PIH1D1

Summary

PIH1D1 (PIH1 domain containing 1, HGNC:26075) is a protein-coding gene on chromosome 19q13.33, encoding PIH1 domain-containing protein 1 (Q9NWS0). Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles.

Enables several functions, including enzyme binding activity; histone binding activity; and phosphoprotein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and protein-containing complex assembly. Located in cytoplasm and nucleolus. Part of R2TP complex; RPAP3/R2TP/prefoldin-like complex; and pre-snoRNP complex.

Source: NCBI Gene 55011 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_017916

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26075
Approved symbol	PIH1D1
Name	PIH1 domain containing 1
Location	19q13.33
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20643, Pih1, MOT48, DNAAF14
Ensembl gene	ENSG00000104872
Ensembl biotype	protein_coding
OMIM	611480
Entrez	55011

Gene structure

Transcript identifiers

Ensembl transcripts: 36 — 18 protein_coding, 9 nonsense_mediated_decay, 8 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000262265, ENST00000593629, ENST00000593900, ENST00000594845, ENST00000595074, ENST00000595516, ENST00000595550, ENST00000595633, ENST00000596049, ENST00000596651, ENST00000596895, ENST00000596916, ENST00000597415, ENST00000597577, ENST00000598175, ENST00000598889, ENST00000599366, ENST00000599791, ENST00000600875, ENST00000601053, ENST00000601807, ENST00000601825, ENST00000602076, ENST00000602226, ENST00000715674, ENST00000715675, ENST00000911064, ENST00000911065, ENST00000911066, ENST00000911067, ENST00000911068, ENST00000911069, ENST00000911070, ENST00000911071, ENST00000919081, ENST00000943281

RefSeq mRNA: 1 — MANE Select: NM_017916 NM_017916

CCDS: CCDS12765

Canonical transcript exons

ENST00000262265 — 9 exons

Exon	Start	End
ENSE00002985313	49451485	49451814
ENSE00003489521	49449475	49449654
ENSE00003541474	49447827	49447908
ENSE00003571964	49448001	49448062
ENSE00003612883	49447338	49447467
ENSE00003614372	49447024	49447099
ENSE00003633124	49450782	49450848
ENSE00003682427	49446551	49446694
ENSE00003846962	49446298	49446423

Expression profiles

Bgee: expression breadth ubiquitous, 287 present calls, max score 97.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 40.7470 / max 377.3761, expressed in 1820 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182041	29.9296	1813
182040	7.3193	1694
182042	1.7878	1246
182043	1.3904	830
182039	0.2893	123
182038	0.0307	8

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	97.93	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.46	gold quality
cerebellar hemisphere	UBERON:0002245	97.39	gold quality
cerebellar cortex	UBERON:0002129	97.27	gold quality
right uterine tube	UBERON:0001302	97.08	gold quality
mucosa of transverse colon	UBERON:0004991	96.96	gold quality
right lobe of thyroid gland	UBERON:0001119	96.95	gold quality
left lobe of thyroid gland	UBERON:0001120	96.79	gold quality
lower esophagus mucosa	UBERON:0035834	96.72	gold quality
small intestine Peyer’s patch	UBERON:0003454	96.69	gold quality
skin of leg	UBERON:0001511	96.64	gold quality
skin of abdomen	UBERON:0001416	96.58	gold quality
metanephros cortex	UBERON:0010533	96.49	gold quality
right lobe of liver	UBERON:0001114	96.47	gold quality
spleen	UBERON:0002106	96.47	gold quality
endocervix	UBERON:0000458	96.42	gold quality
prefrontal cortex	UBERON:0000451	96.39	gold quality
cerebellum	UBERON:0002037	96.37	gold quality
minor salivary gland	UBERON:0001830	96.34	gold quality
body of stomach	UBERON:0001161	96.29	gold quality
adenohypophysis	UBERON:0002196	96.21	gold quality
ganglionic eminence	UBERON:0004023	96.21	gold quality
body of uterus	UBERON:0009853	96.15	gold quality
pituitary gland	UBERON:0000007	96.08	gold quality
lower esophagus	UBERON:0013473	96.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.08	gold quality
transverse colon	UBERON:0001157	96.06	gold quality
left ovary	UBERON:0002119	96.06	gold quality
ventricular zone	UBERON:0003053	96.05	gold quality
thyroid gland	UBERON:0002046	96.02	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-6524	no	262.71
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MTOR

