PITPNM2

Summary

PITPNM2 (phosphatidylinositol transfer protein membrane associated 2, HGNC:21044) is a protein-coding gene on chromosome 12q24.31, encoding Membrane-associated phosphatidylinositol transfer protein 2 (Q9BZ72). Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro).

PITPNM2 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).

Source: NCBI Gene 57605 — RefSeq curated summary.

At a glance

• GWAS associations: 56
• Clinical variants (ClinVar): 193 total
• MANE Select transcript: NM_020845

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21044
Approved symbol	PITPNM2
Name	phosphatidylinositol transfer protein membrane associated 2
Location	12q24.31
Locus type	gene with protein product
Status	Approved
Aliases	RDGBA2, RDGB2, NIR3
Ensembl gene	ENSG00000090975
Ensembl biotype	protein_coding
OMIM	608920
Entrez	57605

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 10 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000280562, ENST00000320201, ENST00000436074, ENST00000451868, ENST00000535289, ENST00000541244, ENST00000542210, ENST00000546049, ENST00000876868, ENST00000876869, ENST00000876870, ENST00000876871, ENST00000931311

RefSeq mRNA: 11 — MANE Select: NM_020845 NM_001300801, NM_001384660, NM_001384661, NM_001384662, NM_001384663, NM_001384664, NM_001384665, NM_001384666, NM_001384667, NM_001384668, NM_020845

CCDS: CCDS73543, CCDS9242

Canonical transcript exons

ENST00000320201 — 26 exons

Exon	Start	End
ENSE00000757145	122988234	122988350
ENSE00000757148	122987785	122987901
ENSE00000881272	122986436	122986564
ENSE00000881276	122987511	122987659
ENSE00000881286	122995389	122995660
ENSE00000881291	122997325	122997572
ENSE00000996966	122996458	122996577
ENSE00001112355	122988724	122988872
ENSE00001112357	122986646	122986829
ENSE00001112359	122992499	122992669
ENSE00001112363	122987281	122987430
ENSE00001112366	122994801	122994979
ENSE00001112369	122996721	122996910
ENSE00001112371	122990545	122990709
ENSE00001177042	122989787	122989948
ENSE00001240978	122983480	122986350
ENSE00002319339	123110385	123110488
ENSE00003475482	123013828	123014042
ENSE00003486638	123034513	123034685
ENSE00003506986	123005240	123005548
ENSE00003568544	123004394	123004489
ENSE00003572802	123001054	123001158
ENSE00003612409	123009850	123010077
ENSE00003613029	123000778	123000848
ENSE00003639487	123012613	123012734
ENSE00003920563	123150753	123151090

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 88.67.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.2033 / max 333.6375, expressed in 1545 samples.

FANTOM5 promoters (18 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133895	3.6415	1388
133894	1.0000	596
133879	0.5024	87
133885	0.4460	187
133893	0.1841	72
133897	0.1119	48
133886	0.0937	28
133896	0.0619	17
133877	0.0531	13
133878	0.0227	9

