PIK3CD-AS1

Summary

PIK3CD-AS1 (PIK3CD antisense RNA 1, HGNC:32346) is a long non-coding RNA gene on chromosome 1p36.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product.
• Sense gene: antisense to PIK3CD — the sense gene carries 9 GWAS associations, 66 ChEMBL molecules (the sense gene’s biology, not this transcript’s)

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32346
Approved symbol	PIK3CD-AS1
Name	PIK3CD antisense RNA 1
Location	1p36.22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000179840
Ensembl biotype	lncRNA
Entrez	644997
RNAcentral	URS000075D430 — lncRNA, 1840 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1

ENST00000377320

RefSeq mRNA: 0

Canonical transcript exons

ENST00000377320 — 2 exons

Exon	Start	End
ENSE00001473539	9652610	9654043
ENSE00001473545	9654198	9654586

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 78.03.

Highest expression (Bgee): skeletal muscle tissue of biceps brachii, skeletal muscle tissue of rectus abdominis, vastus lateralis, quadriceps femoris, skeletal muscle tissue.

Genetic regulation across tissues (GTEx eQTL / sQTL)

PIK3CD-AS1 is not an eGene in any GTEx v10 tissue: no tissue shows a variant significantly associated with its expression or splicing (q < 0.05).

Top tissues by expression

showing 100 of 171 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	78.03	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	75.53	gold quality
vastus lateralis	UBERON:0001379	75.49	gold quality
quadriceps femoris	UBERON:0001377	75.32	gold quality
skeletal muscle tissue	UBERON:0001134	75.20	gold quality
heart right ventricle	UBERON:0002080	74.29	gold quality
biceps brachii	UBERON:0001507	73.50	gold quality
bone marrow cell	CL:0002092	73.30	silver quality
nasal cavity epithelium	UBERON:0005384	72.97	gold quality
colonic epithelium	UBERON:0000397	72.45	silver quality
secondary oocyte	CL:0000655	72.03	gold quality
blood	UBERON:0000178	71.37	gold quality
oocyte	CL:0000023	71.10	gold quality
mammary duct	UBERON:0001765	70.34	gold quality
deltoid	UBERON:0001476	68.70	gold quality
parotid gland	UBERON:0001831	67.15	gold quality
granulocyte	CL:0000094	67.08	gold quality
esophagus squamous epithelium	UBERON:0006920	67.07	gold quality
postcentral gyrus	UBERON:0002581	66.32	gold quality
myocardium	UBERON:0002349	65.89	gold quality
entorhinal cortex	UBERON:0002728	65.81	gold quality
leukocyte	CL:0000738	65.80	gold quality
superior frontal gyrus	UBERON:0002661	65.71	gold quality
tibia	UBERON:0000979	65.60	gold quality
monocyte	CL:0000576	65.59	gold quality
parietal lobe	UBERON:0001872	65.10	gold quality
epithelium of nasopharynx	UBERON:0001951	64.89	gold quality
bone marrow	UBERON:0002371	63.91	gold quality
gingival epithelium	UBERON:0001949	63.86	gold quality
palpebral conjunctiva	UBERON:0001812	63.53	gold quality
trabecular bone tissue	UBERON:0002483	63.12	gold quality
pigmented layer of retina	UBERON:0001782	63.11	gold quality
bronchial epithelial cell	CL:0002328	63.09	gold quality
bronchus	UBERON:0002185	62.89	gold quality
parietal pleura	UBERON:0002400	62.54	gold quality
substantia nigra pars reticulata	UBERON:0001966	62.45	gold quality
visceral pleura	UBERON:0002401	62.43	gold quality
metanephros	UBERON:0000081	62.42	gold quality
caudate nucleus	UBERON:0001873	62.08	gold quality
gingiva	UBERON:0001828	61.96	gold quality
mammary gland	UBERON:0001911	61.89	silver quality
thoracic mammary gland	UBERON:0005200	61.85	silver quality
tonsil	UBERON:0002372	61.76	gold quality
jejunal mucosa	UBERON:0000399	61.70	gold quality
body of tongue	UBERON:0011876	61.55	gold quality
jejunum	UBERON:0002115	61.19	gold quality
lateral globus pallidus	UBERON:0002476	61.10	gold quality
putamen	UBERON:0001874	60.90	gold quality
neocortex	UBERON:0001950	60.86	silver quality
Brodmann (1909) area 23	UBERON:0013554	60.80	gold quality
oral cavity	UBERON:0000167	60.76	gold quality
tongue	UBERON:0001723	60.75	gold quality
subthalamic nucleus	UBERON:0001906	60.75	gold quality
anatomical system	UBERON:0000467	60.56	gold quality
adrenal cortex	UBERON:0001235	60.53	gold quality
superficial temporal artery	UBERON:0001614	60.41	gold quality
cardiac atrium	UBERON:0002081	60.38	gold quality
cauda epididymis	UBERON:0004360	60.35	gold quality
multicellular organism	UBERON:0000468	60.28	gold quality
material anatomical entity	UBERON:0000465	60.26	gold quality
primary visual cortex	UBERON:0002436	60.26	gold quality
dorsal plus ventral thalamus	UBERON:0001897	60.22	gold quality
ventral tegmental area	UBERON:0002691	60.20	gold quality
corpus epididymis	UBERON:0004359	60.18	gold quality
substantia nigra pars compacta	UBERON:0001965	60.17	gold quality
inferior vagus X ganglion	UBERON:0005363	59.99	gold quality
cerebellum	UBERON:0002037	59.92	gold quality
lateral nuclear group of thalamus	UBERON:0002736	59.89	gold quality
Brodmann (1909) area 46	UBERON:0006483	59.77	gold quality
saphenous vein	UBERON:0007318	59.74	gold quality
caput epididymis	UBERON:0004358	59.64	gold quality
middle temporal gyrus	UBERON:0002771	59.59	gold quality
pericardium	UBERON:0002407	59.50	gold quality
medulla oblongata	UBERON:0001896	59.48	gold quality
corpus callosum	UBERON:0002336	59.44	gold quality
mammalian vulva	UBERON:0000997	59.40	gold quality
occipital lobe	UBERON:0002021	59.30	gold quality
superior vestibular nucleus	UBERON:0007227	59.30	gold quality
nipple	UBERON:0002030	59.22	gold quality
liver	UBERON:0002107	58.96	gold quality
superior surface of tongue	UBERON:0007371	58.93	gold quality
pons	UBERON:0000988	58.91	gold quality
cardia of stomach	UBERON:0001162	58.87	gold quality
cortex of kidney	UBERON:0001225	58.86	gold quality
renal medulla	UBERON:0000362	58.85	gold quality
myometrium	UBERON:0001296	58.76	silver quality
cerebellar vermis	UBERON:0004720	58.70	gold quality
pharyngeal mucosa	UBERON:0000355	58.67	gold quality
decidua	UBERON:0002450	58.67	gold quality
seminal vesicle	UBERON:0000998	58.66	gold quality
cerebellar hemisphere	UBERON:0002245	58.65	gold quality
trachea	UBERON:0003126	58.63	gold quality
pylorus	UBERON:0001166	58.57	gold quality
penis	UBERON:0000989	58.56	gold quality
dorsal root ganglion	UBERON:0000044	58.55	gold quality
thymus	UBERON:0002370	58.50	gold quality
layer of synovial tissue	UBERON:0007616	58.46	gold quality
anterior cingulate cortex	UBERON:0009835	58.44	gold quality
placenta	UBERON:0001987	57.90	silver quality
lymph node	UBERON:0000029	57.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.95

