PDIA5

Summary

PDIA5 (protein disulfide isomerase family A member 5, HGNC:24811) is a protein-coding gene on chromosome 3q21.1, encoding Protein disulfide-isomerase A5 (Q14554).

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants.

Source: NCBI Gene 10954 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 112 total
• Druggable target: yes
• MANE Select transcript: NM_006810

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24811
Approved symbol	PDIA5
Name	protein disulfide isomerase family A member 5
Location	3q21.1
Locus type	gene with protein product
Status	Approved
Aliases	PDIR, FLJ30401
Ensembl gene	ENSG00000065485
Ensembl biotype	protein_coding
OMIM	616942
Entrez	10954

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 5 protein_coding, 4 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000316218, ENST00000467157, ENST00000469649, ENST00000472319, ENST00000484644, ENST00000485208, ENST00000489923, ENST00000495004, ENST00000872609, ENST00000872610, ENST00000933695

RefSeq mRNA: 1 — MANE Select: NM_006810 NM_006810

CCDS: CCDS3020

Canonical transcript exons

ENST00000316218 — 17 exons

Exon	Start	End
ENSE00001078808	123110944	123111004
ENSE00001078828	123130480	123130616
ENSE00001149277	123116231	123116298
ENSE00001866959	123067025	123067206
ENSE00003462824	123106749	123106841
ENSE00003469190	123150234	123150364
ENSE00003486364	123161880	123162104
ENSE00003493250	123146099	123146259
ENSE00003497134	123102411	123102494
ENSE00003500252	123102751	123102796
ENSE00003501781	123145522	123145592
ENSE00003516624	123089168	123089294
ENSE00003553395	123092355	123092442
ENSE00003590493	123161321	123161455
ENSE00003590930	123124272	123124343
ENSE00003662909	123124066	123124157
ENSE00003679611	123154971	123155041

Expression profiles

Bgee: expression breadth ubiquitous, 259 present calls, max score 95.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.2298 / max 347.1718, expressed in 1792 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
38274	16.6031	1739
38273	4.6267	1562

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	95.65	gold quality
right lobe of liver	UBERON:0001114	95.64	gold quality
placenta	UBERON:0001987	94.69	gold quality
pylorus	UBERON:0001166	94.51	gold quality
type B pancreatic cell	CL:0000169	93.93	silver quality
stromal cell of endometrium	CL:0002255	92.70	gold quality
colonic epithelium	UBERON:0000397	92.20	gold quality
decidua	UBERON:0002450	91.58	gold quality
left adrenal gland	UBERON:0001234	91.06	gold quality
left adrenal gland cortex	UBERON:0035825	91.03	gold quality
right adrenal gland	UBERON:0001233	91.02	gold quality
stomach	UBERON:0000945	90.88	gold quality
body of pancreas	UBERON:0001150	90.83	gold quality
body of stomach	UBERON:0001161	90.81	gold quality
adrenal cortex	UBERON:0001235	90.66	gold quality
calcaneal tendon	UBERON:0003701	90.63	gold quality
adrenal gland	UBERON:0002369	90.54	gold quality
right adrenal gland cortex	UBERON:0035827	90.53	gold quality
rectum	UBERON:0001052	90.49	gold quality
secondary oocyte	CL:0000655	90.47	gold quality
corpus epididymis	UBERON:0004359	90.10	gold quality
tibia	UBERON:0000979	90.02	gold quality
cartilage tissue	UBERON:0002418	89.95	gold quality
left lobe of thyroid gland	UBERON:0001120	89.86	gold quality
pancreas	UBERON:0001264	89.84	gold quality
right lobe of thyroid gland	UBERON:0001119	89.78	gold quality
bone marrow cell	CL:0002092	89.74	gold quality
gall bladder	UBERON:0002110	89.65	gold quality
mucosa of sigmoid colon	UBERON:0004993	89.61	gold quality
thyroid gland	UBERON:0002046	89.55	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-7316	yes	19.76
E-ANND-3	yes	12.75
E-GEOD-137537	yes	3.73
E-CURD-10	no	108.12
E-MTAB-4850	no	10.16

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting PDIA5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-6124	99.87	69.78	3551
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-6833-5P	99.50	68.93	1161
HSA-MIR-892C-5P	99.16	70.56	2116
HSA-MIR-224-3P	98.91	68.42	1815
HSA-MIR-522-3P	98.91	68.56	1817
HSA-MIR-382-3P	98.83	67.10	1074
HSA-MIR-3187-3P	97.38	65.80	904

Literature-anchored findings (GeneRIF, showing 9)