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
metanephros cortex	UBERON:0010533	88.67	gold quality
right frontal lobe	UBERON:0002810	87.37	gold quality
right lobe of liver	UBERON:0001114	87.19	gold quality
left ovary	UBERON:0002119	86.63	gold quality
right adrenal gland	UBERON:0001233	86.39	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.23	gold quality
left adrenal gland cortex	UBERON:0035825	86.22	gold quality
left adrenal gland	UBERON:0001234	86.04	gold quality
right adrenal gland cortex	UBERON:0035827	85.64	gold quality
right ovary	UBERON:0002118	85.54	gold quality
right lung	UBERON:0002167	85.13	gold quality
mucosa of stomach	UBERON:0001199	85.06	gold quality
anterior cingulate cortex	UBERON:0009835	84.60	gold quality
apex of heart	UBERON:0002098	84.56	gold quality
prefrontal cortex	UBERON:0000451	84.45	gold quality
cerebellar hemisphere	UBERON:0002245	84.42	gold quality
upper lobe of left lung	UBERON:0008952	84.31	gold quality
cerebellar cortex	UBERON:0002129	84.30	gold quality
sural nerve	UBERON:0015488	84.14	gold quality
thymus	UBERON:0002370	83.88	silver quality
adrenal cortex	UBERON:0001235	83.75	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	83.57	gold quality
adrenal gland	UBERON:0002369	83.52	gold quality
lower esophagus muscularis layer	UBERON:0035833	82.78	gold quality
granulocyte	CL:0000094	82.76	gold quality
lower esophagus	UBERON:0013473	82.75	gold quality
nucleus accumbens	UBERON:0001882	82.63	gold quality
heart left ventricle	UBERON:0002084	82.40	gold quality
upper lobe of lung	UBERON:0008948	82.30	gold quality
cerebellum	UBERON:0002037	82.28	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.96
E-CURD-10	no	14.78

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

168 targeting PITPNM2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-4650-5P	99.98	64.69	999
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-6825-5P	99.96	69.81	3431

Literature-anchored findings (GeneRIF, showing 1)

• PITPNM2 was associated with bipolar disorder. (PMID:28195573)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
		ENSDARG00000111528
mus_musculus	Pitpnm2	ENSMUSG00000029406
rattus_norvegicus	Pitpnm2	ENSRNOG00000029260

Paralogs (5): PITPNM3 (ENSG00000091622), PITPNM1 (ENSG00000110697), PITPNC1 (ENSG00000154217), PITPNA (ENSG00000174238), PITPNB (ENSG00000180957)

Protein

Protein identifiers

Membrane-associated phosphatidylinositol transfer protein 2 — Q9BZ72 (reviewed: Q9BZ72)

Alternative names: Phosphatidylinositol transfer protein, membrane-associated 2, Pyk2 N-terminal domain-interacting receptor 3

All UniProt accessions (4): Q9BZ72, F5H361, F5H664, S4R414

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions.

Subunit / interactions. Interacts with PTK2B via its C-terminus. Interacts with CPNE4 (via VWFA domain).

Subcellular location. Endomembrane system.

Tissue specificity. Highly expressed in brain, heart, ovary, testis and thymus. Detected in small intestine, prostate, pancreas, skeletal muscle, liver, colon and placenta.

Similarity. Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9BZ72-1	1	yes
Q9BZ72-2	2
Q9BZ72-3	3

RefSeq proteins (11): NP_001287730, NP_001371589, NP_001371590, NP_001371591, NP_001371592, NP_001371593, NP_001371594, NP_001371595, NP_001371596, NP_001371597, NP_065896* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001666	PI_transfer	Family
IPR004177	DDHD_dom	Domain
IPR023214	HAD_sf	Homologous_superfamily
IPR023393	START-like_dom_sf	Homologous_superfamily
IPR031315	LNS2/PITP	Domain
IPR036412	HAD-like_sf	Homologous_superfamily
IPR055261	PI_transfer_N	Domain

Pfam: PF02121, PF02862, PF24694, PF24695

UniProt features (25 total): modified residue 10, region of interest 4, compositionally biased region 4, splice variant 3, sequence variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BZ72-F1	67.96	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 337, 341, 368, 589, 644, 700, 701, 702, 828, 1277

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-1483226	Synthesis of PI

MSigDB gene sets: 182 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, GOBP_PHOSPHOLIPID_METABOLIC_PROCESS, GOBP_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS, GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, GOBP_GLYCEROLIPID_METABOLIC_PROCESS, GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS, GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS, GOBP_LIPID_METABOLIC_PROCESS, NKX22_01, GOBP_LIPID_BIOSYNTHETIC_PROCESS

GO Biological Process (3): phosphatidylinositol biosynthetic process (GO:0006661), phospholipid transport (GO:0015914), intermembrane lipid transfer (GO:0120009)

