PICART1

Summary

PICART1 (p53 inducible cancer associated RNA transcript 1, HGNC:27576) is a long non-coding RNA gene on chromosome 17q21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27576
Approved symbol	PICART1
Name	p53 inducible cancer associated RNA transcript 1
Location	17q21.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246640
Ensembl biotype	lncRNA
Entrez	284080
RNAcentral	URS0000144468 — lncRNA, 2533 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000499842, ENST00000691013, ENST00000826198, ENST00000826199, ENST00000826200, ENST00000826201, ENST00000826202, ENST00000826203, ENST00000826204, ENST00000826205

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499842 — 3 exons

Exon	Start	End
ENSE00001961305	50053493	50053627
ENSE00001970634	50050349	50052635
ENSE00001981675	50055629	50055739

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 69.88.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4367 / max 12.5491, expressed in 246 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166842	0.4367	246

Top tissues by expression

226 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	69.88	gold quality
right lung	UBERON:0002167	67.26	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	63.95	gold quality
skin of leg	UBERON:0001511	62.70	gold quality
right coronary artery	UBERON:0001625	62.25	gold quality
apex of heart	UBERON:0002098	61.30	gold quality
popliteal artery	UBERON:0002250	60.52	gold quality
tibial artery	UBERON:0007610	60.51	gold quality
skin of abdomen	UBERON:0001416	60.36	gold quality
cortical plate	UBERON:0005343	59.37	gold quality
aorta	UBERON:0000947	59.21	gold quality
zone of skin	UBERON:0000014	59.18	gold quality
descending thoracic aorta	UBERON:0002345	58.57	gold quality
upper lobe of left lung	UBERON:0008952	58.38	gold quality
ascending aorta	UBERON:0001496	57.81	gold quality
thoracic aorta	UBERON:0001515	57.72	gold quality
upper lobe of lung	UBERON:0008948	57.72	gold quality
metanephros cortex	UBERON:0010533	57.30	gold quality
left coronary artery	UBERON:0001626	57.10	gold quality
coronary artery	UBERON:0001621	56.56	gold quality
left lobe of thyroid gland	UBERON:0001120	56.01	gold quality
mucosa of stomach	UBERON:0001199	55.96	gold quality
thyroid gland	UBERON:0002046	55.40	gold quality
right lobe of thyroid gland	UBERON:0001119	55.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	54.69	gold quality
lung	UBERON:0002048	54.09	gold quality
stromal cell of endometrium	CL:0002255	53.74	silver quality
minor salivary gland	UBERON:0001830	53.22	gold quality
adult mammalian kidney	UBERON:0000082	52.82	gold quality
cerebellar hemisphere	UBERON:0002245	52.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Together these data suggest that PICART1 is a novel p53-inducible tumor-suppressor lncRNA, functioning through the AKT/GSK3beta/beta-catenin signaling cascade. (PMID:28339031)
• Long non-coding RNA PICART1 inhibits cell proliferation by regulating the PI3K/AKT and MAPK/ERK signaling pathways in gastric cancer. (PMID:30720166)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.