PCSEAT

Summary

PCSEAT (prostate cancer expressed EZH2 associated transcript, HGNC:54485) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54485
Approved symbol	PCSEAT
Name	prostate cancer expressed EZH2 associated transcript
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	PRCAT38
Ensembl gene	ENSG00000286027
Ensembl biotype	lncRNA
Entrez	105372808
RNAcentral	URS0000E6ADE6 — lncRNA, 2413 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000650670, ENST00000651009

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000650670 — 3 exons

Exon	Start	End
ENSE00003841450	41582599	41582766
ENSE00003846410	41581269	41581466
ENSE00003847962	41580479	41580680

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 90.13.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	90.13	gold quality
brain	UBERON:0000955	73.47	silver quality
colonic epithelium	UBERON:0000397	65.09	silver quality
rectum	UBERON:0001052	64.36	gold quality
adrenal gland	UBERON:0002369	60.87	silver quality
colon	UBERON:0001155	55.03	gold quality
transverse colon	UBERON:0001157	54.49	gold quality
mucosa of transverse colon	UBERON:0004991	53.10	gold quality
intestine	UBERON:0000160	52.22	gold quality
muscle layer of sigmoid colon	UBERON:0035805	51.82	gold quality
blood	UBERON:0000178	51.81	silver quality
lung	UBERON:0002048	50.97	silver quality
prostate gland	UBERON:0002367	50.61	gold quality
multicellular organism	UBERON:0000468	50.53	gold quality
prefrontal cortex	UBERON:0000451	49.67	silver quality
vermiform appendix	UBERON:0001154	49.32	gold quality
gastrocnemius	UBERON:0001388	47.30	silver quality
duodenum	UBERON:0002114	47.21	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	46.64	gold quality
left coronary artery	UBERON:0001626	45.82	silver quality
small intestine	UBERON:0002108	44.68	gold quality
small intestine Peyer’s patch	UBERON:0003454	43.44	silver quality
smooth muscle tissue	UBERON:0001135	43.38	gold quality
minor salivary gland	UBERON:0001830	42.38	silver quality
subcutaneous adipose tissue	UBERON:0002190	41.89	silver quality
lower esophagus muscularis layer	UBERON:0035833	41.74	gold quality
left ovary	UBERON:0002119	41.45	silver quality
esophagus mucosa	UBERON:0002469	41.03	silver quality
stomach	UBERON:0000945	40.12	silver quality
body of stomach	UBERON:0001161	39.22	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• results show chromatin looping by enhancers E1 and E2 with the promoters for PRCAT38 and TMPRSS2, indicating the co-regulation of PRCAT38 and TMPRSS2 by the same enhancers; findings demonstrate the utilization of shared enhancers in the joint regulation of two oncogenes in prostate cancer cells (PMID:31405024)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.