PITPNA-AS1

Summary

PITPNA-AS1 (PITPNA antisense RNA 1, HGNC:44116) is a long non-coding RNA gene on chromosome 17p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44116
Approved symbol	PITPNA-AS1
Name	PITPNA antisense RNA 1
Location	17p13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236618
Ensembl biotype	lncRNA
Entrez	100306951
RNAcentral	URS000075B2EC — lncRNA, 570 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000425081

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425081 — 2 exons

Exon	Start	End
ENSE00004259016	1517718	1518106
ENSE00004259017	1516815	1517093

Expression profiles

Bgee: expression breadth ubiquitous, 252 present calls, max score 93.89.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.0271 / max 166.5056, expressed in 1760 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
158724	20.2678	1758
158725	0.7593	392

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	93.89	gold quality
parotid gland	UBERON:0001831	92.63	gold quality
tendon of biceps brachii	UBERON:0008188	92.22	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.51	gold quality
left testis	UBERON:0004533	90.67	gold quality
right testis	UBERON:0004534	90.53	gold quality
hindlimb stylopod muscle	UBERON:0004252	90.03	gold quality
testis	UBERON:0000473	89.67	gold quality
vastus lateralis	UBERON:0001379	88.83	gold quality
body of pancreas	UBERON:0001150	88.67	gold quality
quadriceps femoris	UBERON:0001377	88.49	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.27	gold quality
muscle of leg	UBERON:0001383	87.90	gold quality
gastrocnemius	UBERON:0001388	87.89	gold quality
biceps brachii	UBERON:0001507	87.82	gold quality
epithelial cell of pancreas	CL:0000083	87.52	gold quality
secondary oocyte	CL:0000655	87.46	gold quality
skeletal muscle tissue	UBERON:0001134	87.45	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	87.43	gold quality
left ovary	UBERON:0002119	86.83	gold quality
endothelial cell	CL:0000115	86.76	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	86.24	gold quality
corpus epididymis	UBERON:0004359	85.99	gold quality
amniotic fluid	UBERON:0000173	85.92	gold quality
ovary	UBERON:0000992	85.44	gold quality
adenohypophysis	UBERON:0002196	85.21	gold quality
muscle tissue	UBERON:0002385	85.09	gold quality
pituitary gland	UBERON:0000007	84.69	gold quality
adipose tissue	UBERON:0001013	84.69	gold quality
pancreatic ductal cell	CL:0002079	84.36	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.54

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression. (PMID:31700026)
• Long noncoding RNA PITPNA-AS1 promotes cervical cancer progression through regulating the cell cycle and apoptosis by targeting the miR-876-5p/c-MET axis. (PMID:32460193)
• LncRNA PITPNA-AS1 boosts the proliferation and migration of lung squamous cell carcinoma cells by recruiting TAF15 to stabilize HMGB3 mRNA. (PMID:32871048)
• Long noncoding RNA PITPNAAS1 silencing suppresses proliferation, metastasis and epithelialmesenchymal transition in nonsmall cell lung cancer cells by targeting microRNA325p. (PMID:33495838)
• LncRNA PITPNA-AS1 stimulates cell proliferation and suppresses cell apoptosis in glioblastoma via targeting miR-223-3p/EGFR axis and activating PI3K/AKT signaling pathway. (PMID:34470587)
• LncRNA PITPNA-AS1/miR-223-3p/PTN axis regulates malignant progression and stemness in lung squamous cell carcinoma. (PMID:35588441)
• lncRNA PITPNA-AS1 promotes cell proliferation and metastasis in hepatocellular carcinoma by upregulating PDGFD. (PMID:37253627)
• PITPNA-AS1 Inhibits Cell Proliferation and Migration in Ovarian Cancer by Regulating the MIR-223-3p/RHOB Axis. (PMID:38753591)
• LncRNA PITPNA-AS1 mediates the diagnostic potential of miR-129-5p in prostate cancer. (PMID:39003446)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.