PIWIL4-AS1

Summary

PIWIL4-AS1 (PIWIL4 antisense RNA 1, HGNC:55493) is a long non-coding RNA gene on chromosome 11q21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55493
Approved symbol	PIWIL4-AS1
Name	PIWIL4 antisense RNA 1
Location	11q21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000255929
Ensembl biotype	lncRNA
Entrez	105369438
RNAcentral	URS0000A76BE8 — lncRNA, 1038 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000536540, ENST00000537874, ENST00000700837, ENST00000767899, ENST00000767901, ENST00000767903, ENST00000767904, ENST00000767905, ENST00000767906, ENST00000767907, ENST00000767908, ENST00000767909

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000536540 — 5 exons

Exon	Start	End
ENSE00002214177	94545330	94545846
ENSE00002234741	94740218	94740269
ENSE00002251509	94675636	94675782
ENSE00002258802	94679386	94679536
ENSE00002300189	94695821	94695907

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 85.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2201 / max 21.5547, expressed in 79 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
121852	0.2201	79

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.34	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.48	gold quality
ovary	UBERON:0000992	66.64	silver quality
ventricular zone	UBERON:0003053	66.01	gold quality
blood	UBERON:0000178	65.86	gold quality
corpus callosum	UBERON:0002336	64.54	gold quality
prefrontal cortex	UBERON:0000451	63.92	gold quality
superior frontal gyrus	UBERON:0002661	63.64	gold quality
liver	UBERON:0002107	63.33	gold quality
adult mammalian kidney	UBERON:0000082	61.49	gold quality
ganglionic eminence	UBERON:0004023	61.30	gold quality
skeletal muscle tissue	UBERON:0001134	60.83	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.08	gold quality
small intestine	UBERON:0002108	59.10	gold quality
kidney	UBERON:0002113	58.64	gold quality
gall bladder	UBERON:0002110	58.28	gold quality
cortical plate	UBERON:0005343	58.23	silver quality
frontal cortex	UBERON:0001870	58.14	gold quality
lymph node	UBERON:0000029	56.35	gold quality
tonsil	UBERON:0002372	55.89	silver quality
anterior cingulate cortex	UBERON:0009835	55.74	gold quality
cerebral cortex	UBERON:0000956	55.41	gold quality
urinary bladder	UBERON:0001255	54.81	gold quality
monocyte	CL:0000576	54.78	gold quality
cortex of kidney	UBERON:0001225	54.44	gold quality
islet of Langerhans	UBERON:0000006	53.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	53.86	gold quality
Brodmann (1909) area 9	UBERON:0013540	53.30	gold quality
primary visual cortex	UBERON:0002436	52.51	gold quality
placenta	UBERON:0001987	52.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.