PICSAR

Summary

PICSAR (P38 inhibited cutaneous squamous cell carcinoma associated lincRNA, HGNC:19725) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19725
Approved symbol	PICSAR
Name	P38 inhibited cutaneous squamous cell carcinoma associated lincRNA
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	NLC1-C, PRED74, lnc-NLC1-C
Ensembl gene	ENSG00000275874
Ensembl biotype	lncRNA
OMIM	617191
Entrez	378825
RNAcentral	URS000075EA8F — lncRNA, 749 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000615826, ENST00000758108, ENST00000758109, ENST00000758110, ENST00000758111, ENST00000758112, ENST00000758113, ENST00000758114, ENST00000758115

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615826 — 2 exons

Exon	Start	End
ENSE00004109850	44999140	44999656
ENSE00004109852	45004444	45004753

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 74.77.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5864 / max 54.2742, expressed in 113 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190815	0.3047	83
190813	0.1210	51
190814	0.0984	49
190816	0.0623	36

Top tissues by expression

219 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	74.77	gold quality
skin of leg	UBERON:0001511	73.03	gold quality
skin of abdomen	UBERON:0001416	72.43	gold quality
spinal cord	UBERON:0002240	71.66	gold quality
right lung	UBERON:0002167	70.14	gold quality
zone of skin	UBERON:0000014	69.00	gold quality
left testis	UBERON:0004533	66.80	gold quality
descending thoracic aorta	UBERON:0002345	66.07	gold quality
popliteal artery	UBERON:0002250	65.60	gold quality
tibial artery	UBERON:0007610	65.56	gold quality
aorta	UBERON:0000947	65.33	gold quality
thoracic aorta	UBERON:0001515	65.30	gold quality
ascending aorta	UBERON:0001496	65.18	gold quality
testis	UBERON:0000473	64.14	gold quality
left coronary artery	UBERON:0001626	63.76	gold quality
mucosa of stomach	UBERON:0001199	63.24	gold quality
lower esophagus	UBERON:0013473	62.93	gold quality
upper lobe of left lung	UBERON:0008952	62.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.89	gold quality
right coronary artery	UBERON:0001625	62.78	gold quality
coronary artery	UBERON:0001621	62.28	gold quality
right testis	UBERON:0004534	61.54	gold quality
upper lobe of lung	UBERON:0008948	61.08	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.56	gold quality
calcaneal tendon	UBERON:0003701	57.08	gold quality
gall bladder	UBERON:0002110	56.89	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.88	gold quality
esophagus	UBERON:0001043	56.42	gold quality
left uterine tube	UBERON:0001303	56.22	gold quality
lung	UBERON:0002048	55.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.96

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• The accumulation of NLC1-C in the nucleus repressed miR-320a and miR-383 transcript and promoted testicular embryonal carcinoma cell proliferation by binding to Nucleolin. (PMID:26539909)
• PICSAR has a role in promoting cSCC progression via activation of extracellular signal-regulated kinase 1/2 signaling pathway by downregulating DUSP6 expression (PMID:27049681)
• LINC00162 overexpression increased the sensitivity, enhanced cell cycle arrest and apoptosis induced by 5-aza-dC, but did not affect its DNA demethylation effect. Mechanistically, LINC00162 interacted with an RNA splicing protein, HNRNPH1, and decreased splicing of an anti-apoptotic splicing variant, BCL-XL. LINC00162 may have translational value to predict patients who will respond to 5-aza-dC. (PMID:30914798)
• Our results reveal PICSAR may exert an essential role in promoting synovial invasion and joint destruction by sponging miR-4701-5p in RA and that lncRNA PICSAR may act as a biomarker of RA. (PMID:31791845)
• Long non-coding RNA PICSAR knockdown inhibits the progression of cutaneous squamous cell carcinoma by regulating miR-125b/YAP1 axis. (PMID:32841663)
• LncRNA PICSAR binds to miR-485-5p and activates TGF-beta1/Smad to promote abnormal proliferation of hypertrophic scar fibroblasts (HSFs) and excessive deposition of extracellular matrix (ECM). (PMID:34255190)
• LINC00162 regulates cell proliferation and apoptosis by sponging PAQR4-targeting miR-485-5p. (PMID:35491694)
• Long Intergenic Non-Coding 00162 as Diagnostic Biomarker for Early-Stage Pancreatic Cancer. (PMID:36197769)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.