00000954678, ENST00000954679, ENST00000954680, ENST00000954681

RefSeq mRNA: 9 — MANE Select: NM_006315 NM_001317836, NM_001395245, NM_001395246, NM_001395247, NM_001395248, NM_001395249, NM_001395250, NM_001395251, NM_006315

CCDS: CCDS3339

Canonical transcript exons

ENST00000362003 — 11 exons

Exon	Start	End
ENSE00001354120	730970	731110
ENSE00001354124	730630	730668
ENSE00003495438	734931	735027
ENSE00003543410	733672	733789
ENSE00003569995	743474	743584
ENSE00003580193	744600	744688
ENSE00003633495	761279	761416
ENSE00003654200	737466	737521
ENSE00003669111	764984	765064
ENSE00003978152	705832	705970
ENSE00003978153	766032	770089

Expression profiles

Bgee: expression breadth ubiquitous, 286 present calls, max score 96.36.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.6190 / max 137.5056, expressed in 1813 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
46515	11.7034	1803
46514	10.2795	1792
46516	0.6173	344
46517	0.0123	5
46518	0.0065	3

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.36	gold quality
left ovary	UBERON:0002119	96.26	gold quality
lower esophagus mucosa	UBERON:0035834	96.02	gold quality
skin of abdomen	UBERON:0001416	95.76	gold quality
skin of leg	UBERON:0001511	95.64	gold quality
right ovary	UBERON:0002118	95.62	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.55	gold quality
cerebellar hemisphere	UBERON:0002245	95.50	gold quality
cerebellar cortex	UBERON:0002129	95.22	gold quality
granulocyte	CL:0000094	95.21	gold quality
endocervix	UBERON:0000458	95.14	gold quality
body of uterus	UBERON:0009853	95.14	gold quality
right lobe of thyroid gland	UBERON:0001119	95.12	gold quality
right lung	UBERON:0002167	95.06	gold quality
minor salivary gland	UBERON:0001830	94.90	gold quality
cortical plate	UBERON:0005343	94.89	gold quality
right adrenal gland cortex	UBERON:0035827	94.86	gold quality
left lobe of thyroid gland	UBERON:0001120	94.80	gold quality
ganglionic eminence	UBERON:0004023	94.66	gold quality
ectocervix	UBERON:0012249	94.61	gold quality
cerebellum	UBERON:0002037	94.54	gold quality
right uterine tube	UBERON:0001302	94.49	gold quality
tibia	UBERON:0000979	94.48	gold quality
small intestine Peyer’s patch	UBERON:0003454	94.48	gold quality
left uterine tube	UBERON:0001303	94.32	gold quality
ovary	UBERON:0000992	94.30	gold quality
left adrenal gland cortex	UBERON:0035825	94.22	gold quality
tibial nerve	UBERON:0001323	94.21	gold quality
zone of skin	UBERON:0000014	94.18	gold quality
spleen	UBERON:0002106	94.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.57

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

231 targeting PCGF3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-1184	99.99	68.19	1458

Literature-anchored findings (GeneRIF, showing 3)

• We demonstrate that promoter binding by TRF2 mediates PCGF3 promoter activity, and both the N-terminal and C-terminal domains of TRF2 are necessary for promoter activity. (PMID:29589913)
• PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study. (PMID:32397904)
• PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway. (PMID:33485844)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Pcgf3	ENSMUSG00000033623
rattus_norvegicus	Pcgf3	ENSRNOG00000000062
drosophila_melanogaster	l(3)73Ah	FBGN0002283
caenorhabditis_elegans		WBGENE00008684

Paralogs (7): PCGF1 (ENSG00000115289), RNF2 (ENSG00000121481), PCGF6 (ENSG00000156374), BMI1 (ENSG00000168283), PCGF5 (ENSG00000180628), RING1 (ENSG00000204227), PCGF2 (ENSG00000277258)

Protein

Protein identifiers

Polycomb group RING finger protein 3 — Q3KNV8 (reviewed: Q3KNV8)

Alternative names: RING finger protein 3A

All UniProt accessions (7): A0A087WVH5, B5MEC4, C9J3G7, C9JGV3, C9JYD0, Q3KNV8, F2Z3P3

UniProt curated annotations — full annotation on UniProt →

Function. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A ‘Lys-119’ on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females.

Subunit / interactions. Component of a PRC1-like complex that contains PCGF3, RNF2 and RYBP. Interacts with CBX6, CBX7 and CBX8. Interacts with BCORL1.

Subcellular location. Nucleus. Nucleoplasm.

