PGM2

Summary

PGM2 (phosphoglucomutase 2, HGNC:8906) is a protein-coding gene on chromosome 4p14, encoding Phosphopentomutase (Q96G03). Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses.

Enables phosphoglucomutase activity and phosphopentomutase activity. Predicted to be involved in purine ribonucleoside salvage. Predicted to act upstream of or within glucose metabolic process. Located in cytosol.

Source: NCBI Gene 55276 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 107 total
• Druggable target: yes
• MANE Select transcript: NM_018290

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8906
Approved symbol	PGM2
Name	phosphoglucomutase 2
Location	4p14
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10983
Ensembl gene	ENSG00000169299
Ensembl biotype	protein_coding
OMIM	172000
Entrez	55276

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 10 protein_coding, 4 nonsense_mediated_decay

ENST00000381967, ENST00000505986, ENST00000510084, ENST00000512556, ENST00000515668, ENST00000625312, ENST00000880101, ENST00000880102, ENST00000880103, ENST00000880104, ENST00000880105, ENST00000880106, ENST00000940590, ENST00000955601

RefSeq mRNA: 1 — MANE Select: NM_018290 NM_018290

CCDS: CCDS3443

Canonical transcript exons

ENST00000381967 — 14 exons

Exon	Start	End
ENSE00002026873	37861510	37862937
ENSE00002087586	37826686	37826813
ENSE00003466121	37845633	37845730
ENSE00003473680	37848522	37848651
ENSE00003478276	37840066	37840259
ENSE00003493893	37855608	37855741
ENSE00003512455	37850184	37850373
ENSE00003528359	37846931	37847111
ENSE00003560244	37839848	37839931
ENSE00003620758	37847202	37847295
ENSE00003632259	37834618	37834724
ENSE00003633570	37844364	37844553
ENSE00003635124	37829964	37830131
ENSE00003639115	37837529	37837613

Expression profiles

Bgee: expression breadth ubiquitous, 250 present calls, max score 99.34.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 43.6886 / max 530.7622, expressed in 1826 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
47303	43.6886	1826

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gingival epithelium	UBERON:0001949	99.34	gold quality
esophagus squamous epithelium	UBERON:0006920	99.17	gold quality
gingiva	UBERON:0001828	99.05	gold quality
epithelial cell of pancreas	CL:0000083	98.67	gold quality
oral cavity	UBERON:0000167	97.59	gold quality
germinal epithelium of ovary	UBERON:0001304	97.10	gold quality
parietal pleura	UBERON:0002400	96.93	gold quality
pharyngeal mucosa	UBERON:0000355	96.58	gold quality
epithelium of nasopharynx	UBERON:0001951	96.32	gold quality
visceral pleura	UBERON:0002401	96.21	gold quality
penis	UBERON:0000989	95.85	gold quality
secondary oocyte	CL:0000655	95.80	gold quality
palpebral conjunctiva	UBERON:0001812	95.56	gold quality
esophagus mucosa	UBERON:0002469	95.28	gold quality
mammalian vulva	UBERON:0000997	95.04	gold quality
tibia	UBERON:0000979	94.97	gold quality
upper leg skin	UBERON:0004262	94.90	gold quality
amniotic fluid	UBERON:0000173	94.59	gold quality
upper arm skin	UBERON:0004263	94.25	gold quality
cartilage tissue	UBERON:0002418	93.06	gold quality
monocyte	CL:0000576	93.02	gold quality
ventricular zone	UBERON:0003053	93.00	gold quality
skin of hip	UBERON:0001554	92.97	gold quality
placenta	UBERON:0001987	92.92	gold quality
leukocyte	CL:0000738	92.70	gold quality
trabecular bone tissue	UBERON:0002483	92.55	gold quality
pancreatic ductal cell	CL:0002079	92.01	gold quality
smooth muscle tissue	UBERON:0001135	91.64	gold quality
bone marrow	UBERON:0002371	91.51	gold quality
lower esophagus mucosa	UBERON:0035834	91.35	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-137537	yes	30.55
E-ANND-3	yes	7.54
E-GEOD-36552	no	240.14

