PEDS1

Summary

PEDS1 (plasmanylethanolamine desaturase 1, HGNC:16735) is a protein-coding gene on chromosome 20q13.13, encoding Plasmanylethanolamine desaturase 1 (A5PLL7). Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane.

Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 387521 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 8 total
• MANE Select transcript: NM_199129

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16735
Approved symbol	PEDS1
Name	plasmanylethanolamine desaturase 1
Location	20q13.13
Locus type	gene with protein product
Status	Approved
Aliases	Kua
Ensembl gene	ENSG00000240849
Ensembl biotype	protein_coding
OMIM	610994
Entrez	387521

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 10 protein_coding, 2 nonsense_mediated_decay

ENST00000371650, ENST00000371652, ENST00000371656, ENST00000371658, ENST00000453505, ENST00000879855, ENST00000879856, ENST00000879857, ENST00000879858, ENST00000879859, ENST00000879860, ENST00000879861

RefSeq mRNA: 2 — MANE Select: NM_199129 NM_001162505, NM_199129

CCDS: CCDS13428, CCDS54473

Canonical transcript exons

ENST00000371652 — 6 exons

Exon	Start	End
ENSE00003522796	50127975	50128187
ENSE00003597588	50143502	50143621
ENSE00003628060	50129546	50129690
ENSE00003694667	50130856	50130947
ENSE00003730383	50118254	50125179
ENSE00003847338	50153517	50153723

Expression profiles

Bgee: expression breadth ubiquitous, 234 present calls, max score 95.72.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.0576 / max 174.6032, expressed in 1803 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
187828	24.7195	1803
187829	21.3703	1810
187823	0.3381	135

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	95.72	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	95.43	gold quality
spinal cord	UBERON:0002240	94.91	gold quality
upper arm skin	UBERON:0004263	94.11	gold quality
stromal cell of endometrium	CL:0002255	93.46	gold quality
esophagus mucosa	UBERON:0002469	93.20	gold quality
skin of leg	UBERON:0001511	93.10	gold quality
skin of abdomen	UBERON:0001416	92.97	gold quality
esophagus	UBERON:0001043	91.38	gold quality
zone of skin	UBERON:0000014	91.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	90.98	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.91	gold quality
inferior vagus X ganglion	UBERON:0005363	90.22	gold quality
gastrocnemius	UBERON:0001388	90.11	gold quality
upper lobe of left lung	UBERON:0008952	90.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	89.96	gold quality
tibial nerve	UBERON:0001323	89.78	gold quality
smooth muscle tissue	UBERON:0001135	89.67	gold quality
lower esophagus	UBERON:0013473	89.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.40	gold quality
apex of heart	UBERON:0002098	89.34	gold quality
substantia nigra	UBERON:0002038	89.30	gold quality
vagina	UBERON:0000996	89.29	gold quality
mucosa of transverse colon	UBERON:0004991	89.09	gold quality
upper lobe of lung	UBERON:0008948	89.07	gold quality
muscle of leg	UBERON:0001383	88.92	gold quality
ectocervix	UBERON:0012249	88.79	gold quality
midbrain	UBERON:0001891	88.76	gold quality
left coronary artery	UBERON:0001626	88.70	gold quality
putamen	UBERON:0001874	88.70	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7303	no	370.27
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

61 targeting PEDS1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-4719	99.73	72.10	3329
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-6081	99.48	66.07	1446
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-6722-3P	99.45	67.62	1919
HSA-MIR-128-1-5P	99.33	60.46	332

Literature-anchored findings (GeneRIF, showing 4)

• TMEM189 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. (PMID:21555518)
• TMEM189 could functionally replace CarF in M. xanthus, and knockout of TMEM189 in a human cell line eliminated plasmalogens; study reveals TMEM189 as the long-sought desaturase for animal plasmalogen biosynthesis (PMID:31604315)
• these results assign the TMEM189 gene to plasmanylethanolamine desaturase and suggest that the previously characterized phenotype of Tmem189-deficient mice may be caused by a lack of plasmalogens. (PMID:32209662)
• TMEM189 promotes breast cancer through inhibition of autophagy-regulated ferroptosis. (PMID:35843092)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Peds1	ENSMUSG00000090213
rattus_norvegicus	Ube2v1	ENSRNOG00000025580

