PIK3IP1

Summary

PIK3IP1 (phosphoinositide-3-kinase interacting protein 1, HGNC:24942) is a protein-coding gene on chromosome 22q12.2, encoding Phosphoinositide-3-kinase-interacting protein 1 (Q96FE7). Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.

Enables phosphatidylinositol 3-kinase inhibitor activity. Involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in plasma membrane. Predicted to be active in extracellular space.

Source: NCBI Gene 113791 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 47 total
• MANE Select transcript: NM_052880

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24942
Approved symbol	PIK3IP1
Name	phosphoinositide-3-kinase interacting protein 1
Location	22q12.2
Locus type	gene with protein product
Status	Approved
Aliases	HGFL, MGC17330, TrIP
Ensembl gene	ENSG00000100100
Ensembl biotype	protein_coding
OMIM	619158
Entrez	113791

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 5 protein_coding, 3 retained_intron

ENST00000215912, ENST00000402249, ENST00000441972, ENST00000443175, ENST00000480654, ENST00000493034, ENST00000715258, ENST00000885856

RefSeq mRNA: 2 — MANE Select: NM_052880 NM_001135911, NM_052880

CCDS: CCDS13893, CCDS46690

Canonical transcript exons

ENST00000215912 — 6 exons

Exon	Start	End
ENSE00000653144	31290965	31291084
ENSE00000653149	31291180	31291296
ENSE00001048693	31292275	31292488
ENSE00001857358	31281600	31283288
ENSE00003521281	31289315	31289393
ENSE00003644320	31289499	31289699

Expression profiles

Bgee: expression breadth ubiquitous, 284 present calls, max score 96.31.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 32.6229 / max 1642.0285, expressed in 1622 samples.

FANTOM5 promoters (11 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193696	24.8563	1547
193691	2.0334	288
193694	1.3843	275
193692	1.3640	261
193690	0.8441	118
193695	0.6894	218
193697	0.6354	361
193689	0.4992	100
193687	0.1255	46
193688	0.1019	40

Top tissues by expression

299 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	96.31	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	96.16	gold quality
right lung	UBERON:0002167	96.12	gold quality
granulocyte	CL:0000094	95.35	gold quality
blood	UBERON:0000178	95.12	gold quality
mucosa of stomach	UBERON:0001199	94.84	gold quality
spleen	UBERON:0002106	94.75	gold quality
nerve	UBERON:0001021	94.34	gold quality
tibial nerve	UBERON:0001323	94.34	gold quality
skin of leg	UBERON:0001511	94.19	gold quality
skin of abdomen	UBERON:0001416	93.85	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.75	gold quality
minor salivary gland	UBERON:0001830	93.59	gold quality
vermiform appendix	UBERON:0001154	93.50	gold quality
pancreatic ductal cell	CL:0002079	93.41	gold quality
subcutaneous adipose tissue	UBERON:0002190	92.80	gold quality
calcaneal tendon	UBERON:0003701	92.76	gold quality
saliva-secreting gland	UBERON:0001044	92.64	gold quality
zone of skin	UBERON:0000014	92.44	gold quality
right coronary artery	UBERON:0001625	92.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	92.25	gold quality
caecum	UBERON:0001153	92.04	gold quality
right adrenal gland cortex	UBERON:0035827	91.93	gold quality
right adrenal gland	UBERON:0001233	91.89	gold quality
gall bladder	UBERON:0002110	91.83	gold quality
upper lobe of left lung	UBERON:0008952	91.47	gold quality
nasal cavity epithelium	UBERON:0005384	91.44	gold quality
spinal cord	UBERON:0002240	91.38	gold quality
left adrenal gland	UBERON:0001234	91.35	gold quality
small intestine	UBERON:0002108	91.24	gold quality

Single-cell (SCXA)

