PHOSPHO2

Summary

PHOSPHO2 (phosphatase, orphan 2, HGNC:28316) is a protein-coding gene on chromosome 2q31.1, encoding Pyridoxal phosphate phosphatase PHOSPHO2 (Q8TCD6). Phosphatase that has high activity toward pyridoxal 5’-phosphate (PLP).

Predicted to enable phosphatase activity.

Source: NCBI Gene 493911 — automated summary from GO annotations (Alliance of Genome Resources).

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 32 total
• GTEx eGene: eQTL in 47 tissues, sQTL in 39 (q < 0.05)
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 1.30 (unconstrained)
• MANE Select transcript: NM_001008489

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28316
Approved symbol	PHOSPHO2
Name	phosphatase, orphan 2
Location	2q31.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC22679
Ensembl gene	ENSG00000144362
Ensembl biotype	protein_coding
Entrez	493911

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 34 protein_coding, 1 protein_coding_CDS_not_defined

MANE Select: ENST00000359744

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 2: 2, TSL 3: 5

ENST00000359744, ENST00000438710, ENST00000438838, ENST00000449906, ENST00000476919, ENST00000616481, ENST00000616524, ENST00000617738, ENST00000857416, ENST00000857417, ENST00000857418, ENST00000857419, ENST00000857420, ENST00000857421, ENST00000857422, ENST00000857423, ENST00000857424, ENST00000931227, ENST00000931228, ENST00000931229, ENST00000931230, ENST00000931231, ENST00000931232, ENST00000931233, ENST00000931234, ENST00000931235, ENST00000931236, ENST00000931237, ENST00000931238, ENST00000931239, ENST00000931240, ENST00000961207, ENST00000961208, ENST00000961209, ENST00001144211

RefSeq mRNA: 5 — MANE Select: NM_001008489 NM_001008489, NM_001199285, NM_001199286, NM_001199287, NM_001199288

CCDS: CCDS33319

Canonical transcript exons

ENST00000359744 — 4 exons

Exon	Start	End
ENSE00001413182	169700946	169701708
ENSE00001466648	169694469	169694622
ENSE00003515401	169697361	169697531
ENSE00003520671	169695215	169695247

Expression profiles

Bgee: expression breadth ubiquitous, 237 present calls, max score 96.30.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0250 / max 4.5835, expressed in 15 samples.

Highest expression (Bgee): secondary oocyte, oocyte, sperm, male germ line stem cell (sensu Vertebrata) in testis, primordial germ cell in gonad.

Genetic regulation across tissues (GTEx eQTL / sQTL)

PHOSPHO2 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 47 tissues and its splicing (sQTL) in 39 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 86 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Testis	sqtl	2.1e-93	-3.08	2:169694622:G:A
Nerve Tibial	sqtl	1.7e-74	-2.18	2:169694622:G:A
Artery Tibial	sqtl	3.4e-74	-2.22	2:169694622:G:A
Thyroid	sqtl	1.2e-73	-2.25	2:169694622:G:A
Adipose Subcutaneous	sqtl	1.9e-71	-2.20	2:169694622:G:A
Cells Cultured fibroblasts	sqtl	1.5e-56	-1.97	2:169694622:G:A
Breast Mammary Tissue	sqtl	1.9e-54	-2.27	2:169694622:G:A
Muscle Skeletal	sqtl	4.8e-53	-1.74	2:169694622:G:A
Colon Transverse	sqtl	4.9e-42	-2.08	2:169694622:G:A
Skin Sun Exposed Lower leg	sqtl	1.4e-41	-1.67	2:169694622:G:A
Esophagus Muscularis	sqtl	2.4e-41	-2.24	2:169694622:G:A
Colon Sigmoid	sqtl	7.0e-40	-2.25	2:169694622:G:A
Adipose Visceral Omentum	sqtl	1.5e-37	-1.96	2:169694622:G:A
Skin Not Sun Exposed Suprapubic	sqtl	6.7e-37	-1.80	2:169694622:G:A
Artery Tibial	eqtl	1.9e-36	-0.55	2:169701721:T:C
Artery Aorta	sqtl	5.1e-35	-1.95	2:169694622:G:A
Nerve Tibial	eqtl	1.8e-33	-0.56	2:169712014:C:T
Thyroid	eqtl	2.6e-33	-0.59	2:169699317:TC:T
Colon Transverse	eqtl	3.3e-29	-0.50	2:169706187:T:TCA
Adipose Subcutaneous	eqtl	5.1e-29	-0.41	2:169712014:C:T

