PCGF5

Summary

PCGF5 (polycomb group ring finger 5, HGNC:28264) is a protein-coding gene on chromosome 10q23.32, encoding Polycomb group RING finger protein 5 (Q86SE9). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.

Predicted to enable histone H2AK119 ubiquitin ligase activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; centrosome; and nucleoplasm. Part of PcG protein complex.

Source: NCBI Gene 84333 — RefSeq curated summary.

At a glance

• GWAS associations: 11
• Clinical variants (ClinVar): 32 total
• MANE Select transcript: NM_032373

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28264
Approved symbol	PCGF5
Name	polycomb group ring finger 5
Location	10q23.32
Locus type	gene with protein product
Status	Approved
Aliases	MGC16202
Ensembl gene	ENSG00000180628
Ensembl biotype	protein_coding
OMIM	617407
Entrez	84333

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 22 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000336126, ENST00000490164, ENST00000496708, ENST00000543648, ENST00000614189, ENST00000888206, ENST00000888207, ENST00000888208, ENST00000888209, ENST00000888210, ENST00000888211, ENST00000888212, ENST00000888213, ENST00000888214, ENST00000888215, ENST00000888216, ENST00000888217, ENST00000888218, ENST00000888219, ENST00000888220, ENST00000888221, ENST00000942712, ENST00000942713, ENST00000942714

RefSeq mRNA: 3 — MANE Select: NM_032373 NM_001256549, NM_001257101, NM_032373

CCDS: CCDS7413

Canonical transcript exons

ENST00000336126 — 10 exons

Exon	Start	End
ENSE00001338260	91271638	91271697
ENSE00001338263	91264431	91264520
ENSE00001338266	91261326	91261424
ENSE00001338268	91251292	91251440
ENSE00001338271	91248665	91248724
ENSE00001338274	91248505	91248560
ENSE00001338277	91240484	91240580
ENSE00001403390	91278269	91284337
ENSE00001931090	91220663	91220836
ENSE00003478992	91222689	91222983

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 97.75.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 42.3806 / max 1485.3660, expressed in 1817 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
106203	15.8312	1705
106209	13.0471	1754
106211	7.1670	1373
106208	2.5655	1307
106201	2.0878	906
106202	1.2903	639
106204	0.2679	59
106207	0.1026	25
106206	0.0212	6

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cardiac muscle of right atrium	UBERON:0003379	97.75	gold quality
left ventricle myocardium	UBERON:0006566	97.62	gold quality
blood	UBERON:0000178	96.87	gold quality
myocardium	UBERON:0002349	96.68	gold quality
substantia nigra pars compacta	UBERON:0001965	96.51	gold quality
upper arm skin	UBERON:0004263	96.49	gold quality
superior vestibular nucleus	UBERON:0007227	96.40	gold quality
saphenous vein	UBERON:0007318	96.31	gold quality
substantia nigra pars reticulata	UBERON:0001966	96.19	gold quality
monocyte	CL:0000576	96.09	gold quality
medulla oblongata	UBERON:0001896	96.05	gold quality
oocyte	CL:0000023	96.03	gold quality
lateral nuclear group of thalamus	UBERON:0002736	95.98	gold quality
leukocyte	CL:0000738	95.93	gold quality
urethra	UBERON:0000057	95.85	gold quality
globus pallidus	UBERON:0001875	95.66	gold quality
medial globus pallidus	UBERON:0002477	95.60	gold quality
lateral globus pallidus	UBERON:0002476	95.59	gold quality
subthalamic nucleus	UBERON:0001906	95.42	gold quality
sperm	CL:0000019	95.22	gold quality
germinal epithelium of ovary	UBERON:0001304	95.18	gold quality
deltoid	UBERON:0001476	95.09	gold quality
tibialis anterior	UBERON:0001385	95.02	gold quality
dorsal plus ventral thalamus	UBERON:0001897	95.02	gold quality
gastrocnemius	UBERON:0001388	95.00	gold quality
pons	UBERON:0000988	94.93	gold quality
epithelial cell of pancreas	CL:0000083	94.85	gold quality
muscle of leg	UBERON:0001383	94.84	gold quality
renal medulla	UBERON:0000362	94.76	gold quality
adrenal tissue	UBERON:0018303	94.76	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-13	yes	7.84
E-MTAB-9388	yes	7.57
E-HCAD-10	yes	4.17
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