Detected in 12 experiment(s), a significant marker in 8.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	669.22
E-MTAB-9467	yes	66.95
E-CURD-122	yes	39.95
E-CURD-88	yes	38.81
E-MTAB-8410	yes	36.62
E-HCAD-1	yes	36.39
E-CURD-112	yes	5.24
E-MTAB-7606	no	2613.73
E-CURD-89	no	1285.56
E-GEOD-150728	no	586.14
E-CURD-120	no	567.60
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CUX1, FOXO3

miRNA regulators (miRDB)

68 targeting PIK3IP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-4500	99.99	72.72	2367
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-4295	99.90	73.11	1838
HSA-MIR-202-3P	99.84	71.41	1290

Literature-anchored findings (GeneRIF, showing 8)

• PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Suggested that PIK3IP1 is a new type of PI3K regulator. (PMID:17475214)
• PIK3IP1 is an important regulator of PI3K in vivo, and its dysregulation can contribute to liver carcinogenesis (PMID:18632611)
• PIK3IP1-v1 is a novel splicing isoform of PIK3IP1. Both of them are located on cell membrane and can induce cell apoptosis. (PMID:19088825)
• These results suggest that the novel PI3K regulator PIK3IP1 plays an inhibitory role in T-cell activation. (PMID:22706993)
• Findings indicate that colon cancer associated transcript 1 (non-protein coding) (CCAT1) was upregulated in osteosarcoma tissues and cells, and was involved in the proliferation and migration of osteosarcoma via regulating miR-148a/phosphatidyl inositol 3-kinase interacting protein 1 (PIK3IP1) signal pathway. (PMID:28549102)
• Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor T-Cell Immunity. (PMID:31350312)
• Downregulation of PIK3IP1 in retinal microglia promotes retinal pathological neovascularization via PI3K-AKT pathway activation. (PMID:37550343)
• CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1. (PMID:38658954)

Cross-species orthologs

14 orthologs

Organism	Symbol	Gene ID
danio_rerio	pik3ip1	ENSDARG00000003281
mus_musculus	Pik3ip1	ENSMUSG00000034614
rattus_norvegicus	Pik3ip1	ENSRNOG00000018859
drosophila_melanogaster	CG14780	FBGN0025383
drosophila_melanogaster	CG14227	FBGN0031058
drosophila_melanogaster	CG11664	FBGN0040341
drosophila_melanogaster	CG30287	FBGN0050287
drosophila_melanogaster	CG30288	FBGN0050288
drosophila_melanogaster	CG30289	FBGN0050289
drosophila_melanogaster	CG30414	FBGN0050414
drosophila_melanogaster	CG31205	FBGN0051205
drosophila_melanogaster	CG33225	FBGN0053225
drosophila_melanogaster	CG33226	FBGN0069056
drosophila_melanogaster	CG30283	FBGN0260477

Paralogs (5): HGF (ENSG00000019991), GZMK (ENSG00000113088), GZMA (ENSG00000145649), HABP2 (ENSG00000148702), MST1 (ENSG00000173531)

Protein

Protein identifiers

Phosphoinositide-3-kinase-interacting protein 1 — Q96FE7 (reviewed: Q96FE7)

Alternative names: Kringle domain-containing protein HGFL

All UniProt accessions (2): C9JMK5, Q96FE7

UniProt curated annotations — full annotation on UniProt →

Function. Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.

Subcellular location. Cell membrane.

Post-translational modifications. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-66: dHex1Hex5HexNAc4 (major) and dHex1Hex6HexNAc5 (minor).

Isoforms (5)

UniProt ID	Names	Canonical?
Q96FE7-1	1, HGFL(L)	yes
Q96FE7-2	2, HGFL(S)
Q96FE7-3	3
Q96FE7-4	4
Q96FE7-5	5, PIK3IP1-v1

RefSeq proteins (2): NP_001129383, NP_443112* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000001	Kringle	Domain
IPR013806	Kringle-like	Homologous_superfamily
IPR018056	Kringle_CS	Conserved_site
IPR038178	Kringle_sf	Homologous_superfamily

Pfam: PF00051

UniProt features (21 total): splice variant 5, disulfide bond 3, sequence conflict 2, topological domain 2, glycosylation site 2, signal peptide 1, chain 1, sequence variant 1, transmembrane region 1, domain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96FE7-F1	67.90	0.14