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
PIK3CD-AS2	ncRNA	101929074
PIK3CD	protein-coding	5293
CLSTN1	protein-coding	22883
TMEM201	protein-coding	199953
SLC25A33	protein-coding	84275
CTNNBIP1-AS1	ncRNA	139355239
CTNNBIP1	protein-coding	56998

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 5 curated MSigDB gene sets — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

chr1p36, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, OSMAN_BLOOD_CHAD63_KH_AGE_18_50YO_HIGH_DOSE_SUBJECTS_24HR_UP, GSE29615_CTRL_VS_DAY7_LAIV_FLU_VACCINE_PBMC_DN, GSE29615_CTRL_VS_LAIV_FLU_VACCINE_PBMC_DN

ncRNA interactions

Experimentally supported non-coding-RNA interaction partners (NPInter).

2 interaction partners:

Partner	Partner type	Level	Source
IGF2BP3	protein	RNA-Protein	High-throughput data
IGF2BP1	protein	RNA-Protein	High-throughput data

Disease & clinical

ncRNA disease associations

Curated non-coding-RNA → disease associations (LncRNADisease, HMDD) — these are RNA-level associations for this gene, not the positional variant data omitted above.

1 ncRNA–disease associations:

Disease	Causal?	Validated by
Carcinoma, Hepatocellular	Yes	RNA Pull-Down, Western Blot, Transwell Assay, CCK8, FISH, qRT-PCR, Flow Cytometry, Luciferase Report Assay, Colony Formation Assay, EdU Staining, IF

Drugs & pharmacology

No curated drug or pharmacology associations for this gene.