PDCD11

Summary

PDCD11 (programmed cell death 11, HGNC:13408) is a protein-coding gene on chromosome 10q24.33, encoding Protein RRP5 homolog (Q14690). Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. It is a common-essential gene (DepMap: required in 99.6% of cancer cell lines).

PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).

Source: NCBI Gene 22984 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 301 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 99.6% of screened cell lines (common-essential)
• MANE Select transcript: NM_014976

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13408
Approved symbol	PDCD11
Name	programmed cell death 11
Location	10q24.33
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0185, ALG-4, RRP5, NFBP
Ensembl gene	ENSG00000148843
Ensembl biotype	protein_coding
OMIM	612333
Entrez	22984

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 14 protein_coding, 4 retained_intron, 1 nonsense_mediated_decay

ENST00000369797, ENST00000466959, ENST00000471061, ENST00000478543, ENST00000493610, ENST00000648051, ENST00000649849, ENST00000902786, ENST00000930107, ENST00000930108, ENST00000930109, ENST00000930110, ENST00000930111, ENST00000930112, ENST00000930113, ENST00000930114, ENST00000930115, ENST00000930116, ENST00000930117

RefSeq mRNA: 2 — MANE Select: NM_014976 NM_001411058, NM_014976

CCDS: CCDS31276, CCDS91342

Canonical transcript exons

ENST00000369797 — 36 exons

Exon	Start	End
ENSE00000987739	103405985	103406108
ENSE00000987740	103406609	103406790
ENSE00000987741	103409699	103409806
ENSE00000987742	103413116	103413322
ENSE00000987743	103413966	103414090
ENSE00000987744	103414270	103414330
ENSE00000987745	103415005	103415151
ENSE00000987746	103416491	103416742
ENSE00000987747	103417792	103417932
ENSE00000987749	103419538	103419708
ENSE00001025994	103444517	103444682
ENSE00001025995	103427329	103427391
ENSE00001025997	103418440	103418634
ENSE00001025998	103439746	103439868
ENSE00001026000	103443165	103443333
ENSE00001026002	103432129	103432234
ENSE00001026003	103443915	103444068
ENSE00001026005	103442213	103442460
ENSE00001026006	103441826	103441975
ENSE00001026007	103434248	103434350
ENSE00001026008	103438686	103438808
ENSE00001026009	103434798	103434975
ENSE00001026011	103440290	103440581
ENSE00001026012	103438015	103438071
ENSE00001026013	103424984	103425525
ENSE00001026014	103440734	103440850
ENSE00001026016	103433948	103434037
ENSE00001092404	103421348	103421567
ENSE00001092405	103423543	103423658
ENSE00001092406	103422988	103423137
ENSE00001450934	103445378	103446294
ENSE00003492214	103405022	103405183
ENSE00003505969	103398416	103398528
ENSE00003649254	103403118	103403285
ENSE00003683824	103400397	103400528
ENSE00003831406	103396626	103396730

Expression profiles

Bgee: expression breadth ubiquitous, 261 present calls, max score 90.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 31.6963 / max 270.0191, expressed in 1814 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
106809	30.8141	1813
106810	0.8823	502