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

82 targeting PGM2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-8067	99.86	69.59	2260
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-544A	99.84	68.66	1965

Literature-anchored findings (GeneRIF, showing 2)

• In the present work, phosphopentomutase was purified from human erythrocytes and found it to copurify with a 68-kDa polypeptide that was identified by mass spectrometry as PGM2, sharing about 20% identity with mammalian phosphoglucomutase 1. (PMID:17804405)
• FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies. (PMID:36255742)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	pgm2	ENSDARG00000018178
mus_musculus	Pgm2	ENSMUSG00000029171
rattus_norvegicus	Pgm2	ENSRNOG00000002185
drosophila_melanogaster	Pgm1	FBGN0003076
caenorhabditis_elegans		WBGENE00019890

Paralogs (6): PGM3 (ENSG00000013375), PGM1 (ENSG00000079739), PRTFDC1 (ENSG00000099256), PGM5 (ENSG00000154330), PGM2L1 (ENSG00000165434), HPRT1 (ENSG00000165704)

Protein

Protein identifiers

Phosphopentomutase — Q96G03 (reviewed: Q96G03)

Alternative names: Glucose phosphomutase 2, Phosphodeoxyribomutase, Phosphoglucomutase-2

All UniProt accessions (4): Q96G03, E7ENQ8, E9PD70, H0Y921

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate but with a lower catalytic efficiency. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. In vitro, also has a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant.

Subunit / interactions. Monomer.

Subcellular location. Cytoplasm. Cytosol.

Activity regulation. The phosphomutase activity is stimulated by glucose 1,6-bisphosphate.

Cofactor. Binds 1 Mg(2+) ion per subunit.

Similarity. Belongs to the phosphohexose mutase family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96G03-1	1	yes
Q96G03-2	2

RefSeq proteins (1): NP_060760* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005841	Alpha-D-phosphohexomutase_SF	Family
IPR005844	A-D-PHexomutase_a/b/a-I	Domain
IPR005845	A-D-PHexomutase_a/b/a-II	Domain
IPR005846	A-D-PHexomutase_a/b/a-III	Domain
IPR016055	A-D-PHexomutase_a/b/a-I/II/III	Homologous_superfamily
IPR016066	A-D-PHexomutase_CS	Conserved_site
IPR036900	A-D-PHexomutase_C_sf	Homologous_superfamily

Pfam: PF02878, PF02879, PF02880

Catalyzed reactions (Rhea), 5 shown:

• alpha-D-ribose 1-phosphate = D-ribose 5-phosphate (RHEA:18793)
• alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (RHEA:23536)
• 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate (RHEA:27658)
• O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] (RHEA:68748)
• alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate (RHEA:68752)

UniProt features (26 total): binding site 11, splice variant 4, sequence conflict 4, modified residue 2, sequence variant 2, initiator methionine 1, chain 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96G03-F1	95.60	0.93

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 165 (phosphoserine intermediate)

Ligand- & substrate-binding residues (11): 327; 400; 424; 438; 63; 165; 165 (via phosphate group); 322; 324; 326; 326

Post-translational modifications (2): 2, 165

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation
R-HSA-71336	Pentose phosphate pathway

MSigDB gene sets: 181 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, REACTOME_INNATE_IMMUNE_SYSTEM, GOBP_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS, GOCC_SECRETORY_GRANULE, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, KEGG_GLYCOLYSIS_GLUCONEOGENESIS, GOBP_PURINE_CONTAINING_COMPOUND_SALVAGE, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOLDRATH_ANTIGEN_RESPONSE, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_POLYSACCHARIDE_CATABOLIC_PROCESS

GO Biological Process (5): glycogen biosynthetic process (GO:0005978), glycogen catabolic process (GO:0005980), glucose metabolic process (GO:0006006), purine ribonucleoside salvage (GO:0006166), carbohydrate metabolic process (GO:0005975)

GO Molecular Function (8): magnesium ion binding (GO:0000287), phosphoglucomutase activity (GO:0004614), phosphopentomutase activity (GO:0008973), catalytic activity (GO:0003824), protein binding (GO:0005515), isomerase activity (GO:0016853), intramolecular phosphotransferase activity (GO:0016868), metal ion binding (GO:0046872)

