PLET1

Summary

PLET1 (placenta expressed transcript 1, HGNC:30053) is a protein-coding gene on chromosome 11q23.1, encoding Placenta-expressed transcript 1 protein (Q6UQ28). Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair.

Predicted to be involved in negative regulation of cell-matrix adhesion; positive regulation of cell migration; and wound healing, spreading of epidermal cells. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in apical plasma membrane and external side of plasma membrane.

Source: NCBI Gene 349633 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 16 total
• MANE Select transcript: NM_001145024

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30053
Approved symbol	PLET1
Name	placenta expressed transcript 1
Location	11q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000188771
Ensembl biotype	protein_coding
OMIM	611904
Entrez	349633

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000338832

RefSeq mRNA: 1 — MANE Select: NM_001145024 NM_001145024

CCDS: CCDS44732

Canonical transcript exons

ENST00000338832 — 4 exons

Exon	Start	End
ENSE00001366153	112260406	112260860
ENSE00001367798	112252348	112252409
ENSE00001384074	112255388	112255589
ENSE00001733150	112248153	112248974

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 80.93.

Top tissues by expression

92 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.93	gold quality
colonic epithelium	UBERON:0000397	63.65	silver quality
sural nerve	UBERON:0015488	61.50	silver quality
bone marrow cell	CL:0002092	56.04	gold quality
calcaneal tendon	UBERON:0003701	54.48	gold quality
adrenal tissue	UBERON:0018303	49.94	gold quality
bone marrow	UBERON:0002371	49.38	gold quality
islet of Langerhans	UBERON:0000006	42.70	gold quality
tonsil	UBERON:0002372	42.13	gold quality
monocyte	CL:0000576	40.39	gold quality
stromal cell of endometrium	CL:0002255	40.32	gold quality
skeletal muscle tissue	UBERON:0001134	40.16	gold quality
mucosa of stomach	UBERON:0001199	39.88	silver quality
leukocyte	CL:0000738	39.86	gold quality
hindlimb stylopod muscle	UBERON:0004252	39.85	gold quality
granulocyte	CL:0000094	38.44	gold quality
right lung	UBERON:0002167	38.10	silver quality
adrenal gland	UBERON:0002369	37.52	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
left adrenal gland cortex	UBERON:0035825	36.23	silver quality
apex of heart	UBERON:0002098	36.07	gold quality
blood	UBERON:0000178	35.93	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	35.44	silver quality
adenohypophysis	UBERON:0002196	34.39	silver quality
pancreas	UBERON:0001264	34.28	gold quality
right adrenal gland	UBERON:0001233	34.17	silver quality
skin of leg	UBERON:0001511	33.51	silver quality
pituitary gland	UBERON:0000007	33.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

42 targeting PLET1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-4799-5P	99.82	70.60	2663
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-578	99.46	68.36	1787
HSA-MIR-6722-3P	99.45	67.62	1919
HSA-MIR-542-3P	99.34	67.58	1270
HSA-MIR-4506	99.34	67.47	526
HSA-MIR-7974	99.24	65.48	1137
HSA-MIR-4504	99.10	69.14	1328
HSA-MIR-548L	99.06	70.90	2560
HSA-MIR-10524-5P	99.05	66.08	963
HSA-MIR-1909-3P	99.03	66.56	1662
HSA-MIR-1909-5P	98.94	64.01	484
HSA-MIR-4763-5P	98.75	63.89	854
HSA-MIR-4266	98.53	67.29	1035
HSA-MIR-3138	98.41	67.53	744
HSA-MIR-6842-3P	98.07	66.33	1325

Literature-anchored findings (GeneRIF, showing 1)

• Plet-1 will thus provide an invaluable tool for genetic analysis of the lineage relationships and molecular mechanisms operating in the development, homeostasis, and injury in several organ/tissue systems (PMID:18195351)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Plet1	ENSMUSG00000032068
rattus_norvegicus	Plet1	ENSRNOG00000024346

Protein

Protein identifiers

Placenta-expressed transcript 1 protein — Q6UQ28 (reviewed: Q6UQ28)

All UniProt accessions (1): Q6UQ28

UniProt curated annotations — full annotation on UniProt →

Function. Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.

