PISRT1

Summary

PISRT1 (PISRT1 lncRNA, HGNC:16671) is a long non-coding RNA gene on chromosome 3q23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16671
Approved symbol	PISRT1
Name	PISRT1 lncRNA
Location	3q23
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00195
Ensembl gene	ENSG00000281473
Ensembl biotype	lncRNA
Entrez	140464
RNAcentral	URS000075CDA3 — lncRNA, 531 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000626175

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000626175 — 1 exons

Exon	Start	End
ENSE00003768924	139232992	139233522

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 90.48.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.48	gold quality
adrenal gland	UBERON:0002369	61.15	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	59.70	gold quality
sural nerve	UBERON:0015488	56.23	silver quality
ovary	UBERON:0000992	53.96	silver quality
monocyte	CL:0000576	53.46	gold quality
tibial artery	UBERON:0007610	53.29	gold quality
blood	UBERON:0000178	52.43	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	50.78	gold quality
tibial nerve	UBERON:0001323	47.76	silver quality
esophagus mucosa	UBERON:0002469	44.14	silver quality
spleen	UBERON:0002106	43.17	silver quality
ectocervix	UBERON:0012249	40.24	silver quality
skin of abdomen	UBERON:0001416	37.77	silver quality
skin of leg	UBERON:0001511	37.61	silver quality
Brodmann (1909) area 9	UBERON:0013540	36.84	silver quality
prostate gland	UBERON:0002367	36.64	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	36.15	silver quality
adenohypophysis	UBERON:0002196	36.14	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	36.10	silver quality
pituitary gland	UBERON:0000007	36.03	silver quality
omental fat pad	UBERON:0010414	34.79	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The novel deletion found could be involved in FOXL2 regulation and constitutes the smallest deletion described in a female with Blepharophimosis, ptosis and epicanthus inversus syndrome (BPES). (PMID:22171663)
• We describe a girl and her father with isolated BPES without an intragenic mutation in FOXL2. MLPA of a FOXL2 enhancer region identified a small microdeletion at 234 kb upstream of FOXL2. This deletion fully includes the PISRT1 gene, a noncoding gene which is part of a cis-regulatory element of FOXL2 (PMID:29481440)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm55625	ENSMUSG00002076308

Paralogs (1): (ENSG00000276304)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.