PHOX2B-AS1

Summary

PHOX2B-AS1 (PHOX2B antisense RNA 1, HGNC:40457) is a long non-coding RNA gene on chromosome 4p13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40457
Approved symbol	PHOX2B-AS1
Name	PHOX2B antisense RNA 1
Location	4p13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250467
Ensembl biotype	lncRNA
Entrez	105374425
RNAcentral	URS00026A210B — lncRNA, 1240 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 21 lncRNA

ENST00000508038, ENST00000510602, ENST00000819353, ENST00000819354, ENST00000819355, ENST00000819356, ENST00000819357, ENST00000819358, ENST00000819359, ENST00000819360, ENST00000819361, ENST00000819362, ENST00000819363, ENST00000819364, ENST00000819365, ENST00000819366, ENST00000819367, ENST00000819368, ENST00000819369, ENST00000819370, ENST00000819371

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000508038 — 5 exons

Exon	Start	End
ENSE00002064868	41823143	41823225
ENSE00002065799	41795056	41795214
ENSE00002079571	41794205	41794339
ENSE00004224179	41748293	41748586
ENSE00004224182	41823884	41824185

Expression profiles

Bgee: expression breadth broad, 35 present calls, max score 52.09.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1544 / max 200.6130, expressed in 13 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
47497	0.1273	12
47496	0.0271	4

Top tissues by expression

35 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal gland	UBERON:0002369	52.09	gold quality
left adrenal gland	UBERON:0001234	51.25	gold quality
monocyte	CL:0000576	51.19	silver quality
adrenal tissue	UBERON:0018303	50.46	gold quality
duodenum	UBERON:0002114	50.35	gold quality
stomach	UBERON:0000945	49.58	gold quality
islet of Langerhans	UBERON:0000006	49.52	gold quality
left adrenal gland cortex	UBERON:0035825	49.47	gold quality
blood	UBERON:0000178	49.24	silver quality
vermiform appendix	UBERON:0001154	47.65	gold quality
smooth muscle tissue	UBERON:0001135	45.46	gold quality
muscle layer of sigmoid colon	UBERON:0035805	45.41	gold quality
body of stomach	UBERON:0001161	45.27	gold quality
intestine	UBERON:0000160	44.40	gold quality
right atrium auricular region	UBERON:0006631	44.39	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	44.37	gold quality
heart	UBERON:0000948	43.94	silver quality
colon	UBERON:0001155	43.67	gold quality
small intestine	UBERON:0002108	43.38	gold quality
lower esophagus muscularis layer	UBERON:0035833	42.65	silver quality
esophagus	UBERON:0001043	42.63	silver quality
body of pancreas	UBERON:0001150	42.25	silver quality
right adrenal gland	UBERON:0001233	41.14	gold quality
transverse colon	UBERON:0001157	40.36	silver quality
substantia nigra	UBERON:0002038	39.12	silver quality
vagina	UBERON:0000996	39.08	silver quality
small intestine Peyer’s patch	UBERON:0003454	39.05	silver quality
right adrenal gland cortex	UBERON:0035827	38.55	silver quality
fundus of stomach	UBERON:0001160	37.98	silver quality
omental fat pad	UBERON:0010414	35.00	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.