PIK3R6

Summary

PIK3R6 (phosphoinositide-3-kinase regulatory subunit 6, HGNC:27101) is a protein-coding gene on chromosome 17p13.1, encoding Phosphoinositide 3-kinase regulatory subunit 6 (Q5UE93). Regulatory subunit of the PI3K gamma complex.

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 146850 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 130 total
• MANE Select transcript: NM_001010855

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27101
Approved symbol	PIK3R6
Name	phosphoinositide-3-kinase regulatory subunit 6
Location	17p13.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ34500, HsT41028, p87PIKAP
Ensembl gene	ENSG00000276231
Ensembl biotype	protein_coding
OMIM	611462
Entrez	146850

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 2 nonsense_mediated_decay

ENST00000611951, ENST00000613555, ENST00000619866, ENST00000907451, ENST00000907452, ENST00000907453

RefSeq mRNA: 2 — MANE Select: NM_001010855 NM_001010855, NM_001290211

CCDS: CCDS73985

Canonical transcript exons

ENST00000619866 — 20 exons

Exon	Start	End
ENSE00003711945	8829706	8829792
ENSE00003712013	8821846	8821936
ENSE00003712353	8835273	8835456
ENSE00003718901	8827172	8827294
ENSE00003722091	8828567	8828990
ENSE00003722696	8832889	8833045
ENSE00003724569	8836547	8836616
ENSE00003725179	8837803	8837871
ENSE00003728741	8849782	8849885
ENSE00003731252	8823387	8823497
ENSE00003734103	8804041	8804153
ENSE00003737438	8819083	8819198
ENSE00003743098	8802722	8803429
ENSE00003743812	8822587	8822657
ENSE00003745735	8828112	8828190
ENSE00003746402	8822996	8823086
ENSE00003752469	8836791	8836923
ENSE00003752662	8838564	8838655
ENSE00003754856	8839614	8839697
ENSE00003897457	8867529	8867674

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 79.83.

FANTOM5 (CAGE): breadth broad, TPM avg 6.0397 / max 435.9539, expressed in 479 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
164455	6.0397	479

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	79.83	gold quality
monocyte	CL:0000576	79.72	gold quality
leukocyte	CL:0000738	79.43	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.70	gold quality
spleen	UBERON:0002106	73.15	gold quality
vermiform appendix	UBERON:0001154	72.24	gold quality
apex of heart	UBERON:0002098	72.16	gold quality
blood	UBERON:0000178	71.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.66	gold quality
gall bladder	UBERON:0002110	68.50	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.83	gold quality
lymph node	UBERON:0000029	66.67	gold quality
bone marrow cell	CL:0002092	66.39	silver quality
mucosa of transverse colon	UBERON:0004991	65.68	gold quality
caecum	UBERON:0001153	65.35	gold quality
small intestine	UBERON:0002108	65.33	gold quality
upper lobe of left lung	UBERON:0008952	65.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.54	gold quality
lower esophagus	UBERON:0013473	64.53	gold quality
smooth muscle tissue	UBERON:0001135	64.47	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.27	gold quality
ganglionic eminence	UBERON:0004023	64.00	gold quality
heart left ventricle	UBERON:0002084	63.96	gold quality
right coronary artery	UBERON:0001625	63.50	gold quality
upper lobe of lung	UBERON:0008948	63.37	gold quality
cardiac ventricle	UBERON:0002082	63.16	gold quality
putamen	UBERON:0001874	62.92	gold quality
lower esophagus mucosa	UBERON:0035834	62.82	gold quality
rectum	UBERON:0001052	62.68	gold quality
esophagus	UBERON:0001043	62.07	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-6678	yes	23.57
E-MTAB-9067	yes	15.35
E-ANND-3	yes	6.86
E-MTAB-9801	yes	6.35

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

66 targeting PIK3R6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-7856-5P	99.75	69.99	2901
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-3659	99.70	67.97	694
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-646	99.68	67.84	1645
HSA-MIR-3177-5P	99.65	70.38	1174
HSA-MIR-6134	99.63	65.68	1537
HSA-MIR-142-3P	99.62	71.30	974
HSA-MIR-762	99.58	66.61	1994
HSA-MIR-4276	99.56	67.66	2514
HSA-MIR-4687-3P	99.48	66.41	968
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-190B-3P	99.33	68.29	1382
HSA-MIR-6719-3P	99.29	67.78	1387
HSA-MIR-6731-5P	99.28	67.42	2375

Literature-anchored findings (GeneRIF, showing 10)