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.92	gold quality
sural nerve	UBERON:0015488	89.03	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.95	gold quality
left testis	UBERON:0004533	88.80	gold quality
right testis	UBERON:0004534	88.60	gold quality
testis	UBERON:0000473	87.88	gold quality
lower esophagus mucosa	UBERON:0035834	87.80	gold quality
tongue squamous epithelium	UBERON:0006919	87.75	gold quality
cervix squamous epithelium	UBERON:0006922	87.61	silver quality
mucosa of transverse colon	UBERON:0004991	86.21	gold quality
granulocyte	CL:0000094	86.17	gold quality
gastrocnemius	UBERON:0001388	85.91	gold quality
right uterine tube	UBERON:0001302	85.83	gold quality
muscle of leg	UBERON:0001383	85.52	gold quality
esophagus mucosa	UBERON:0002469	85.49	gold quality
stromal cell of endometrium	CL:0002255	85.47	gold quality
adrenal tissue	UBERON:0018303	85.44	gold quality
body of pancreas	UBERON:0001150	85.27	gold quality
tibialis anterior	UBERON:0001385	85.27	gold quality
ganglionic eminence	UBERON:0004023	85.17	gold quality
skin of leg	UBERON:0001511	85.10	gold quality
skin of abdomen	UBERON:0001416	84.98	gold quality
cortical plate	UBERON:0005343	84.93	gold quality
right ovary	UBERON:0002118	84.83	gold quality
embryo	UBERON:0000922	84.64	gold quality
pancreas	UBERON:0001264	84.42	gold quality
ventricular zone	UBERON:0003053	84.25	gold quality
left ovary	UBERON:0002119	84.11	gold quality
right lobe of liver	UBERON:0001114	84.08	gold quality
islet of Langerhans	UBERON:0000006	84.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.40

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
FASLG	Unknown

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.6% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 3)

• Evidence is presented for involvement of PDCD11 in processing of ribosomal RNA. (PMID:17654514)
• The 50S U3 snoRNP is an small subunit assembly intermediate that is likely recruited to the pre-rRNA through the RNA-binding proteins nucleolin and RRP5.[RRP5, DBP4] (PMID:19332556)
• data provide no evidence for the contribution of rare PDCD11 variations to the risk of schizophrenia in the Japanese population. (PMID:28657695)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	pdcd11	ENSDARG00000052480
mus_musculus	Pdcd11	ENSMUSG00000025047
rattus_norvegicus	Pdcd11	ENSRNOG00000020304
drosophila_melanogaster	Rrp5	FBGN0039182
caenorhabditis_elegans		WBGENE00002850

Protein

Protein identifiers

Protein RRP5 homolog — Q14690 (reviewed: Q14690)

Alternative names: NF-kappa-B-binding protein, Programmed cell death protein 11

All UniProt accessions (3): Q14690, A0A3B3IUD7, S4R3Q4

UniProt curated annotations — full annotation on UniProt →

Function. Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. Involved in the biogenesis of rRNA.

Subunit / interactions. Interacts with NF-kappa-B p50/NFKB1 and NF-kappa-B p65/RELA.

Subcellular location. Nucleus. Nucleolus.

RefSeq proteins (2): NP_001397987, NP_055791* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003029	S1_domain	Domain
IPR003107	HAT	Repeat
IPR008847	Suf	Domain
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR012340	NA-bd_OB-fold	Homologous_superfamily
IPR045209	Rrp5	Family
IPR048058	Rrp5_S1_rpt_hs11_sc8	Domain
IPR048059	Rrp5_S1_rpt_hs1_sc1	Domain
IPR057302	Rrp5_S1	Domain

Pfam: PF00575, PF05843, PF23459

UniProt features (52 total): domain 12, modified residue 8, sequence variant 7, strand 6, repeat 4, region of interest 4, compositionally biased region 4, cross-link 2, initiator methionine 1, chain 1, sequence conflict 1, turn 1, helix 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1WI5	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14690-F1	74.40	0.18

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 2, 7, 438, 1360, 1362, 1476, 1493, 1498, 1030, 1416

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-6790901	rRNA modification in the nucleus and cytosol
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72312	rRNA processing
R-HSA-8868773	rRNA processing in the nucleus and cytosol
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 89 (showing top): GOBP_RIBOSOME_BIOGENESIS, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, CAGCAGG_MIR370, MARZEC_IL2_SIGNALING_UP, LAU_APOPTOSIS_CDKN2A_UP, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, REACTOME_METABOLISM_OF_RNA, GOCC_PRERIBOSOME, GOCC_SMALL_SUBUNIT_PROCESSOME, GOCC_NUCLEOLUS, GOCC_RIBONUCLEOPROTEIN_COMPLEX, COLDREN_GEFITINIB_RESISTANCE_UP, GOMF_NF_KAPPAB_BINDING, GOMF_TRANSCRIPTION_FACTOR_BINDING, KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN

GO Biological Process (2): rRNA processing (GO:0006364), RNA processing (GO:0006396)

GO Molecular Function (4): RNA binding (GO:0003723), NF-kappaB binding (GO:0051059), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829), small-subunit processome (GO:0032040)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
rRNA processing in the nucleus and cytosol	2
Metabolism of RNA	1
rRNA processing	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
nuclear lumen	2
cellular anatomical structure	2
RNA processing	1
rRNA metabolic process	1
ribosome biogenesis	1
gene expression	1
RNA biosynthetic process	1
primary metabolic process	1
nucleic acid binding	1
RNA polymerase II-specific DNA-binding transcription factor binding	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
cytoplasm	1
nucleolus	1
preribosome	1
t-UTP complex	1
nuclear protein-containing complex	1

Protein interactions and networks

STRING

4015 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PDCD11	CEBPZ	Q03701	959
PDCD11	DDX52	Q9Y2R4	917
PDCD11	DDX10	Q13206	825
PDCD11	PWP2	Q15269	819
PDCD11	UTP20	O75691	815
PDCD11	HEATR1	Q9H583	814
PDCD11	BYSL	Q13895	812
PDCD11	NOL6	Q9H6R4	796
PDCD11	EBNA1BP2	Q99848	789
PDCD11	RRP7A	Q9Y3A4	785
PDCD11	DHX15	O43143	755
PDCD11	KRR1	Q13601	737
PDCD11	RRP12	Q5JTH9	736
PDCD11	URB1	O60287	718
PDCD11	RPF2	Q9H7B2	718
PDCD11	PAK1IP1	Q9NWT1	718

IntAct

201 interactions, top by confidence:

A	B	Type	Score
ZSCAN32	ZNF24	psi-mi:“MI:0914”(association)	0.880
PDIK1L	CTDSPL2	psi-mi:“MI:0914”(association)	0.840
SRP68	SRP72	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
FANCC	FANCA	psi-mi:“MI:0914”(association)	0.680
USE1	NBAS	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
PLEKHO1	UBA6	psi-mi:“MI:0914”(association)	0.530
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
RSBN1	SETD1A	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
RPS3	ZNF316	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
PAIP2B	CASC3	psi-mi:“MI:0914”(association)	0.530
RBM4	NVL	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530

BioGRID (452): PDCD11 (Affinity Capture-MS), PDCD11 (Affinity Capture-MS), PDCD11 (Affinity Capture-MS), PDCD11 (Affinity Capture-MS), PDCD11 (Affinity Capture-MS), PDCD11 (Affinity Capture-MS), PDCD11 (Affinity Capture-MS), PDCD11 (Affinity Capture-MS), PDCD11 (Affinity Capture-MS), PDCD11 (Affinity Capture-MS), SUPT6H (Co-fractionation), PDCD11 (Affinity Capture-RNA), PDCD11 (Affinity Capture-MS), PDCD11 (Proximity Label-MS), PDCD11 (Proximity Label-MS)

ESM2 similar proteins: A0A1L8HX76, A2RV18, A6NAF9, A7MB10, A9CPT4, E2RDV1, E7FDW8, E9PYK3, F1P4W9, F1R237, F4J8K6, O60522, O74835, O75616, P57075, P61407, Q0P4R5, Q0P5H9, Q14690, Q15061, Q3U3W5, Q3U821, Q3V3E1, Q58EK5, Q5BK48, Q5M7P8, Q5R5N8, Q5U2P0, Q6DFC6, Q6GN11, Q6NS46, Q6NU04, Q6ZQL4, Q86WJ1, Q8BGG7, Q8C0S1, Q8K1H1, Q8N0Z6, Q8R3C6, Q8TF42