GO Cellular Component (6): extracellular region (GO:0005576), cytosol (GO:0005829), secretory granule lumen (GO:0034774), extracellular exosome (GO:0070062), ficolin-1-rich granule lumen (GO:1904813), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Innate Immune System	1
Metabolism of carbohydrates and carbohydrate derivatives	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
glycogen metabolic process	2
intramolecular phosphotransferase activity	2
glucan biosynthetic process	1
glucan catabolic process	1
hexose metabolic process	1
purine-containing compound salvage	1
nucleoside salvage	1
purine ribonucleoside biosynthetic process	1
primary metabolic process	1
metal ion binding	1
molecular_function	1
binding	1
catalytic activity	1
intramolecular transferase activity	1
cation binding	1
cytoplasm	1
secretory granule	1
cytoplasmic vesicle lumen	1
extracellular vesicle	1
intracellular organelle lumen	1
ficolin-1-rich granule	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2612 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PGM2	PGM1	P36871	968
PGM2	PGM3	O95394	929
PGM2	PGM5	Q15124	909
PGM2	PGD	P52209	842
PGM2	UPP2	O95045	841
PGM2	AK2	P54819	730
PGM2	PPAT	Q06203	729
PGM2	ENO1	P06733	728
PGM2	UPP1	Q16831	724
PGM2	FUCA1	P04066	724
PGM2	LAP3	P28838	719
PGM2	UTP3	Q9NQZ2	687
PGM2	PNP	P00491	682
PGM2	JCHAIN	P01591	647
PGM2	GPI	P06744	646

IntAct

37 interactions, top by confidence:

A	B	Type	Score
AKR7A3	AKR7A2	psi-mi:“MI:0914”(association)	0.890
CD27	TCAF2	psi-mi:“MI:0914”(association)	0.640
TPD52L1	TPD52L2	psi-mi:“MI:0914”(association)	0.530
TINF2	PGM2	psi-mi:“MI:0915”(physical association)	0.510
HSPB1	PGM2	psi-mi:“MI:0915”(physical association)	0.510
PGM2	TERF1	psi-mi:“MI:0915”(physical association)	0.370
ACD	PGM2	psi-mi:“MI:0915”(physical association)	0.370
POT1	PGM2	psi-mi:“MI:0915”(physical association)	0.370
NEK4	E2F8	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
	CLIC1	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
STX17	A2ML1	psi-mi:“MI:0914”(association)	0.350
OR2A4	A2ML1	psi-mi:“MI:0914”(association)	0.350
GOT1	A2ML1	psi-mi:“MI:0914”(association)	0.350
CCR1	UBA6	psi-mi:“MI:0914”(association)	0.350
AZU1	UBA6	psi-mi:“MI:0914”(association)	0.350
BCAS2	ISY1-RAB43	psi-mi:“MI:0914”(association)	0.350
DDX28	UBA6	psi-mi:“MI:0914”(association)	0.350
GAB2	UBA6	psi-mi:“MI:0914”(association)	0.350
HEY1	A2ML1	psi-mi:“MI:0914”(association)	0.350
ITM2C	UBA6	psi-mi:“MI:0914”(association)	0.350
KANSL3	GSPT1	psi-mi:“MI:0914”(association)	0.350
MRPL49	UBA6	psi-mi:“MI:0914”(association)	0.350
NPPB	ACOT7	psi-mi:“MI:0914”(association)	0.350
PCDHGA9	UBA6	psi-mi:“MI:0914”(association)	0.350
PCGF6	UBA6	psi-mi:“MI:0914”(association)	0.350
PEX7	UBA6	psi-mi:“MI:0914”(association)	0.350

BioGRID (69): PGM2 (Two-hybrid), PGM2 (Affinity Capture-Western), C11orf54 (Co-fractionation), PGM2 (Co-fractionation), PGM2 (Co-fractionation), PGM2 (Co-fractionation), PGM2 (Co-fractionation), PGM2 (Co-fractionation), PGM2 (Co-fractionation), PGM2 (Affinity Capture-MS), PGM2 (Proximity Label-MS), PGM2 (Proximity Label-MS), PGM2 (Affinity Capture-RNA), PGM2 (Affinity Capture-MS), PGM2 (Affinity Capture-MS)

