PCSK6-AS1

Summary

PCSK6-AS1 (PCSK6 antisense RNA 1, HGNC:51448) is a long non-coding RNA gene on chromosome 15q26.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51448
Approved symbol	PCSK6-AS1
Name	PCSK6 antisense RNA 1
Location	15q26.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259764
Ensembl biotype	lncRNA
Entrez	105371027
RNAcentral	URS00008E39B7 — lncRNA, 642 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000558696, ENST00000762431

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558696 — 3 exons

Exon	Start	End
ENSE00002548498	101337027	101337428
ENSE00002554925	101334437	101334513
ENSE00002562698	101336778	101336937

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 81.49.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.49	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.90	silver quality
bone marrow cell	CL:0002092	70.22	silver quality
skeletal muscle tissue	UBERON:0001134	64.52	silver quality
ventricular zone	UBERON:0003053	63.79	gold quality
corpus callosum	UBERON:0002336	63.02	gold quality
liver	UBERON:0002107	62.56	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.12	gold quality
muscle tissue	UBERON:0002385	60.22	silver quality
bone marrow	UBERON:0002371	58.64	silver quality
duodenum	UBERON:0002114	58.34	gold quality
right lobe of liver	UBERON:0001114	56.26	gold quality
leukocyte	CL:0000738	54.79	gold quality
monocyte	CL:0000576	54.11	gold quality
adrenal tissue	UBERON:0018303	52.67	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	52.62	gold quality
spleen	UBERON:0002106	52.02	gold quality
islet of Langerhans	UBERON:0000006	51.72	gold quality
testis	UBERON:0000473	51.48	gold quality
calcaneal tendon	UBERON:0003701	51.42	silver quality
blood	UBERON:0000178	51.14	silver quality
right testis	UBERON:0004534	50.87	gold quality
left testis	UBERON:0004533	50.63	gold quality
prefrontal cortex	UBERON:0000451	50.53	gold quality
muscle of leg	UBERON:0001383	50.17	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	49.84	gold quality
gastrocnemius	UBERON:0001388	49.55	gold quality
placenta	UBERON:0001987	49.28	gold quality
right adrenal gland	UBERON:0001233	49.10	gold quality
lymph node	UBERON:0000029	48.82	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA PSCK6-AS1-HIPK2 promotes Th1 differentiation via STAT1 phosphorylation to regulate colitis-related mucosal barrier damage. (PMID:37012876)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.