FANTOM5 promoters

2 alternative TSS:

Promoter ID	TPM avg	Samples expressed
23564	5.7217	1471
23566	0.0250	15

Top tissues by expression

showing 100 of 249 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	96.30	gold quality
oocyte	CL:0000023	96.21	gold quality
sperm	CL:0000019	94.25	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.33	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.95	gold quality
corpus epididymis	UBERON:0004359	86.54	gold quality
caput epididymis	UBERON:0004358	86.45	gold quality
tibia	UBERON:0000979	85.69	gold quality
epithelial cell of pancreas	CL:0000083	84.81	gold quality
left testis	UBERON:0004533	84.42	gold quality
right testis	UBERON:0004534	84.06	gold quality
testis	UBERON:0000473	83.61	gold quality
bronchial epithelial cell	CL:0002328	82.38	gold quality
cauda epididymis	UBERON:0004360	82.18	gold quality
bronchus	UBERON:0002185	81.39	gold quality
calcaneal tendon	UBERON:0003701	80.91	gold quality
germinal epithelium of ovary	UBERON:0001304	80.43	gold quality
rectum	UBERON:0001052	80.18	gold quality
epithelium of mammary gland	UBERON:0003244	80.11	gold quality
mammary duct	UBERON:0001765	80.03	gold quality
thoracic mammary gland	UBERON:0005200	79.68	gold quality
mammary gland	UBERON:0001911	79.57	gold quality
mucosa of paranasal sinus	UBERON:0005030	79.20	gold quality
duodenum	UBERON:0002114	79.19	gold quality
islet of Langerhans	UBERON:0000006	78.82	gold quality
right uterine tube	UBERON:0001302	78.77	gold quality
prostate gland	UBERON:0002367	78.76	gold quality
thyroid gland	UBERON:0002046	78.63	gold quality
adipose tissue	UBERON:0001013	78.48	gold quality
muscle layer of sigmoid colon	UBERON:0035805	78.41	gold quality
left lobe of thyroid gland	UBERON:0001120	78.40	gold quality
body of pancreas	UBERON:0001150	78.34	gold quality
adult organism	UBERON:0007023	78.25	gold quality
jejunal mucosa	UBERON:0000399	78.18	gold quality
right lobe of thyroid gland	UBERON:0001119	78.00	gold quality
pancreas	UBERON:0001264	77.86	gold quality
left ovary	UBERON:0002119	77.83	gold quality
parietal pleura	UBERON:0002400	77.59	gold quality
ventricular zone	UBERON:0003053	77.51	gold quality
transverse colon	UBERON:0001157	77.50	gold quality
subcutaneous adipose tissue	UBERON:0002190	77.41	gold quality
popliteal artery	UBERON:0002250	77.40	gold quality
tibial artery	UBERON:0007610	77.38	gold quality
colon	UBERON:0001155	77.25	gold quality
right ovary	UBERON:0002118	77.20	gold quality
large intestine	UBERON:0000059	77.17	gold quality
pancreatic ductal cell	CL:0002079	77.05	silver quality
ovary	UBERON:0000992	76.86	gold quality
colonic mucosa	UBERON:0000317	76.83	gold quality
intestine	UBERON:0000160	76.81	gold quality
ganglionic eminence	UBERON:0004023	76.66	gold quality
mucosa of transverse colon	UBERON:0004991	76.65	gold quality
pituitary gland	UBERON:0000007	76.57	gold quality
minor salivary gland	UBERON:0001830	76.53	gold quality
saliva-secreting gland	UBERON:0001044	76.51	gold quality
adenohypophysis	UBERON:0002196	76.51	gold quality
mucosa of sigmoid colon	UBERON:0004993	76.46	gold quality
ectocervix	UBERON:0012249	76.43	gold quality
smooth muscle tissue	UBERON:0001135	76.37	gold quality
cortical plate	UBERON:0005343	76.37	gold quality
body of uterus	UBERON:0009853	76.36	gold quality
aorta	UBERON:0000947	76.16	gold quality
pigmented layer of retina	UBERON:0001782	76.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	76.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.07	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.04	gold quality
lower esophagus	UBERON:0013473	76.02	gold quality
visceral pleura	UBERON:0002401	75.93	gold quality
endocervix	UBERON:0000458	75.51	gold quality
gastrocnemius	UBERON:0001388	75.43	gold quality
parotid gland	UBERON:0001831	75.42	silver quality
small intestine Peyer’s patch	UBERON:0003454	75.30	gold quality
skin of hip	UBERON:0001554	75.28	gold quality
left coronary artery	UBERON:0001626	75.27	gold quality
left uterine tube	UBERON:0001303	75.25	gold quality
adipose tissue of abdominal region	UBERON:0007808	75.19	gold quality
tibial nerve	UBERON:0001323	75.16	gold quality
small intestine	UBERON:0002108	75.14	gold quality
endometrium	UBERON:0001295	75.04	gold quality
adrenal tissue	UBERON:0018303	75.03	gold quality
mucosa of stomach	UBERON:0001199	74.96	gold quality
ascending aorta	UBERON:0001496	74.87	gold quality
mouth mucosa	UBERON:0003729	74.79	gold quality
right coronary artery	UBERON:0001625	74.76	gold quality
urinary bladder	UBERON:0001255	74.74	gold quality
palpebral conjunctiva	UBERON:0001812	74.73	gold quality
thoracic aorta	UBERON:0001515	74.72	gold quality
peritoneum	UBERON:0002358	74.64	gold quality
omental fat pad	UBERON:0010414	74.64	gold quality
muscle of leg	UBERON:0001383	74.61	gold quality
gall bladder	UBERON:0002110	74.60	gold quality
descending thoracic aorta	UBERON:0002345	74.33	gold quality
ileal mucosa	UBERON:0000331	74.23	gold quality
uterus	UBERON:0000995	74.20	gold quality
body of stomach	UBERON:0001161	74.17	gold quality
right atrium auricular region	UBERON:0006631	74.12	gold quality
coronary artery	UBERON:0001621	74.01	gold quality
Brodmann (1909) area 23	UBERON:0013554	73.90	gold quality
epithelium of nasopharynx	UBERON:0001951	73.84	gold quality
female reproductive system	UBERON:0000474	73.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.44