Isoforms (2)

UniProt ID	Names	Canonical?
Q3KNV8-1	1	yes
Q3KNV8-2	2

RefSeq proteins (9): NP_001304765, NP_001382174, NP_001382175, NP_001382176, NP_001382177, NP_001382178, NP_001382179, NP_001382180, NP_006306* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001841	Znf_RING	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR017907	Znf_RING_CS	Conserved_site
IPR032443	RAWUL	Domain
IPR051507	PcG_RING_finger	Family

Pfam: PF13923, PF16207

UniProt features (6 total): region of interest 2, chain 1, zinc finger region 1, compositionally biased region 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q3KNV8-F1	85.76	0.75

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 197 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, TTTGTAG_MIR520D, TATTATA_MIR374, BROWNE_HCMV_INFECTION_16HR_UP, MODULE_503, CCATCCA_MIR432, LI_WILMS_TUMOR_ANAPLASTIC_UP, GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC, BROWNE_HCMV_INFECTION_24HR_UP, ONKEN_UVEAL_MELANOMA_UP, MODULE_195, GENTILE_UV_RESPONSE_CLUSTER_D2, GENTILE_UV_HIGH_DOSE_DN, chr4p16, MODULE_147

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), random inactivation of X chromosome (GO:0060816)

GO Molecular Function (4): zinc ion binding (GO:0008270), histone H2AK119 ubiquitin ligase activity (GO:0140862), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (6): X chromosome (GO:0000805), nucleus (GO:0005634), nucleoplasm (GO:0005654), PcG protein complex (GO:0031519), PRC1 complex (GO:0035102), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
dosage compensation by inactivation of X chromosome	1
transition metal ion binding	1
histone H2A ubiquitin ligase activity	1
binding	1
cation binding	1
sex chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
nuclear protein-containing complex	1
nuclear ubiquitin ligase complex	1
PcG protein complex	1

Protein interactions and networks

STRING

964 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PCGF3	RING1	Q06587	981
PCGF3	ZNRF3	Q9ULT6	968
PCGF3	RYBP	Q8N488	921
PCGF3	PCGF5	Q86SE9	913
PCGF3	YAF2	Q8IY57	903
PCGF3	HNRNPK	P61978	843
PCGF3	PCGF2	P35227	805
PCGF3	PCGF6	Q9BYE7	777
PCGF3	PCGF1	Q9BSM1	755
PCGF3	AUTS2	Q8WXX7	736
PCGF3	FBRS	Q9HAH7	682
PCGF3	BMI1	P35226	681
PCGF3	R4GMX3	R4GMX3	681
PCGF3	RNF2	Q99496	679
PCGF3	RNF5	Q99942	644

IntAct

77 interactions, top by confidence:

A	B	Type	Score
CBX8	BMI1	psi-mi:“MI:0914”(association)	0.970
CBX7	BMI1	psi-mi:“MI:0914”(association)	0.940
RYBP	CSNK2A2	psi-mi:“MI:0914”(association)	0.900
RYBP	BMI1	psi-mi:“MI:0914”(association)	0.850
CSNK2A2	EIF3J	psi-mi:“MI:0914”(association)	0.790
RYBP	E2F6	psi-mi:“MI:0914”(association)	0.740
RING1	CBX4	psi-mi:“MI:0914”(association)	0.730
RNF2	E2F6	psi-mi:“MI:0914”(association)	0.730
DCAF7	DIAPH1	psi-mi:“MI:0914”(association)	0.730
RING1	PCGF3	psi-mi:“MI:0915”(physical association)	0.720
PCGF3	RNF2	psi-mi:“MI:0915”(physical association)	0.720
RNF2	PCGF3	psi-mi:“MI:0915”(physical association)	0.720
CBX8	PCGF3	psi-mi:“MI:0915”(physical association)	0.690
PCGF3	CBX8	psi-mi:“MI:0407”(direct interaction)	0.690
CBX7	PCGF3	psi-mi:“MI:0915”(physical association)	0.660
PCGF3	CBX7	psi-mi:“MI:0407”(direct interaction)	0.660
CSNK2B	RPS6KA5	psi-mi:“MI:0914”(association)	0.660
CSNK2B	NMT2	psi-mi:“MI:0914”(association)	0.660
RNF2	CBX4	psi-mi:“MI:0914”(association)	0.660
YAF2	E2F6	psi-mi:“MI:0914”(association)	0.640
CSNK2B	RPS6KA4	psi-mi:“MI:0914”(association)	0.640
CSNK2A2	PES1	psi-mi:“MI:0914”(association)	0.640
CSNK2A1	SURF6	psi-mi:“MI:0914”(association)	0.590

BioGRID (182): PCGF3 (Two-hybrid), PCGF3 (Two-hybrid), BCOR (Two-hybrid), PCGF3 (Affinity Capture-MS), PCGF3 (Affinity Capture-MS), PCGF3 (Affinity Capture-MS), PCGF3 (Affinity Capture-MS), PCGF3 (Affinity Capture-MS), RNF2 (Reconstituted Complex), PCGF3 (Biochemical Activity), UBE2D3 (Reconstituted Complex), PCGF3 (Reconstituted Complex), PCGF3 (Affinity Capture-MS), PCGF3 (Affinity Capture-MS), PCGF3 (Affinity Capture-MS)

