PITPNB

Summary

PITPNB (phosphatidylinositol transfer protein beta, HGNC:9002) is a protein-coding gene on chromosome 22q12.1, encoding Phosphatidylinositol transfer protein beta isoform (P48739). Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes.

This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants.

Source: NCBI Gene 23760 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 28 total
• Druggable target: yes
• MANE Select transcript: NM_012399

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9002
Approved symbol	PITPNB
Name	phosphatidylinositol transfer protein beta
Location	22q12.1
Locus type	gene with protein product
Status	Approved
Aliases	VIB1B
Ensembl gene	ENSG00000180957
Ensembl biotype	protein_coding
OMIM	606876
Entrez	23760

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 5 protein_coding, 5 retained_intron

ENST00000320996, ENST00000335272, ENST00000415296, ENST00000436663, ENST00000460566, ENST00000465179, ENST00000471825, ENST00000477861, ENST00000493007, ENST00000634017

RefSeq mRNA: 3 — MANE Select: NM_012399 NM_001284277, NM_001284278, NM_012399

CCDS: CCDS13842, CCDS63432, CCDS63433

Canonical transcript exons

ENST00000335272 — 12 exons

Exon	Start	End
ENSE00001344136	27919172	27919256
ENSE00001650357	27854854	27854939
ENSE00001883424	27851669	27853663
ENSE00003532048	27914317	27914347
ENSE00003573097	27897801	27897892
ENSE00003604936	27860131	27860241
ENSE00003612427	27897130	27897137
ENSE00003613456	27910964	27911109
ENSE00003623733	27873738	27873815
ENSE00003634112	27896552	27896626
ENSE00003685652	27858387	27858509
ENSE00003693284	27894555	27894638

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 98.72.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 48.6455 / max 953.6721, expressed in 1818 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193477	48.3401	1818
193478	0.3054	151

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gingival epithelium	UBERON:0001949	98.72	gold quality
secondary oocyte	CL:0000655	98.19	gold quality
gingiva	UBERON:0001828	98.18	gold quality
endothelial cell	CL:0000115	98.02	gold quality
middle temporal gyrus	UBERON:0002771	97.93	gold quality
germinal epithelium of ovary	UBERON:0001304	97.67	gold quality
squamous epithelium	UBERON:0006914	97.61	gold quality
Brodmann (1909) area 23	UBERON:0013554	97.42	gold quality
superficial temporal artery	UBERON:0001614	97.36	gold quality
esophagus squamous epithelium	UBERON:0006920	97.34	gold quality
hair follicle	UBERON:0002073	97.16	gold quality
cartilage tissue	UBERON:0002418	97.15	gold quality
parietal pleura	UBERON:0002400	96.93	gold quality
Brodmann (1909) area 46	UBERON:0006483	96.92	gold quality
cauda epididymis	UBERON:0004360	96.89	gold quality
colonic epithelium	UBERON:0000397	96.88	gold quality
pleura	UBERON:0000977	96.85	gold quality
popliteal artery	UBERON:0002250	96.82	gold quality
saphenous vein	UBERON:0007318	96.81	gold quality
tibial artery	UBERON:0007610	96.81	gold quality
cervix squamous epithelium	UBERON:0006922	96.75	gold quality
visceral pleura	UBERON:0002401	96.74	gold quality
epithelium of esophagus	UBERON:0001976	96.63	gold quality
blood vessel layer	UBERON:0004797	96.63	gold quality
heart right ventricle	UBERON:0002080	96.53	gold quality
amniotic fluid	UBERON:0000173	96.45	gold quality
orbitofrontal cortex	UBERON:0004167	96.41	gold quality
aorta	UBERON:0000947	96.30	gold quality
oral cavity	UBERON:0000167	96.26	gold quality
tibia	UBERON:0000979	96.25	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-6678	no	3.47
E-HCAD-5	no	2.20
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CREB1

miRNA regulators (miRDB)

115 targeting PITPNB, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-9718	99.94	68.91	918
HSA-MIR-329-3P	99.91	66.56	1234
HSA-MIR-362-3P	99.91	66.38	1267

Literature-anchored findings (GeneRIF, showing 3)

• Role of PITPNB- not required for sphingomyelin trafficking (PMID:12023904)
• The presence of PITPbeta splice variants adds an extra level of proteome complexity (PMID:16780419)
• Phosphatidylinositol and phosphatidylcholine exchange activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum. (PMID:20332109)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	pitpnb	ENSDARG00000036005
mus_musculus	Pitpnb	ENSMUSG00000050017
rattus_norvegicus	Pitpnb	ENSRNOG00000000665

Paralogs (5): PITPNM2 (ENSG00000090975), PITPNM3 (ENSG00000091622), PITPNM1 (ENSG00000110697), PITPNC1 (ENSG00000154217), PITPNA (ENSG00000174238)

Protein

Protein identifiers

Phosphatidylinositol transfer protein beta isoform — P48739 (reviewed: P48739)

All UniProt accessions (3): B3KYB6, B3KYB7, P48739

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Also catalyzes the transfer of sphingomyelin. Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function.

