PHACTR2-AS1

Summary

PHACTR2-AS1 (PHACTR2 antisense RNA 1, HGNC:40943) is a long non-coding RNA gene on chromosome 6q24.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40943
Approved symbol	PHACTR2-AS1
Name	PHACTR2 antisense RNA 1
Location	6q24.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	NR027113, lncIHS
Ensembl gene	ENSG00000235740
Ensembl biotype	lncRNA
Entrez	285740
RNAcentral	URS000075E59A — lncRNA, 2134 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000450575, ENST00000657644, ENST00000661155

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000450575 — 5 exons

Exon	Start	End
ENSE00001613570	143561167	143561468
ENSE00001675814	143561885	143562031
ENSE00001689174	143554325	143555230
ENSE00001722798	143557999	143558131
ENSE00001786426	143557531	143557741

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 97.69.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0271 / max 22.1032, expressed in 3 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
76044	0.0181	3
76043	0.0090	3

Top tissues by expression

171 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	97.69	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.12	gold quality
left testis	UBERON:0004533	84.56	gold quality
right testis	UBERON:0004534	83.67	gold quality
testis	UBERON:0000473	82.00	gold quality
colonic epithelium	UBERON:0000397	71.99	gold quality
bone marrow cell	CL:0002092	66.64	silver quality
epithelium of nasopharynx	UBERON:0001951	59.18	gold quality
adult organism	UBERON:0007023	58.28	gold quality
uterine cervix	UBERON:0000002	58.20	silver quality
mucosa of paranasal sinus	UBERON:0005030	57.90	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.18	silver quality
ganglionic eminence	UBERON:0004023	56.07	gold quality
monocyte	CL:0000576	55.90	gold quality
superficial temporal artery	UBERON:0001614	55.73	gold quality
cardia of stomach	UBERON:0001162	54.41	gold quality
inferior vagus X ganglion	UBERON:0005363	54.33	gold quality
superior vestibular nucleus	UBERON:0007227	54.17	gold quality
ventral tegmental area	UBERON:0002691	53.92	gold quality
mammary duct	UBERON:0001765	53.89	gold quality
saphenous vein	UBERON:0007318	53.85	gold quality
trigeminal ganglion	UBERON:0001675	53.83	gold quality
subthalamic nucleus	UBERON:0001906	53.83	gold quality
layer of synovial tissue	UBERON:0007616	53.81	gold quality
dorsal plus ventral thalamus	UBERON:0001897	53.80	gold quality
pericardium	UBERON:0002407	53.73	gold quality
dorsal root ganglion	UBERON:0000044	53.57	gold quality
thymus	UBERON:0002370	53.48	gold quality
nipple	UBERON:0002030	53.41	gold quality
renal medulla	UBERON:0000362	53.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• lncRNA NR027113 can promote the proliferation, invasion and metastasis of hepatocellular carcinoma via the PTEN/PI3K/AKT signaling pathway. (PMID:30468465)
• LncRNA NR027113 promotes malignant progression of gastric carcinoma via EMT signaling pathway. (PMID:31210301)
• The EZH2-PHACTR2-AS1-Ribosome Axis induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer. (PMID:32312833)
• Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell carcinoma metastasis by regulating Snail. (PMID:32702100)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.