PLGLB1

Summary

PLGLB1 (plasminogen like B1, HGNC:9072) is a protein-coding gene on chromosome 2p11.2, encoding Plasminogen-like protein B (Q02325). May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen.

Predicted to be located in extracellular region.

Source: NCBI Gene 5343 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 4 total
• MANE Select transcript: NM_001032392

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9072
Approved symbol	PLGLB1
Name	plasminogen like B1
Location	2p11.2
Locus type	gene with protein product
Status	Approved
Aliases	PRP-B
Ensembl gene	ENSG00000183281
Ensembl biotype	protein_coding
OMIM	173340
Entrez	5343

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 12 protein_coding, 3 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000355705, ENST00000409310, ENST00000409795, ENST00000409801, ENST00000467745, ENST00000478636, ENST00000494194, ENST00000899344, ENST00000899345, ENST00000899346, ENST00000899347, ENST00000899348, ENST00000899349, ENST00000899350, ENST00000899351, ENST00000899352, ENST00000899353

RefSeq mRNA: 1 — MANE Select: NM_001032392 NM_001032392

CCDS: CCDS33238

Canonical transcript exons

ENST00000355705 — 4 exons

Exon	Start	End
ENSE00001853856	87010224	87013119
ENSE00003550167	87017553	87017688
ENSE00003558969	87016302	87016408
ENSE00003913800	87021735	87021844

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 99.20.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	99.20	gold quality
liver	UBERON:0002107	98.86	gold quality
cerebellar hemisphere	UBERON:0002245	94.64	gold quality
cerebellar cortex	UBERON:0002129	94.55	gold quality
cerebellum	UBERON:0002037	94.37	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.02	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.40	gold quality
nucleus accumbens	UBERON:0001882	86.51	gold quality
primary visual cortex	UBERON:0002436	84.86	gold quality
corpus callosum	UBERON:0002336	84.71	gold quality
right frontal lobe	UBERON:0002810	84.49	gold quality
caudate nucleus	UBERON:0001873	84.28	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.22	gold quality
pituitary gland	UBERON:0000007	84.01	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.89	gold quality
brain	UBERON:0000955	83.87	gold quality
putamen	UBERON:0001874	83.69	gold quality
hypothalamus	UBERON:0001898	83.62	gold quality
Ammon’s horn	UBERON:0001954	83.44	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.27	gold quality
amygdala	UBERON:0001876	83.04	gold quality
anterior cingulate cortex	UBERON:0009835	82.88	gold quality
temporal lobe	UBERON:0001871	82.79	gold quality
substantia nigra	UBERON:0002038	82.14	gold quality
adenohypophysis	UBERON:0002196	82.06	gold quality
lower esophagus mucosa	UBERON:0035834	82.06	gold quality
right uterine tube	UBERON:0001302	81.76	gold quality
endometrium	UBERON:0001295	81.61	gold quality
colonic epithelium	UBERON:0000397	81.45	gold quality
left ovary	UBERON:0002119	81.07	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-10553	yes	29.93
E-ANND-3	no	3.84

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

151 targeting PLGLB1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-6888-3P	99.97	65.95	1170

Cross-species orthologs

0 orthologs

Paralogs (14): PRSS33 (ENSG00000103355), PLAT (ENSG00000104368), PLG (ENSG00000122194), PLGLB2 (ENSG00000125551), PRSS37 (ENSG00000165076), PRSS27 (ENSG00000172382), KLK15 (ENSG00000174562), PRSS57 (ENSG00000185198), TMPRSS12 (ENSG00000186452), OVCH1 (ENSG00000187950), PRSS48 (ENSG00000189099), GZMM (ENSG00000197540), KLK9 (ENSG00000213022), PRSS50 (ENSG00000283706)

Protein

Protein identifiers

Plasminogen-like protein B — Q02325 (reviewed: Q02325)

Alternative names: Plasminogen-related protein B

All UniProt accessions (2): Q02325, F8WCD6

UniProt curated annotations — full annotation on UniProt →

Function. May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Subcellular location. Secreted.

RefSeq proteins (1): NP_001027564* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003609	Pan_app	Domain
IPR016351	Plasminogen-rel	Family

Pfam: PF00024

UniProt features (5 total): disulfide bond 2, signal peptide 1, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q02325-F1	91.42	0.78

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (2): 49–73, 53–61

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 26 (showing top): chr2p11, MIR153_5P, MIR3529_3P, MIR1250_3P, MIR6825_5P, MIR548AZ_5P, MIR548T_5P, MIR6873_3P, MIR4503, MIR1275, MIR183_3P, MIR518D_5P_MIR518F_5P_MIR520C_5P_MIR526A_5P, MIR7703, MIR518E_5P_MIR519A_5P_MIR519B_5P_MIR519C_5P_MIR522_5P_MIR523_5P, MIR2276_5P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