264 targeting PCGF5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	pcgf5b	ENSDARG00000052388
mus_musculus	Pcgf5	ENSMUSG00000024805
rattus_norvegicus	Pcgf5	ENSRNOG00000018532
drosophila_melanogaster	Psc	FBGN0005624
drosophila_melanogaster	Su(z)2	FBGN0265623

Paralogs (7): PCGF1 (ENSG00000115289), RNF2 (ENSG00000121481), PCGF6 (ENSG00000156374), BMI1 (ENSG00000168283), PCGF3 (ENSG00000185619), RING1 (ENSG00000204227), PCGF2 (ENSG00000277258)

Protein

Protein identifiers

Polycomb group RING finger protein 5 — Q86SE9 (reviewed: Q86SE9)

Alternative names: RING finger protein 159

All UniProt accessions (1): Q86SE9

UniProt curated annotations — full annotation on UniProt →

Function. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A ‘Lys-119’ on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females.

Subunit / interactions. Component of a PRC1-like complex that contains PCGF5, RNF2 and UBE2D3. Interacts with RNF2; the interaction is direct. Interacts with CBX6, CBX7 and CBX8. Interacts with AUTS2; the interaction is direct. Identified in a complex that contains AUTS2, PCGF5, CSNK2B and RNF2.

Subcellular location. Nucleus. Nucleoplasm.

Isoforms (2)

UniProt ID	Names	Canonical?
Q86SE9-1	1	yes
Q86SE9-2	2

RefSeq proteins (3): NP_001243478, NP_001244030, NP_115749* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001841	Znf_RING	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR017907	Znf_RING_CS	Conserved_site
IPR032443	RAWUL	Domain
IPR051507	PcG_RING_finger	Family

Pfam: PF13923, PF16207

UniProt features (21 total): helix 6, strand 4, turn 4, compositionally biased region 2, splice variant 2, chain 1, zinc finger region 1, region of interest 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4S3O	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86SE9-F1	81.17	0.59

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

MSigDB gene sets: 274 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, BENPORATH_ES_WITH_H3K27ME3, GGTGTGT_MIR329, MYOGENIN_Q6, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GOZGIT_ESR1_TARGETS_DN, GTCTACC_MIR379, GGGTGGRR_PAX4_03, IWANAGA_E2F1_TARGETS_INDUCED_BY_SERUM, GOCC_MICROTUBULE_ORGANIZING_CENTER, IRF7_01, GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC, FOSTER_TOLERANT_MACROPHAGE_UP, KOYAMA_SEMA3B_TARGETS_UP, GOCC_CENTROSOME

GO Biological Process (4): regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of transcription by RNA polymerase II (GO:0045944), random inactivation of X chromosome (GO:0060816), regulation of gene expression (GO:0010468)

GO Molecular Function (4): zinc ion binding (GO:0008270), histone H2AK119 ubiquitin ligase activity (GO:0140862), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (7): X chromosome (GO:0000805), nucleus (GO:0005634), nucleoplasm (GO:0005654), Golgi apparatus (GO:0005794), centrosome (GO:0005813), PcG protein complex (GO:0031519), PRC1 complex (GO:0035102)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Transcriptional regulation by RUNX1	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transcription by RNA polymerase II	2
intracellular membrane-bounded organelle	2
regulation of DNA-templated transcription	1
regulation of transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
dosage compensation by inactivation of X chromosome	1
gene expression	1
regulation of macromolecule biosynthetic process	1
transition metal ion binding	1
histone H2A ubiquitin ligase activity	1
binding	1
cation binding	1
sex chromosome	1
nuclear lumen	1
cellular anatomical structure	1
cytoplasm	1
endomembrane system	1
centriole	1
microtubule organizing center	1
nuclear protein-containing complex	1
nuclear ubiquitin ligase complex	1
PcG protein complex	1