Literature-anchored findings (GeneRIF, showing 8)

• Is part of an RNA polymerase II-associated complex with possible chaperone activity. (PMID:19450687)
• PIH1D1 may stabilize SNF5 by attenuating its proteasome degradation pathway. (PMID:20078948)
• These results suggest that PIH1D1 may also function as a novel modulator of apoptosis pathway. (PMID:21078300)
• Human PIH1 domain-containing protein 1 (PIH1) interacts directly with histone H4 and recruits the Brg1-SWI/SNF complex via SNF5 to human rRNA genes. (PMID:22368283)
• this study investigated the interaction between RPAP3 and PIH1D1. (PMID:23159623)
• PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription. (PMID:24036451)
• We propose that protein complexes assembled by the R2TP complex are defined by phosphorylation of a specific motif and recognition by the PIH1D1 subunit (PMID:24656813)
• An RPAP3:PIH1D1 sub-complex is found demonstrating the need for a 34-residue insertion, specific of RPAP3 isoform 1, for the tight binding of PIH1D1. (PMID:30033218)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	pih1d1	ENSDARG00000037955
mus_musculus	Pih1d1	ENSMUSG00000003423
rattus_norvegicus	Pih1d1	ENSRNOG00000020634

Paralogs (2): PIH1D2 (ENSG00000150773), DNAAF2 (ENSG00000165506)

Protein

Protein identifiers

PIH1 domain-containing protein 1 — Q9NWS0 (reviewed: Q9NWS0)

Alternative names: Nucleolar protein 17 homolog

All UniProt accessions (16): Q9NWS0, A0AAQ5BIG8, A0AAQ5BIK2, M0QXD5, M0QYA2, M0QYF4, M0QZ61, M0QZM3, M0QZZ1, M0R028, M0R0J2, M0R1R3, M0R2H3, M0R2P8, M0R3A4, M0R3A8

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.

Subunit / interactions. Component of the R2TP complex composed at least of RUVBL1, RUVBL2, RPAP3 and PIHD1. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92. Interacts with phosphorylated TELO2 and mediates interaction of TELO2 with the R2TP complex. Interacts with phosphorylated ECD, EFTUD2/SNRP116, RPB1 and UBR5 and with RPB1 in a phosphorylation-independent manner. Interacts with the core C/D box snoRNP particle components NOP58 and FBL and with RUVBL1/TIP49. Interacts with RPAP3 and DNAAF10. Interacts with histone H4 and with SWI/SNF complex member SMARCB1/SNF5. Interacts with the mTORC1 complex member RPTOR. Interacts with MSL1.

Subcellular location. Nucleus.

Tissue specificity. Expressed at low levels in normal mammary epithelial cells (at protein level). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus.

Domain organisation. The N-terminal region is required for binding to phosphorylated substrates while the C-terminal region binds to the other R2TP complex components.

Similarity. Belongs to the PIH1 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NWS0-1	1	yes
Q9NWS0-2	2
Q9NWS0-3	3

RefSeq proteins (1): NP_060386* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012981	PIH1_N	Domain
IPR041442	PIH1D1/2/3_CS-like	Domain
IPR050734	PIH1/Kintoun_subfamily	Family

Pfam: PF08190, PF18201

UniProt features (40 total): strand 13, mutagenesis site 8, sequence variant 5, site 3, helix 3, sequence conflict 2, modified residue 2, splice variant 2, chain 1, turn 1

Structure

Experimental structures (PDB)

8 structures.

PDB	Method	Resolution (Å)
7AVC	X-RAY DIFFRACTION	1.2
9THX	X-RAY DIFFRACTION	1.36
4PSF	X-RAY DIFFRACTION	1.58
9TIA	X-RAY DIFFRACTION	2.07
9TJQ	X-RAY DIFFRACTION	2.19
4PSI	X-RAY DIFFRACTION	2.45
8BDU	X-RAY DIFFRACTION	2.47
6GXZ	X-RAY DIFFRACTION	2.96

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NWS0-F1	79.27	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (3): 57 (interacts with telo2); 64 (interacts with telo2); 113 (interacts with telo2)