HPA expression

RNA tissue specificity: Low tissue specificity

showing 60 of 80 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Frontal cortex	tissue	24.4
Caudate putamen	tissue	23.0
Cerebellum	tissue	18.1	medium
Putamen	tissue	14.2
Prostate	tissue	12.2	medium
Choroid plexus	tissue	12.1
Testis	tissue	11.8	medium
Basal ganglia	tissue	11.2	low
Cerebral cortex	tissue	10.9	low
Somatosensory cortex	tissue	10.9
Occipital cortex	tissue	10.9
Ventral forebrain	tissue	10.8
Olfactory bulb	tissue	10.5
Hippocampal formation	tissue	10.3
Entorhinal cortex	tissue	10.3
Prefrontal cortex	tissue	10.0
Retrosplenial and cingulate cortex	tissue	10.0
Breast	tissue	9.9	medium
Motor cortex	tissue	9.8
Septum	tissue	9.8
Thalamus	tissue	9.7
Pons	tissue	9.6
Retrosplenial cortex	tissue	9.6
Temporal cortex	tissue	9.6
Thyroid gland	tissue	9.2	medium
Midbrain	tissue	9.1
Insular cortex	tissue	9.1
Superior colliculi	tissue	8.9
Amygdala	tissue	8.8
Hypothalamus	tissue	8.6
Substantia nigra	tissue	8.3
Periaqueductal gray	tissue	8.3
Salivary gland	tissue	8.0	medium
Nucleus accumbens	tissue	7.3
Medulla oblongata	tissue	7.3
Locus coeruleus	tissue	7.2
Spinal cord	tissue	7.2
Parathyroid gland	tissue	6.8	medium
Retina	tissue	6.7
Hippocampus	tissue	6.7	not detected
Small intestine	tissue	6.0	medium
Duodenum	tissue	6.0	medium
Corpus callosum	tissue	6.0
Fallopian tube	tissue	5.6	medium
Rectum	tissue	5.5	medium
Colon	tissue	5.5	medium
Kidney	tissue	5.2	medium
Postcentral gyrus	tissue	5.0
Endometrium 1	tissue	4.9	medium
Pancreas	tissue	4.8	medium
Adipose tissue	tissue	4.7	low
Stomach 1	tissue	4.5	medium
Seminal vesicle	tissue	4.5	medium
Cervix	tissue	4.4	medium
Pituitary gland	tissue	4.3
Ovary	tissue	4.2	not detected
Epididymis	tissue	4.0	medium
Gallbladder	tissue	3.7	medium
Liver	tissue	3.4	not detected
Skin 1	tissue	3.3	medium

Brain sub-regions (HPA Brain Atlas): detected in 192; highest nTPM — Cerebellar cortex (12.7), Vermis (12.5), Flocculonodular lobe (11.9), Arcuate nucleus (10.0), Subiculum (9.4).

