PINK1-AS

Summary

PINK1-AS (PINK1 antisense RNA, HGNC:38872) is a long non-coding RNA gene on chromosome 1p36.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38872
Approved symbol	PINK1-AS
Name	PINK1 antisense RNA
Location	1p36.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ00387, PINK1AS, naPINK1
Ensembl gene	ENSG00000117242
Ensembl biotype	lncRNA
Entrez	100861548
RNAcentral	URS000052446E — lncRNA, 4443 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000451424

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000451424 — 3 exons

Exon	Start	End
ENSE00001453288	20642657	20643118
ENSE00001711022	20645585	20645686
ENSE00001717360	20648315	20652193

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 79.73.

Top tissues by expression

150 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	79.73	gold quality
gastrocnemius	UBERON:0001388	74.11	gold quality
skeletal muscle tissue	UBERON:0001134	74.08	gold quality
muscle of leg	UBERON:0001383	74.04	gold quality
islet of Langerhans	UBERON:0000006	73.69	gold quality
heart left ventricle	UBERON:0002084	73.68	gold quality
heart	UBERON:0000948	72.28	gold quality
spleen	UBERON:0002106	72.21	gold quality
bone marrow	UBERON:0002371	72.07	gold quality
endometrium	UBERON:0001295	72.04	gold quality
bone marrow cell	CL:0002092	71.85	silver quality
hindlimb stylopod muscle	UBERON:0004252	71.83	gold quality
granulocyte	CL:0000094	71.77	gold quality
leukocyte	CL:0000738	71.64	gold quality
pancreas	UBERON:0001264	71.62	gold quality
monocyte	CL:0000576	71.49	gold quality
smooth muscle tissue	UBERON:0001135	71.44	gold quality
right atrium auricular region	UBERON:0006631	71.30	gold quality
left adrenal gland cortex	UBERON:0035825	70.72	gold quality
left adrenal gland	UBERON:0001234	70.66	gold quality
body of pancreas	UBERON:0001150	70.61	gold quality
uterus	UBERON:0000995	70.37	gold quality
apex of heart	UBERON:0002098	70.26	gold quality
right adrenal gland cortex	UBERON:0035827	70.19	gold quality
cortical plate	UBERON:0005343	70.16	gold quality
right adrenal gland	UBERON:0001233	70.12	gold quality
colonic epithelium	UBERON:0000397	70.05	silver quality
body of uterus	UBERON:0009853	69.95	gold quality
ovary	UBERON:0000992	69.93	gold quality
adrenal gland	UBERON:0002369	69.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Expression analysis of PINK1 and PINK1-AS in multiple sclerosis patients versus healthy subjects. (PMID:33161812)
• MKL-1-induced PINK1-AS overexpression contributes to the malignant progression of hepatocellular carcinoma via ALDOA-mediated glycolysis. (PMID:36494481)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.