PCOTH

Summary

PCOTH (prostate and testis expressed opposite C1QTNF9B and MIPEP, HGNC:39839) is a long non-coding RNA gene on chromosome 13q12.12. May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.

Predicted to be located in cytoplasm.

Source: NCBI Gene 542767 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39839
Approved symbol	PCOTH
Name	prostate and testis expressed opposite C1QTNF9B and MIPEP
Location	13q12.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000205861
Ensembl biotype	lncRNA
OMIM	617122
Entrez	542767
RNAcentral	URS00022782FE — lncRNA, 825 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000382133, ENST00000417034, ENST00000663394, ENST00000849006, ENST00000849007, ENST00000849008, ENST00000849009, ENST00000849010, ENST00000849011

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000382133 — 4 exons

Exon	Start	End
ENSE00001543655	23890000	23890042
ENSE00001619644	23891385	23891531
ENSE00004279052	23888749	23889011
ENSE00004279056	23891613	23892106

Expression profiles

Bgee: expression breadth ubiquitous, 170 present calls, max score 88.50.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7586 / max 84.3529, expressed in 425 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134415	0.5022	262
134416	0.2564	64

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	88.50	gold quality
left testis	UBERON:0004533	88.47	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.53	gold quality
sperm	CL:0000019	86.25	silver quality
testis	UBERON:0000473	85.85	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.98	gold quality
male germ cell	CL:0000015	83.76	silver quality
skin of leg	UBERON:0001511	81.39	gold quality
buccal mucosa cell	CL:0002336	81.28	gold quality
skin of abdomen	UBERON:0001416	80.52	gold quality
zone of skin	UBERON:0000014	78.55	gold quality
tongue squamous epithelium	UBERON:0006919	76.10	silver quality
prostate gland	UBERON:0002367	75.21	gold quality
apex of heart	UBERON:0002098	74.41	gold quality
minor salivary gland	UBERON:0001830	73.98	gold quality
stromal cell of endometrium	CL:0002255	72.86	gold quality
mouth mucosa	UBERON:0003729	71.66	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.45	gold quality
adult organism	UBERON:0007023	71.25	gold quality
saliva-secreting gland	UBERON:0001044	70.64	gold quality
esophagus mucosa	UBERON:0002469	70.46	gold quality
right atrium auricular region	UBERON:0006631	69.31	gold quality
lower esophagus mucosa	UBERON:0035834	68.57	gold quality
esophagus	UBERON:0001043	68.28	gold quality
right adrenal gland cortex	UBERON:0035827	68.20	gold quality
heart left ventricle	UBERON:0002084	68.03	gold quality
right adrenal gland	UBERON:0001233	67.71	gold quality
cardiac atrium	UBERON:0002081	67.63	gold quality
pancreatic ductal cell	CL:0002079	67.55	silver quality
cardiac ventricle	UBERON:0002082	67.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• PCOTH is involved in growth and survival of prostate cancer cells thorough, in parts, the TAF-Ibeta pathway. (PMID:15930275)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.