PLGLB2

Summary

PLGLB2 (plasminogen like B2, HGNC:9073) is a protein-coding gene on chromosome 2p11.2, encoding Plasminogen-like protein B (Q02325). May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen.

Predicted to be located in extracellular region.

Source: NCBI Gene 5342 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 6 total
• MANE Select transcript: NM_002665

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9073
Approved symbol	PLGLB2
Name	plasminogen like B2
Location	2p11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000125551
Ensembl biotype	protein_coding
Entrez	5342

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000359481, ENST00000410086, ENST00000465361, ENST00000868167, ENST00000868168, ENST00000971354, ENST00000971355

RefSeq mRNA: 1 — MANE Select: NM_002665 NM_002665

CCDS: CCDS1999

Canonical transcript exons

ENST00000359481 — 4 exons

Exon	Start	End
ENSE00002432091	87752247	87752382
ENSE00002495578	87748087	87748202
ENSE00003594415	87753528	87753634
ENSE00003893507	87756820	87759476

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 97.84.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	97.84	gold quality
liver	UBERON:0002107	97.84	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.39	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.19	gold quality
cerebellar hemisphere	UBERON:0002245	78.91	gold quality
cerebellar cortex	UBERON:0002129	78.87	gold quality
cerebellum	UBERON:0002037	78.72	gold quality
endometrium	UBERON:0001295	74.34	gold quality
granulocyte	CL:0000094	74.15	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.04	gold quality
bone marrow cell	CL:0002092	73.82	silver quality
blood	UBERON:0000178	72.88	gold quality
spleen	UBERON:0002106	72.79	gold quality
lower esophagus mucosa	UBERON:0035834	72.15	gold quality
body of pancreas	UBERON:0001150	71.30	gold quality
mucosa of transverse colon	UBERON:0004991	71.17	gold quality
lymph node	UBERON:0000029	71.16	gold quality
pituitary gland	UBERON:0000007	70.78	gold quality
skeletal muscle tissue	UBERON:0001134	70.69	gold quality
endocervix	UBERON:0000458	70.36	gold quality
monocyte	CL:0000576	69.62	gold quality
gastrocnemius	UBERON:0001388	69.61	gold quality
adenohypophysis	UBERON:0002196	69.60	gold quality
leukocyte	CL:0000738	69.53	gold quality
right adrenal gland cortex	UBERON:0035827	69.51	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.35	gold quality
cortex of kidney	UBERON:0001225	69.32	gold quality
muscle of leg	UBERON:0001383	69.09	gold quality
muscle tissue	UBERON:0002385	69.06	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.60

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

146 targeting PLGLB2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-1250-3P	99.96	70.04	4038

Cross-species orthologs

0 orthologs

Paralogs (14): PRSS33 (ENSG00000103355), PLAT (ENSG00000104368), PLG (ENSG00000122194), PRSS37 (ENSG00000165076), PRSS27 (ENSG00000172382), KLK15 (ENSG00000174562), PLGLB1 (ENSG00000183281), PRSS57 (ENSG00000185198), TMPRSS12 (ENSG00000186452), OVCH1 (ENSG00000187950), PRSS48 (ENSG00000189099), GZMM (ENSG00000197540), KLK9 (ENSG00000213022), PRSS50 (ENSG00000283706)

Protein

Protein identifiers

Plasminogen-like protein B — Q02325 (reviewed: Q02325)

Alternative names: Plasminogen-related protein B

All UniProt accessions (1): Q02325

UniProt curated annotations — full annotation on UniProt →

Function. May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Subcellular location. Secreted.

RefSeq proteins (1): NP_002656* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003609	Pan_app	Domain
IPR016351	Plasminogen-rel	Family

Pfam: PF00024

UniProt features (5 total): disulfide bond 2, signal peptide 1, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q02325-F1	91.42	0.78

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (2): 49–73, 53–61

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 39 (showing top): MODULE_255, MODULE_317, HOSHIDA_LIVER_CANCER_SUBCLASS_S3, MODULE_301, chr2p11, MODULE_209, MODULE_69, MODULE_212, MODULE_37, MIR153_5P, MIR3529_3P, MIR1250_3P, MIR6825_5P, MIR548AZ_5P, MIR548T_5P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

473 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PLGLB2	OPRPN	P85047	847
PLGLB2	ZP2	Q05996	742
PLGLB2	VTN	P01141	459
PLGLB2	B3KSW5	B3KSW5	445
PLGLB2	ANPEP	P15144	437
PLGLB2	GART	P22102	400
PLGLB2	ERV3-1	Q14264	379
PLGLB2	ERVFRD-1	P60508	378
PLGLB2	GAGE12B	A1L429	368
PLGLB2	ERVW-1	Q9UQF0	359
PLGLB2	FAM47B	Q8NA70	348
PLGLB2	APEH	P13798	342
PLGLB2	MMP7	P09237	338
PLGLB2	PDZK1IP1	Q13113	337
PLGLB2	MMP9	P14780	327