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (3): 25–101, 46–82, 70–96

Glycosylation sites (2): 39, 66

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 335 (showing top): KOBAYASHI_EGFR_SIGNALING_24HR_UP, ATACCTC_MIR202, NFKB_Q6, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, HAHTOLA_MYCOSIS_FUNGOIDES_DN, GTGCCTT_MIR506, MODULE_379, GOBP_NEGATIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_PROTEIN_KINASE_B_SIGNAL_TRANSDUCTION, ROZANOV_MMP14_TARGETS_UP, GOBP_PHOSPHATIDYLINOSITOL_3_KINASE_PROTEIN_KINASE_B_SIGNAL_TRANSDUCTION, GGARNTKYCCA_UNKNOWN, LEE_EARLY_T_LYMPHOCYTE_DN, HIF1_Q3, P300_01, MODULE_242

GO Biological Process (1): negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)

GO Molecular Function (4): endopeptidase activity (GO:0004175), signaling receptor binding (GO:0005102), phosphatidylinositol 3-kinase inhibitor activity (GO:0141039), protein binding (GO:0005515)

GO Cellular Component (3): obsolete extracellular space (GO:0005615), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
phosphatidylinositol 3-kinase/protein kinase B signal transduction	1
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1
negative regulation of intracellular signal transduction	1
peptidase activity	1
protein binding	1
phosphatidylinositol 3-kinase regulator activity	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

570 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PIK3IP1	PIK3CA	P42336	533
PIK3IP1	LRRC14B	A6NHZ5	448
PIK3IP1	LRRC14	Q15048	424
PIK3IP1	DNAJC30	Q96LL9	421
PIK3IP1	H7C2Y5	H7C2Y5	417
PIK3IP1	BAHD1	Q8TBE0	400
PIK3IP1	ARID1A	O14497	396
PIK3IP1	PIP4K2C	Q8TBX8	394
PIK3IP1	PIP4K2B	P78356	391
PIK3IP1	PIP4K2A	P48426	375
PIK3IP1	TAF3	Q5VWG9	371
PIK3IP1	MXD4	Q14582	369
PIK3IP1	SAMD10	Q9BYL1	366
PIK3IP1	PLEKHF1	Q96S99	364
PIK3IP1	PIK3R3	Q92569	358

IntAct

29 interactions, top by confidence:

A	B	Type	Score
UBQLN1	PIK3IP1	psi-mi:“MI:0915”(physical association)	0.560
PIK3IP1	UBQLN1	psi-mi:“MI:0915”(physical association)	0.560
PIK3IP1	UBQLN2	psi-mi:“MI:0915”(physical association)	0.560
MAGEA11	PIK3IP1	psi-mi:“MI:0915”(physical association)	0.560
SLC35A1	PIK3IP1	psi-mi:“MI:0915”(physical association)	0.560
MFSD11	PIK3IP1	psi-mi:“MI:0915”(physical association)	0.560
TMEM218	PIK3IP1	psi-mi:“MI:0915”(physical association)	0.560
UPK1B	PIK3IP1	psi-mi:“MI:0915”(physical association)	0.560
PIK3IP1	TFRC	psi-mi:“MI:0914”(association)	0.350
PIK3IP1	PODXL	psi-mi:“MI:0914”(association)	0.350
PIK3IP1	POTEF	psi-mi:“MI:0914”(association)	0.350
PIK3IP1	SEL1L3	psi-mi:“MI:0914”(association)	0.350
PIK3IP1	UBQLN2	psi-mi:“MI:0915”(physical association)	0.000
PIK3IP1	MAGEA11	psi-mi:“MI:0915”(physical association)	0.000
SLC35A1	PIK3IP1	psi-mi:“MI:0915”(physical association)	0.000
MFSD11	PIK3IP1	psi-mi:“MI:0915”(physical association)	0.000
UPK1B	PIK3IP1	psi-mi:“MI:0915”(physical association)	0.000
TMEM218	PIK3IP1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (20): PIK3IP1 (Two-hybrid), PIK3IP1 (Two-hybrid), UPK1B (Two-hybrid), TMEM218 (Two-hybrid), SLC35A1 (Two-hybrid), MAGEA11 (Two-hybrid), UBQLN2 (Two-hybrid), EPHA7 (Affinity Capture-MS), FAM114A2 (Affinity Capture-MS), IPO7 (Affinity Capture-MS), SAAL1 (Affinity Capture-MS), TFRC (Affinity Capture-MS), GOLGB1 (Affinity Capture-MS), SRPR (Affinity Capture-MS), PODXL (Affinity Capture-MS)