Post-translational modifications (2): 12, 173

Mutagenesis-validated functional residues (8):

Position	Phenotype
54	abolishes binding to histone h4.
55	no effect on binding to histone h4.
57	abolishes binding to telo2.
64	abolishes binding to ecd, eftud2, rpb1, telo2 and ubr5.
113	reduces binding to telo2.
163	reduces binding to telo2.
166	reduces binding to telo2.
168	abolishes binding to telo2.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 157 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_EPITHELIUM_DEVELOPMENT, MODULE_151, GOBP_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS, GOBP_POSITIVE_REGULATION_OF_TOR_SIGNALING, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_RRNA_TRANSCRIPTION, TERAMOTO_OPN_TARGETS_CLUSTER_6, GOBP_PROTEIN_STABILIZATION, GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_REGULATION_OF_PROTEIN_STABILITY, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_INTRACELLULAR_GLUCOSE_HOMEOSTASIS, GOBP_CARBOHYDRATE_HOMEOSTASIS

GO Biological Process (10): box C/D snoRNP assembly (GO:0000492), chromatin remodeling (GO:0006338), rRNA processing (GO:0006364), epithelial cell differentiation (GO:0030855), snoRNA localization (GO:0048254), protein stabilization (GO:0050821), positive regulation of transcription of nucleolar large rRNA by RNA polymerase I (GO:1901838), positive regulation of glucose mediated signaling pathway (GO:1902661), positive regulation of TORC1 signaling (GO:1904263), TORC1 complex assembly (GO:1905669)

GO Molecular Function (6): protein kinase binding (GO:0019901), histone binding (GO:0042393), ATPase binding (GO:0051117), phosphoprotein binding (GO:0051219), histone reader activity (GO:0140566), protein binding (GO:0005515)

GO Cellular Component (7): nucleus (GO:0005634), nucleolus (GO:0005730), cytoplasm (GO:0005737), pre-snoRNP complex (GO:0070761), R2TP complex (GO:0097255), RPAP3/R2TP/prefoldin-like complex (GO:1990062), ribonucleoprotein complex (GO:1990904)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein-containing complex	3
protein binding	2
small nucleolar ribonucleoprotein complex assembly	1
chromatin organization	1
RNA processing	1
rRNA metabolic process	1
ribosome biogenesis	1
cell differentiation	1
epithelium development	1
RNA localization	1
regulation of protein stability	1
nucleolar large rRNA transcription by RNA polymerase I	1
positive regulation of transcription by RNA polymerase I	1
regulation of transcription of nucleolar large rRNA by RNA polymerase I	1
positive regulation of signal transduction	1
glucose mediated signaling pathway	1
regulation of glucose mediated signaling pathway	1
positive regulation of TOR signaling	1
TORC1 signaling	1
regulation of TORC1 signaling	1
protein-containing complex assembly	1
kinase binding	1
enzyme binding	1
nucleosome	1
histone binding	1
chromatin-protein adaptor activity	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1
ribonucleoprotein complex	1

Protein interactions and networks

STRING

2156 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PIH1D1	RPAP3	Q9H6T3	998
PIH1D1	RUVBL1	P82276	997
PIH1D1	RUVBL2	Q9Y230	997
PIH1D1	HSP90AA1	P07900	977
PIH1D1	HSP90AB1	P08238	963
PIH1D1	NOP58	Q9Y2X3	864
PIH1D1	DNAAF10	Q96MX6	861
PIH1D1	NOP56	O00567	835
PIH1D1	ZNHIT3	Q15649	798
PIH1D1	NUFIP1	Q9UHK0	790
PIH1D1	SNU13	P55769	770
PIH1D1	PFDN6	O15212	769
PIH1D1	SPAG1	Q07617	754
PIH1D1	PFDN2	Q9UHV9	750
PIH1D1	RNF113A	O15541	739

IntAct

208 interactions, top by confidence:

A	B	Type	Score
RPTOR	MTOR	psi-mi:“MI:0914”(association)	0.980
PARD6A	PRKCI	psi-mi:“MI:0914”(association)	0.950
NPHP1	NPHP4	psi-mi:“MI:2364”(proximity)	0.930
POLR2E	POLR3A	psi-mi:“MI:0914”(association)	0.870
PIH1D1	RUVBL2	psi-mi:“MI:0914”(association)	0.860
POLR2J	POLR1C	psi-mi:“MI:0914”(association)	0.830
RPAP2	PIH1D1	psi-mi:“MI:0915”(physical association)	0.800
ECD	PIH1D1	psi-mi:“MI:0915”(physical association)	0.740
PIH1D1	ECD	psi-mi:“MI:0914”(association)	0.740
PIH1D1	ECD	psi-mi:“MI:0915”(physical association)	0.740
PPP1CC	CCDC85C	psi-mi:“MI:0914”(association)	0.740
PIH1D1	ECD	psi-mi:“MI:0407”(direct interaction)	0.740
POLR2E	MED19	psi-mi:“MI:0914”(association)	0.730
POLR2A	POLR2D	psi-mi:“MI:0914”(association)	0.730
POLR3E	POLR3A	psi-mi:“MI:0914”(association)	0.730
POLR2J	POLR2D	psi-mi:“MI:0914”(association)	0.730
RPRD1B	POLR2D	psi-mi:“MI:0914”(association)	0.730
PIH1D1	RPAP3	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710

BioGRID (941): PIH1D1 (Two-hybrid), TSC22D4 (Two-hybrid), PIH1D1 (Affinity Capture-RNA), PIH1D1 (Affinity Capture-MS), PIH1D1 (Affinity Capture-MS), POLR2G (Affinity Capture-MS), PDRG1 (Affinity Capture-MS), RUVBL1 (Affinity Capture-MS), POLR1A (Affinity Capture-MS), POLR3A (Affinity Capture-MS), RPAP2 (Affinity Capture-MS), POLR3E (Affinity Capture-MS), UXT (Affinity Capture-MS), POLR2A (Affinity Capture-MS), POLR2M (Affinity Capture-MS)

ESM2 similar proteins: D3ZND0, F1MX48, O95382, P47823, Q0VCI6, Q1RM55, Q2KIJ6, Q2YD98, Q3SYU1, Q4V7F5, Q58CQ5, Q5PPF5, Q5PRB3, Q64350, Q66H85, Q6IUP3, Q6P5E6, Q6P6S4, Q6V7V2, Q7TMX5, Q80TT2, Q8BRN9, Q8C6B2, Q8CHW4, Q8N0W3, Q8VDM1, Q924T7, Q96EP0, Q96NY9, Q99L85, Q99PL6, Q9BST9, Q9BXL6, Q9BZV1, Q9CQJ2, Q9D479, Q9EPK6, Q9H173, Q9H8Y5, Q9NWS0

Diamond homologs: P38768, Q0VCI6, Q4V7F5, Q7Q9F6, Q9NWS0, P0CU29, Q1RM55, Q7ZWY2, Q9CQJ2, Q499A3, B5BUZ8, B4J4Y2

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
PIH1D1	“up-regulates quantity by stabilization”	mTORC1	binding
MRE11	“up-regulates activity”	PIH1D1	binding
PIH1D1	“form complex”	“R2TP core co-chaperone”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 128 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
RNA Polymerase III Chain Elongation	8	60.4×	4e-11
FGFR2 mutant receptor activation	6	54.4×	1e-08
Signaling by FGFR2 IIIa TM	7	50.1×	2e-09
Abortive elongation of HIV-1 transcript in the absence of Tat	8	47.3×	2e-10
RNA Polymerase III Transcription Termination	8	47.3×	2e-10
RNA Polymerase III Transcription Initiation From Type 2 Promoter	9	45.3×	4e-11
RNA Polymerase III Transcription Initiation From Type 1 Promoter	9	43.7×	4e-11
RNA Polymerase III Transcription Initiation From Type 3 Promoter	9	43.7×	4e-11

GO biological processes:

GO term	Partners	Fold	FDR
protein stabilization	17	9.9×	9e-10

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1665 predictions. Top by Δscore:

