PENK-AS1

Summary

PENK-AS1 (PENK antisense RNA 1, HGNC:55519) is a long non-coding RNA gene on chromosome 8q12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55519
Approved symbol	PENK-AS1
Name	PENK antisense RNA 1
Location	8q12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254254
Ensembl biotype	lncRNA
Entrez	101929415
RNAcentral	URS0000319020 — lncRNA, 2643 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000518662, ENST00000522511, ENST00000662661, ENST00000671375, ENST00000685796, ENST00000756351, ENST00000756352, ENST00000756353, ENST00000756354, ENST00000756355, ENST00000756356, ENST00000756357, ENST00000756358, ENST00000756359, ENST00000756360

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000518662 — 4 exons

Exon	Start	End
ENSE00002112655	56548293	56548358
ENSE00002116439	56445807	56446500
ENSE00002120002	56496223	56496355
ENSE00002128989	56550318	56552067

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 82.16.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1668 / max 48.0909, expressed in 55 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
88942	0.1190	42
88943	0.0416	12
205189	0.0062	3

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.16	gold quality
colonic epithelium	UBERON:0000397	72.51	gold quality
testis	UBERON:0000473	72.06	gold quality
left testis	UBERON:0004533	71.33	gold quality
right testis	UBERON:0004534	70.33	gold quality
ganglionic eminence	UBERON:0004023	67.82	gold quality
liver	UBERON:0002107	67.74	silver quality
ventricular zone	UBERON:0003053	61.84	gold quality
cortical plate	UBERON:0005343	61.44	gold quality
monocyte	CL:0000576	59.74	gold quality
skeletal muscle tissue	UBERON:0001134	58.72	gold quality
tonsil	UBERON:0002372	57.74	silver quality
myometrium	UBERON:0001296	57.05	silver quality
calcaneal tendon	UBERON:0003701	55.68	gold quality
nucleus accumbens	UBERON:0001882	55.46	gold quality
bone marrow	UBERON:0002371	55.10	silver quality
right lung	UBERON:0002167	54.97	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.63	gold quality
endometrium	UBERON:0001295	54.32	gold quality
putamen	UBERON:0001874	54.10	gold quality
primary visual cortex	UBERON:0002436	54.03	gold quality
blood	UBERON:0000178	54.00	gold quality
right adrenal gland	UBERON:0001233	52.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	52.42	gold quality
cerebellum	UBERON:0002037	52.21	gold quality
adrenal gland	UBERON:0002369	52.04	gold quality
cerebellar cortex	UBERON:0002129	51.88	gold quality
cerebellar hemisphere	UBERON:0002245	51.87	gold quality
prefrontal cortex	UBERON:0000451	51.59	gold quality
multicellular organism	UBERON:0000468	51.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.87

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.