PDE6B-AS1

Summary

PDE6B-AS1 (PDE6B antisense RNA 1, HGNC:40438) is a long non-coding RNA gene on chromosome 4p16.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40438
Approved symbol	PDE6B-AS1
Name	PDE6B antisense RNA 1
Location	4p16.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000242686
Ensembl biotype	lncRNA
Entrez	101928521
RNAcentral	URS00026A2464 — lncRNA, 1112 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000468356, ENST00000489312, ENST00000598370, ENST00000599030

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000468356 — 4 exons

Exon	Start	End
ENSE00001836187	655082	656213
ENSE00001918115	653758	653971
ENSE00001931450	654065	654213
ENSE00001948486	653059	653683

Expression profiles

Bgee: expression breadth ubiquitous, 146 present calls, max score 85.50.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0272 / max 4.0021, expressed in 14 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
50989	0.0272	14

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right frontal lobe	UBERON:0002810	85.50	gold quality
cortical plate	UBERON:0005343	82.39	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.89	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.41	gold quality
ganglionic eminence	UBERON:0004023	80.96	gold quality
anterior cingulate cortex	UBERON:0009835	80.43	gold quality
putamen	UBERON:0001874	80.24	gold quality
caudate nucleus	UBERON:0001873	80.04	gold quality
right uterine tube	UBERON:0001302	79.86	gold quality
hypothalamus	UBERON:0001898	79.82	gold quality
nucleus accumbens	UBERON:0001882	79.75	gold quality
bone marrow cell	CL:0002092	78.13	gold quality
amygdala	UBERON:0001876	77.41	gold quality
pituitary gland	UBERON:0000007	76.33	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	76.30	gold quality
ventricular zone	UBERON:0003053	75.88	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.80	gold quality
adenohypophysis	UBERON:0002196	75.57	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	75.11	gold quality
cerebellar hemisphere	UBERON:0002245	73.70	gold quality
cerebellar cortex	UBERON:0002129	73.58	gold quality
neocortex	UBERON:0001950	73.38	gold quality
spinal cord	UBERON:0002240	73.10	gold quality
forebrain	UBERON:0001890	72.81	gold quality
frontal cortex	UBERON:0001870	71.99	gold quality
prefrontal cortex	UBERON:0000451	71.98	gold quality
brain	UBERON:0000955	71.77	gold quality
cerebellum	UBERON:0002037	71.22	gold quality
cerebral cortex	UBERON:0000956	70.71	gold quality
sural nerve	UBERON:0015488	69.46	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.