PIRAT1

Summary

PIRAT1 (PU.1 (SPI1) induced regulator of S100A8 and S100A9 alarmin transcription 1, HGNC:37459) is a long non-coding RNA gene on chromosome 2p22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37459
Approved symbol	PIRAT1
Name	PU.1 (SPI1) induced regulator of S100A8 and S100A9 alarmin transcription 1
Location	2p22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	PIRAT
Ensembl gene	ENSG00000237803
Ensembl biotype	lncRNA
OMIM	621210
Entrez	101929559
RNAcentral	URS000075A591 — lncRNA, 2202 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 42 — 42 lncRNA

ENST00000413792, ENST00000418746, ENST00000446799, ENST00000655678, ENST00000655948, ENST00000656652, ENST00000659701, ENST00000667610, ENST00000751985, ENST00000751986, ENST00000751987, ENST00000751988, ENST00000751989, ENST00000751990, ENST00000751991, ENST00000751992, ENST00000751993, ENST00000751994, ENST00000751995, ENST00000751996, ENST00000751997, ENST00000751998, ENST00000751999, ENST00000752000, ENST00000752001, ENST00000752002, ENST00000752003, ENST00000752004, ENST00000752005, ENST00000752006, ENST00000752007, ENST00000752008, ENST00000752009, ENST00000752010, ENST00000752011, ENST00000752012, ENST00000752013, ENST00000752014, ENST00000752015, ENST00000752016, ENST00000752017, ENST00000752018

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413792 — 3 exons

Exon	Start	End
ENSE00001591498	37829248	37829432
ENSE00001685422	37828933	37829038
ENSE00001797876	37826247	37827878

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 80.52.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3569 / max 76.3553, expressed in 72 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
27834	0.2193	47
27832	0.1040	33
27833	0.0335	15

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	80.52	gold quality
leukocyte	CL:0000738	79.89	gold quality
blood	UBERON:0000178	78.75	gold quality
granulocyte	CL:0000094	69.47	gold quality
bone marrow cell	CL:0002092	68.54	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.14	gold quality
right testis	UBERON:0004534	63.92	gold quality
bone marrow	UBERON:0002371	63.11	gold quality
testis	UBERON:0000473	62.92	gold quality
left testis	UBERON:0004533	62.77	gold quality
ganglionic eminence	UBERON:0004023	59.62	gold quality
skeletal muscle tissue	UBERON:0001134	59.51	silver quality
prefrontal cortex	UBERON:0000451	55.50	gold quality
descending thoracic aorta	UBERON:0002345	55.08	gold quality
stromal cell of endometrium	CL:0002255	54.76	silver quality
multicellular organism	UBERON:0000468	53.47	gold quality
liver	UBERON:0002107	53.05	silver quality
apex of heart	UBERON:0002098	52.87	gold quality
spleen	UBERON:0002106	52.19	gold quality
heart left ventricle	UBERON:0002084	51.51	gold quality
islet of Langerhans	UBERON:0000006	50.69	gold quality
right lobe of liver	UBERON:0001114	50.69	gold quality
vermiform appendix	UBERON:0001154	50.65	gold quality
left uterine tube	UBERON:0001303	50.64	gold quality
Brodmann (1909) area 9	UBERON:0013540	49.85	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	49.40	gold quality
smooth muscle tissue	UBERON:0001135	49.03	gold quality
heart	UBERON:0000948	48.89	gold quality
placenta	UBERON:0001987	48.50	gold quality
calcaneal tendon	UBERON:0003701	48.46	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.91

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.