Paralogs (24): UBE2T (ENSG00000077152), UBE2A (ENSG00000077721), UBE2K (ENSG00000078140), CDC34 (ENSG00000099804), UBE2I (ENSG00000103275), UBE2W (ENSG00000104343), UBE2R2 (ENSG00000107341), UBE2S (ENSG00000108106), UBE2B (ENSG00000119048), UBE2G1 (ENSG00000132388), UBE2Z (ENSG00000159202), UBE2J2 (ENSG00000160087), AKTIP (ENSG00000166971), UBE2V2 (ENSG00000169139), UBE2C (ENSG00000175063), UBE2O (ENSG00000175931), UBE2U (ENSG00000177414), UBE2N (ENSG00000177889), UBE2F (ENSG00000184182), UBE2G2 (ENSG00000184787), UBE2H (ENSG00000186591), UBE2J1 (ENSG00000198833), UBE2V1 (ENSG00000244687), UBE2NL (ENSG00000276380)

Protein

Protein identifiers

Plasmanylethanolamine desaturase 1 — A5PLL7 (reviewed: A5PLL7)

Alternative names: Transmembrane protein 189

All UniProt accessions (4): A5PLL7, F8W924, F8WBY2, Q5TGE2

UniProt curated annotations — full annotation on UniProt →

Function. Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms.

Subcellular location. Endoplasmic reticulum membrane.

Domain organisation. Histidine box-1 and -2 together with other histidine residues are essential for catalytic activity.

Pathway. Lipid metabolism; fatty acid metabolism.

Miscellaneous. In human, PEDS1 and UBE2V1 are adjacent genes which can produce independent proteins and can also be fused to form a PEDS1-UBE2V1 hybrid protein.

Similarity. Belongs to the fatty acid desaturase CarF family.

Isoforms (2)

UniProt ID	Names	Canonical?
A5PLL7-1	1	yes
A5PLL7-2	2

RefSeq proteins (2): NP_001155977, NP_954580* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019547	Lipid_desat	Domain
IPR052601	Plasmalogen_desaturase	Family

Pfam: PF10520

Enzyme classification (BRENDA):

• EC 1.14.19.77 — plasmanylethanolamine desaturase (BRENDA: 6 organisms, 22 substrates, 11 inhibitors, 0 Km, 0 kcat entries)

Catalyzed reactions (Rhea), 4 shown:

• a 1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O (RHEA:22956)
• a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O (RHEA:61960)
• a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O (RHEA:61964)
• a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O (RHEA:61968)

UniProt features (31 total): mutagenesis site 12, site 8, transmembrane region 3, sequence conflict 3, short sequence motif 2, chain 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A5PLL7-F1	90.82	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (8): 190 (essential for catalytic activity); 214 (essential for catalytic activity); 217 (essential for catalytic activity); 218 (essential for catalytic activity); 95 (essential for catalytic activity); 120 (essential for catalytic activity); 121 (essential for catalytic activity); 186 (essential for catalytic activity)

Mutagenesis-validated functional residues (12):

Position	Phenotype
95	loss of plasmanylethanolamine desaturase activity.
120	loss of plasmanylethanolamine desaturase activity.
121	loss of plasmanylethanolamine desaturase activity.
130	loss of plasmanylethanolamine desaturase activity.
186	loss of plasmanylethanolamine desaturase activity.
190	loss of plasmanylethanolamine desaturase activity.
206	no effect on plasmanylethanolamine desaturase activity.
213	no effect on plasmanylethanolamine desaturase activity.
214	loss of plasmanylethanolamine desaturase activity.
217	loss of plasmanylethanolamine desaturase activity.
218	loss of plasmanylethanolamine desaturase activity.
222	no effect on desaturase plasmanylethanolamine activity.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 112 (showing top): GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN, AAGCCAT_MIR135A_MIR135B, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, FOSTER_TOLERANT_MACROPHAGE_DN, GOBP_LIPID_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_METABOLIC_PROCESS, GOBP_LIPID_BIOSYNTHETIC_PROCESS, VANTVEER_BREAST_CANCER_ESR1_DN, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK, GOBP_FATTY_ACID_METABOLIC_PROCESS, GOCC_ORGANELLE_SUBCOMPARTMENT, NIKOLSKY_BREAST_CANCER_20Q12_Q13_AMPLICON, CHEN_METABOLIC_SYNDROM_NETWORK, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A, KASLER_HDAC7_TARGETS_1_UP