• Three thioredoxin motifs (CXXC) of purified PDIR were found to contribute to its isomerase activity. (PMID:14627699)
• Protein disulfide isomerases are enzymes that mediate oxidative protein folding in the endoplasmic reticulum. (PMID:20796029)
• protein disulfide isomerase 5 is deregulated in the mucopolysaccharidoses, although the unfolded protein response is not activated (PMID:22002444)
• This study demonistrated that Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer’s disease. (PMID:24037032)
• PDIA5 is a key regulator ATF6alpha-mediated cellular functions in cancer. (PMID:24636989)
• Data suggest that upon activation of integrins, protein disulfide isomerase (PDI) is released from endothelial cells and forms a disulfide bond complex with alphaVbeta3 integrin. (PMID:29293453)
• PDIA5 is Correlated With Immune Infiltration and Predicts Poor Prognosis in Gliomas. (PMID:33664747)
• Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy. (PMID:36003400)
• RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by Regulating CCAR1 Protein Expression. (PMID:39247813)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	pdia5	ENSDARG00000069242
mus_musculus	Pdia5	ENSMUSG00000022844
rattus_norvegicus	Pdia5	ENSRNOG00000032327
drosophila_melanogaster	CG9302	FBGN0032514
caenorhabditis_elegans		WBGENE00003962
caenorhabditis_elegans	M04D5.1	WBGENE00014807

Paralogs (13): ERP44 (ENSG00000023318), TMX4 (ENSG00000125827), ERP27 (ENSG00000139055), TMX1 (ENSG00000139921), PDIA6 (ENSG00000143870), TXNDC11 (ENSG00000153066), PDIA4 (ENSG00000155660), TMX3 (ENSG00000166479), PDIA3 (ENSG00000167004), PDILT (ENSG00000169340), PDIA2 (ENSG00000185615), P4HB (ENSG00000185624), TXNDC5 (ENSG00000239264)

Protein

Protein identifiers

Protein disulfide-isomerase A5 — Q14554 (reviewed: Q14554)

Alternative names: Protein disulfide isomerase-related protein

All UniProt accessions (3): Q14554, C9JY10, H7C4F9

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Interacts with CALR (via P-domain).

Subcellular location. Endoplasmic reticulum lumen.

Similarity. Belongs to the protein disulfide isomerase family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q14554-1	1	yes
Q14554-2	2

RefSeq proteins (1): NP_006801* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013766	Thioredoxin_domain	Domain
IPR017937	Thioredoxin_CS	Conserved_site
IPR036249	Thioredoxin-like_sf	Homologous_superfamily
IPR041865	PDI_b_PDIR_N	Domain
IPR046374	PDI_a_PDIR	Domain
IPR051063	PDI	Family

Pfam: PF00085

UniProt features (22 total): helix 4, strand 4, disulfide bond 4, domain 3, splice variant 2, signal peptide 1, chain 1, sequence variant 1, turn 1, short sequence motif 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4I6X	X-RAY DIFFRACTION	1.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14554-F1	89.49	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (4): 85–94, 182–185, 305–308, 426–429

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-381038	XBP1(S) activates chaperone genes

MSigDB gene sets: 191 (showing top): REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR, GRUETZMANN_PANCREATIC_CANCER_DN, TGCGCANK_UNKNOWN, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GGGTGGRR_PAX4_03, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, BROWNE_HCMV_INFECTION_48HR_DN, GOBP_PROTEIN_MATURATION, GOBP_ELECTRON_TRANSPORT_CHAIN, GOBP_PROTEIN_FOLDING, BROWN_MYELOID_CELL_DEVELOPMENT_DN, chr3q21, IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR, SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, MILI_PSEUDOPODIA_CHEMOTAXIS_DN

GO Biological Process (2): protein folding (GO:0006457), electron transport chain (GO:0022900)

GO Molecular Function (5): protein disulfide isomerase activity (GO:0003756), protein-disulfide reductase activity (GO:0015035), oxidoreductase activity (GO:0016491), protein binding (GO:0005515), isomerase activity (GO:0016853)

GO Cellular Component (3): endoplasmic reticulum (GO:0005783), endoplasmic reticulum lumen (GO:0005788), endoplasmic reticulum membrane (GO:0005789)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
IRE1alpha activates chaperones	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
catalytic activity, acting on a protein	2
catalytic activity	2
cellular process	1
protein maturation	1
generation of precursor metabolites and energy	1
intramolecular oxidoreductase activity, transposing S-S bonds	1
disulfide oxidoreductase activity	1
binding	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
endoplasmic reticulum	1
intracellular organelle lumen	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1

Protein interactions and networks

STRING

1719 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PDIA5	ATF6	P18850	701
PDIA5	ERP27	Q96DN0	558
PDIA5	TXNDC12	O95881	548
PDIA5	ERP29	P30040	519
PDIA5	HSPA5	P11021	488
PDIA5	ERO1B	Q86YB8	478
PDIA5	HYOU1	Q9Y4L1	475
PDIA5	TMX4	Q9H1E5	463
PDIA5	ABHD5	Q8WTS1	437
PDIA5	CNDP2	Q96KP4	431
PDIA5	SEC22A	Q96IW7	429
PDIA5	DNAJB9	Q9UBS3	423
PDIA5	TMX2	Q9Y320	417
PDIA5	AGR3	Q8TD06	415
PDIA5	MARCO	Q9UEW3	411