GO Molecular Function (10): calcium ion binding (GO:0005509), phosphatidylcholine intramembrane carrier activity (GO:0008525), phosphatidylinositol transfer activity (GO:0008526), receptor tyrosine kinase binding (GO:0030971), phosphatidylcholine binding (GO:0031210), phosphatidylinositol binding (GO:0035091), protein binding (GO:0005515), obsolete phospholipid transporter activity (GO:0005548), lipid binding (GO:0008289), metal ion binding (GO:0046872)

GO Cellular Component (4): cytoplasm (GO:0005737), cytosol (GO:0005829), endomembrane system (GO:0012505), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Glycerophospholipid biosynthesis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
lipid transport	2
cation binding	2
binding	2
biosynthetic process	1
phosphatidylinositol metabolic process	1
organophosphate ester transport	1
membrane organization	1
metal ion binding	1
intramembrane lipid carrier activity	1
phosphatidylinositol binding	1
lipid transfer activity	1
signaling receptor binding	1
protein tyrosine kinase binding	1
phospholipid binding	1
quaternary ammonium group binding	1
anion binding	1
intracellular anatomical structure	1
cytoplasm	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

822 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PITPNM2	PTK2B	Q14289	828
PITPNM2	ESYT1	Q9BSJ8	524
PITPNM2	OGFOD2	Q6N063	510
PITPNM2	C2CD2L	O14523	473
PITPNM2	VAPA	Q9P0L0	455
PITPNM2	VAPB	O95292	436
PITPNM2	OSBPL5	Q9H0X9	430
PITPNM2	OSBP	P22059	425
PITPNM2	TAMM41	Q96BW9	401
PITPNM2	OSBPL8	Q9BZF1	400
PITPNM2	CDIPT	O14735	397
PITPNM2	ESYT3	A0FGR9	397
PITPNM2	FAXC	Q5TGI0	394
PITPNM2	SBNO1	A3KN83	392
PITPNM2	PRKACA	P17612	386

IntAct

10 interactions, top by confidence:

A	B	Type	Score
VAPB	FAM83G	psi-mi:“MI:0914”(association)	0.730
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.640
VAPA	PITPNM1	psi-mi:“MI:0914”(association)	0.640
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
	PITPNM2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (13): PITPNM2 (Affinity Capture-MS), PITPNM2 (Affinity Capture-MS), PITPNM2 (Affinity Capture-MS), PITPNM2 (Affinity Capture-MS), PITPNM2 (Affinity Capture-MS), PITPNM2 (Affinity Capture-RNA), PITPNM2 (Two-hybrid), PITPNM2 (Affinity Capture-Western), PITPNM2 (Affinity Capture-MS), PITPNM2 (Affinity Capture-MS), PITPNM2 (Affinity Capture-RNA), PITPNM2 (Affinity Capture-MS), PITPNM2 (Affinity Capture-RNA)

ESM2 similar proteins: A0A072VIM5, A0A0K0PU92, A2CIR7, F4IG73, F4JD14, G3LSH3, G8GTN7, O23052, O35954, O42132, O80560, P03372, P0CI65, P57753, Q07DW4, Q09YJ3, Q0JJ01, Q2HW56, Q2IBF8, Q2QLG9, Q2QM47, Q2QXZ2, Q2RAQ5, Q4JHE0, Q53AD2, Q5D0W8, Q5KS50, Q5U2N3, Q5YLM1, Q651A1, Q67UU0, Q6WQJ1, Q75HA6, Q7EZ44, Q7XAP4, Q7Y0V7, Q8CFE5, Q8IZ41, Q9BWC9, Q9BZ72