• p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP] (PMID:16476736)
• ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells (PMID:18323525)
• RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma (PMID:18596232)
• knockdown of p84 in MDA-MB-231 cells enhanced Akt phosphorylation and lung colonization (PMID:21996737)
• GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. (PMID:22728827)
• expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. (PMID:24014027)
• Our findings suggest that p84 binding to p110gamma may represent a novel negative feedback signal that terminates PI3Kgamma activity. (PMID:25753393)
• RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6. (PMID:33155192)
• PIK3R6 Promotes Angiogenesis in Hepatocellular carcinoma by Activating STAT3 Signaling Pathway. (PMID:37708538)
• Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma. (PMID:38831518)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	pik3r6b	ENSDARG00000091140
mus_musculus	Pik3r6	ENSMUSG00000046207
rattus_norvegicus	Pik3r6	ENSRNOG00000003992

Paralogs (1): PIK3R5 (ENSG00000141506)

Protein

Protein identifiers

Phosphoinositide 3-kinase regulatory subunit 6 — Q5UE93 (reviewed: Q5UE93)

Alternative names: Phosphoinositide 3-kinase gamma adapter protein of 87 kDa, p84 PI3K adapter protein, p87 PI3K adapter protein

All UniProt accessions (2): Q5UE93, A0A087X1F3

UniProt curated annotations — full annotation on UniProt →

Function. Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.

Subunit / interactions. Heterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG. Interacts with beta-gamma G protein dimers. Interacts with PDE3B and RAPGEF3; form a signaling complex that regulates phosphatidylinositol 3-kinase gamma in angiogenesis.

Subcellular location. Cytoplasm. Cell membrane.

RefSeq proteins (2): NP_001010855, NP_001277140 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019522	PIK3R5/6	Family

Pfam: PF10486

UniProt features (2 total): chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5UE93-F1	75.19	0.38

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-114604	GPVI-mediated activation cascade
R-HSA-1257604	PIP3 activates AKT signaling
R-HSA-1660499	Synthesis of PIPs at the plasma membrane
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-389357	CD28 dependent PI3K/Akt signaling
R-HSA-392451	G beta:gamma signalling through PI3Kgamma
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9927354	Co-stimulation by ICOS

MSigDB gene sets: 205 (showing top): GOBP_REGULATION_OF_CELL_ACTIVATION, GOBP_POSITIVE_REGULATION_OF_HEMOPOIESIS, GOBP_REGULATION_OF_PHOSPHORYLATION, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION, GOBP_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT, GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE, GOBP_LEUKOCYTE_MEDIATED_CYTOTOXICITY, GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY, GOBP_LEUKOCYTE_MEDIATED_IMMUNITY, REACTOME_CO_STIMULATION_BY_CD28, GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION, GOBP_CELL_CELL_ADHESION, GOBP_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION, GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY

GO Biological Process (7): angiogenesis (GO:0001525), immune response (GO:0006955), G protein-coupled receptor signaling pathway (GO:0007186), regulation of natural killer cell mediated cytotoxicity (GO:0042269), positive regulation of MAP kinase activity (GO:0043406), positive regulation of T cell differentiation (GO:0045582), positive regulation of angiogenesis (GO:0045766)

GO Molecular Function (3): 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934), 1-phosphatidylinositol-3-kinase regulator activity (GO:0046935), protein binding (GO:0005515)

GO Cellular Component (7): cytosol (GO:0005829), plasma membrane (GO:0005886), phosphatidylinositol 3-kinase complex (GO:0005942), phosphatidylinositol 3-kinase complex, class IA (GO:0005943), phosphatidylinositol 3-kinase complex, class IB (GO:0005944), membrane (GO:0016020), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-8 pathways:

Category	Pathways
Platelet activation, signaling and aggregation	1
Intracellular signaling by second messengers	1
PI Metabolism	1
PI3K/AKT Signaling in Cancer	1
Co-stimulation by CD28	1
G-protein beta:gamma signalling	1
Negative regulation of the PI3K/AKT network	1
Regulation of T cell activation by CD28 family	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
phosphatidylinositol 3-kinase complex, class I	2
blood vessel morphogenesis	1
anatomical structure formation involved in morphogenesis	1
immune system process	1
response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
regulation of leukocyte mediated cytotoxicity	1
regulation of natural killer cell mediated immunity	1
natural killer cell mediated cytotoxicity	1
MAP kinase activity	1
regulation of MAP kinase activity	1
positive regulation of MAPK cascade	1
positive regulation of protein serine/threonine kinase activity	1
T cell differentiation	1
regulation of T cell differentiation	1
positive regulation of lymphocyte differentiation	1
positive regulation of T cell activation	1
angiogenesis	1
regulation of angiogenesis	1
positive regulation of vasculature development	1
phosphatidylinositol kinase activity	1
1-phosphatidylinositol-3-kinase activity	1
kinase regulator activity	1
binding	1
cytoplasm	1
membrane	1
cell periphery	1
extrinsic component of membrane	1
transferase complex, transferring phosphorus-containing groups	1
membrane protein complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

