PLCG1-AS1

Summary

PLCG1-AS1 (PLCG1 antisense RNA 1, HGNC:40450) is a long non-coding RNA gene on chromosome 20q12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40450
Approved symbol	PLCG1-AS1
Name	PLCG1 antisense RNA 1
Location	20q12
Locus type	RNA, long non-coding
Status	Approved
Aliases	TOP1-AS1
Ensembl gene	ENSG00000226648
Ensembl biotype	lncRNA
Entrez	101927117
RNAcentral	URS0000759E22 — lncRNA, 1807 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000454626, ENST00000660264, ENST00000661983, ENST00000662554, ENST00000667669, ENST00000669288, ENST00000812219

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000454626 — 7 exons

Exon	Start	End
ENSE00001595520	41101172	41101289
ENSE00001597638	41135702	41135811
ENSE00001607746	41098329	41098824
ENSE00001679951	41133487	41133645
ENSE00001698295	41100658	41100792
ENSE00001699113	41137714	41138003
ENSE00001734129	41135139	41135292

Expression profiles

Bgee: expression breadth ubiquitous, 166 present calls, max score 86.88.

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	86.88	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.35	gold quality
bone marrow cell	CL:0002092	76.51	gold quality
oviduct epithelium	UBERON:0004804	75.53	gold quality
colonic epithelium	UBERON:0000397	73.41	gold quality
sperm	CL:0000019	72.88	gold quality
mucosa of stomach	UBERON:0001199	70.87	gold quality
sural nerve	UBERON:0015488	70.34	silver quality
calcaneal tendon	UBERON:0003701	69.53	gold quality
left lobe of thyroid gland	UBERON:0001120	68.99	gold quality
right ovary	UBERON:0002118	68.87	gold quality
left ovary	UBERON:0002119	68.66	gold quality
tibial nerve	UBERON:0001323	68.02	gold quality
thyroid gland	UBERON:0002046	67.92	gold quality
stromal cell of endometrium	CL:0002255	67.86	gold quality
body of uterus	UBERON:0009853	67.77	gold quality
hindlimb stylopod muscle	UBERON:0004252	67.72	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.31	gold quality
cerebellar hemisphere	UBERON:0002245	67.29	gold quality
cerebellar cortex	UBERON:0002129	67.25	gold quality
skin of leg	UBERON:0001511	67.16	gold quality
right lobe of thyroid gland	UBERON:0001119	67.10	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.08	gold quality
endocervix	UBERON:0000458	66.91	gold quality
tibial artery	UBERON:0007610	66.82	gold quality
popliteal artery	UBERON:0002250	66.80	gold quality
ectocervix	UBERON:0012249	66.65	gold quality
ascending aorta	UBERON:0001496	66.56	gold quality
descending thoracic aorta	UBERON:0002345	66.55	gold quality
aorta	UBERON:0000947	66.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.78

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.