Regulation

Is transcription factor: no

Functional genomics

gnomAD constraint: pLI 6.28e-05, LOEUF 1.3, missense Z 1.03 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000359744 — one region, missense o/e 0.87.

Literature-anchored findings (GeneRIF, showing 1)

• Models of PHOSPHO2 and PHOSPHO1 suggest subtle differences in the charge distributions around the putative substrate entry site and in the location of potential H-bond donors. (PMID:16054448)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	phospho2	ENSDARG00000102202
mus_musculus	Phospho2	ENSMUSG00000027088
rattus_norvegicus	Phospho2	ENSRNOG00000007979
drosophila_melanogaster	CG14212	FBGN0031045
drosophila_melanogaster	CG12237	FBGN0031048

Paralogs (1): PHOSPHO1 (ENSG00000173868)

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Bos taurus	Q2KI06	85.5%	Diamond
Arabidopsis thaliana	Q9FZ62	77.0%	Diamond
Xenopus tropicalis	Q66KD6	62.5%	Diamond
Gallus gallus	O73884	61.1%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
PHOSPHO2-KLHL23	protein-coding	100526832
CFAP210	protein-coding	129881
FASTKD1	protein-coding	79675
PPIG	protein-coding	9360
KLHL23	protein-coding	151230
KLHL41	protein-coding	10324

Protein

Protein identifiers

Pyridoxal phosphate phosphatase PHOSPHO2 — Q8TCD6 (reviewed: Q8TCD6)

All UniProt accessions (4): C9J4G2, C9JD35, C9JZQ7, Q8TCD6

UniProt curated annotations — full annotation on UniProt →

Function. Phosphatase that has high activity toward pyridoxal 5’-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.

Similarity. Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

RefSeq proteins (5): NP_001008489, NP_001186214, NP_001186215, NP_001186216, NP_001186217 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006384	HAD_hydro_PyrdxlP_Pase-like	Family
IPR016965	Pase_PHOSPHO-typ	Family
IPR023214	HAD_sf	Homologous_superfamily
IPR036412	HAD-like_sf	Homologous_superfamily

Pfam: PF06888

Catalyzed reactions (Rhea)

• pyridoxal 5’-phosphate + H2O = pyridoxal + phosphate (RHEA:20533)

UniProt features (9 total): binding site 5, active site 2, chain 1, sequence variant 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TCD6-F1	96.04	0.94

Human Protein Atlas

Protein class: Enzymes, ENZYME proteins, Hydrolases, Metabolic proteins, Predicted intracellular proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): vesicles; nucleoplasm

Antibody reliability (HPA): IH uncertain · IF approved

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (2)

Position	Role
8	nucleophile
10	proton donor

Ligand- & substrate-binding residues (5)

Position	Role
8	Mg(2+)
10	Mg(2+)
19	substrate
99	substrate
179	Mg(2+)

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 52 (showing top): GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS, GOMF_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY, JOHNSTONE_PARVB_TARGETS_3_DN, WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D, FORTSCHEGGER_PHF8_TARGETS_DN, GOMF_PHOSPHATASE_ACTIVITY, WNT_UP.V1_DN, FOXJ2_TARGET_GENES, FOXN3_TARGET_GENES, ZNF711_TARGET_GENES, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2, GSE14769_UNSTIM_VS_120MIN_LPS_BMDM_UP, GSE14769_UNSTIM_VS_240MIN_LPS_BMDM_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_48H_CD8_T_CELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN

GO Molecular Function (5): phosphatase activity (GO:0016791), pyridoxal phosphatase activity (GO:0033883), metal ion binding (GO:0046872), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO top-level categories

5 GO namespaces:

Category	Terms
phosphoric ester hydrolase activity	1
phosphatase activity	1
cation binding	1
binding	1
catalytic activity	1

