PDCD4-AS1

Summary

PDCD4-AS1 (PDCD4 antisense RNA 1, HGNC:27425) is a long non-coding RNA gene on chromosome 10q25.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27425
Approved symbol	PDCD4-AS1
Name	PDCD4 antisense RNA 1
Location	10q25.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000203497
Ensembl biotype	lncRNA
Entrez	282997
RNAcentral	URS000075AE47 — lncRNA, 2015 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000420367, ENST00000813596, ENST00000813597, ENST00000813598, ENST00000813599

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420367 — 2 exons

Exon	Start	End
ENSE00004213847	110872027	110872366
ENSE00004213852	110868890	110870438

Expression profiles

Bgee: expression breadth ubiquitous, 186 present calls, max score 87.90.

FANTOM5 (CAGE): breadth broad, TPM avg 1.5632 / max 72.6116, expressed in 625 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111401	1.3598	507
111402	0.2035	103

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	87.90	gold quality
sural nerve	UBERON:0015488	86.79	gold quality
blood	UBERON:0000178	84.79	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.46	gold quality
granulocyte	CL:0000094	80.62	gold quality
body of pancreas	UBERON:0001150	80.05	gold quality
mucosa of transverse colon	UBERON:0004991	79.14	gold quality
bone marrow cell	CL:0002092	78.83	gold quality
leukocyte	CL:0000738	76.37	gold quality
spleen	UBERON:0002106	76.36	gold quality
bone marrow	UBERON:0002371	75.94	gold quality
monocyte	CL:0000576	75.59	gold quality
mononuclear cell	CL:0000842	75.58	gold quality
pancreas	UBERON:0001264	75.13	gold quality
tibia	UBERON:0000979	75.00	gold quality
colonic epithelium	UBERON:0000397	74.84	gold quality
lymph node	UBERON:0000029	74.63	gold quality
small intestine Peyer’s patch	UBERON:0003454	74.56	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.54	gold quality
left lobe of thyroid gland	UBERON:0001120	74.50	gold quality
thyroid gland	UBERON:0002046	74.11	gold quality
transverse colon	UBERON:0001157	73.98	gold quality
vermiform appendix	UBERON:0001154	73.84	gold quality
lower esophagus mucosa	UBERON:0035834	73.68	gold quality
rectum	UBERON:0001052	72.97	gold quality
right lobe of thyroid gland	UBERON:0001119	72.30	gold quality
small intestine	UBERON:0002108	72.30	gold quality
adenohypophysis	UBERON:0002196	71.97	gold quality
body of uterus	UBERON:0009853	71.36	gold quality
left ovary	UBERON:0002119	71.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.19

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.