PLEKHG3

Summary

PLEKHG3 (pleckstrin homology and RhoGEF domain containing G3, HGNC:20364) is a protein-coding gene on chromosome 14q23.3, encoding Pleckstrin homology domain-containing family G member 3 (A1L390). Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization.

Enables actin binding activity. Involved in regulation of cell migration and regulation of establishment of cell polarity. Predicted to be located in cytosol.

Source: NCBI Gene 26030 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 314 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_001308147

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20364
Approved symbol	PLEKHG3
Name	pleckstrin homology and RhoGEF domain containing G3
Location	14q23.3
Locus type	gene with protein product
Status	Approved
Aliases	ARHGEF43
Ensembl gene	ENSG00000126822
Ensembl biotype	protein_coding
OMIM	617940
Entrez	26030

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 13 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000247226, ENST00000394691, ENST00000471182, ENST00000484731, ENST00000490180, ENST00000492928, ENST00000554499, ENST00000555982, ENST00000556801, ENST00000634379, ENST00000864150, ENST00000864151, ENST00000864152, ENST00000864153, ENST00000967516, ENST00000967517

RefSeq mRNA: 1 — MANE Select: NM_001308147 NM_001308147

CCDS: CCDS76690

Canonical transcript exons

ENST00000247226 — 17 exons

Exon	Start	End
ENSE00001519234	64730243	64730312
ENSE00001519239	64704424	64704704
ENSE00001631122	64737356	64737375
ENSE00001741894	64731361	64731543
ENSE00001744014	64731714	64731806
ENSE00001801653	64736853	64736891
ENSE00001955111	64742982	64750249
ENSE00002429829	64727593	64727982
ENSE00003464790	64741036	64742455
ENSE00003479499	64732095	64732181
ENSE00003568864	64730799	64730949
ENSE00003590952	64732803	64732901
ENSE00003632044	64738742	64738855
ENSE00003632097	64732427	64732460
ENSE00003668892	64731038	64731169
ENSE00003685960	64728996	64729093
ENSE00003784208	64730642	64730688

Expression profiles

Bgee: expression breadth ubiquitous, 247 present calls, max score 96.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 20.4821 / max 338.7218, expressed in 1540 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140129	18.2835	1519
140130	1.1018	532
140126	0.2508	81
140131	0.2436	90
140125	0.1971	74
140127	0.1853	65
140124	0.1126	53
140132	0.0625	34
140128	0.0449	20

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.22	gold quality
popliteal artery	UBERON:0002250	96.15	gold quality
tibial artery	UBERON:0007610	96.14	gold quality
right coronary artery	UBERON:0001625	94.94	gold quality
corpus callosum	UBERON:0002336	94.81	gold quality
granulocyte	CL:0000094	94.71	gold quality
body of uterus	UBERON:0009853	93.72	gold quality
aorta	UBERON:0000947	93.35	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	92.41	gold quality
left uterine tube	UBERON:0001303	92.30	gold quality
left coronary artery	UBERON:0001626	92.28	gold quality
metanephros cortex	UBERON:0010533	92.22	gold quality
coronary artery	UBERON:0001621	92.09	gold quality
spinal cord	UBERON:0002240	91.29	gold quality
nerve	UBERON:0001021	91.11	gold quality
tibial nerve	UBERON:0001323	91.11	gold quality
blood	UBERON:0000178	90.88	gold quality
ectocervix	UBERON:0012249	90.67	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.67	gold quality
lower esophagus mucosa	UBERON:0035834	90.63	gold quality
olfactory bulb	UBERON:0002264	90.61	silver quality
skin of leg	UBERON:0001511	90.52	gold quality
esophagus mucosa	UBERON:0002469	90.44	gold quality
right ovary	UBERON:0002118	90.06	gold quality
skin of abdomen	UBERON:0001416	90.02	gold quality
ascending aorta	UBERON:0001496	89.88	gold quality
descending thoracic aorta	UBERON:0002345	89.88	gold quality
thoracic aorta	UBERON:0001515	89.84	gold quality
mucosa of stomach	UBERON:0001199	89.71	gold quality
smooth muscle tissue	UBERON:0001135	89.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• This is the first implication of chr14q23.2-23.3 in the etiology of autism and points to MTHFD1, PLEKHG3, and CHURC1 as potential candidate genes contributing to autism risk. (PMID:21360829)
• PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. (PMID:27555588)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:ch73-212j7.3	ENSDARG00000058835
danio_rerio	si:ch73-212j7.3	ENSDARG00000096613
mus_musculus	Plekhg3	ENSMUSG00000052609
rattus_norvegicus	Plekhg3	ENSRNOG00000006570

Protein

Protein identifiers

Pleckstrin homology domain-containing family G member 3 — A1L390 (reviewed: A1L390)

All UniProt accessions (7): A1L390, A0A0U1RR71, A0A2X0SFH4, A0A8C8NWT4, G3V278, G3V311, G3V3I3

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization.

