PLEKHM2-AS1

Summary

PLEKHM2-AS1 (PLEKHM2 antisense RNA 1, HGNC:58402) is a long non-coding RNA gene on chromosome 1p36.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58402
Approved symbol	PLEKHM2-AS1
Name	PLEKHM2 antisense RNA 1
Location	1p36.21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237938
Ensembl biotype	lncRNA
Entrez	141725172

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000453804, ENST00000615472, ENST00000623689

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000453804 — 4 exons

Exon	Start	End
ENSE00001602432	15732387	15732561
ENSE00001659102	15723203	15723287
ENSE00001749879	15722719	15723067
ENSE00001775121	15736861	15736896

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 84.41.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.41	gold quality
bone marrow	UBERON:0002371	76.14	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.42	gold quality
colonic epithelium	UBERON:0000397	74.07	gold quality
apex of heart	UBERON:0002098	73.79	gold quality
sural nerve	UBERON:0015488	73.46	gold quality
bone marrow cell	CL:0002092	73.40	silver quality
left adrenal gland cortex	UBERON:0035825	73.29	gold quality
blood	UBERON:0000178	72.98	gold quality
left adrenal gland	UBERON:0001234	72.85	gold quality
gastrocnemius	UBERON:0001388	72.55	gold quality
right lobe of thyroid gland	UBERON:0001119	72.08	gold quality
right adrenal gland	UBERON:0001233	71.87	gold quality
adrenal gland	UBERON:0002369	71.87	gold quality
esophagus mucosa	UBERON:0002469	71.83	gold quality
muscle of leg	UBERON:0001383	71.66	gold quality
right adrenal gland cortex	UBERON:0035827	71.51	gold quality
right ovary	UBERON:0002118	71.27	gold quality
vagina	UBERON:0000996	71.20	gold quality
upper lobe of left lung	UBERON:0008952	71.18	gold quality
lower esophagus mucosa	UBERON:0035834	71.12	gold quality
mucosa of stomach	UBERON:0001199	71.07	gold quality
left ovary	UBERON:0002119	70.77	gold quality
spleen	UBERON:0002106	70.76	gold quality
skin of leg	UBERON:0001511	70.66	gold quality
stromal cell of endometrium	CL:0002255	70.54	gold quality
skeletal muscle tissue	UBERON:0001134	70.53	gold quality
zone of skin	UBERON:0000014	70.45	gold quality
esophagus	UBERON:0001043	70.43	gold quality
descending thoracic aorta	UBERON:0002345	70.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.80

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.