Diamond homologs: G5EEM9, O00562, O35954, O46606, P16446, P43125, P48738, P48739, P53810, P53811, P53812, Q00169, Q28CA0, Q2HJ54, Q3UHE1, Q54D93, Q54VC7, Q5R6F0, Q5U2N3, Q6NZC7, Q6ZPQ6, Q80YA3, Q8K4R4, Q8NEL9, Q8W5R2, Q9BZ71, Q9BZ72, Q9NCL7, Q9NCL8, Q9TR36, Q9U9P7, Q9UKF7, Q12204, Q9Y6Y8, Q8ET41, O94830, Q495M9, Q80T11, Q80Y98, Q8N8V4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

193 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	164
Likely benign	14
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

6303 predictions. Top by Δscore:

Variant	Effect	Δscore
12:122984761:T:TA	donor_gain	1.0000
12:122986347:TGAA:T	acceptor_gain	1.0000
12:122986348:GAACT:G	acceptor_loss	1.0000
12:122986350:ACTGC:A	acceptor_loss	1.0000
12:122986351:C:CC	acceptor_gain	1.0000
12:122986432:TCA:T	donor_loss	1.0000
12:122986434:A:AC	donor_gain	1.0000
12:122986434:AC:A	donor_gain	1.0000
12:122986434:ACCTG:A	donor_loss	1.0000
12:122986435:C:CG	donor_gain	1.0000
12:122986435:CC:C	donor_gain	1.0000
12:122986435:CCT:C	donor_gain	1.0000
12:122986435:CCTGG:C	donor_gain	1.0000
12:122986560:TGCAG:T	acceptor_gain	1.0000
12:122986561:GCAG:G	acceptor_gain	1.0000
12:122986562:CAG:C	acceptor_gain	1.0000
12:122986562:CAGC:C	acceptor_gain	1.0000
12:122986563:AG:A	acceptor_gain	1.0000
12:122986564:GC:G	acceptor_loss	1.0000
12:122986565:C:CC	acceptor_gain	1.0000
12:122986565:CT:C	acceptor_loss	1.0000
12:122986640:CCCCA:C	donor_loss	1.0000
12:122986641:CCCA:C	donor_loss	1.0000
12:122986642:CCAC:C	donor_loss	1.0000
12:122986643:CACC:C	donor_loss	1.0000
12:122986644:A:AT	donor_loss	1.0000
12:122986663:T:TA	donor_gain	1.0000
12:122987426:CTCCC:C	acceptor_gain	1.0000
12:122987428:CCC:C	acceptor_gain	1.0000
12:122987429:CC:C	acceptor_gain	1.0000

AlphaMissense

8863 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:122986524:T:A	D1213V	1.000
12:122986524:T:C	D1213G	1.000
12:122986524:T:G	D1213A	1.000
12:122986525:C:G	D1213H	1.000
12:122986526:C:A	K1212N	1.000
12:122986526:C:G	K1212N	1.000
12:122986536:C:T	G1209D	1.000
12:122986537:C:G	G1209R	1.000
12:122986540:A:C	Y1208D	1.000
12:122986676:C:A	K1189N	1.000
12:122986676:C:G	K1189N	1.000
12:122986733:G:C	F1170L	1.000
12:122986733:G:T	F1170L	1.000
12:122986734:A:C	F1170C	1.000
12:122986734:A:G	F1170S	1.000
12:122986735:A:G	F1170L	1.000
12:122986741:G:C	H1168D	1.000
12:122986749:A:G	L1165P	1.000
12:122986751:C:A	W1164C	1.000
12:122986751:C:G	W1164C	1.000
12:122986753:A:G	W1164R	1.000
12:122986753:A:T	W1164R	1.000
12:122986789:C:G	G1152R	1.000
12:122986825:A:G	W1140R	1.000
12:122986825:A:T	W1140R	1.000
12:122987281:C:G	R1138P	1.000
12:122987296:G:T	A1133D	1.000
12:122987299:C:T	G1132E	1.000
12:122987300:C:A	G1132W	1.000
12:122987300:C:G	G1132R	1.000