Subcellular location. Cytoplasm. Cytoskeleton.

Isoforms (3)

UniProt ID	Names	Canonical?
A1L390-1	1	yes
A1L390-2	2
A1L390-3	3

RefSeq proteins (1): NP_001295076* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000219	DH_dom	Domain
IPR001849	PH_domain	Domain
IPR011993	PH-like_dom_sf	Homologous_superfamily
IPR035899	DBL_dom_sf	Homologous_superfamily
IPR043324	PH_PLEKHG1_G2_G3	Domain
IPR055251	SOS1_NGEF_PH	Domain

Pfam: PF00621, PF22697

UniProt features (50 total): modified residue 19, compositionally biased region 11, region of interest 8, sequence conflict 4, splice variant 3, domain 2, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A1L390-F1	55.28	0.15

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (19): 76, 433, 576, 577, 618, 631, 640, 643, 647, 741, 779, 827, 962, 1011, 1023, 1037, 1040, 1081, 1107

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-8980692	RHOA GTPase cycle
R-HSA-9013148	CDC42 GTPase cycle
R-HSA-9013149	RAC1 GTPase cycle
R-HSA-9013406	RHOQ GTPase cycle
R-HSA-9013408	RHOG GTPase cycle

MSigDB gene sets: 153 (showing top): GOBP_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY, GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, GOMF_GTPASE_BINDING, GOBP_ESTABLISHMENT_OF_CELL_POLARITY, CATTTCA_MIR203, ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN, chr14q23, GOMF_ACTIN_BINDING, GOBP_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY, MULLIGHAN_NPM1_SIGNATURE_3_DN, MORF_PDPK1, GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, LEIN_OLIGODENDROCYTE_MARKERS, GOMF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY, BOCHKIS_FOXA2_TARGETS

GO Biological Process (3): regulation of cell migration (GO:0030334), regulation of small GTPase mediated signal transduction (GO:0051056), regulation of establishment of cell polarity (GO:2000114)

GO Molecular Function (3): actin binding (GO:0003779), guanyl-nucleotide exchange factor activity (GO:0005085), small GTPase binding (GO:0031267)

GO Cellular Component (3): cytosol (GO:0005829), cytoskeleton (GO:0005856), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RHO GTPase cycle	5

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cell migration	1
regulation of cell motility	1
small GTPase-mediated signal transduction	1
regulation of intracellular signal transduction	1
establishment of cell polarity	1
regulation of establishment or maintenance of cell polarity	1
cytoskeletal protein binding	1
GTP binding	1
GDP binding	1
GTPase regulator activity	1
GTPase binding	1
cytoplasm	1
intracellular membraneless organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

626 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PLEKHG3	GRIFIN	A4D1Z8	512
PLEKHG3	PPP1R36	Q96LQ0	439
PLEKHG3	PLEKHG7	Q6ZR37	393
PLEKHG3	SGSM1	Q2NKQ1	385
PLEKHG3	ARHGEF33	A8MVX0	370
PLEKHG3	CHURC1	Q8WUH1	369
PLEKHG3	SERPINE3	A8MV23	367
PLEKHG3	TET1	Q8NFU7	353
PLEKHG3	NOS1AP	O75052	352
PLEKHG3	PRMT2IP	Q6ZRI6	348
PLEKHG3	PPIL1	Q9Y3C6	348
PLEKHG3	DNMT3A	Q9Y6K1	348
PLEKHG3	ARL11	Q969Q4	331
PLEKHG3	SYDE1	Q6ZW31	328
PLEKHG3	RGPD1	P0C839	324

IntAct

103 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
YWHAB	BLTP3B	psi-mi:“MI:2364”(proximity)	0.610
PLEKHG3	YWHAG	psi-mi:“MI:0914”(association)	0.610
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
CFTR	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
YWHAB	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
YWHAQ	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
MYH9	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Bmpr1a	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
ANLN	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Flot1	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
MYO18A	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
MYO1C	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
MYO19	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
FLNA	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Lima1	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
LIMA1	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Calml3	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Tmod3	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Tpm1	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Coro1c	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
Ppp6c	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
DBN1	PLEKHG3	psi-mi:“MI:0914”(association)	0.350