Diamond homologs: A7MB10, B0R3M0, B4UHG5, B8JFZ1, P46837, P57072, P71353, Q14690, Q45388, Q51062, Q51152, Q57581, Q5UX22, Q6NS46, Q9HRT8, Q9VC94, Q9SZD6, A0KND9, A0QYY6, A1IR09, A1K7B5, A1KT19, A2SFM2, A3QGU0, A4SJR9, A4SXQ7, A5N848, A6Q4N2, A6TRK1, A8FYR5, A8H735, A8MFB4, A8ZZ59, A9KFK6, A9M3J0, A9ND62, B0TQ97, B1KRQ5, B1XUJ5, B1Y823

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 242 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	19	14.9×	3e-15
Viral mRNA Translation	19	14.9×	3e-15
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	19	14.7×	3e-15
Selenocysteine synthesis	19	14.1×	5e-15
Eukaryotic Translation Termination	19	14.1×	5e-15
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	19	13.8×	7e-15
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	19	13.8×	7e-15
Eukaryotic Translation Initiation	7	13.3×	3e-05

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	20	16.6×	5e-16
positive regulation of viral genome replication	5	13.0×	5e-03
ribosomal large subunit biogenesis	6	11.9×	2e-03
negative regulation of viral genome replication	7	11.8×	5e-04
dorsal/ventral pattern formation	6	11.3×	2e-03
ribosomal small subunit biogenesis	11	11.2×	1e-06
negative regulation of translation	12	10.5×	7e-07
translation	21	9.7×	3e-12

Disease & clinical

Clinical variants and AI predictions

ClinVar

301 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	240
Likely benign	15
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

6206 predictions. Top by Δscore:

Variant	Effect	Δscore
10:103398405:A:AG	acceptor_gain	1.0000
10:103398405:ATT:A	acceptor_gain	1.0000
10:103398406:T:G	acceptor_gain	1.0000
10:103398407:T:TA	acceptor_gain	1.0000
10:103398411:TTTAG:T	acceptor_loss	1.0000
10:103398412:TTA:T	acceptor_loss	1.0000
10:103398413:TA:T	acceptor_loss	1.0000
10:103398414:A:AG	acceptor_gain	1.0000
10:103398414:AG:A	acceptor_gain	1.0000
10:103398415:G:GT	acceptor_gain	1.0000
10:103398415:GG:G	acceptor_gain	1.0000
10:103398415:GGA:G	acceptor_gain	1.0000
10:103398415:GGAGA:G	acceptor_gain	1.0000
10:103398524:TTGAT:T	donor_gain	1.0000
10:103398525:TGAT:T	donor_gain	1.0000
10:103398526:GAT:G	donor_gain	1.0000
10:103398526:GATG:G	donor_gain	1.0000
10:103398527:AT:A	donor_gain	1.0000
10:103398529:G:GG	donor_gain	1.0000
10:103398533:GTA:G	donor_gain	1.0000
10:103400504:G:GT	donor_gain	1.0000
10:103403113:TCTA:T	acceptor_loss	1.0000
10:103403114:CTA:C	acceptor_loss	1.0000
10:103403116:A:AG	acceptor_gain	1.0000
10:103403116:AGTC:A	acceptor_loss	1.0000
10:103403117:G:GT	acceptor_gain	1.0000
10:103403117:GT:G	acceptor_gain	1.0000
10:103403117:GTC:G	acceptor_gain	1.0000
10:103403117:GTCC:G	acceptor_gain	1.0000
10:103403117:GTCCC:G	acceptor_gain	1.0000

