PGM5P4-AS1

Summary

PGM5P4-AS1 (PGM5P4 antisense RNA 1, HGNC:51195) is a long non-coding RNA gene on chromosome 2q14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51195
Approved symbol	PGM5P4-AS1
Name	PGM5P4 antisense RNA 1
Location	2q14.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FAM233C
Ensembl gene	ENSG00000231943
Ensembl biotype	lncRNA
Entrez	103344932
RNAcentral	URS000075B6E7 — lncRNA, 950 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000416105, ENST00000416758, ENST00000446595, ENST00000450636, ENST00000652488, ENST00000655915, ENST00000686046, ENST00000686399, ENST00000701751, ENST00000803373, ENST00000803374, ENST00000803375, ENST00000803376, ENST00000803377, ENST00000803378, ENST00000803379, ENST00000803380

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416105 — 4 exons

Exon	Start	End
ENSE00001699589	113535807	113535999
ENSE00001743426	113534560	113534716
ENSE00004193744	113542547	113542748
ENSE00004193760	113528395	113529102

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 81.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0649 / max 14.3992, expressed in 35 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
30326	0.0649	35

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.34	silver quality
smooth muscle tissue	UBERON:0001135	78.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	77.60	gold quality
lower esophagus	UBERON:0013473	77.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	77.12	gold quality
mucosa of stomach	UBERON:0001199	76.89	gold quality
left uterine tube	UBERON:0001303	76.34	gold quality
omental fat pad	UBERON:0010414	75.64	gold quality
fallopian tube	UBERON:0003889	74.41	gold quality
colonic epithelium	UBERON:0000397	73.52	gold quality
spleen	UBERON:0002106	73.14	gold quality
bone marrow cell	CL:0002092	73.09	gold quality
body of uterus	UBERON:0009853	72.95	gold quality
endometrium	UBERON:0001295	72.91	gold quality
myometrium	UBERON:0001296	71.98	gold quality
urinary bladder	UBERON:0001255	71.69	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.23	gold quality
adipose tissue	UBERON:0001013	70.47	gold quality
cortical plate	UBERON:0005343	70.47	gold quality
muscle tissue	UBERON:0002385	70.01	gold quality
tibial nerve	UBERON:0001323	69.47	gold quality
stromal cell of endometrium	CL:0002255	69.41	gold quality
gall bladder	UBERON:0002110	68.73	gold quality
lymph node	UBERON:0000029	68.59	gold quality
esophagus	UBERON:0001043	68.59	gold quality
apex of heart	UBERON:0002098	68.31	gold quality
right uterine tube	UBERON:0001302	67.86	gold quality
fundus of stomach	UBERON:0001160	67.84	gold quality
right lung	UBERON:0002167	66.64	gold quality
thoracic mammary gland	UBERON:0005200	66.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.70

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275. (PMID:33315502)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.