GO Biological Process (3): fatty acid metabolic process (GO:0006631), ether lipid biosynthetic process (GO:0008611), lipid metabolic process (GO:0006629)

GO Molecular Function (3): plasmanylethanolamine desaturase activity (GO:0050207), protein binding (GO:0005515), oxidoreductase activity (GO:0016491)

GO Cellular Component (3): endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
lipid metabolic process	1
monocarboxylic acid metabolic process	1
lipid biosynthetic process	1
ether lipid metabolic process	1
glycerol ether biosynthetic process	1
primary metabolic process	1
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1
binding	1
catalytic activity	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cellular anatomical structure	1

Protein interactions and networks

STRING

810 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PEDS1	G3V2F7	G3V2F7	864
PEDS1	UBB	P02248	731
PEDS1	UBB	P02248	726
PEDS1	PDCL	Q13371	714
PEDS1	GHITM	Q9H3K2	596
PEDS1	COPS7A	Q9UBW8	583
PEDS1	UBE2D2	P51669	574
PEDS1	AGPS	O00116	572
PEDS1	UBE2V2	Q15819	548
PEDS1	LALBA	P00709	540
PEDS1	UBE2K	P27924	530
PEDS1	FAR1	Q8WVX9	510
PEDS1	GNPAT	O15228	506
PEDS1	UBE2I	P50550	463
PEDS1	UBE2D1	P51668	462

IntAct

12 interactions, top by confidence:

A	B	Type	Score
LAMP2	PEDS1	psi-mi:“MI:0915”(physical association)	0.560
SH3GLB1	PEDS1	psi-mi:“MI:0915”(physical association)	0.560
PEDS1		psi-mi:“MI:0915”(physical association)	0.370
CHRNA4	TMEM223	psi-mi:“MI:0914”(association)	0.350
NCR3LG1	PEDS1	psi-mi:“MI:0914”(association)	0.350
RHBG	PEDS1	psi-mi:“MI:0914”(association)	0.350
TCTN3	TMEM120B	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (87): UBC (Reconstituted Complex), CHORDC1 (Co-fractionation), RAB7A (Co-fractionation), TAGLN2 (Co-fractionation), UBE2K (Co-fractionation), UBE2N (Co-fractionation), TMEM189-UBE2V1 (Co-fractionation), TMEM189-UBE2V1 (Co-fractionation), TMEM189-UBE2V1 (Co-fractionation), TMEM189-UBE2V1 (Co-fractionation), TMEM189-UBE2V1 (Co-fractionation), TMEM189-UBE2V1 (Co-fractionation), TMEM189-UBE2V1 (Co-fractionation), TMEM189-UBE2V1 (Proximity Label-MS), TMEM189 (Affinity Capture-MS)

ESM2 similar proteins: A2VE61, A5PLL7, A6QLM0, B1AZA5, B8BIM2, D3ZXD8, E9PTA2, O35052, O75907, O94759, P48631, P52848, P98191, Q02353, Q05B45, Q0P5C0, Q0VCJ8, Q2QZ14, Q3UHN9, Q4R4U1, Q4R766, Q5EA70, Q5HZE2, Q5R5F8, Q5R7B1, Q61115, Q6DD32, Q6NYY9, Q6P360, Q6PHN7, Q84VT2, Q8BFQ2, Q8C1E7, Q8GZC3, Q8MK44, Q8NBD8, Q8NBT3, Q8VWZ8, Q90693, Q91YD4

Diamond homologs: A5PLL7, A6QLM0, Q5UR78, Q99LQ7, Q9AE87, Q9SZ42, O81006, O04584

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

8 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	6
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1052 predictions. Top by Δscore:

Variant	Effect	Δscore
20:50127969:CCGCA:C	donor_loss	1.0000
20:50127970:CGCA:C	donor_loss	1.0000
20:50127970:CGCAC:C	donor_loss	1.0000
20:50127971:GCA:G	donor_loss	1.0000
20:50127971:GCACC:G	donor_loss	1.0000
20:50127972:CAC:C	donor_loss	1.0000
20:50127973:AC:A	donor_loss	1.0000
20:50127974:C:CG	donor_loss	1.0000
20:50129541:CTCA:C	donor_loss	1.0000
20:50129543:CA:C	donor_loss	1.0000
20:50129544:A:AC	donor_gain	1.0000
20:50129545:C:A	donor_loss	1.0000
20:50129545:C:CC	donor_gain	1.0000
20:50129545:C:CG	donor_loss	1.0000
20:50129689:GCC:G	acceptor_loss	1.0000
20:50129691:C:CA	acceptor_loss	1.0000
20:50129692:T:G	acceptor_loss	1.0000
20:50129697:T:C	acceptor_gain	1.0000
20:50129697:T:TC	acceptor_gain	1.0000
20:50143500:A:AC	donor_gain	1.0000
20:50143501:C:CC	donor_gain	1.0000
20:50143501:CCAA:C	donor_gain	1.0000
20:50153511:TCTTA:T	donor_loss	1.0000
20:50153512:CTTA:C	donor_loss	1.0000
20:50153513:TTA:T	donor_loss	1.0000
20:50153513:TTAC:T	donor_loss	1.0000
20:50153514:TA:T	donor_loss	1.0000
20:50153515:ACC:A	donor_loss	1.0000
20:50153516:C:CA	donor_loss	1.0000
20:50128185:CTT:C	acceptor_gain	0.9900

AlphaMissense

1760 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:50128017:G:C	H217D	1.000
20:50125169:G:C	N234K	0.999
20:50125169:G:T	N234K	0.999
20:50127985:G:C	C227W	0.999
20:50127986:C:T	C227Y	0.999
20:50127988:G:C	F226L	0.999
20:50127988:G:T	F226L	0.999
20:50127990:A:G	F226L	0.999
20:50128012:G:C	H218Q	0.999
20:50128012:G:T	H218Q	0.999
20:50128014:G:C	H218D	0.999
20:50128015:G:C	H217Q	0.999
20:50128015:G:T	H217Q	0.999
20:50128017:G:T	H217N	0.999
20:50128026:G:C	H214D	0.999
20:50128026:G:T	H214N	0.999
20:50128096:G:C	H190Q	0.999
20:50128096:G:T	H190Q	0.999
20:50128098:G:C	H190D	0.999
20:50128110:G:C	H186D	0.999
20:50128117:G:C	N183K	0.999
20:50128117:G:T	N183K	0.999
20:50129638:C:G	R129P	0.999
20:50129661:G:C	H121Q	0.999
20:50129661:G:T	H121Q	0.999
20:50129663:G:C	H121D	0.999
20:50129664:G:C	H120Q	0.999
20:50129664:G:T	H120Q	0.999
20:50129666:G:C	H120D	0.999
20:50129666:G:T	H120N	0.999

dbSNP variants (sampled 300 via entrez): RS1000070167 (20:50151211 C>A,T), RS1000101479 (20:50144441 A>G), RS1000149984 (20:50121955 C>G,T), RS1000174731 (20:50117944 G>A), RS1000223296 (20:50143436 C>T), RS1000229490 (20:50121554 TAAG>T), RS1000283527 (20:50121825 T>C), RS1000307000 (20:50127840 A>T), RS1000336555 (20:50155040 G>A,C), RS1000351762 (20:50149033 A>T), RS1000407317 (20:50149318 C>T), RS1000460333 (20:50155660 C>G), RS1000502451 (20:50122204 G>C), RS1000548095 (20:50139928 AC>A), RS1000629907 (20:50145185 G>A,C)

Disease associations

OMIM: gene MIM:610994 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST004608_113	Granulocyte percentage of myeloid white cells	3.000000e-16
GCST004609_161	Monocyte percentage of white cells	1.000000e-18

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007997	granulocyte percentage of myeloid white cells
EFO:0007989	monocyte percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression	2
aristolochic acid I	increases expression	1
ginger extract	decreases expression, increases abundance	1
methylmercuric chloride	increases expression	1
bisphenol A	decreases methylation	1
trichostatin A	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	decreases methylation	1
Diazinon	increases methylation	1
Estradiol	increases expression	1
Oils, Volatile	decreases expression, increases abundance	1
Smoke	decreases expression	1
Thimerosal	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Cyclosporine	increases expression	1
Okadaic Acid	increases expression	1
Particulate Matter	increases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B5L1	HAP1 TMEM189 (-) 2	Cancer cell line	Male
CVCL_B5L2	HAP1 TMEM189 (-) 3	Cancer cell line	Male
CVCL_XU44	HAP1 TMEM189 (-) 1	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.