Protein interactions and networks

STRING

882 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PCGF5	RYBP	Q8N488	952
PCGF5	RING1	Q06587	927
PCGF5	PCGF3	Q3KNV8	913
PCGF5	YAF2	Q8IY57	862
PCGF5	AUTS2	Q8WXX7	812
PCGF5	PCGF2	P35227	809
PCGF5	PCGF1	Q9BSM1	789
PCGF5	RNF2	Q99496	774
PCGF5	BMI1	P35226	682
PCGF5	R4GMX3	R4GMX3	681
PCGF5	FBRS	Q9HAH7	679
PCGF5	PCGF6	Q9BYE7	646
PCGF5	PHC1	P78364	621
PCGF5	FBRSL1	Q9HCM7	610
PCGF5	A0A087WY85	A0A087WY85	599

IntAct

109 interactions, top by confidence:

A	B	Type	Score
CBX8	BMI1	psi-mi:“MI:0914”(association)	0.970
RYBP	CSNK2A2	psi-mi:“MI:0914”(association)	0.900
RNF2	PCGF5	psi-mi:“MI:0914”(association)	0.890
PCGF5	RNF2	psi-mi:“MI:0915”(physical association)	0.890
PCGF5	CSNK2A2	psi-mi:“MI:0914”(association)	0.880
RING1	PCGF5	psi-mi:“MI:0915”(physical association)	0.860
PCGF5	RING1	psi-mi:“MI:0915”(physical association)	0.860
AUTS2	PCGF5	psi-mi:“MI:0915”(physical association)	0.790
AUTS2	PCGF5	psi-mi:“MI:0914”(association)	0.790
PCGF5	AUTS2	psi-mi:“MI:0914”(association)	0.790
CSNK2A2	EIF3J	psi-mi:“MI:0914”(association)	0.790
AUTS2	CSNK2B	psi-mi:“MI:0914”(association)	0.760
RYBP	E2F6	psi-mi:“MI:0914”(association)	0.740
RING1	CBX4	psi-mi:“MI:0914”(association)	0.730
RNF2	E2F6	psi-mi:“MI:0914”(association)	0.730
PCGF5	CBX8	psi-mi:“MI:0407”(direct interaction)	0.720
CSNK2B	RPS6KA5	psi-mi:“MI:0914”(association)	0.660
CSNK2B	NMT2	psi-mi:“MI:0914”(association)	0.660
RNF2	CBX4	psi-mi:“MI:0914”(association)	0.660
YAF2	E2F6	psi-mi:“MI:0914”(association)	0.640
CSNK2A2	PES1	psi-mi:“MI:0914”(association)	0.640
CSNK2A1	SURF6	psi-mi:“MI:0914”(association)	0.590
DCAF7	PFDN6	psi-mi:“MI:0914”(association)	0.570

BioGRID (211): PCGF5 (Two-hybrid), PCGF5 (Two-hybrid), PCGF5 (Two-hybrid), PCGF5 (Affinity Capture-MS), PCGF5 (Affinity Capture-MS), AUTS2 (Affinity Capture-MS), RYBP (Affinity Capture-MS), FBRS (Affinity Capture-MS), CSNK2A2 (Affinity Capture-MS), CSNK2A1 (Affinity Capture-MS), CSNK2B (Affinity Capture-MS), RNF2 (Affinity Capture-MS), RING1 (Affinity Capture-MS), YAF2 (Affinity Capture-MS), PCGF5 (Affinity Capture-MS)