ESM2 similar proteins: A1A5C7, A6H7A0, B0BMW8, B0CM95, B0KWE9, B1MTH4, B2KI79, O43688, O62772, O75147, P0CK96, P35438, P35439, P52875, P57791, Q05586, Q28D01, Q2KJ29, Q3KNV8, Q3SZQ2, Q3UHH2, Q4L208, Q4V899, Q5R1P0, Q5R890, Q5SP67, Q5ZJ75, Q7TPB4, Q86YN1, Q8BTQ0, Q8C6G8, Q8C811, Q8R4D1, Q8VDI9, Q8VE98, Q90812, Q9BWV1, Q9D9E0, Q9H6U8, Q9H7D7

Diamond homologs: A0JN86, B3DK16, P23798, P25916, P35226, P35227, Q07G17, Q0WX00, Q14527, Q1JPS1, Q28H21, Q2KJ29, Q2YDF9, Q32KX7, Q3KNV8, Q3UK78, Q4QR06, Q5R8L2, Q5SDR3, Q5XI70, Q640D5, Q6CJM4, Q6DLV9, Q7T3E6, Q7ZYZ7, Q86SE9, Q8BTQ0, Q8JIR0, Q8R023, Q91648, Q94AY3, Q99NA9, Q9BSM1, Q9BYE7, Q9FKW0, Q9LS86, Q9M9Y4, Q9TST0, O60106, Q19336

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	PCGF3	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 61 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SUMOylation of DNA methylation proteins	6	89.6×	4e-09
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	12	80.1×	3e-18
Transcriptional Regulation by E2F6	6	39.0×	5e-07
SUMOylation of transcription cofactors	7	37.8×	4e-08
SUMOylation of RNA binding proteins	6	31.7×	1e-06
Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)	9	29.3×	3e-09
Regulation of PTEN gene transcription	7	27.8×	3e-07
SUMOylation of chromatin organization proteins	6	21.1×	2e-05

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	6	43.0×	2e-06
negative regulation of translation	5	17.5×	8e-04
chromatin remodeling	6	7.8×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

41 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	0
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

3574 predictions. Top by Δscore:

Variant	Effect	Δscore
4:730625:CGCA:C	acceptor_loss	1.0000
4:730626:GCA:G	acceptor_loss	1.0000
4:730627:CAGGC:C	acceptor_loss	1.0000
4:730628:A:AG	acceptor_gain	1.0000
4:730628:AG:A	acceptor_gain	1.0000
4:730629:G:GT	acceptor_gain	1.0000
4:730629:G:T	acceptor_loss	1.0000
4:730629:GG:G	acceptor_gain	1.0000
4:730629:GGC:G	acceptor_gain	1.0000
4:730629:GGCGT:G	acceptor_gain	1.0000
4:730665:TCAGG:T	donor_loss	1.0000
4:730666:CAGGT:C	donor_loss	1.0000
4:730667:AGG:A	donor_loss	1.0000
4:730668:GGTA:G	donor_loss	1.0000
4:730669:G:C	donor_loss	1.0000
4:730670:T:A	donor_loss	1.0000
4:733668:GTA:G	acceptor_loss	1.0000
4:733669:TAGAA:T	acceptor_gain	1.0000
4:733670:A:AG	acceptor_gain	1.0000
4:733670:AGAAG:A	acceptor_gain	1.0000
4:733671:G:GT	acceptor_gain	1.0000
4:733671:GA:G	acceptor_gain	1.0000
4:733671:GAA:G	acceptor_gain	1.0000
4:733671:GAAGC:G	acceptor_gain	1.0000
4:733790:G:GG	donor_gain	1.0000
4:733816:G:GT	donor_gain	1.0000
4:733817:G:T	donor_gain	1.0000
4:737464:A:AG	acceptor_gain	1.0000
4:737465:G:GA	acceptor_gain	1.0000
4:737465:GTC:G	acceptor_gain	1.0000