473 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PLGLB1	OPRPN	P85047	847
PLGLB1	ZP2	Q05996	742
PLGLB1	VTN	P01141	459
PLGLB1	B3KSW5	B3KSW5	445
PLGLB1	ANPEP	P15144	437
PLGLB1	GART	P22102	400
PLGLB1	ERV3-1	Q14264	379
PLGLB1	ERVFRD-1	P60508	378
PLGLB1	GAGE12B	A1L429	368
PLGLB1	ERVW-1	Q9UQF0	359
PLGLB1	FAM47B	Q8NA70	348
PLGLB1	APEH	P13798	342
PLGLB1	MMP7	P09237	338
PLGLB1	PDZK1IP1	Q13113	337
PLGLB1	MMP9	P14780	327

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A1XRN2, A8WH72, B1A4M7, B1A4N2, B1A4N8, B1A4P2, B1A4P6, B1A4P7, B1A4P8, B1A4P9, B1A4Q0, B1A4Q2, B1A4Q3, B1A4Q5, B1A4Q6, B1A4Q8, B1A4Q9, B1A4R0, B1A4R4, C0STK6, L0GB04, O55159, O60575, P00996, P0DMY9, P0DPU8, P0DPX6, P0DPX8, P0DQG4, P0DQP8, P29392, P35495, P35496, P37109, Q02325, Q09271, Q15195, Q28920, Q3T0L5, Q3T113

Diamond homologs: D3ZTE0, O18783, O35453, P00735, P00747, P00749, P00750, P00774, P04185, P04813, P05981, P06867, P06868, P06869, P08419, P08519, P11214, P12545, P14210, P14417, P15638, P16227, P17538, P17945, P18292, P19221, P19637, P20918, P26262, P26927, P26928, P27435, P29598, P40313, P47796, P49150, P57727, P80009, P80010, P80646

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

4 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	4
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

722 predictions. Top by Δscore:

Variant	Effect	Δscore
2:86997555:A:AG	acceptor_gain	1.0000
2:86997556:A:G	acceptor_gain	1.0000
2:86997561:A:AG	acceptor_gain	1.0000
2:86997562:G:GG	acceptor_gain	1.0000
2:86997562:GCT:G	acceptor_gain	1.0000
2:86997562:GCTT:G	acceptor_gain	1.0000
2:86997771:A:T	donor_gain	1.0000
2:87016300:A:AC	donor_gain	1.0000
2:87016301:C:CC	donor_gain	1.0000
2:87016301:CTTTA:C	donor_gain	1.0000
2:87017686:GACC:G	acceptor_loss	1.0000
2:87017687:ACC:A	acceptor_loss	1.0000
2:87017689:C:A	acceptor_loss	1.0000
2:87017690:T:A	acceptor_loss	1.0000
2:86997558:A:AG	acceptor_gain	0.9900
2:86997559:C:G	acceptor_gain	0.9900
2:86997560:CAGCT:C	acceptor_loss	0.9900
2:86997561:AGCTT:A	acceptor_loss	0.9900
2:86997562:G:A	acceptor_loss	0.9900
2:86997562:GC:G	acceptor_gain	0.9900
2:86997562:GCTTC:G	acceptor_gain	0.9900
2:86997754:TCAAG:T	donor_loss	0.9900
2:86997755:CAAG:C	donor_loss	0.9900
2:86997757:AGG:A	donor_loss	0.9900
2:86997757:AGGTG:A	donor_gain	0.9900
2:86997759:GTG:G	donor_loss	0.9900
2:86997760:T:G	donor_loss	0.9900
2:87016295:TAC:T	donor_loss	0.9900
2:87016296:AC:A	donor_loss	0.9900
2:87016298:TC:T	donor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000983139 (2:87016505 T>C), RS1001255706 (2:87022948 G>A,T), RS1001256822 (2:87022299 C>T), RS1001328627 (2:87017476 C>G,T), RS1003899757 (2:87010632 G>T), RS1005157643 (2:87014935 G>C), RS1005375241 (2:87019280 C>G,T), RS1005453055 (2:87014575 T>C), RS1009118434 (2:87012011 A>G), RS1009569399 (2:87018350 C>A), RS1009865292 (2:87016554 GC>G), RS1011116294 (2:87022658 T>C), RS1011917052 (2:87010709 A>G), RS1012031822 (2:87011734 C>T), RS1013587599 (2:87014998 C>T)

Disease associations

OMIM: gene MIM:173340 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Silicon Dioxide	decreases expression, increases expression	2
Aflatoxin B1	decreases expression, decreases methylation	2
di-n-butylphosphoric acid	affects expression	1
Cadmium	increases abundance, increases expression	1
Diethylhexyl Phthalate	decreases expression	1
Mercury	increases expression	1
Urethane	increases expression	1
Valproic Acid	decreases methylation	1
Cadmium Chloride	increases abundance, increases expression	1
Okadaic Acid	decreases expression	1
Copper Sulfate	increases expression	1
S-Nitrosoglutathione	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.