PGM5-AS1

Summary

PGM5-AS1 (PGM5 antisense RNA 1, HGNC:44181) is a long non-coding RNA gene on chromosome 9q21.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44181
Approved symbol	PGM5-AS1
Name	PGM5 antisense RNA 1
Location	9q21.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	FAM233A, LOC572558
Ensembl gene	ENSG00000224958
Ensembl biotype	lncRNA
Entrez	572558
RNAcentral	URS000075D2DD — lncRNA, 586 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000417887, ENST00000420855, ENST00000653382, ENST00000653727, ENST00000657969, ENST00000668093, ENST00000671372, ENST00000763099, ENST00000763100, ENST00000763101, ENST00000763102, ENST00000763103, ENST00000763104, ENST00000763105, ENST00000763106, ENST00000763107, ENST00000763108

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417887 — 2 exons

Exon	Start	End
ENSE00001752371	68357723	68357852
ENSE00001792626	68355189	68355605

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 95.57.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle layer of sigmoid colon	UBERON:0035805	95.57	gold quality
prostate gland	UBERON:0002367	94.48	gold quality
lower esophagus muscularis layer	UBERON:0035833	94.17	gold quality
lower esophagus	UBERON:0013473	94.10	gold quality
body of uterus	UBERON:0009853	94.05	gold quality
urinary bladder	UBERON:0001255	93.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	93.46	gold quality
myometrium	UBERON:0001296	91.92	gold quality
mucosa of stomach	UBERON:0001199	91.64	gold quality
left uterine tube	UBERON:0001303	88.84	gold quality
smooth muscle tissue	UBERON:0001135	86.93	gold quality
colon	UBERON:0001155	86.47	gold quality
fundus of stomach	UBERON:0001160	86.46	gold quality
esophagus	UBERON:0001043	85.03	gold quality
right adrenal gland cortex	UBERON:0035827	84.75	gold quality
endocervix	UBERON:0000458	83.88	gold quality
colonic epithelium	UBERON:0000397	83.77	gold quality
popliteal artery	UBERON:0002250	83.64	gold quality
tibial artery	UBERON:0007610	83.64	gold quality
left adrenal gland cortex	UBERON:0035825	83.53	gold quality
right adrenal gland	UBERON:0001233	83.45	gold quality
intestine	UBERON:0000160	83.42	gold quality
uterine cervix	UBERON:0000002	83.16	gold quality
left adrenal gland	UBERON:0001234	83.08	gold quality
ectocervix	UBERON:0012249	82.55	gold quality
lower esophagus mucosa	UBERON:0035834	82.19	gold quality
fallopian tube	UBERON:0003889	82.15	gold quality
adrenal gland	UBERON:0002369	81.87	gold quality
transverse colon	UBERON:0001157	81.64	gold quality
right atrium auricular region	UBERON:0006631	80.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Long non-coding RNA LOC572558 functions as a tumor suppressor and regulates the p53 signaling pathway in bladder cancer. (PMID:27130667)
• High PGM5-AS1 expression levels were associated with worse overall survival in colorectal cancer. (PMID:28797257)
• our data indicate that PGM5-AS1 is a novel tumor suppressor in esophageal squamous cell carcinoma (ESCC) and restoration of PGM5-AS1 may be a promising avenue for treatment of ESCC patient. (PMID:31185143)
• Down-regulation of long noncoding RNA PGM5-AS1 correlates with tumor progression and predicts poor prognosis in clear cell renal cell carcinoma. (PMID:31858536)
• The Downregulation of lncRNA pgm5-as1 Inhibits the Proliferation and Metastasis Via Increasing miR-484 Expression in Colorectal Cancer. (PMID:32354224)
• Reduced long noncoding RNA PGM5-AS1 facilitated proliferation and invasion of colorectal cancer through sponging miR-100-5p. (PMID:32767323)
• Circulating lncRNA UCA1 and lncRNA PGM5-AS1 act as potential diagnostic biomarkers for early-stage colorectal cancer. (PMID:34212174)
• Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284. (PMID:35420507)
• LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis. (PMID:36017912)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.