Subcellular location. Golgi apparatus. Golgi apparatus membrane. Endoplasmic reticulum membrane.

Tissue specificity. Widely expressed in various tissues including brain.

Post-translational modifications. Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.

Activity regulation. Phosphatidylinositol transfer activity is inhibited by N-ethylmaleimide.

Similarity. Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
P48739-1	1	yes
P48739-2	2
P48739-3	3

RefSeq proteins (3): NP_001271206, NP_001271207, NP_036531* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001666	PI_transfer	Family
IPR023393	START-like_dom_sf	Homologous_superfamily
IPR055261	PI_transfer_N	Domain

Pfam: PF02121

Catalyzed reactions (Rhea), 3 shown:

• a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) (RHEA:38571)
• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out) (RHEA:38691)
• an N-(acyl)-sphingosylphosphocholine(in) = an N-(acyl)-sphingosylphosphocholine(out) (RHEA:43776)

UniProt features (10 total): mutagenesis site 5, modified residue 2, splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P48739-F1	95.59	0.91

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 215, 262

Mutagenesis-validated functional residues (5):

Position	Phenotype
60	loss of phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity. fails to rescue t
89	loss of phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity. fails to rescue t
94	loss of phosphatidylcholine transfer activity but no effect on phosphatidylinositol transfer activity. not inhibited by
187	no effect on phosphatidylinositol transfer activity.
202–203	loss of phosphatidylinositol transfer activity. fails to rescue the retrograde transport defect from the golgi to endopl

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-1483196	PI and PC transport between ER and Golgi membranes

MSigDB gene sets: 214 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOBP_VESICLE_MEDIATED_TRANSPORT, MORF_PSMC2, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, MODULE_66, MARTINEZ_RB1_TARGETS_UP, GOBP_NUCLEUS_ORGANIZATION, GENTILE_UV_HIGH_DOSE_DN, GENTILE_UV_RESPONSE_CLUSTER_D5, BYSTROEM_CORRELATED_WITH_IL5_DN, GOBP_LIPID_METABOLIC_PROCESS, DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP, DODD_NASOPHARYNGEAL_CARCINOMA_UP

GO Biological Process (6): lipid metabolic process (GO:0006629), retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890), nucleus organization (GO:0006997), phospholipid transport (GO:0015914), lipid transport (GO:0006869), intermembrane lipid transfer (GO:0120009)

GO Molecular Function (10): phosphatidylcholine intramembrane carrier activity (GO:0008525), phosphatidylinositol transfer activity (GO:0008526), phosphatidylcholine binding (GO:0031210), phosphatidylinositol binding (GO:0035091), phosphatidylcholine transfer activity (GO:0120019), sphingomyelin transfer activity (GO:0140338), protein binding (GO:0005515), obsolete phospholipid transporter activity (GO:0005548), lipid binding (GO:0008289), quaternary ammonium group binding (GO:0050997)

GO Cellular Component (6): Golgi membrane (GO:0000139), cytoplasm (GO:0005737), endoplasmic reticulum membrane (GO:0005789), Golgi apparatus (GO:0005794), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Glycerophospholipid biosynthesis	1
PI Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
lipid transport	2
phospholipid transfer activity	2
binding	2
cellular anatomical structure	2
cytoplasm	2
endomembrane system	2
intracellular membrane-bounded organelle	2
primary metabolic process	1
Golgi vesicle transport	1
organelle organization	1
organophosphate ester transport	1
transport	1
lipid localization	1
membrane organization	1
intramembrane lipid carrier activity	1
phosphatidylinositol binding	1
lipid transfer activity	1
phospholipid binding	1
cation binding	1
quaternary ammonium group binding	1
anion binding	1
phosphatidylcholine binding	1
sphingolipid transfer activity	1
small molecule binding	1
Golgi apparatus	1
bounding membrane of organelle	1
intracellular anatomical structure	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1