682 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PIK3R6	PIK3CG	P48736	988
PIK3R6	PDE3B	Q13370	695
PIK3R6	PIK3R3	Q92569	693
PIK3R6	GNG2	P59768	661
PIK3R6	GNB1	P04697	581
PIK3R6	SUCLG2	Q96I99	558
PIK3R6	PIK3R2	O00459	482
PIK3R6	PIK3C2B	O00750	471
PIK3R6	PIK3CB	P42338	448
PIK3R6	PIK3CD	O00329	447
PIK3R6	TLR9	Q9NR96	429
PIK3R6	PIK3C2G	O75747	419
PIK3R6	PIK3R1	P27986	405
PIK3R6	PIK3R5	Q8WYR1	390
PIK3R6	IMMT	Q16891	380

IntAct

13 interactions, top by confidence:

A	B	Type	Score
PDE3B	RAPGEF3	psi-mi:“MI:0914”(association)	0.640
PDE3B	PIK3R6	psi-mi:“MI:0915”(physical association)	0.590
PIK3R6	PDE3B	psi-mi:“MI:0407”(direct interaction)	0.590
PIK3R6	S100A10	psi-mi:“MI:0915”(physical association)	0.400
PIK3R6	STX3	psi-mi:“MI:0915”(physical association)	0.400
PIK3R6	TCP1	psi-mi:“MI:0915”(physical association)	0.400
PIK3R6	RPL10A	psi-mi:“MI:0915”(physical association)	0.400
PIK3R6	DHX9	psi-mi:“MI:0915”(physical association)	0.400
PIK3R6	H1-1	psi-mi:“MI:0915”(physical association)	0.400
PIK3R6	RFC5	psi-mi:“MI:0915”(physical association)	0.400
RAPGEF3	PIK3R6	psi-mi:“MI:0915”(physical association)	0.400
PIK3R6	HSPA8	psi-mi:“MI:0914”(association)	0.350

BioGRID (18): PIK3R6 (Affinity Capture-Western), PIK3R6 (FRET), PIK3R6 (Proximity Label-MS), PIK3R6 (Proximity Label-MS), PIK3R6 (Proximity Label-MS), PIK3R6 (Proximity Label-MS), PIK3R6 (Proximity Label-MS), PIK3R6 (Proximity Label-MS), PIK3R6 (Proximity Label-MS), PIK3R6 (Affinity Capture-MS), ASRGL1 (Affinity Capture-MS), HSPA8 (Affinity Capture-MS), STUB1 (Affinity Capture-MS), PIK3R6 (Cross-Linking-MS (XL-MS)), PIK3R6 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A1A4J7, A2A9C3, A2BID5, B1WC10, E7FAW3, E7FCN8, O02696, O15360, O75153, O75800, O95248, Q08D69, Q1JPG0, Q3U6Q4, Q499Q5, Q5BLE2, Q5SW28, Q5SW45, Q5T011, Q5U1Z0, Q5U249, Q5UE93, Q5ZIB8, Q6AXZ5, Q6GLY5, Q6GR21, Q6PGF3, Q6ZNJ1, Q6ZQA0, Q7L4E1, Q8BK03, Q8BM55, Q8BMG7, Q8C3S2, Q8CJF7, Q8ND04, Q8QZV7, Q8TC57, Q8VDR9, Q8VE18

Diamond homologs: Q3U6Q4, Q5UE93

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
AKT1	“up-regulates activity”	PIK3R6	phosphorylation
AKT	“up-regulates activity”	PIK3R6	phosphorylation
PIK3R6	“down-regulates activity”	PI3K	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

130 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	106
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3051 predictions. Top by Δscore:

Variant	Effect	Δscore
17:8804051:C:A	donor_gain	1.0000
17:8804150:CTGT:C	acceptor_gain	1.0000
17:8822991:CTTA:C	donor_loss	1.0000
17:8822995:C:CA	donor_loss	1.0000
17:8823085:AT:A	acceptor_gain	1.0000
17:8823382:CTTA:C	donor_loss	1.0000
17:8823383:TTAC:T	donor_loss	1.0000
17:8823384:TA:T	donor_loss	1.0000
17:8823385:A:AT	donor_loss	1.0000
17:8823498:C:CC	acceptor_gain	1.0000
17:8827171:CCAT:C	donor_gain	1.0000
17:8829673:CCA:C	donor_gain	1.0000
17:8829705:CAGAG:C	donor_gain	1.0000
17:8832883:GCTT:G	donor_loss	1.0000
17:8832884:CTTAC:C	donor_loss	1.0000
17:8832885:TTACC:T	donor_loss	1.0000
17:8832886:TACCA:T	donor_loss	1.0000
17:8832888:C:CA	donor_loss	1.0000
17:8832888:CCA:C	donor_gain	1.0000
17:8833044:GCCT:G	acceptor_loss	1.0000
17:8833045:CCTG:C	acceptor_loss	1.0000
17:8833047:T:C	acceptor_loss	1.0000
17:8835272:CCTG:C	donor_gain	1.0000
17:8835281:T:TA	donor_gain	1.0000
17:8835452:ACACT:A	acceptor_gain	1.0000
17:8835453:CACT:C	acceptor_gain	1.0000
17:8835453:CACTC:C	acceptor_gain	1.0000
17:8835455:CT:C	acceptor_gain	1.0000
17:8835456:TC:T	acceptor_loss	1.0000
17:8835456:TCTG:T	acceptor_gain	1.0000

AlphaMissense

4879 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:8838644:A:G	W37R	0.995
17:8838644:A:T	W37R	0.995
17:8828633:G:T	A416D	0.988
17:8838642:C:A	W37C	0.988
17:8838642:C:G	W37C	0.988
17:8823031:A:G	L561P	0.983
17:8803291:G:C	F749L	0.982
17:8803291:G:T	F749L	0.982
17:8803293:A:G	F749L	0.982
17:8829727:A:G	W290R	0.981
17:8829727:A:T	W290R	0.981
17:8823430:C:G	R528P	0.980
17:8827225:A:C	Y488D	0.980
17:8835340:A:T	V193D	0.980
17:8838571:A:G	L61P	0.979
17:8827228:A:G	W487R	0.977
17:8827228:A:T	W487R	0.977
17:8838637:A:G	L39P	0.976
17:8823042:G:C	F557L	0.972
17:8823042:G:T	F557L	0.972
17:8823044:A:G	F557L	0.972
17:8828615:C:T	G422E	0.972
17:8828860:G:C	S340R	0.969
17:8828860:G:T	S340R	0.969
17:8828862:T:G	S340R	0.969
17:8823425:C:G	G530R	0.968
17:8828616:C:G	G422R	0.968
17:8828616:C:T	G422R	0.968
17:8838643:C:G	W37S	0.967
17:8835445:A:G	F158S	0.966

dbSNP variants (sampled 300 via entrez): RS1000026905 (17:8846256 A>C,G), RS1000040677 (17:8815283 G>A), RS1000105792 (17:8853121 T>C), RS1000243982 (17:8818024 A>G), RS1000292210 (17:8830049 A>T), RS1000293988 (17:8855878 A>G), RS1000355612 (17:8861930 T>G), RS1000396534 (17:8861688 A>G,T), RS1000468862 (17:8823575 C>G,T), RS1000498092 (17:8838808 T>G), RS1000571256 (17:8841637 T>A), RS1000609364 (17:8806290 T>C), RS1000613610 (17:8844025 G>A,T), RS1000661926 (17:8806109 A>G), RS1000763818 (17:8812514 T>A)

Disease associations

OMIM: gene MIM:611462 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009391_1759	Metabolite levels	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010370	lysophosphatidylethanolamine 20:4 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — Phosphatidylinositol kinases

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation, affects methylation, decreases expression	3
Formaldehyde	increases expression	2
Aflatoxin B1	affects expression, decreases methylation	2
GSK-J4	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
aflatoxin B2	increases methylation	1
Air Pollutants	increases abundance, increases expression	1
Allergens	increases expression	1
Oxygen	increases expression	1
Phthalic Acids	increases methylation	1
Cyclosporine	decreases expression	1
Particulate Matter	increases expression, increases abundance	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TD72	HAP1 PIK3R6 (-) 1	Cancer cell line	Male
CVCL_TD73	HAP1 PIK3R6 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.