Protein interactions and networks

STRING

showing 15 of 378 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PHOSPHO2	KLHL23	Q8NBE8	571
PHOSPHO2	ZNF487	B1APH4	540
PHOSPHO2	PALD1	Q9ULE6	534
PHOSPHO2	OXLD1	Q5BKU9	524
PHOSPHO2	A6NDT3	A6NDT3	470
PHOSPHO2	A0A0A6YYL6	A0A0A6YYL6	460
PHOSPHO2	NT5M	Q9NPB1	444
PHOSPHO2	ZSCAN9	O15535	441
PHOSPHO2	CFAP210	Q0VFZ6	435
PHOSPHO2	METTL9	Q9H1A3	362
PHOSPHO2	IWS1	Q96ST2	358
PHOSPHO2	TMEM69	Q5SWH9	356
PHOSPHO2	INPP5K	Q9BT40	355
PHOSPHO2	SNF8	Q96H20	349
PHOSPHO2	C18orf32	Q8TCD1	344

IntAct

Human interaction partners of PHOSPHO2 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

11 partners by confidence:

Partner	Interaction type	MIscore	Records
NAB2	physical association	0.720	6
ATP5PF	physical association	0.560	5
TSEN15	physical association	0.560	5
WASHC3	physical association	0.560	5
C1QTNF2	physical association	0.560	3
FLNA	physical association	0.560	3
GKAP1	physical association	0.560	3
JPH3	physical association	0.560	3
VHL	physical association	0.560	3
SIGLEC5	association	0.530	2
SPARC	physical association	0.400	1

BioGRID (14 interactions; top human partners by supporting records): DNTTIP1 (Affinity Capture-MS; 2 records), NAB2 (Two-hybrid; 2 records), SIGLEC5 (Affinity Capture-MS; 2 records), ATP5J (Two-hybrid), C1QTNF2 (Two-hybrid), CCDC53 (Two-hybrid), CPNE4 (Affinity Capture-MS), DDX39A (Affinity Capture-RNA), FLNA (Two-hybrid), GKAP1 (Two-hybrid), TSEN15 (Two-hybrid)

Disease & clinical

Genetic variants

Variant evidence for PHOSPHO2: 32 ClinVar records (0 pathogenic / likely pathogenic); 1 GWAS association.

ClinVar

32 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	31
Likely benign	1
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 19 predictions of 468):

Position(s)	Effect	Δscore	Sites
2:169695248–169695249	donor_loss	0.9700	5
2:169698246	donor_gain	0.9700
2:169695213–169695214	acceptor_loss	0.9600	6
2:169695249	donor_loss	0.9600
2:169695204	acceptor_loss	0.9400
2:169695252	donor_loss	0.9300
2:169698481	donor_gain	0.9300
2:169695252	donor_loss	0.9000
2:169695212	acceptor_loss	0.8900
2:169698246	donor_gain	0.8900

AlphaMissense

399 missense substitutions predicted likely pathogenic (of 1,621 scored), across 113 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
D8	8	0.965	0.989
D183	8	0.957	0.977
D10	8	0.950	0.975
D179	8	0.923	0.972
D99	8	0.919	0.974
D19	8	0.912	0.958
N150	8	0.840	0.971
M48	8	0.747	0.887
C152	7	0.947	0.971
K153	7	0.937	0.997
W225	7	0.918	0.978
W44	7	0.897	0.960
C185	7	0.888	0.970
C147	7	0.876	0.958
F9	7	0.863	0.968
N101	7	0.856	0.971
N124	7	0.850	0.947
C144	7	0.842	0.898
F104	7	0.829	0.923
N182	7	0.823	0.939

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

3 prognostic cancer types:

Cancer	Prognostic	p-value
Kidney Renal Clear Cell Carcinoma (TCGA)	favorable	2.61e-08
Liver Hepatocellular Carcinoma (TCGA)	unfavorable	9.29e-06
Rectum Adenocarcinoma (TCGA)	favorable	0.000354

Disease associations

OMIM: gene `` | disease phenotypes:

GWAS associations

1 associations:

Study	Trait	p-value
GCST005184_8	Common carotid intima-media thickness in HIV infection	5e-6

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	affects cotreatment, decreases expression	3
Dexamethasone	increases expression, affects cotreatment	2
Nickel	decreases expression	2
Cyclosporine	decreases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases expression	1
potassium chromate(VI)	increases expression	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
(+)-JQ1 compound	decreases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1
Acetaminophen	increases expression	1
Cisplatin	decreases expression	1
Coumestrol	decreases expression	1
Indomethacin	increases expression, affects cotreatment	1
Quercetin	affects expression	1
Dihydrotestosterone	increases expression	1
Urethane	decreases expression	1
Vanadates	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Aflatoxin B1	decreases methylation	1
Copper Sulfate	decreases expression	1
Magnetite Nanoparticles	increases methylation	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.