Subcellular location. Apical cell membrane.

Post-translational modifications. N-glycosylated. GPI-anchored.

RefSeq proteins (1): NP_001138496* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026184	PLET1	Family

UniProt features (7 total): glycosylation site 2, signal peptide 1, chain 1, propeptide 1, lipid moiety-binding region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6UQ28-F1	76.65	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 187

Glycosylation sites (2): 67, 122

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins

MSigDB gene sets: 65 (showing top): GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM, GOBP_EPITHELIUM_DEVELOPMENT, STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN, GOCC_CELL_SURFACE, HUMMERICH_MALIGNANT_SKIN_TUMOR_UP, DARWICHE_SKIN_TUMOR_PROMOTER_UP, DARWICHE_PAPILLOMA_RISK_LOW_DN, DARWICHE_PAPILLOMA_RISK_HIGH_DN, DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP, GOBP_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION, GOBP_WOUND_HEALING, GOBP_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION, CADWELL_ATG16L1_TARGETS_DN, GOBP_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET, MCBRYAN_PUBERTAL_BREAST_3_4WK_UP

GO Biological Process (4): negative regulation of cell-matrix adhesion (GO:0001953), cell differentiation (GO:0030154), positive regulation of cell migration (GO:0030335), wound healing, spreading of epidermal cells (GO:0035313)

GO Molecular Function (0):

GO Cellular Component (6): extracellular region (GO:0005576), plasma membrane (GO:0005886), external side of plasma membrane (GO:0009897), apical plasma membrane (GO:0016324), membrane (GO:0016020), side of membrane (GO:0098552)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
membrane	2
regulation of cell-matrix adhesion	1
cell-matrix adhesion	1
negative regulation of cell-substrate adhesion	1
cellular developmental process	1
cell migration	1
regulation of cell migration	1
positive regulation of cell motility	1
wound healing, spreading of cells	1
cell periphery	1
plasma membrane	1
cell surface	1
side of membrane	1
apical part of cell	1
plasma membrane region	1
leaflet of membrane bilayer	1

Protein interactions and networks

STRING

218 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PLET1	LRIG1	Q96JA1	585
PLET1	LGR6	Q9HBX8	572
PLET1	PSMB11	A5LHX3	541
PLET1	FOXN1	O15353	532
PLET1	KRT79	Q5XKE5	447
PLET1	KRT15	P19012	445
PLET1	PAX1	P15863	368
PLET1	LY75	O60449	325
PLET1	LGR5	O75473	323
PLET1	AIRE	O43918	320
PLET1	ELF5	Q9UKW6	315
PLET1	KRT5	P13647	312
PLET1	CLDN3	O15551	300
PLET1	KRT14	P02533	299
PLET1	LRRC23	Q53EV4	295

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0A6YXX9, A0A1Z2R986, A0A2R8Y4Y8, A0A2R8YFL7, A0A2R8YFM6, A0A8J1K1A4, A6MFL5, A6MFL6, A6MFL7, A6NHS7, A8MZH6, F8RKW5, G5E8D7, O54767, O77726, O88393, P17219, P20239, P26342, P34128, P35054, P42099, P47983, P47984, P70041, Q03167, Q05996, Q07G34, Q14CH0, Q1W7Q6, Q2Q0J1, Q3HXY1, Q3HXY2, Q3HXY3, Q3HXY4, Q3HXY5, Q3HXY6, Q3HXY8, Q3HXZ1, Q4FZG8

Diamond homologs: A5D7U1, Q5W9T8, Q6UQ28, Q7YQE5, Q8VEN2, Q5HZW7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

16 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	11
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

554 predictions. Top by Δscore:

Variant	Effect	Δscore
11:112255386:A:AC	donor_gain	1.0000
11:112255387:C:CC	donor_gain	1.0000
11:112255400:T:TA	donor_gain	0.9900
11:112255586:AATA:A	acceptor_gain	0.9900
11:112255588:TA:T	acceptor_gain	0.9900
11:112255590:C:CC	acceptor_gain	0.9900
11:112255585:AAATA:A	acceptor_gain	0.9800
11:112255392:T:C	donor_gain	0.9700
11:112255587:ATA:A	acceptor_gain	0.9700
11:112255589:AC:A	acceptor_loss	0.9400
11:112255590:CTGGG:C	acceptor_loss	0.9400
11:112255591:T:G	acceptor_loss	0.9400
11:112250889:C:CT	acceptor_gain	0.9300
11:112255382:TCTTA:T	donor_loss	0.9300
11:112255383:CT:C	donor_loss	0.9300
11:112255384:TT:T	donor_loss	0.9300
11:112255385:TA:T	donor_loss	0.9300
11:112255386:AC:A	donor_loss	0.9300
11:112255387:CT:C	donor_gain	0.9300
11:112255600:A:C	acceptor_loss	0.9300
11:112255380:GTTCT:G	donor_loss	0.9200
11:112255381:TTCTT:T	donor_loss	0.9200
11:112255603:A:AC	acceptor_loss	0.9200
11:112250890:A:T	acceptor_gain	0.9100
11:112255587:A:C	acceptor_gain	0.9100
11:112255659:G:GC	acceptor_gain	0.9100
11:112255387:CTGT:C	donor_gain	0.9000
11:112255666:C:CT	acceptor_gain	0.9000
11:112255387:CTGTA:C	donor_gain	0.8800
11:112255592:G:C	acceptor_loss	0.8800

AlphaMissense

1365 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:112252403:G:C	F131L	0.950
11:112252403:G:T	F131L	0.950
11:112252405:A:G	F131L	0.950
11:112255429:C:A	W115C	0.940
11:112255429:C:G	W115C	0.940
11:112255431:A:G	W115R	0.936
11:112255431:A:T	W115R	0.936
11:112260479:A:C	F37L	0.923
11:112260479:A:T	F37L	0.923
11:112260481:A:G	F37L	0.923
11:112255510:C:A	W88C	0.922
11:112255510:C:G	W88C	0.922
11:112255512:A:G	W88R	0.898
11:112255512:A:T	W88R	0.898
11:112255391:A:G	I128T	0.891
11:112255430:C:G	W115S	0.857
11:112255583:A:T	V64D	0.834
11:112255560:C:G	A72P	0.830
11:112248823:A:C	F200L	0.819
11:112248823:A:T	F200L	0.819
11:112248825:A:G	F200L	0.819
11:112260485:G:C	F35L	0.812
11:112260485:G:T	F35L	0.812
11:112260487:A:G	F35L	0.812
11:112260412:A:C	Y60D	0.809
11:112255391:A:T	I128K	0.802
11:112252404:A:G	F131S	0.797
11:112255388:T:G	Q129P	0.794
11:112252404:A:C	F131C	0.792
11:112260488:G:C	C34W	0.790

dbSNP variants (sampled 300 via entrez): RS1000103241 (11:112254317 TGTG>T), RS1000204814 (11:112249982 A>G), RS1000377507 (11:112247865 G>A,C), RS1000399129 (11:112262235 A>G), RS1000686652 (11:112256318 C>T), RS1001540600 (11:112255925 C>G), RS1001664564 (11:112261501 T>C), RS1001847646 (11:112260387 G>A), RS1002054643 (11:112249629 C>T), RS1002510616 (11:112253470 G>A), RS1002617130 (11:112260175 G>T), RS1002688579 (11:112251698 C>T), RS1003027671 (11:112247881 A>G), RS1003079465 (11:112259921 C>T), RS1003683175 (11:112258511 T>C)

Disease associations

OMIM: gene MIM:611904 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003159_1	Objective response to lithium treatment	1.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium	decreases expression, increases abundance	2
bisphenol A	affects cotreatment, increases methylation	1
Fulvestrant	affects cotreatment, increases methylation	1
Benzo(a)pyrene	decreases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.