Protein interactions and networks

STRING

1116 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PITPNB	OSBP	P22059	521
PITPNB	UAP1L1	Q3KQV9	458
PITPNB	CERT1	Q9Y5P4	454
PITPNB	SLC35F6	Q8N357	452
PITPNB	PI4KB	P78405	429
PITPNB	ESD	P10768	425
PITPNB	FAF2	Q96CS3	424
PITPNB	VAPA	Q9P0L0	422
PITPNB	FBXO6	Q9NRD1	418
PITPNB	TTC28	Q96AY4	418
PITPNB	PDXK	O00764	410
PITPNB	UBQLN4	Q9NRR5	401
PITPNB	PCTP	Q9UKL6	398
PITPNB	TAMM41	Q96BW9	391
PITPNB	PLEKHA3	Q9HB20	390

IntAct

35 interactions, top by confidence:

A	B	Type	Score
HRAS	RGL2	psi-mi:“MI:0914”(association)	0.660
CASP6	PITPNB	psi-mi:“MI:0915”(physical association)	0.560
LAMP2	PITPNB	psi-mi:“MI:0915”(physical association)	0.560
SH3GLB1	PITPNB	psi-mi:“MI:0915”(physical association)	0.560
PRPF40A	PITPNB	psi-mi:“MI:0915”(physical association)	0.560
	MYL12B	psi-mi:“MI:0914”(association)	0.460
	TK2	psi-mi:“MI:0915”(physical association)	0.400
PITPNB	LMO4	psi-mi:“MI:0915”(physical association)	0.370
DNAJC11		psi-mi:“MI:0914”(association)	0.350
DLD	NFKBIE	psi-mi:“MI:0914”(association)	0.350
HSD17B10	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
SOD1	NPEPPSL1	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
	SDCBP	psi-mi:“MI:0914”(association)	0.350
	AGPS	psi-mi:“MI:0914”(association)	0.350
	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
PITPNB	PITPNA	psi-mi:“MI:0914”(association)	0.350
PITPNB	PRKCA	psi-mi:“MI:0914”(association)	0.350
MTCH2	IPO5	psi-mi:“MI:0914”(association)	0.350
SLC44A5	UPK3BL1	psi-mi:“MI:0914”(association)	0.350

BioGRID (61): PITPNB (Affinity Capture-RNA), PITPNB (Affinity Capture-RNA), PITPNB (Affinity Capture-RNA), PITPNB (Affinity Capture-MS), PITPNB (Co-fractionation), PITPNB (Co-fractionation), PITPNB (Co-fractionation), PITPNB (Co-fractionation), PITPNB (Co-fractionation), PITPNB (Co-fractionation), PITPNB (Co-fractionation), PITPNB (Co-fractionation), PITPNB (Co-fractionation), PITPNB (Co-fractionation), PITPNB (Co-fractionation)

ESM2 similar proteins: A8K855, O95299, P0CB89, P0CB90, P11881, P16446, P19824, P29994, P29995, P34942, P48603, P48738, P48739, P53810, P53811, P53812, P60670, P70227, Q00169, Q0E908, Q0MQB6, Q0MQB7, Q14571, Q14573, Q14643, Q14849, Q2HJ54, Q4G005, Q54VC7, Q5BJI9, Q5M7Y0, Q5R6F0, Q63269, Q6IQC7, Q6NRZ4, Q6P3Q6, Q7K556, Q8H1S0, Q8TAT6, Q8WN95

Diamond homologs: G5EEM9, O00562, O35954, O46606, P16446, P43125, P48738, P48739, P53810, P53811, P53812, Q00169, Q28CA0, Q2HJ54, Q3UHE1, Q54D93, Q54VC7, Q5R6F0, Q5U2N3, Q6NZC7, Q6ZPQ6, Q80YA3, Q8K4R4, Q8NEL9, Q8W5R2, Q9BZ71, Q9BZ72, Q9NCL7, Q9NCL8, Q9TR36, Q9U9P7, Q9UKF7, Q12204

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

28 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	13
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2388 predictions. Top by Δscore:

Variant	Effect	Δscore
22:27858381:TCTTA:T	donor_loss	1.0000
22:27858382:CTTA:C	donor_loss	1.0000
22:27858383:TTACT:T	donor_loss	1.0000
22:27858384:TACTG:T	donor_loss	1.0000
22:27858385:A:AC	donor_gain	1.0000
22:27858385:AC:A	donor_loss	1.0000
22:27858386:C:CT	donor_gain	1.0000
22:27858386:CT:C	donor_gain	1.0000
22:27858386:CTG:C	donor_gain	1.0000
22:27858386:CTGT:C	donor_gain	1.0000
22:27858386:CTGTT:C	donor_gain	1.0000
22:27858506:CTTG:C	acceptor_gain	1.0000
22:27858507:TTG:T	acceptor_gain	1.0000
22:27858510:C:CC	acceptor_gain	1.0000
22:27858511:T:C	acceptor_gain	1.0000
22:27858511:T:TC	acceptor_gain	1.0000
22:27858512:T:C	acceptor_gain	1.0000
22:27858512:T:TC	acceptor_gain	1.0000
22:27858513:T:C	acceptor_gain	1.0000
22:27858513:T:TC	acceptor_gain	1.0000
22:27858520:A:T	acceptor_gain	1.0000
22:27860125:TTTTA:T	donor_loss	1.0000
22:27860126:TTTAC:T	donor_loss	1.0000
22:27860127:TTAC:T	donor_loss	1.0000
22:27860128:TACCT:T	donor_loss	1.0000
22:27860129:A:C	donor_loss	1.0000
22:27860237:TCCTT:T	acceptor_gain	1.0000
22:27860238:CCTTC:C	acceptor_gain	1.0000
22:27860239:CTT:C	acceptor_gain	1.0000
22:27860242:C:CC	acceptor_gain	1.0000

