PGLS-DT

Summary

PGLS-DT (PGLS divergent transcript, HGNC:55274) is a long non-coding RNA gene on chromosome 19p13.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55274
Approved symbol	PGLS-DT
Name	PGLS divergent transcript
Location	19p13.11
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000269439
Ensembl biotype	lncRNA
Entrez	100507551
RNAcentral	URS00004AAEAB — lncRNA, 775 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000595116, ENST00000596643, ENST00000598141, ENST00000615939, ENST00000655024, ENST00000799627, ENST00000799628

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000595116 — 2 exons

Exon	Start	End
ENSE00004188339	17503416	17503622
ENSE00004188342	17511343	17511562

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 91.70.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.2804 / max 87.8434, expressed in 1504 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179873	2.3673	1261
179875	0.7287	376
179874	0.1845	69

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.70	gold quality
apex of heart	UBERON:0002098	84.45	gold quality
skeletal muscle tissue	UBERON:0001134	82.68	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.31	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.92	gold quality
muscle tissue	UBERON:0002385	80.93	gold quality
tibial nerve	UBERON:0001323	80.85	gold quality
cerebellar hemisphere	UBERON:0002245	80.78	gold quality
cerebellum	UBERON:0002037	80.76	gold quality
cerebellar cortex	UBERON:0002129	80.70	gold quality
right hemisphere of cerebellum	UBERON:0014890	80.28	gold quality
left ovary	UBERON:0002119	80.18	gold quality
right ovary	UBERON:0002118	80.17	gold quality
monocyte	CL:0000576	80.09	gold quality
Ammon’s horn	UBERON:0001954	80.06	gold quality
stromal cell of endometrium	CL:0002255	79.94	gold quality
substantia nigra	UBERON:0002038	79.77	gold quality
ovary	UBERON:0000992	79.76	gold quality
corpus callosum	UBERON:0002336	79.73	gold quality
leukocyte	CL:0000738	79.53	gold quality
endocervix	UBERON:0000458	78.92	gold quality
muscle of leg	UBERON:0001383	78.73	gold quality
primary visual cortex	UBERON:0002436	78.61	gold quality
colonic epithelium	UBERON:0000397	78.44	gold quality
gastrocnemius	UBERON:0001388	78.32	gold quality
temporal lobe	UBERON:0001871	78.21	gold quality
amygdala	UBERON:0001876	78.20	gold quality
right adrenal gland cortex	UBERON:0035827	77.85	gold quality
putamen	UBERON:0001874	77.70	gold quality
right lobe of thyroid gland	UBERON:0001119	77.67	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	33.42
E-ANND-3	yes	3.02

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.