dbSNP variants (sampled 300 via entrez): RS1000036548 (12:123099208 C>G,T), RS1000049838 (12:123123380 G>A), RS1000068353 (12:123042144 G>A), RS1000090975 (12:123143458 T>C), RS1000096373 (12:122998009 T>G), RS1000101475 (12:123099470 C>G,T), RS1000103074 (12:123033170 C>T), RS1000114669 (12:123006710 C>T), RS1000117827 (12:123045981 G>A), RS1000150122 (12:123133572 T>C), RS1000156369 (12:123053637 G>A), RS1000170545 (12:123046427 C>A,T), RS1000190698 (12:123093035 T>C), RS1000214741 (12:123060141 C>T), RS1000234147 (12:123096963 C>T)

Disease associations

OMIM: gene MIM:608920 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

56 associations (top):

Study	Trait	p-value
GCST001061_9	Platelet count	3.000000e-06
GCST002149_20	Schizophrenia	2.000000e-08
GCST002539_19	Schizophrenia	2.000000e-14
GCST002598_15	Educational attainment	7.000000e-08
GCST004067_183	Hip circumference adjusted for BMI	6.000000e-14
GCST004067_65	Hip circumference adjusted for BMI	8.000000e-14
GCST004521_72	Autism spectrum disorder or schizophrenia	8.000000e-12
GCST004599_198	Mean platelet volume	7.000000e-11
GCST004946_85	Schizophrenia	6.000000e-18
GCST005312_30	Menopause (age at onset)	2.000000e-09
GCST005316_377	Intelligence (MTAG)	1.000000e-13
GCST005316_378	Intelligence (MTAG)	5.000000e-13
GCST005531_58	Multiple sclerosis	2.000000e-13
GCST006803_10	Schizophrenia	6.000000e-16
GCST006867_120	Type 2 diabetes	2.000000e-09
GCST006976_64	Macular thickness	4.000000e-10
GCST007277_17	Tourette syndrome	2.000000e-06
GCST007294_159	Body fat distribution (trunk fat ratio)	5.000000e-06
GCST007294_67	Body fat distribution (trunk fat ratio)	2.000000e-09
GCST007295_126	Body fat distribution (leg fat ratio)	3.000000e-08
GCST007295_59	Body fat distribution (leg fat ratio)	1.000000e-07
GCST007800_66	Asthma (childhood onset)	4.000000e-11
GCST009158_14	Uterine fibroids	2.000000e-08
GCST009524_215	Household income (MTAG)	8.000000e-09
GCST009597_272	Multiple sclerosis	3.000000e-13
GCST009600_21	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy)	5.000000e-10
GCST010043_63	Asthma	3.000000e-11
GCST010703_43	Brain morphology (MOSTest)	1.000000e-08
GCST012227_565	Hip circumference adjusted for BMI	2.000000e-08
GCST012227_566	Hip circumference adjusted for BMI	7.000000e-09

EFO canonical traits (13, from GWAS)

EFO ID	Trait name
EFO:0004309	platelet count
EFO:0004784	self reported educational attainment
EFO:0008039	BMI-adjusted hip circumference
EFO:0004704	age at menopause
EFO:0004337	intelligence
EFO:0004341	body fat distribution
EFO:0009695	household income
EFO:0004346	neuroimaging measurement
EFO:0004980	appendicular lean mass
EFO:0007991	eosinophil percentage of leukocytes
EFO:0007986	reticulocyte count
EFO:0007789	BMI-adjusted waist circumference
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs12425009	PITPNM2		0.00	0

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	decreases expression	2
Air Pollutants	increases abundance, increases expression	2
Estradiol	affects cotreatment, increases expression	2
Particulate Matter	increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases expression, increases methylation	1
butyraldehyde	decreases expression	1
perfluorooctanoic acid	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	decreases methylation	1
Sunitinib	increases expression	1
Acetaminophen	increases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	decreases expression	1
Doxorubicin	decreases expression	1
Lead	affects expression	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Thimerosal	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.