AlphaMissense

12241 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:103442369:T:A	W1622R	0.999
10:103442369:T:C	W1622R	0.999
10:103442394:T:C	L1630P	0.999
10:103443209:T:C	L1667P	0.999
10:103443190:T:A	W1661R	0.998
10:103443190:T:C	W1661R	0.998
10:103443259:G:C	A1684P	0.998
10:103444630:T:A	W1798R	0.998
10:103444630:T:C	W1798R	0.998
10:103413167:A:C	S344R	0.997
10:103413169:C:A	S344R	0.997
10:103413169:C:G	S344R	0.997
10:103442373:T:C	L1623P	0.997
10:103442421:G:C	R1639P	0.997
10:103442438:G:C	A1645P	0.997
10:103442439:C:A	A1645D	0.997
10:103443260:C:A	A1684D	0.997
10:103443299:T:C	L1697P	0.997
10:103419632:G:A	G734D	0.996
10:103419692:G:A	G754E	0.996
10:103419698:C:A	A756D	0.996
10:103421445:G:C	R792P	0.996
10:103442417:G:C	A1638P	0.996
10:103442429:G:C	A1642P	0.996
10:103442430:C:A	A1642D	0.996
10:103443203:T:C	L1665P	0.996
10:103444541:C:A	A1768D	0.996
10:103444619:G:C	R1794P	0.996
10:103443200:T:C	L1664P	0.995
10:103445494:T:A	V1854D	0.995

dbSNP variants (sampled 300 via entrez): RS1000043549 (10:103439203 G>A), RS1000071275 (10:103403701 T>C), RS1000101911 (10:103403421 AAGTCTGGG>A), RS1000125660 (10:103419226 C>T), RS1000184300 (10:103401558 C>T), RS1000296052 (10:103395727 T>C), RS1000308596 (10:103438947 A>G,T), RS1000312489 (10:103407829 C>T), RS1000320703 (10:103408238 A>C,G), RS1000458992 (10:103435431 T>C), RS1000548339 (10:103414496 T>C), RS1000554748 (10:103421201 G>A), RS1000636224 (10:103401742 T>A), RS1000654932 (10:103428319 A>AC,AT), RS1000658501 (10:103414856 G>C)

Disease associations

OMIM: gene MIM:612333 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST002149_2	Schizophrenia	4.000000e-13
GCST002539_4	Schizophrenia	6.000000e-19
GCST003013_17	White matter hyperintensity burden	2.000000e-09
GCST003013_3	White matter hyperintensity burden	3.000000e-08
GCST004521_172	Autism spectrum disorder or schizophrenia	4.000000e-14
GCST008058_239	Estimated glomerular filtration rate	1.000000e-13
GCST008059_163	Estimated glomerular filtration rate	1.000000e-10
GCST008361_2	Response to cognitive-behavioural therapy in major depressive disorder	2.000000e-06
GCST90000025_176	Appendicular lean mass	2.000000e-14

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0005665	white matter hyperintensity measurement
EFO:0007820	cognitive behavioural therapy
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067274 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.47	Kd	33.94	nM	CHEMBL3752910
7.47	ED50	33.94	nM	CHEMBL3752910
7.14	Kd	71.72	nM	CHEMBL5653589
7.14	ED50	71.72	nM	CHEMBL5653589

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148952: Binding affinity to human PDCD11 incubated for 45 mins by Kinobead based pull down assay	kd	0.0339	uM
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148952: Binding affinity to human PDCD11 incubated for 45 mins by Kinobead based pull down assay	kd	0.0717	uM

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, increases methylation, decreases expression	2
sodium arsenite	increases expression, decreases expression, affects cotreatment, increases abundance	2
Estradiol	increases expression	2
aristolochic acid I	increases expression	1
FR900359	decreases phosphorylation	1
TAK-243	decreases sumoylation	1
dicrotophos	increases expression	1
beauvericin	decreases expression	1
triphenyl phosphate	affects expression	1
coumarin	decreases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
motexafin gadolinium	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
bisphenol S	affects expression	1
LDN 193189	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Cadmium	increases abundance, increases expression	1
Caffeine	decreases phosphorylation	1
Cannabidiol	increases expression	1
Cisplatin	decreases expression	1
Clozapine	increases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Nickel	increases expression	1
Ribonucleotides	affects binding	1
Tretinoin	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651994	Binding	Binding affinity to human PDCD11 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.