AlphaMissense

1616 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:733724:T:A	I15N	1.000
4:733729:T:A	C17S	1.000
4:733729:T:C	C17R	1.000
4:733730:G:A	C17Y	1.000
4:733730:G:C	C17S	1.000
4:733730:G:T	C17F	1.000
4:733731:C:G	C17W	1.000
4:733738:T:A	C20S	1.000
4:733738:T:C	C20R	1.000
4:733739:G:A	C20Y	1.000
4:733739:G:C	C20S	1.000
4:733739:G:T	C20F	1.000
4:733740:C:G	C20W	1.000
4:733744:G:T	G22W	1.000
4:733745:G:A	G22E	1.000
4:733745:G:T	G22V	1.000
4:733747:T:C	Y23H	1.000
4:733751:T:C	L24P	1.000
4:733760:C:A	A27D	1.000
4:733766:C:A	T29K	1.000
4:733769:T:A	V30E	1.000
4:733774:G:A	E32K	1.000
4:733775:A:T	E32V	1.000
4:733777:T:A	C33S	1.000
4:733777:T:C	C33R	1.000
4:733778:G:A	C33Y	1.000
4:733778:G:C	C33S	1.000
4:733778:G:T	C33F	1.000
4:733779:T:G	C33W	1.000
4:733781:T:A	L34Q	1.000

dbSNP variants (sampled 300 via entrez): RS1000006109 (4:769010 G>A), RS1000045520 (4:717673 C>T), RS1000049992 (4:737412 A>G), RS1000074377 (4:769577 G>A,C,T), RS1000213127 (4:748701 C>G,T), RS1000224039 (4:735609 C>G), RS1000277082 (4:767584 C>G,T), RS1000324774 (4:704887 C>G,T), RS1000413032 (4:733321 T>G), RS10004172 (4:739433 C>A,G), RS1000431285 (4:764667 C>A,T), RS1000436839 (4:733519 A>G), RS1000468389 (4:720148 G>A,C,T), RS1000468936 (4:752561 G>A), RS1000493017 (4:750380 A>G)

Disease associations

OMIM: gene MIM:617543 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

25 associations (top):

Study	Trait	p-value
GCST001378_6	Hemostatic factors and hematological phenotypes	6.000000e-06
GCST004608_83	Granulocyte percentage of myeloid white cells	2.000000e-11
GCST004609_120	Monocyte percentage of white cells	2.000000e-10
GCST004610_64	White blood cell count	5.000000e-09
GCST004613_103	Sum neutrophil eosinophil counts	4.000000e-11
GCST004614_144	Granulocyte count	7.000000e-11
GCST004620_140	Sum basophil neutrophil counts	2.000000e-11
GCST004626_32	Myeloid white cell count	1.000000e-09
GCST004629_56	Neutrophil count	1.000000e-11
GCST004865_73	Itch intensity from mosquito bite adjusted by bite size	7.000000e-06
GCST005316_146	Intelligence (MTAG)	1.000000e-08
GCST006269_1225	General cognitive ability	5.000000e-08
GCST006979_315	Heel bone mineral density	6.000000e-17
GCST009379_150	Type 2 diabetes	8.000000e-06
GCST009379_151	Type 2 diabetes	4.000000e-14
GCST009379_152	Type 2 diabetes	4.000000e-07
GCST010118_34	Type 2 diabetes	3.000000e-16
GCST011769_12	Schizophrenia	2.000000e-09
GCST90000025_251	Appendicular lean mass	3.000000e-10
GCST90002394_268	Monocyte percentage of white cells	5.000000e-28
GCST90002398_441	Neutrophil count	8.000000e-28
GCST90002399_411	Neutrophil percentage of white cells	4.000000e-17
GCST90002407_421	White blood cell count	6.000000e-22
GCST90020025_1039	Waist-to-hip ratio adjusted for BMI	2.000000e-08
GCST90020027_1862	Waist-hip index	2.000000e-08

EFO canonical traits (15, from GWAS)

EFO ID	Trait name
EFO:0004503	hematological measurement
EFO:0004637	protein S measurement
EFO:0007997	granulocyte percentage of myeloid white cells
EFO:0007989	monocyte percentage of leukocytes
EFO:0004833	neutrophil count
EFO:0004842	eosinophil count
EFO:0007987	granulocyte count
EFO:0005090	basophil count
EFO:0008377	mosquito bite reaction itch intensity measurement
EFO:0008378	mosquito bite reaction size measurement
EFO:0004337	intelligence
EFO:0009270	heel bone mineral density
EFO:0004980	appendicular lean mass
EFO:0007990	neutrophil percentage of leukocytes
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs1044147	PCGF3		0.00	0

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic	affects methylation, affects cotreatment, decreases expression, increases abundance	2
Benzo(a)pyrene	affects methylation	2
Valproic Acid	decreases expression, increases methylation	2
Aflatoxin B1	decreases methylation, increases methylation	2
bisphenol A	decreases methylation	1
trichostatin A	decreases expression	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	decreases expression, increases abundance, affects cotreatment	1
butyraldehyde	decreases expression	1
benzo(e)pyrene	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
monomethylarsonous acid	increases expression	1
Bortezomib	increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	increases methylation	1
Atrazine	increases expression	1
Folic Acid	increases expression	1
Methapyrilene	increases methylation	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Antirheumatic Agents	decreases expression	1
Cadmium Chloride	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2G9	HAP1 PCGF3 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.