PKN2-AS1

Summary

PKN2-AS1 (PKN2 antisense RNA 1, HGNC:50597) is a long non-coding RNA gene on chromosome 1p22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50597
Approved symbol	PKN2-AS1
Name	PKN2 antisense RNA 1
Location	1p22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	uc.31
Ensembl gene	ENSG00000237505
Ensembl biotype	lncRNA
Entrez	101927891
RNAcentral	URS00001F9C2F — lncRNA, 3542 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 76 — 76 lncRNA

ENST00000425750, ENST00000437598, ENST00000458097, ENST00000623157, ENST00000642677, ENST00000643530, ENST00000643720, ENST00000644540, ENST00000645056, ENST00000645890, ENST00000646400, ENST00000657030, ENST00000669398, ENST00000670439, ENST00000716021, ENST00000716022, ENST00000716025, ENST00000716031, ENST00000716032, ENST00000716033, ENST00000716034, ENST00000716035, ENST00000716036, ENST00000716039, ENST00000716040, ENST00000716041, ENST00000716092, ENST00000716093, ENST00000719831, ENST00000719832, ENST00000731981, ENST00000731982, ENST00000731983, ENST00000731984, ENST00000731985, ENST00000731986, ENST00000731987, ENST00000731988, ENST00000731989, ENST00000731990, ENST00000731991, ENST00000731992, ENST00000731993, ENST00000731994, ENST00000731995, ENST00000731996, ENST00000731997, ENST00000731998, ENST00000731999, ENST00000732000, ENST00000759848, ENST00000759849, ENST00000759850, ENST00000759851, ENST00000759852, ENST00000759853, ENST00000759854, ENST00000759855, ENST00000759856, ENST00000759857, ENST00000759858, ENST00000759859, ENST00000759860, ENST00000759861, ENST00000759862, ENST00000759863, ENST00000759864, ENST00000759865, ENST00000759866, ENST00000759867, ENST00000759868, ENST00000759869, ENST00000759870, ENST00000759871, ENST00000759872, ENST00000759873

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425750 — 4 exons

Exon	Start	End
ENSE00001619618	88556904	88557048
ENSE00001654122	88570810	88570860
ENSE00001662112	88569987	88570195
ENSE00001741437	88540303	88540659

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 78.51.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1777 / max 15.0808, expressed in 61 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
13120	0.1777	61

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.51	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.34	gold quality
skeletal muscle tissue	UBERON:0001134	73.86	gold quality
hindlimb stylopod muscle	UBERON:0004252	72.11	gold quality
sural nerve	UBERON:0015488	67.10	gold quality
ventricular zone	UBERON:0003053	64.61	gold quality
anterior cingulate cortex	UBERON:0009835	63.21	gold quality
muscle of leg	UBERON:0001383	63.08	gold quality
prefrontal cortex	UBERON:0000451	62.59	gold quality
superior frontal gyrus	UBERON:0002661	62.53	gold quality
cortical plate	UBERON:0005343	62.47	gold quality
corpus callosum	UBERON:0002336	61.50	gold quality
gastrocnemius	UBERON:0001388	60.82	gold quality
monocyte	CL:0000576	60.51	gold quality
frontal cortex	UBERON:0001870	60.06	gold quality
cerebral cortex	UBERON:0000956	59.76	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	59.69	gold quality
testis	UBERON:0000473	59.36	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	59.03	gold quality
ganglionic eminence	UBERON:0004023	58.98	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.66	gold quality
adrenal tissue	UBERON:0018303	58.42	gold quality
left testis	UBERON:0004533	58.13	gold quality
Ammon’s horn	UBERON:0001954	57.56	gold quality
amygdala	UBERON:0001876	57.53	gold quality
stromal cell of endometrium	CL:0002255	56.42	gold quality
right frontal lobe	UBERON:0002810	56.26	gold quality
brain	UBERON:0000955	56.22	gold quality
thyroid gland	UBERON:0002046	56.21	gold quality
left lobe of thyroid gland	UBERON:0001120	56.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.41

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.