ESM2 similar proteins: A3KG59, A4IFH5, B9N1F9, D3ZVR9, O04059, O35331, O35621, O46560, P11172, P24298, P37111, Q03154, Q04609, Q15124, Q17QK3, Q2R483, Q501L1, Q5E9T8, Q5I0K3, Q5NAY4, Q5R514, Q5R5C9, Q5RDE7, Q5RDN7, Q5RFB0, Q5RFI8, Q6AY30, Q6AYS7, Q6K2E8, Q6PTT0, Q6Q0N1, Q6ZV70, Q7TSV4, Q7X7L3, Q8BZF8, Q8CG45, Q8CG76, Q8IYS1, Q8K183, Q8N0X4

Diamond homologs: A0R8M4, A1K5A1, A2CCG3, A2REP8, A3PAW2, A4FX97, A4VWE5, A4W2Q0, A5GII9, A5UKY3, A6TW06, A6UP86, A6UU47, A7HV12, A9KSW8, B0B944, B0BAS3, B0C132, B1N017, B1WR00, B1XP15, B4U3I6, B7ITV9, B9DSE8, C0M9C4, C0MDT1, C0ZIM8, C1B058, C1CWA3, C4KZK4, C4Z1Z8, C5A2H8, O74478, O84822, P0DB38, P0DB39, P18159, P45632, Q027B2, Q03262

SIGNOR signaling

8 interactions.

A	Effect	B	Mechanism
PGM2	“down-regulates quantity”	“alpha-D-ribose 1-phosphate(2-)”	“chemical modification”
PGM2	“up-regulates quantity”	“D-ribofuranose 5-phosphate(2-)”	“chemical modification”
PGM2	“down-regulates quantity”	“2-deoxy-alpha-D-ribose 1-phosphate”	“chemical modification”
PGM2	“up-regulates quantity”	“2-deoxy-D-ribose 5-phosphate”	“chemical modification”
PGM2	“up-regulates quantity”	“alpha-D-glucose 1-phosphate(2-)”	“chemical modification”
PGM2	“up-regulates quantity”	“alpha-D-glucose 6-phosphate(2-)”	“chemical modification”
PGM2	“down-regulates quantity”	“alpha-D-glucose 1-phosphate(2-)”	“chemical modification”
PGM2	“down-regulates quantity”	“alpha-D-glucose 6-phosphate(2-)”	“chemical modification”

Disease & clinical

Clinical variants and AI predictions

ClinVar

107 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	77
Likely benign	5
Benign	7

Top pathogenic / likely-pathogenic (0)

SpliceAI

2103 predictions. Top by Δscore:

Variant	Effect	Δscore
4:37826809:ACAAG:A	donor_loss	1.0000
4:37826811:AAGG:A	donor_loss	1.0000
4:37826812:AGG:A	donor_loss	1.0000
4:37826813:GGTG:G	donor_loss	1.0000
4:37829959:TTCA:T	acceptor_loss	1.0000
4:37829960:TCAG:T	acceptor_loss	1.0000
4:37829961:CAG:C	acceptor_loss	1.0000
4:37829962:AGA:A	acceptor_loss	1.0000
4:37829963:GA:G	acceptor_gain	1.0000
4:37829963:GAATT:G	acceptor_gain	1.0000
4:37830130:AGGTA:A	donor_loss	1.0000
4:37830131:GGTAC:G	donor_loss	1.0000
4:37830132:GT:G	donor_loss	1.0000
4:37830133:T:A	donor_loss	1.0000
4:37839924:GTTA:G	donor_gain	1.0000
4:37839925:TTAT:T	donor_gain	1.0000
4:37839927:ATAAG:A	donor_gain	1.0000
4:37840054:T:A	acceptor_gain	1.0000
4:37840258:AG:A	donor_loss	1.0000
4:37840259:GGT:G	donor_loss	1.0000
4:37840260:G:GA	donor_loss	1.0000
4:37840261:T:G	donor_loss	1.0000
4:37845620:T:G	acceptor_gain	1.0000
4:37845621:A:AG	acceptor_gain	1.0000
4:37845629:TCA:T	acceptor_loss	1.0000
4:37845631:A:AG	acceptor_gain	1.0000
4:37845631:A:T	acceptor_loss	1.0000
4:37845632:G:GC	acceptor_gain	1.0000
4:37845632:GA:G	acceptor_gain	1.0000
4:37845632:GAC:G	acceptor_gain	1.0000

