PELATON

Summary

PELATON (plaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulation, HGNC:50328) is a long non-coding RNA gene on chromosome 20q13.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50328
Approved symbol	PELATON
Name	plaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulation
Location	20q13.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	GCRL1
Ensembl gene	ENSG00000224397
Ensembl biotype	lncRNA
OMIM	621216
Entrez	100506115
RNAcentral	URS0002123246 — lncRNA, 2011 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000421019, ENST00000422459, ENST00000425497, ENST00000445003, ENST00000622604, ENST00000651466, ENST00000651976, ENST00000656332, ENST00000658717, ENST00000663009, ENST00000691395, ENST00000692392, ENST00000702208, ENST00000718352, ENST00000718353, ENST00000718354, ENST00000718355

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421019 — 2 exons

Exon	Start	End
ENSE00001607732	50277534	50277980
ENSE00001771701	50278177	50278415

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 96.75.

FANTOM5 (CAGE): breadth broad, TPM avg 19.0627 / max 1075.9715, expressed in 445 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
185225	10.2939	345
185231	8.2374	267
185232	0.3272	66
185230	0.2042	52

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	96.75	gold quality
leukocyte	CL:0000738	96.17	gold quality
monocyte	CL:0000576	96.07	gold quality
spleen	UBERON:0002106	88.51	gold quality
right lung	UBERON:0002167	88.09	gold quality
upper lobe of left lung	UBERON:0008952	87.94	gold quality
vermiform appendix	UBERON:0001154	86.26	gold quality
blood	UBERON:0000178	85.62	gold quality
upper lobe of lung	UBERON:0008948	84.17	gold quality
bone marrow cell	CL:0002092	78.46	gold quality
caecum	UBERON:0001153	76.44	gold quality
omental fat pad	UBERON:0010414	74.65	gold quality
peritoneum	UBERON:0002358	74.56	gold quality
lung	UBERON:0002048	73.08	gold quality
adipose tissue of abdominal region	UBERON:0007808	72.79	gold quality
right adrenal gland	UBERON:0001233	72.70	gold quality
minor salivary gland	UBERON:0001830	72.62	gold quality
right adrenal gland cortex	UBERON:0035827	71.94	gold quality
left adrenal gland	UBERON:0001234	71.91	gold quality
left adrenal gland cortex	UBERON:0035825	71.23	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.37	gold quality
right lobe of liver	UBERON:0001114	69.76	gold quality
apex of heart	UBERON:0002098	69.49	gold quality
saliva-secreting gland	UBERON:0001044	69.41	gold quality
adrenal gland	UBERON:0002369	69.38	gold quality
left coronary artery	UBERON:0001626	69.24	gold quality
adrenal cortex	UBERON:0001235	69.22	gold quality
gall bladder	UBERON:0002110	69.12	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.75	gold quality
colonic epithelium	UBERON:0000397	68.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• there were significantly positive correlations in KIF9AS1, LINC01272 and DIO3OS expression between IBD tissue and plasma samples. Therefore, the present study indicated that KIF9AS1, LINC01272 and DIO3OS may be potential diagnostic biomarkers for IBD. (PMID:29207070)
• Co-expression and functional annotation enrichment analyses across several tissues and cell types showed that the upregulated LINC01272 is associated with a myeloid pro-inflammatory signature, whereas the downregulated HNF4A-AS1 exhibits association with an epithelial metabolic signature. The study identified significant correlations between LINC01272 and HNF4A-AS1 expression and more severe mucosal injury. (PMID:29361088)
• PELATON is a nuclear expressed, monocyte- and macrophage-specific lncRNA, upregulated in unstable atherosclerotic plaque. (PMID:31826651)
• LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction. (PMID:33237828)
• LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer. (PMID:34099597)
• High expression of lncRNA PELATON serves as a risk factor for the incidence and prognosis of acute coronary syndrome. (PMID:35577857)
• Discovery of PELATON links to the INHBA gene in the TGF-beta pathway in colorectal cancer using a combination of bioinformatics and experimental investigations. (PMID:38735606)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.