PEG3-AS1

Summary

PEG3-AS1 (PEG3 antisense RNA 1, HGNC:35127) is a long non-coding RNA gene on chromosome 19q13.43.

This gene is located in the paternally expressed gene 3 (PEG3) imprinted region on chromosome 19. The corresponding transcript in mouse is imprinted and regulates expression of the mouse Peg3 gene.

Source: NCBI Gene 100169890 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35127
Approved symbol	PEG3-AS1
Name	PEG3 antisense RNA 1
Location	19q13.43
Locus type	RNA, long non-coding
Status	Approved
Aliases	APEG3, NCRNA00155
Entrez	100169890
RNAcentral	URS000075DAE7 — lncRNA, 1314 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The mammalian PEG3 locus harbors an antisense transcript gene displaying paternal allele-specific expression, and the evolutionary conservation further suggests potential roles of this transcript gene for the function of this imprinted domain. [APeg3] (PMID:18166281)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001644049 (19:56813626 G>T), RS1001991369 (19:56813919 T>C), RS1003233655 (19:56811741 T>C,G), RS1003266405 (19:56812373 G>A), RS1003695501 (19:56812026 T>A,C), RS1004772142 (19:56812095 C>A), RS1006037218 (19:56813596 C>G), RS1008037878 (19:56810667 C>T), RS1008091931 (19:56810891 G>C), RS1008215364 (19:56813171 A>G), RS1008457541 (19:56813404 A>C), RS1009316236 (19:56811384 C>G,T), RS1009730773 (19:56812400 T>G), RS1011352891 (19:56811423 A>G), RS1011405159 (19:56811069 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Nickel	decreases expression	2
Valproic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.