ESM2 similar proteins: A0JN86, A2AHJ4, A2APV2, A2AQW0, A9JRL3, B3DK16, O08874, O35099, P0CF52, P19447, P23798, P25916, P32866, P35226, P35227, P49135, Q07139, Q1JPS1, Q1RMT1, Q21029, Q28H21, Q2YDF9, Q32KX7, Q3UK78, Q4QR06, Q5R8L2, Q5RA62, Q5SDR3, Q5ZKK7, Q640D5, Q6DD21, Q6DLV9, Q6GN16, Q6RI45, Q6ZN16, Q7T3E6, Q7Z569, Q7ZYZ7, Q86SE9, Q8BPM2

Diamond homologs: A0JN86, B3DK16, P23798, P25916, P35226, P35227, Q07G17, Q0WX00, Q14527, Q1JPS1, Q28H21, Q2KJ29, Q2YDF9, Q32KX7, Q3KNV8, Q3UK78, Q4QR06, Q5R8L2, Q5SDR3, Q5XI70, Q640D5, Q6CJM4, Q6DLV9, Q7T3E6, Q7ZYZ7, Q86SE9, Q8BTQ0, Q8JIR0, Q8R023, Q91648, Q94AY3, Q99NA9, Q9BSM1, Q9BYE7, Q9FKW0, Q9LS86, Q9M9Y4, Q9TST0, O60106, Q19336

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	PCGF5	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 103 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SUMOylation of DNA methylation proteins	6	65.0×	4e-08
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	13	63.0×	2e-18
Transcriptional Regulation by E2F6	6	28.3×	3e-06
SUMOylation of transcription cofactors	7	27.4×	6e-07
SUMOylation of RNA binding proteins	6	23.0×	9e-06
Regulation of PTEN gene transcription	7	20.1×	3e-06
Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)	8	18.9×	7e-07
Transcriptional regulation by RUNX1	7	16.5×	9e-06

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	5	23.3×	6e-04
negative regulation of translation	6	13.7×	8e-04
double-strand break repair	5	11.8×	3e-03
chromatin remodeling	9	7.6×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

32 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	17
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2158 predictions. Top by Δscore:

Variant	Effect	Δscore
10:91222669:T:TA	acceptor_gain	1.0000
10:91222672:AAT:A	acceptor_gain	1.0000
10:91222674:T:G	acceptor_gain	1.0000
10:91222674:T:TA	acceptor_gain	1.0000
10:91240482:A:AG	acceptor_gain	1.0000
10:91240482:AGTCT:A	acceptor_gain	1.0000
10:91240483:G:GG	acceptor_gain	1.0000
10:91240483:GT:G	acceptor_gain	1.0000
10:91240483:GTCT:G	acceptor_gain	1.0000
10:91240483:GTCTG:G	acceptor_gain	1.0000
10:91240581:GT:G	donor_loss	1.0000
10:91240582:T:G	donor_loss	1.0000
10:91248557:GAAC:G	donor_gain	1.0000
10:91248561:G:GG	donor_gain	1.0000
10:91248658:A:AG	acceptor_gain	1.0000
10:91248659:A:G	acceptor_gain	1.0000
10:91248663:A:AG	acceptor_gain	1.0000
10:91248664:G:GG	acceptor_gain	1.0000
10:91251281:A:AG	acceptor_gain	1.0000
10:91251284:T:G	acceptor_gain	1.0000
10:91251286:A:AG	acceptor_gain	1.0000
10:91251287:T:G	acceptor_gain	1.0000
10:91251287:TACA:T	acceptor_loss	1.0000
10:91251288:A:AG	acceptor_gain	1.0000
10:91251288:ACAG:A	acceptor_loss	1.0000
10:91251289:C:G	acceptor_gain	1.0000
10:91251289:CA:C	acceptor_loss	1.0000
10:91251290:A:AG	acceptor_gain	1.0000
10:91251290:AGAT:A	acceptor_gain	1.0000
10:91251290:AGATG:A	acceptor_loss	1.0000