AlphaMissense

4074 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:37839902:C:G	H166D	1.000
4:37845700:A:T	D326V	1.000
4:37848552:A:T	K438I	1.000
4:37830051:T:C	F57L	0.999
4:37830053:T:A	F57L	0.999
4:37830053:T:G	F57L	0.999
4:37839904:C:A	H166Q	0.999
4:37839904:C:G	H166Q	0.999
4:37839931:G:C	K175N	0.999
4:37839931:G:T	K175N	0.999
4:37844506:T:C	F288L	0.999
4:37844508:T:A	F288L	0.999
4:37844508:T:G	F288L	0.999
4:37844529:T:A	N295K	0.999
4:37844529:T:G	N295K	0.999
4:37845688:A:G	D322G	0.999
4:37845688:A:T	D322V	0.999
4:37845699:G:C	D326H	0.999
4:37845700:A:C	D326A	0.999
4:37845701:T:A	D326E	0.999
4:37845701:T:G	D326E	0.999
4:37847052:A:C	S377R	0.999
4:37847054:C:A	S377R	0.999
4:37847054:C:G	S377R	0.999
4:37847217:T:C	F402L	0.999
4:37847219:T:A	F402L	0.999
4:37847219:T:G	F402L	0.999
4:37847220:A:G	K403E	0.999
4:37847222:G:C	K403N	0.999
4:37847222:G:T	K403N	0.999

dbSNP variants (sampled 300 via entrez): RS10000528 (4:37843257 G>A,T), RS1000054876 (4:37826735 G>A), RS10000814 (4:37843632 G>A), RS10001580 (4:37850235 A>C,T), RS1000251733 (4:37832577 T>G), RS1000306900 (4:37845130 G>A), RS10003112 (4:37854647 C>A,T), RS1000488819 (4:37862416 G>A), RS1000501602 (4:37844106 T>C), RS1000658837 (4:37844923 G>T), RS1000789712 (4:37831344 C>T), RS1000836669 (4:37850850 G>T), RS1000852382 (4:37833145 A>G), RS1000889087 (4:37850657 C>G,T), RS1000928950 (4:37856076 T>C)

Disease associations

OMIM: gene MIM:172000 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010397_58	Gut microbiota (bacterial taxa, rank normal transformation method)	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067285 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 3 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.54	Kd	286.1	nM	CHEMBL3752910
6.54	ED50	286.1	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 4 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148990: Binding affinity to human PGM2 incubated for 45 mins by Kinobead based pull down assay	kd	0.2861	uM

CTD chemical–gene interactions

64 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	5
bisphenol A	affects cotreatment, decreases methylation, decreases expression	3
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	2
Temozolomide	increases expression, affects response to substance	2
Air Pollutants	decreases expression, increases abundance, increases expression	2
Benzo(a)pyrene	increases methylation, increases mutagenesis	2
Nickel	decreases expression, increases expression	2
Phenylmercuric Acetate	increases expression, affects cotreatment	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Cyclosporine	decreases expression, increases expression	2
Particulate Matter	increases expression, decreases expression, increases abundance	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
bisphenol F	increases expression	1
dicrotophos	decreases expression	1
2,4,6-tribromophenol	increases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	increases activity, affects binding, decreases expression	1
pyrogallol 1,3-dimethyl ether	affects localization, increases expression, decreases expression, affects cotreatment	1
decabromobiphenyl ether	increases expression	1
kojic acid	increases expression	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
cobaltous chloride	decreases expression	1
tetrabromobisphenol A	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	decreases expression	1
bisphenol B	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652032	Binding	Binding affinity to human PGM2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.