IntAct

94 interactions, top by confidence:

A	B	Type	Score
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
MUCL1	PDIA5	psi-mi:“MI:0914”(association)	0.640
KRTAP10-7	PDIA5	psi-mi:“MI:0915”(physical association)	0.560
PDIA5		psi-mi:“MI:0915”(physical association)	0.560
MDFI	PDIA5	psi-mi:“MI:0915”(physical association)	0.560
	PDIA5	psi-mi:“MI:0915”(physical association)	0.560
PDIA5	MDFI	psi-mi:“MI:0915”(physical association)	0.560
ANTXR1	POTEF	psi-mi:“MI:0914”(association)	0.530
LGMN	ATG7	psi-mi:“MI:0914”(association)	0.530
NENF	BLVRB	psi-mi:“MI:0914”(association)	0.530
RNASET2	PDIA5	psi-mi:“MI:0914”(association)	0.530
CST6	CTSV	psi-mi:“MI:0914”(association)	0.530
CCL22	PLXNA2	psi-mi:“MI:0914”(association)	0.530
CRP	QSOX1	psi-mi:“MI:0914”(association)	0.530
ANTXR1	WFS1	psi-mi:“MI:0914”(association)	0.530
TOR1AIP1	TXN	psi-mi:“MI:0914”(association)	0.530

BioGRID (144): PDIA5 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-3 (Two-hybrid), PDIA5 (Affinity Capture-RNA), PDIA5 (Affinity Capture-MS), PDIA5 (Affinity Capture-MS), PDIA5 (Affinity Capture-MS), PDIA5 (Affinity Capture-MS), PDIA5 (Affinity Capture-MS), PDIA5 (Affinity Capture-MS), PDIA5 (Affinity Capture-MS), PDIA5 (Affinity Capture-MS), PDIA5 (Affinity Capture-MS), PDIA5 (Affinity Capture-MS), PDIA5 (Affinity Capture-MS)

ESM2 similar proteins: A2VE29, A6QLU8, D3Z6P0, H2N4I1, O00391, O08841, P04785, P05307, P07237, P08003, P09102, P09103, P13667, P21195, P30040, P38657, P38659, P57759, P81628, P97278, P97346, Q0VCM5, Q13087, Q14554, Q29052, Q2HWU2, Q2KIL5, Q499T2, Q4VIT4, Q503L9, Q5E936, Q5I0H9, Q5R5B6, Q5RCH2, Q5WA72, Q61702, Q67IX6, Q6DKJ4, Q6GM16, Q6IUU3

Diamond homologs: A0A8M1N5Y4, D3Z6P0, D4B2L8, G4NFB7, H2N4I1, O00391, O08841, O13704, O13811, O22263, O48773, P00275, P04785, P05307, P07237, P08003, P09102, P09103, P0A4L1, P0A4L2, P11598, P12243, P12865, P13667, P17967, P21195, P23400, P27773, P29828, P30101, P32474, P34329, P38657, P38658, P38659, P38660, P38661, P46843, P52230, P52588

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 106 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Innate Immune System	12	4.3×	1e-02

Disease & clinical

Clinical variants and AI predictions

ClinVar

112 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	84
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3487 predictions. Top by Δscore:

Variant	Effect	Δscore
3:123083637:G:GT	donor_gain	1.0000
3:123102495:G:GG	donor_gain	1.0000
3:123106747:A:AG	acceptor_gain	1.0000
3:123106748:G:GA	acceptor_gain	1.0000
3:123106748:GTCC:G	acceptor_gain	1.0000
3:123106838:AAAGG:A	donor_loss	1.0000
3:123106839:AAGG:A	donor_loss	1.0000
3:123106840:AG:A	donor_loss	1.0000
3:123106841:GGTA:G	donor_loss	1.0000
3:123106842:G:T	donor_loss	1.0000
3:123106843:T:G	donor_loss	1.0000
3:123111005:G:GG	donor_gain	1.0000
3:123124154:T:G	donor_gain	1.0000
3:123124154:T:TG	donor_gain	1.0000
3:123124156:GA:G	donor_gain	1.0000
3:123124158:G:GG	donor_gain	1.0000
3:123124262:C:CA	acceptor_gain	1.0000
3:123124262:C:G	acceptor_gain	1.0000
3:123124340:AGAA:A	donor_gain	1.0000
3:123124341:GAA:G	donor_gain	1.0000
3:123124341:GAAG:G	donor_gain	1.0000
3:123124344:G:GG	donor_gain	1.0000
3:123124345:T:A	donor_loss	1.0000
3:123130612:CCCAT:C	donor_gain	1.0000
3:123130617:G:GG	donor_gain	1.0000
3:123145518:ACAG:A	acceptor_gain	1.0000
3:123145519:CAGGG:C	acceptor_loss	1.0000
3:123145520:AG:A	acceptor_gain	1.0000
3:123145521:GG:G	acceptor_gain	1.0000
3:123145521:GGGT:G	acceptor_gain	1.0000