AlphaMissense

1701 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:91222923:T:A	C18S	1.000
10:91222923:T:C	C18R	1.000
10:91222924:G:A	C18Y	1.000
10:91222924:G:C	C18S	1.000
10:91222924:G:T	C18F	1.000
10:91222925:C:G	C18W	1.000
10:91222932:T:A	C21S	1.000
10:91222932:T:C	C21R	1.000
10:91222933:G:A	C21Y	1.000
10:91222933:G:C	C21S	1.000
10:91222933:G:T	C21F	1.000
10:91222934:T:G	C21W	1.000
10:91222945:T:C	L25P	1.000
10:91222954:C:A	P28Q	1.000
10:91222971:T:A	C34S	1.000
10:91222971:T:C	C34R	1.000
10:91222972:G:A	C34Y	1.000
10:91222972:G:C	C34S	1.000
10:91222972:G:T	C34F	1.000
10:91222973:C:G	C34W	1.000
10:91222975:T:C	L35P	1.000
10:91222977:C:A	H36N	1.000
10:91222979:T:A	H36Q	1.000
10:91222979:T:G	H36Q	1.000
10:91222983:T:C	F38L	1.000
10:91240485:C:A	F38L	1.000
10:91240485:C:G	F38L	1.000
10:91240486:T:A	C39S	1.000
10:91240486:T:C	C39R	1.000
10:91240487:G:A	C39Y	1.000

dbSNP variants (sampled 300 via entrez): RS1000042029 (10:91250399 G>A), RS1000044383 (10:91202441 G>A), RS1000100806 (10:91163317 G>A,C,T), RS1000102663 (10:91253485 G>A,T), RS1000117652 (10:91200955 G>A), RS1000140083 (10:91249954 T>A), RS1000178390 (10:91184864 G>A), RS1000244371 (10:91169385 TCAA>T), RS1000256858 (10:91235912 T>C), RS1000289111 (10:91154229 T>G), RS1000311419 (10:91219145 T>C), RS1000315009 (10:91228850 G>T), RS1000322293 (10:91219450 C>T), RS1000359784 (10:91198882 C>G), RS1000365614 (10:91175965 G>T)

Disease associations

OMIM: gene MIM:617407 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST007576_111	Chronotype	2.000000e-08
GCST008163_487	Height	1.000000e-06
GCST010988_446	Adult body size	2.000000e-08
GCST90000025_447	Appendicular lean mass	8.000000e-13
GCST90020028_88	Hip circumference adjusted for BMI	5.000000e-13
GCST90020028_89	Hip circumference adjusted for BMI	4.000000e-13
GCST90020028_90	Hip circumference adjusted for BMI	8.000000e-09
GCST90020028_91	Hip circumference adjusted for BMI	6.000000e-09
GCST90020028_92	Hip circumference adjusted for BMI	2.000000e-10
GCST90020028_93	Hip circumference adjusted for BMI	3.000000e-09
GCST90020029_135	Waist circumference adjusted for body mass index	3.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0008328	chronotype measurement
EFO:0004980	appendicular lean mass
EFO:0008039	BMI-adjusted hip circumference
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, increases methylation	8
sodium arsenite	increases abundance, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	increases expression	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	decreases expression	1
bisphenol A	affects expression	1
trichostatin A	increases expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
butyraldehyde	decreases expression	1
nickel sulfate	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
CGP 52608	increases reaction, affects binding	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
N-butyrylglucosamine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	increases methylation	1
Sunitinib	increases expression	1
Zoledronic Acid	increases expression	1
Vorinostat	increases expression	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Demecolcine	decreases expression	1
Diethylhexyl Phthalate	increases expression	1
Succimer	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2GA	HAP1 PCGF5 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.