BioGRID (126): PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS), PLEKHG3 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2JUG7, A1L390, E9Q0S6, O08774, O14924, O15085, O43182, O54834, O54960, O60307, O75052, P57095, Q13009, Q3U1V8, Q3U214, Q3UHC7, Q4VAC9, Q5DU25, Q5JU85, Q5RBI7, Q5SXA9, Q5VWQ8, Q60610, Q64512, Q6AX33, Q6DN90, Q6NXJ0, Q6P0Q8, Q6P1I6, Q6ZMN7, Q76G19, Q76LL6, Q76M68, Q7T2V3, Q810W7, Q8CGE9, Q8IX03, Q8R0S2, Q8R4H2, Q8WYP3

Diamond homologs: A1L390, F1M0Z1, O43307, O75962, P91620, P91621, Q0KL02, Q13009, Q1ZXH8, Q3UTH8, Q4VAC9, Q58DL7, Q58EX7, Q5DU57, Q5RDK0, Q60610, Q6KAU7, Q6P720, Q6ZPF3, Q7TNR9, Q96N96, Q9H7P9, Q9NR80, Q9QX73, Q9ULL1, A0JNJ1, A4RF61, A6H8I2, A6NI72, A8MVU1, O15068, O43125, O75886, O89100, O93436, P07751, P10569, P14598, P16086, P16546

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
PLEKHG3	“up-regulates activity”	CDC42	“guanine nucleotide exchange factor”

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 86 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	7	96.9×	6e-11
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	6	73.3×	8e-09
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	6	73.3×	8e-09
Activation of BH3-only proteins	7	63.2×	1e-09
RHO GTPases activate PAKs	5	49.4×	1e-06
RHO GTPases activate PKNs	8	46.1×	8e-10
Intrinsic Pathway for Apoptosis	7	37.3×	3e-08
FOXO-mediated transcription	5	30.5×	1e-05

GO biological processes:

GO term	Partners	Fold	FDR
substantia nigra development	5	27.8×	3e-04
actin filament organization	6	10.8×	2e-03
intracellular protein localization	6	9.5×	3e-03
actin cytoskeleton organization	7	8.4×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

314 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	242
Likely benign	37
Benign	11

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3772398	NM_001355436.2(SPTB):c.6640G>T (p.Glu2214Ter)	Pathogenic

SpliceAI

3971 predictions. Top by Δscore:

Variant	Effect	Δscore
14:64704700:GCTCG:G	donor_gain	1.0000
14:64704701:CTCGG:C	donor_loss	1.0000
14:64704703:CGGT:C	donor_loss	1.0000
14:64704705:G:GG	donor_gain	1.0000
14:64727592:GA:G	acceptor_gain	1.0000
14:64727592:GAAT:G	acceptor_gain	1.0000
14:64727981:AGG:A	donor_loss	1.0000
14:64727983:G:GA	donor_loss	1.0000
14:64728992:GCAG:G	acceptor_loss	1.0000
14:64728993:CAGG:C	acceptor_loss	1.0000
14:64730689:G:GG	donor_gain	1.0000
14:64730794:CCCAG:C	acceptor_loss	1.0000
14:64730796:CA:C	acceptor_loss	1.0000
14:64730797:A:AG	acceptor_gain	1.0000
14:64730797:AGCTC:A	acceptor_loss	1.0000
14:64730798:G:GT	acceptor_gain	1.0000
14:64730798:GC:G	acceptor_gain	1.0000
14:64730798:GCT:G	acceptor_gain	1.0000
14:64730798:GCTCC:G	acceptor_gain	1.0000
14:64730931:G:GG	donor_gain	1.0000
14:64730946:CCAG:C	donor_loss	1.0000
14:64730947:CAGGT:C	donor_loss	1.0000
14:64730948:AG:A	donor_loss	1.0000
14:64730949:GGTAG:G	donor_loss	1.0000
14:64730951:T:A	donor_loss	1.0000
14:64731031:T:A	acceptor_gain	1.0000
14:64731033:C:CA	acceptor_gain	1.0000
14:64731036:A:AG	acceptor_gain	1.0000
14:64731036:AG:A	acceptor_gain	1.0000
14:64731037:G:A	acceptor_loss	1.0000