ESM2 similar proteins: A0A1B0GSZ0, A0A1B0GUA5, A0A1B0GVQ0, A0A1B0GVT2, A0JNM1, A2A9G7, A2APA5, A2VE22, A6NLX4, A7E1Z1, A7MB05, A9CBA0, D3ZR35, E9Q942, F5HI25, O39519, P06480, P09517, P0DJ93, P18345, Q0II74, Q0VFL4, Q1RMT9, Q2T9Z2, Q498C7, Q56A20, Q5BIR3, Q5RCS3, Q5XIF1, Q67593, Q6UWT2, Q6UWV7, Q7TMJ8, Q80WB0, Q80WK2, Q86UW2, Q8K1D8, Q8N5W8, Q8TEF2, Q8VEA7

Diamond homologs: D3ZTE0, O18783, O97507, P00734, P00747, P00750, P04185, P06867, P06868, P06869, P08519, P11214, P12545, P14210, P15638, P19221, P19637, P20918, P26927, P26928, P29598, P49150, P80009, P98119, P98121, Q01177, Q04756, Q04962, Q05589, Q14520, Q1RMT9, Q24K22, Q28198, Q29485, Q56A20, Q5E9Z2, Q5R537, Q5R8J0, Q5R8X6, Q5RCS3

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
CUX1	“down-regulates quantity by repression”	PIK3IP1	“transcriptional regulation”
PIK3IP1	“down-regulates activity”	PI3K	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	36
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

935 predictions. Top by Δscore:

Variant	Effect	Δscore
22:31289311:TGA:T	donor_loss	1.0000
22:31289312:GAC:G	donor_loss	1.0000
22:31289313:A:AC	donor_gain	1.0000
22:31289314:C:CC	donor_gain	1.0000
22:31289314:CCT:C	donor_gain	1.0000
22:31289390:TAGC:T	acceptor_gain	1.0000
22:31289391:AGC:A	acceptor_gain	1.0000
22:31289392:GC:G	acceptor_gain	1.0000
22:31289392:GCC:G	acceptor_loss	1.0000
22:31289393:CC:C	acceptor_gain	1.0000
22:31289393:CCTG:C	acceptor_loss	1.0000
22:31289394:C:A	acceptor_loss	1.0000
22:31289394:C:CC	acceptor_gain	1.0000
22:31289395:T:C	acceptor_loss	1.0000
22:31289398:C:CT	acceptor_gain	1.0000
22:31289398:C:T	acceptor_gain	1.0000
22:31289399:A:T	acceptor_gain	1.0000
22:31289403:A:AC	acceptor_gain	1.0000
22:31289403:A:C	acceptor_gain	1.0000
22:31289493:TCATA:T	donor_loss	1.0000
22:31289495:ATACC:A	donor_loss	1.0000
22:31289496:TACC:T	donor_loss	1.0000
22:31289497:A:AC	donor_gain	1.0000
22:31289497:AC:A	donor_gain	1.0000
22:31289498:C:CC	donor_gain	1.0000
22:31289498:CC:C	donor_gain	1.0000
22:31289510:AGGT:A	donor_gain	1.0000
22:31289513:T:TA	donor_gain	1.0000
22:31289700:C:CC	acceptor_gain	1.0000
22:31291081:GCCC:G	acceptor_gain	1.0000

AlphaMissense

1703 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:31291220:C:A	W49C	0.995
22:31291220:C:G	W49C	0.995
22:31291029:C:A	W81C	0.993
22:31291029:C:G	W81C	0.993
22:31291027:C:G	C82S	0.990
22:31291028:A:T	C82S	0.990
22:31291063:C:G	C70S	0.988
22:31291064:A:T	C70S	0.988
22:31291060:C:G	R71P	0.987
22:31291230:C:G	C46S	0.986
22:31291231:A:T	C46S	0.986
22:31283207:G:C	F223L	0.985
22:31283207:G:T	F223L	0.985
22:31283209:A:G	F223L	0.985
22:31291026:G:C	C82W	0.984
22:31289342:C:T	G187D	0.983
22:31289348:C:T	G185E	0.983
22:31289343:C:G	G187R	0.980
22:31289349:C:G	G185R	0.980
22:31289349:C:T	G185R	0.980
22:31291028:A:G	C82R	0.980
22:31289330:C:T	G191D	0.978
22:31291063:C:T	C70Y	0.977
22:31289317:C:A	K195N	0.975
22:31289317:C:G	K195N	0.975
22:31289381:C:T	G174D	0.974
22:31291062:G:C	C70W	0.974
22:31291064:A:G	C70R	0.974
22:31291231:A:G	C46R	0.974
22:31289372:A:T	M177K	0.973

dbSNP variants (sampled 300 via entrez): RS1000017898 (22:31287127 C>T), RS1000402658 (22:31282510 C>G,T), RS1000514021 (22:31287630 A>G,T), RS1000623513 (22:31288779 A>G), RS1000684296 (22:31294128 A>C), RS1000718264 (22:31293437 A>C), RS1000914825 (22:31289054 CTT>C), RS1000948194 (22:31287162 C>T), RS1001194897 (22:31293661 CTT>C,CT,CTTT,CTTTT), RS1001253724 (22:31293187 C>T), RS1001992251 (22:31286317 G>A), RS1002262666 (22:31294287 C>G), RS1002425206 (22:31289495 A>G), RS1002654907 (22:31283643 C>G), RS1002954441 (22:31283994 T>C)

Disease associations

OMIM: gene MIM:619158 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST009391_620	Metabolite levels	7.000000e-06
GCST010135_20	Oily fish consumption	3.000000e-10
GCST010135_5	Oily fish consumption	1.000000e-15
GCST010140_12	Pork consumption	3.000000e-10
GCST010140_49	Pork consumption	1.000000e-15
GCST010142_11	Fish- and plant-related diet	1.000000e-11
GCST010142_79	Fish- and plant-related diet	3.000000e-08
GCST90002404_593	Red cell distribution width	7.000000e-16

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0009793	isoleucine measurement
EFO:0008111	diet measurement
EFO:0009188	Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	affects expression, decreases expression, decreases methylation	3
Acetaminophen	decreases expression, increases expression	2
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	2
Estradiol	affects cotreatment, increases expression, decreases expression	2
Tretinoin	increases expression	2
Valproic Acid	affects expression, decreases expression	2
Cyclosporine	decreases expression	2
aristolochic acid I	increases expression	1
GSK-J4	increases expression	1
sotorasib	affects cotreatment, increases expression	1
pirinixic acid	decreases expression, increases activity, affects binding	1
bisphenol A	increases expression	1
nickel chloride	increases expression	1
potassium chromate(VI)	decreases expression	1
aflatoxin B2	increases methylation	1
hydroquinone	decreases expression	1
avobenzone	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluoro-n-nonanoic acid	decreases expression	1
motexafin gadolinium	increases expression, affects cotreatment	1
nutlin 3	affects cotreatment, increases expression	1
abrine	increases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	increases expression	1
bisphenol S	decreases expression	1
idelalisib	increases expression	1
trametinib	affects cotreatment, increases expression	1
1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one	increases expression	1
NVP-BKM120	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Air Pollutants	increases abundance, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.