Variant	Effect	Δscore
19:49446548:CACCT:C	donor_loss	1.0000
19:49446559:T:TA	donor_gain	1.0000
19:49446804:C:T	acceptor_gain	1.0000
19:49446805:A:T	acceptor_gain	1.0000
19:49447017:AACTC:A	donor_loss	1.0000
19:49447018:ACTC:A	donor_loss	1.0000
19:49447019:CTCA:C	donor_loss	1.0000
19:49447021:CA:C	donor_loss	1.0000
19:49447022:A:AC	donor_gain	1.0000
19:49447022:ACCAG:A	donor_loss	1.0000
19:49447023:C:CT	donor_gain	1.0000
19:49447023:C:T	donor_loss	1.0000
19:49447023:CCAG:C	donor_gain	1.0000
19:49447095:CAGGC:C	acceptor_gain	1.0000
19:49447097:GGC:G	acceptor_gain	1.0000
19:49447099:CCTGA:C	acceptor_loss	1.0000
19:49447100:C:CC	acceptor_gain	1.0000
19:49447100:CTGA:C	acceptor_loss	1.0000
19:49447336:AC:A	donor_gain	1.0000
19:49447337:CC:C	donor_gain	1.0000
19:49447347:G:C	donor_gain	1.0000
19:49447351:T:A	donor_gain	1.0000
19:49447352:C:CA	donor_gain	1.0000
19:49447821:CCTCA:C	donor_loss	1.0000
19:49447822:CTCAC:C	donor_loss	1.0000
19:49447823:TCA:T	donor_loss	1.0000
19:49447824:CA:C	donor_loss	1.0000
19:49447825:A:AC	donor_gain	1.0000
19:49447825:A:AT	donor_loss	1.0000
19:49447825:AC:A	donor_gain	1.0000

AlphaMissense

1887 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:49449608:G:C	N68K	0.998
19:49449608:G:T	N68K	0.998
19:49449614:G:C	F66L	0.998
19:49449614:G:T	F66L	0.998
19:49449616:A:G	F66L	0.998
19:49447871:G:T	A146D	0.997
19:49448029:A:T	V124D	0.997
19:49448042:A:C	Y120D	0.997
19:49449602:G:C	C70W	0.997
19:49449615:A:G	F66S	0.997
19:49449641:C:A	K57N	0.997
19:49449641:C:G	K57N	0.997
19:49447859:A:G	L150P	0.996
19:49447859:A:T	L150H	0.996
19:49448044:G:T	A119D	0.996
19:49449506:A:C	S102R	0.996
19:49449506:A:T	S102R	0.996
19:49449508:T:G	S102R	0.996
19:49449647:G:C	C55W	0.996
19:49449603:C:T	C70Y	0.995
19:49449604:A:G	C70R	0.995
19:49446419:A:G	L279S	0.994
19:49447435:C:G	G172R	0.994
19:49447849:T:A	K153N	0.994
19:49447849:T:G	K153N	0.994
19:49447850:T:A	K153I	0.994
19:49447872:C:G	A146P	0.994
19:49449516:A:G	I99T	0.994
19:49449610:T:C	N68D	0.994
19:49449612:A:T	I67N	0.994

dbSNP variants (sampled 300 via entrez): RS1000550973 (19:49451803 CG>C), RS1000594040 (19:49446686 G>A,T), RS1001046406 (19:49447006 C>G,T), RS1001156061 (19:49450356 G>A,T), RS1001831143 (19:49447613 C>A), RS1001981964 (19:49452895 T>C), RS1002988743 (19:49451676 G>C), RS1004063567 (19:49452067 T>G), RS1004332550 (19:49453508 G>A,C,T), RS1004622272 (19:49453658 A>C,G), RS1004664773 (19:49450774 T>C), RS1005222919 (19:49452595 A>G), RS1005531196 (19:49449325 G>A,C,T), RS1005749031 (19:49452345 G>A,C), RS1005783637 (19:49446035 C>A)

Disease associations

OMIM: gene MIM:611480 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	2
Valproic Acid	increases methylation, affects expression	2
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	affects methylation	1
cobaltous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
ICG 001	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Caffeine	decreases phosphorylation	1
Carbamazepine	affects expression	1
Carcinogens	decreases expression	1
Catechin	affects cotreatment, decreases expression	1
Coumestrol	increases expression	1
Doxorubicin	decreases expression	1
Ivermectin	decreases expression	1
Selenium	increases expression, affects cotreatment	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Vitamin E	affects cotreatment, increases expression	1
Cyclosporine	decreases expression	1
Copper Sulfate	decreases expression	1
Lactic Acid	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XR60	HAP1 PIH1D1 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.