AlphaMissense

3437 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:123106791:T:A	W144R	0.996
3:123106791:T:C	W144R	0.996
3:123106793:G:C	W144C	0.995
3:123106793:G:T	W144C	0.995
3:123089274:T:C	L50P	0.993
3:123150347:T:A	V419D	0.993
3:123130599:T:A	V298D	0.992
3:123106819:T:A	V153D	0.989
3:123116275:G:C	A196P	0.988
3:123089257:A:C	R44S	0.987
3:123089257:A:T	R44S	0.987
3:123102773:T:G	Y122D	0.987
3:123130605:T:C	F300S	0.986
3:123146115:C:A	A333E	0.986
3:123146117:G:C	A334P	0.986
3:123146121:T:A	V335D	0.986
3:123102433:T:A	C94S	0.985
3:123102433:T:C	C94R	0.985
3:123102434:G:C	C94S	0.985
3:123102490:T:G	Y113D	0.985
3:123106761:T:C	F134L	0.984
3:123106763:T:A	F134L	0.984
3:123106763:T:G	F134L	0.984
3:123130519:G:C	W271C	0.984
3:123130519:G:T	W271C	0.984
3:123130596:T:C	L297P	0.984
3:123106750:C:T	S130F	0.983
3:123124073:C:A	A206D	0.983
3:123161334:C:A	A453D	0.983
3:123116242:T:C	C185R	0.982

dbSNP variants (sampled 300 via entrez): RS1000014097 (3:123154316 C>T), RS1000070658 (3:123160282 C>G,T), RS1000093544 (3:123119737 G>A), RS1000110187 (3:123149258 G>A), RS1000147126 (3:123098580 G>A), RS1000165896 (3:123107557 A>G), RS1000238439 (3:123107990 G>A), RS1000245816 (3:123071955 A>G,T), RS1000255189 (3:123154625 C>T), RS1000359369 (3:123101190 A>G), RS1000381945 (3:123095855 G>A), RS1000382957 (3:123136945 T>C), RS1000428022 (3:123148834 G>A), RS1000467757 (3:123090901 C>G), RS1000484562 (3:123160099 G>A)

Disease associations

OMIM: gene MIM:616942 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST001337_12	Platelet count	4.000000e-09
GCST003194_30	Fibrinogen levels	2.000000e-08
GCST004121_24	Fibrinogen levels	8.000000e-09
GCST004122_17	Fibrinogen levels	1.000000e-07
GCST004442_16	Interleukin-17 levels	5.000000e-10
GCST004599_79	Mean platelet volume	1.000000e-32
GCST004603_252	Platelet count	2.000000e-28
GCST004607_257	Plateletcrit	7.000000e-11
GCST004616_143	Platelet distribution width	5.000000e-34
GCST90002395_381	Mean platelet volume	2.000000e-72
GCST90002400_394	Plateletcrit	2.000000e-15
GCST90002401_122	Platelet distribution width	4.000000e-79
GCST90002402_319	Platelet count	3.000000e-52

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004309	platelet count
EFO:0008174	interleukin 17 measurement
EFO:0007985	platelet crit
EFO:0007984	platelet component distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067135 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

57 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, decreases expression	8
trichostatin A	affects cotreatment, increases expression	3
entinostat	increases expression, affects cotreatment	2
Panobinostat	affects cotreatment, increases expression	2
Cisplatin	affects cotreatment, increases expression	2
Tunicamycin	increases expression	2
Cadmium Chloride	decreases expression, increases expression	2
Thapsigargin	increases expression	2
aristolochic acid I	decreases expression	1
chloroacetaldehyde	affects expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	decreases expression	1
cobaltous chloride	decreases expression	1
methacrylaldehyde	affects cotreatment, increases expression	1
perfluorooctane sulfonic acid	increases expression	1
cylindrospermopsin	increases expression	1
JP8 aviation fuel	decreases expression	1
adefovir dipivoxil	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
ICG 001	increases expression	1
abrine	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
bisphenol AF	increases expression	1
Rosiglitazone	decreases expression	1
Cidofovir	increases expression	1
Acetaminophen	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652007	Binding	Binding affinity to human PDIA5 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2AD	Abcam HeLa PDIA5 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.