AlphaMissense

8007 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:64727945:A:T	E105V	1.000
14:64727966:T:C	L112P	1.000
14:64730260:T:C	L156P	1.000
14:64730293:C:A	A167D	1.000
14:64730302:T:C	F170S	1.000
14:64730903:T:C	L224P	1.000
14:64730906:T:C	L225P	1.000
14:64730912:C:A	P227Q	1.000
14:64730912:C:G	P227R	1.000
14:64730915:T:A	V228D	1.000
14:64730919:G:C	Q229H	1.000
14:64730919:G:T	Q229H	1.000
14:64730920:C:A	R230S	1.000
14:64730921:G:C	R230P	1.000
14:64730927:T:A	L232H	1.000
14:64730927:T:C	L232P	1.000
14:64730929:A:G	K233E	1.000
14:64730931:G:C	K233N	1.000
14:64730931:G:T	K233N	1.000
14:64730939:T:C	L236P	1.000
14:64730942:T:C	L237P	1.000
14:64730945:T:C	L238P	1.000
14:64731117:C:A	A266D	1.000
14:64732122:T:A	W385R	1.000
14:64732122:T:C	W385R	1.000
14:64727942:C:T	T104I	0.999
14:64727946:G:C	E105D	0.999
14:64727946:G:T	E105D	0.999
14:64727953:T:C	Y108H	0.999
14:64727953:T:G	Y108D	0.999

dbSNP variants (sampled 300 via entrez): RS1000015681 (14:64748658 C>T), RS1000035216 (14:64748857 C>A), RS1000145896 (14:64716176 C>G,T), RS1000223451 (14:64708214 C>T), RS1000253433 (14:64730556 C>A,G,T), RS1000286042 (14:64743820 G>T), RS1000334298 (14:64736503 C>G), RS1000423511 (14:64710547 C>T), RS1000481054 (14:64709996 G>T), RS1000574577 (14:64727937 G>T), RS1000590554 (14:64719659 G>A,T), RS1000630108 (14:64734264 G>A,T), RS1000680328 (14:64707907 G>A), RS1000764241 (14:64714005 A>T), RS1000807104 (14:64722095 G>A,T)

Disease associations

OMIM: gene MIM:617940 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): familial hemolytic anemia (MONDO:0003689)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST003518_66	Daytime sleep phenotypes	4.000000e-06
GCST009462_79	Optic disc size	3.000000e-16
GCST009723_89	Vertical cup-disc ratio (adjusted for vertical disc diameter)	2.000000e-07
GCST009724_58	Vertical cup-disc ratio (multi-trait analysis)	5.000000e-11
GCST90002397_351	Mean spheric corpuscular volume	4.000000e-14
GCST90002401_74	Platelet distribution width	4.000000e-11

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007828	daytime rest measurement
EFO:0006939	cup-to-disc ratio measurement
EFO:0007984	platelet component distribution width

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D000745	Anemia, Hemolytic, Congenital	C15.378.050.141.150; C16.320.070

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066528 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
9.50	Kd	0.315	nM	CHEMBL3752910
8.26	ED50	5.534	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149913: Binding affinity to human PLEKHG3 incubated for 45 mins by Kinobead based pull down assay	kd	0.0003	uM

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic	affects expression, affects methylation, affects cotreatment, decreases expression, increases abundance	3
sodium arsenite	affects cotreatment, increases abundance, decreases expression	2
Benzo(a)pyrene	decreases methylation, affects methylation, decreases expression	2
Estradiol	increases reaction, affects cotreatment, increases expression, affects binding	2
Smoke	decreases expression	2
aristolochic acid I	increases expression	1
GSK-J4	decreases expression	1
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	increases methylation	1
trichostatin A	affects expression	1
beta-lapachone	increases expression	1
coumarin	affects phosphorylation	1
muconaldehyde	decreases expression	1
beta-methylcholine	affects expression	1
avobenzone	increases expression	1
polyhexamethyleneguanidine	affects expression	1
CGP 52608	affects binding, increases reaction	1
entinostat	increases expression	1
abrine	increases expression	1
NSC 689534	affects binding, decreases expression	1
(+)-JQ1 compound	decreases expression	1
Temozolomide	increases expression	1
Sunitinib	increases expression	1
Arsenic Trioxide	decreases response to substance	1
Acetaminophen	decreases expression	1
Ethanol	affects cotreatment, increases abundance, increases expression	1
Caffeine	affects phosphorylation	1
Copper	affects binding, decreases expression	1
Cytarabine	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652955	Binding	Binding affinity to human PLEKHG3 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

2 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT00061568	PHASE1/PHASE2	UNKNOWN	Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias
NCT04902833	Not specified	COMPLETED	Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms