PLAC4

Summary

PLAC4 (placenta enriched 4, HGNC:14616) is a long non-coding RNA gene on chromosome 21q22.2.

Predicted to be located in plasma membrane.

Source: NCBI Gene 191585 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14616
Approved symbol	PLAC4
Name	placenta enriched 4
Location	21q22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC126664, MGC126666, PRED78
Ensembl gene	ENSG00000280109
Ensembl biotype	lncRNA
OMIM	613770
Entrez	191585
RNAcentral	URS0000BC44D5 — lncRNA, 10009 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000414699, ENST00000430327, ENST00000440221, ENST00000623119, ENST00000645185, ENST00000836721, ENST00000836722, ENST00000836723, ENST00000836724, ENST00000836725, ENST00000836726, ENST00000836727, ENST00000836728, ENST00000836729, ENST00000836730, ENST00000836731, ENST00000836732, ENST00000836733, ENST00000836734

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414699 — 4 exons

Exon	Start	End
ENSE00001753386	41182150	41182245
ENSE00001802711	41186123	41186342
ENSE00004256474	41180092	41180573
ENSE00004256475	41186448	41186788

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 95.15.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 3.5465 / max 2884.6219, expressed in 58 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190555	3.5040	57
190553	0.0156	4
190549	0.0076	3
190550	0.0047	3
190554	0.0044	3
190547	0.0035	3
190551	0.0034	2
190552	0.0034	3

Top tissues by expression

259 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	95.15	gold quality
superficial temporal artery	UBERON:0001614	83.44	gold quality
mucosa of paranasal sinus	UBERON:0005030	82.66	gold quality
sural nerve	UBERON:0015488	80.63	gold quality
colonic epithelium	UBERON:0000397	79.00	gold quality
type B pancreatic cell	CL:0000169	77.48	gold quality
olfactory bulb	UBERON:0002264	77.28	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.73	gold quality
cerebellar vermis	UBERON:0004720	75.77	gold quality
germinal epithelium of ovary	UBERON:0001304	72.24	gold quality
vastus lateralis	UBERON:0001379	71.62	gold quality
tonsil	UBERON:0002372	71.57	gold quality
quadriceps femoris	UBERON:0001377	70.55	silver quality
myocardium	UBERON:0002349	70.20	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	70.07	silver quality
hair follicle	UBERON:0002073	69.47	gold quality
left ventricle myocardium	UBERON:0006566	69.02	gold quality
thymus	UBERON:0002370	68.37	gold quality
embryo	UBERON:0000922	68.18	gold quality
nasal cavity epithelium	UBERON:0005384	67.46	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	66.86	gold quality
cardiac muscle of right atrium	UBERON:0003379	66.61	gold quality
epithelium of nasopharynx	UBERON:0001951	66.59	gold quality
calcaneal tendon	UBERON:0003701	65.89	gold quality
diaphragm	UBERON:0001103	65.61	gold quality
muscle tissue	UBERON:0002385	65.57	gold quality
skeletal muscle tissue	UBERON:0001134	65.50	silver quality
smooth muscle tissue	UBERON:0001135	65.50	gold quality
kidney epithelium	UBERON:0004819	65.18	gold quality
tendon	UBERON:0000043	65.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• For prenatal screening of trisomy 21, the quantification of the total PLAC4 mRNA concentration can be used in a synergistic manner with the RNA-SNP allelic ratio approach (PMID:19892844)
• PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia. (PMID:23312075)
• For samples with heterozygous SNPs, PLAC4 RNA-SNP allelic ratio can be used for noninvasive prenatal detection of trisomy 21 by the multiplex SNaPshot assay. In Southeast China, PLAC4 Rs8130833 and Rs4818219 had higher frequency of heterozygosity. (PMID:24214739)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.