AlphaMissense

1809 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:27858478:C:G	R226P	1.000
22:27860192:A:G	L195P	1.000
22:27860194:C:A	K194N	1.000
22:27860194:C:G	K194N	1.000
22:27896581:G:C	H115D	1.000
22:27897808:A:C	C94W	1.000
22:27897823:A:C	N89K	1.000
22:27897823:A:T	N89K	1.000
22:27910981:T:A	K60N	1.000
22:27910981:T:G	K60N	1.000
22:27911093:A:G	L23P	1.000
22:27911099:C:T	G21E	1.000
22:27911109:A:G	Y18H	1.000
22:27858394:A:G	L254P	0.999
22:27858414:T:A	E247D	0.999
22:27858414:T:G	E247D	0.999
22:27858423:C:A	R244S	0.999
22:27858423:C:G	R244S	0.999
22:27858424:C:A	R244M	0.999
22:27858424:C:G	R244T	0.999
22:27858452:A:G	W235R	0.999
22:27858452:A:T	W235R	0.999
22:27858465:A:C	C230W	0.999
22:27858472:A:G	L228P	0.999
22:27858479:G:T	R226S	0.999
22:27858482:G:C	H225D	0.999
22:27858483:G:C	F224L	0.999
22:27858483:G:T	F224L	0.999
22:27858485:A:G	F224L	0.999
22:27858499:C:G	R219P	0.999

dbSNP variants (sampled 300 via entrez): RS1000053808 (22:27903640 G>C), RS1000060535 (22:27882087 A>G), RS1000112 (22:27877351 G>C), RS1000137534 (22:27888422 T>A), RS1000143091 (22:27865168 A>T), RS1000170825 (22:27888724 G>A), RS1000221739 (22:27915340 A>G), RS1000318958 (22:27920383 C>G), RS1000340061 (22:27868830 A>C), RS1000347080 (22:27920029 A>C,G), RS1000398618 (22:27877949 C>A,G), RS1000482145 (22:27886558 G>A,T), RS1000487389 (22:27870509 G>C), RS1000512838 (22:27886960 G>A), RS1000534571 (22:27919665 A>C,G,T)

Disease associations

OMIM: gene MIM:606876 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001057_3	Obesity	7.000000e-07
GCST003094_4	Mitral valve prolapse	1.000000e-08
GCST012490_157	Femur bone mineral density x serum urate levels interaction	2.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066263 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.95	Kd	1131	nM	CHEMBL5653589
5.95	ED50	1131	nM	CHEMBL5653589
5.77	Kd	1715	nM	CHEMBL3752910
5.77	ED50	1715	nM	CHEMBL3752910

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149015: Binding affinity to human PITPNB incubated for 45 mins by Kinobead based pull down assay	kd	1.1314	uM
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149015: Binding affinity to human PITPNB incubated for 45 mins by Kinobead based pull down assay	kd	1.7147	uM

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, affects expression	2
Hydrogen Peroxide	affects expression, affects cotreatment, increases expression	2
Ozone	affects cotreatment, increases oxidation, increases abundance, affects expression	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Tretinoin	decreases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
Aflatoxin B1	increases methylation, decreases methylation	2
aristolochic acid I	decreases expression	1
FR900359	decreases phosphorylation	1
bisphenol F	increases expression	1
beta-N-methylamino-L-alanine	decreases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	decreases expression	1
kojic acid	increases expression	1
beta-lapachone	decreases expression, increases expression	1
ochratoxin A	decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
tamibarotene	affects expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
bisphenol S	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Aminoglutethimide	increases expression	1
Arbutin	increases expression	1
Atrazine	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652057	Binding	Binding affinity to human PITPNB incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2AW	Abcam HeLa PITPNB KO	Cancer cell line	Female
CVCL_TD96	HAP1 PITPNB (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.