PITX1-AS1

Summary

PITX1-AS1 (PITX1 antisense RNA 1, HGNC:48332) is a long non-coding RNA gene on chromosome 5q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48332
Approved symbol	PITX1-AS1
Name	PITX1 antisense RNA 1
Location	5q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224186
Ensembl biotype	lncRNA
Entrez	100996485
RNAcentral	URS0000E60A7B — lncRNA, 2480 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000505828, ENST00000507058, ENST00000507641, ENST00000513931, ENST00000554670, ENST00000555438, ENST00000624272, ENST00000718110, ENST00000782562, ENST00000782563, ENST00000782564, ENST00000782565, ENST00000782566, ENST00000782567, ENST00000782568, ENST00000782569, ENST00000782570, ENST00000782571, ENST00000806983

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000505828 — 5 exons

Exon	Start	End
ENSE00002039789	135074417	135074528
ENSE00002041789	135033442	135033540
ENSE00002064763	135215416	135215565
ENSE00003703287	135174042	135174172
ENSE00003710318	135052454	135052522

Expression profiles

Bgee: expression breadth ubiquitous, 190 present calls, max score 93.32.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3260 / max 23.8964, expressed in 172 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
58636	0.2878	155
58637	0.0382	15

Top tissues by expression

269 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	93.32	gold quality
lower esophagus mucosa	UBERON:0035834	90.35	gold quality
esophagus mucosa	UBERON:0002469	88.08	gold quality
adenohypophysis	UBERON:0002196	87.99	gold quality
pituitary gland	UBERON:0000007	87.84	gold quality
cervix squamous epithelium	UBERON:0006922	87.06	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.93	gold quality
sperm	CL:0000019	81.41	silver quality
vagina	UBERON:0000996	81.03	gold quality
esophagus	UBERON:0001043	80.98	gold quality
male germ cell	CL:0000015	80.85	silver quality
monocyte	CL:0000576	80.74	gold quality
minor salivary gland	UBERON:0001830	80.74	gold quality
mononuclear cell	CL:0000842	80.61	gold quality
esophagus squamous epithelium	UBERON:0006920	80.47	gold quality
mucosa of stomach	UBERON:0001199	80.38	gold quality
squamous epithelium	UBERON:0006914	80.22	gold quality
epithelium of esophagus	UBERON:0001976	80.03	gold quality
leukocyte	CL:0000738	79.93	gold quality
mouth mucosa	UBERON:0003729	79.40	gold quality
cervix epithelium	UBERON:0004801	78.74	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.70	gold quality
tibialis anterior	UBERON:0001385	78.39	silver quality
saliva-secreting gland	UBERON:0001044	78.11	gold quality
pancreatic ductal cell	CL:0002079	77.70	silver quality
blood	UBERON:0000178	77.49	gold quality
ectocervix	UBERON:0012249	76.55	gold quality
stromal cell of endometrium	CL:0002255	76.25	gold quality
uterine cervix	UBERON:0000002	76.10	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	75.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.38

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Mesenchymal stem cell-derived exosomes block malignant behaviors of hepatocellular carcinoma stem cells through a lncRNA C5orf66-AS1/microRNA-127-3p/DUSP1/ERK axis. (PMID:34431063)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.