PGM5P3-AS1

Summary

PGM5P3-AS1 (PGM5P3 antisense RNA 1, HGNC:51194) is a long non-coding RNA gene on chromosome 9p24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51194
Approved symbol	PGM5P3-AS1
Name	PGM5P3 antisense RNA 1
Location	9p24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FAM233B
Ensembl gene	ENSG00000277631
Ensembl biotype	lncRNA
Entrez	101929127
RNAcentral	URS000075DD3D — lncRNA, 601 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000429980, ENST00000442069, ENST00000613372, ENST00000614900, ENST00000620326, ENST00000621255, ENST00000622412, ENST00000701052, ENST00000701771, ENST00000775648

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429980 — 3 exons

Exon	Start	End
ENSE00001680595	88742	90820
ENSE00004142680	72656	72816
ENSE00004142690	79345	79537

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 79.18.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0504 / max 12.7875, expressed in 17 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
95735	0.0504	17

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
spleen	UBERON:0002106	79.18	gold quality
omental fat pad	UBERON:0010414	77.60	gold quality
smooth muscle tissue	UBERON:0001135	74.23	gold quality
colonic epithelium	UBERON:0000397	72.99	gold quality
body of uterus	UBERON:0009853	72.33	gold quality
mucosa of stomach	UBERON:0001199	71.67	gold quality
fallopian tube	UBERON:0003889	71.60	gold quality
adipose tissue	UBERON:0001013	71.33	gold quality
myometrium	UBERON:0001296	70.68	gold quality
left uterine tube	UBERON:0001303	70.59	gold quality
endometrium	UBERON:0001295	70.15	gold quality
thoracic mammary gland	UBERON:0005200	69.85	gold quality
apex of heart	UBERON:0002098	69.69	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.93	gold quality
lower esophagus	UBERON:0013473	67.85	gold quality
gall bladder	UBERON:0002110	67.76	gold quality
right uterine tube	UBERON:0001302	67.40	gold quality
right lobe of thyroid gland	UBERON:0001119	66.51	gold quality
left lobe of thyroid gland	UBERON:0001120	66.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.03	gold quality
thyroid gland	UBERON:0002046	65.88	gold quality
urinary bladder	UBERON:0001255	65.49	gold quality
uterine cervix	UBERON:0000002	65.44	gold quality
right coronary artery	UBERON:0001625	65.36	gold quality
lymph node	UBERON:0000029	65.28	gold quality
heart left ventricle	UBERON:0002084	65.12	gold quality
ectocervix	UBERON:0012249	64.73	gold quality
fundus of stomach	UBERON:0001160	64.67	gold quality
sural nerve	UBERON:0015488	64.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.50

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN. (PMID:32754899)
• PGM5P3-AS1 regulates MAP1LC3C to promote cell ferroptosis and thus inhibiting the malignant progression of triple-negative breast cancer. (PMID:35325342)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.