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A1XRN2, A8WH72, B1A4M7, B1A4N2, B1A4N8, B1A4P2, B1A4P6, B1A4P7, B1A4P8, B1A4P9, B1A4Q0, B1A4Q2, B1A4Q3, B1A4Q5, B1A4Q6, B1A4Q8, B1A4Q9, B1A4R0, B1A4R4, C0STK6, L0GB04, O55159, O60575, P00996, P0DMY9, P0DPU8, P0DPX6, P0DPX8, P0DQG4, P0DQP8, P29392, P35495, P35496, P37109, Q02325, Q09271, Q15195, Q28920, Q3T0L5, Q3T113

Diamond homologs: D3ZTE0, O18783, O35453, P00735, P00747, P00749, P00750, P00774, P04185, P04813, P05981, P06867, P06868, P06869, P08419, P08519, P11214, P12545, P14210, P14417, P15638, P16227, P17538, P17945, P18292, P19221, P19637, P20918, P26262, P26927, P26928, P27435, P29598, P40313, P47796, P49150, P57727, P80009, P80010, P80646

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

6 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	6
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

465 predictions. Top by Δscore:

Variant	Effect	Δscore
2:87752243:CTAG:C	acceptor_loss	1.0000
2:87753630:GTAAA:G	donor_gain	1.0000
2:87753635:G:GG	donor_gain	1.0000
2:87748166:G:GT	donor_gain	0.9900
2:87748200:CAGG:C	donor_loss	0.9900
2:87748203:G:GA	donor_loss	0.9900
2:87752239:A:AG	acceptor_gain	0.9900
2:87752240:C:G	acceptor_gain	0.9900
2:87752245:A:AG	acceptor_gain	0.9900
2:87752246:G:GG	acceptor_gain	0.9900
2:87752378:TGCAG:T	donor_loss	0.9900
2:87752380:CAG:C	donor_loss	0.9900
2:87752381:AG:A	donor_loss	0.9900
2:87752382:G:GC	donor_loss	0.9900
2:87752383:G:GG	donor_loss	0.9900
2:87752384:T:G	donor_loss	0.9900
2:87753631:TAAA:T	donor_gain	0.9900
2:87753631:TAAAG:T	donor_loss	0.9900
2:87753632:AAAG:A	donor_loss	0.9900
2:87753633:AAGTG:A	donor_loss	0.9900
2:87753634:AG:A	donor_loss	0.9900
2:87753635:GT:G	donor_loss	0.9900
2:87753636:T:TG	donor_loss	0.9900
2:87753637:GAGTA:G	donor_loss	0.9900
2:87753638:AGT:A	donor_loss	0.9900
2:87753639:G:C	donor_loss	0.9900
2:87757205:A:G	acceptor_gain	0.9900
2:87748204:T:A	donor_loss	0.9800
2:87753523:TGCA:T	acceptor_loss	0.9800
2:87753524:GCAGG:G	acceptor_loss	0.9800

AlphaMissense

632 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:87753532:T:C	F64L	0.936
2:87753534:C:A	F64L	0.936
2:87753534:C:G	F64L	0.936
2:87752372:T:C	F59L	0.852
2:87752374:C:A	F59L	0.852
2:87752374:C:G	F59L	0.852
2:87753622:T:C	F94L	0.805
2:87753624:T:A	F94L	0.805
2:87753624:T:G	F94L	0.805
2:87753533:T:G	F64C	0.797
2:87753630:G:C	K96N	0.755
2:87753630:G:T	K96N	0.755
2:87753559:T:A	C73S	0.739
2:87753560:G:C	C73S	0.739
2:87753629:A:T	K96M	0.703
2:87753627:A:C	E95D	0.699
2:87753627:A:T	E95D	0.699
2:87752354:T:A	C53S	0.697
2:87752355:G:C	C53S	0.697
2:87753626:A:T	E95V	0.693
2:87752342:T:A	C49S	0.687
2:87752343:G:C	C49S	0.687
2:87753629:A:C	K96T	0.687
2:87753559:T:C	C73R	0.670
2:87752373:T:G	F59C	0.647
2:87753533:T:C	F64S	0.645
2:87752300:A:C	S35R	0.642
2:87752302:T:A	S35R	0.642
2:87752302:T:G	S35R	0.642
2:87752342:T:C	C49R	0.637

dbSNP variants (sampled 300 via entrez): RS1001594829 (2:87747918 G>A,C,T), RS1001930945 (2:87749082 A>G), RS1002541870 (2:87753672 C>T), RS1004935061 (2:87758153 G>A,C), RS1005433062 (2:87746964 G>A,C), RS1005899632 (2:87746478 G>T), RS1008184992 (2:87750961 G>A), RS1008783274 (2:87755683 CCT>C), RS1009250356 (2:87755046 C>T), RS1011630339 (2:87749929 A>C,G), RS1011684573 (2:87749117 CTTTT>C), RS1012632394 (2:87754958 G>A), RS1012808887 (2:87758417 G>C), RS1016477442 (2:87751100 G>C), RS1016809433 (2:87747001 C>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST011878_14	Mitochondrial heteroplasmy measurement	2.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0600008	mitochondrial heteroplasmy measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases methylation, increases expression	2
9-hydroxyoctadecadienoic acid	increases expression	1
trichostatin A	increases expression	1
Acetaminophen	decreases expression	1
Benzo(a)pyrene	decreases expression	1
Cadmium	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Silver	increases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.