PLGRKT

Summary

PLGRKT (plasminogen receptor with a C-terminal lysine, HGNC:23633) is a protein-coding gene on chromosome 9p24.1, encoding Plasminogen receptor (KT) (Q9HBL7). Receptor for plasminogen.

Predicted to be involved in positive regulation of plasminogen activation. Located in mitochondrion.

Source: NCBI Gene 55848 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 39 total
• MANE Select transcript: NM_018465

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23633
Approved symbol	PLGRKT
Name	plasminogen receptor with a C-terminal lysine
Location	9p24.1
Locus type	gene with protein product
Status	Approved
Aliases	MDS030, FLJ14688, AD025, Plg-RKT
Ensembl gene	ENSG00000107020
Ensembl biotype	protein_coding
OMIM	618444
Entrez	55848

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 12 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000223864, ENST00000472145, ENST00000473877, ENST00000482696, ENST00000905572, ENST00000905573, ENST00000905574, ENST00000905575, ENST00000905576, ENST00000905577, ENST00000905578, ENST00000905579, ENST00000940710, ENST00000948189, ENST00000948190

RefSeq mRNA: 1 — MANE Select: NM_018465 NM_018465

CCDS: CCDS6463

Canonical transcript exons

ENST00000223864 — 6 exons

Exon	Start	End
ENSE00000688135	5361078	5361187
ENSE00001165313	5357971	5358360
ENSE00001356605	5436569	5436694
ENSE00001356617	5437789	5437925
ENSE00003571162	5431897	5431983
ENSE00003634387	5361758	5361888

Expression profiles

Bgee: expression breadth ubiquitous, 242 present calls, max score 95.34.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.2855 / max 102.6818, expressed in 1796 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
99819	13.5589	1789
99820	2.4407	976
99824	1.1378	274
99821	0.6349	385
99822	0.3356	157
99817	0.0634	20
99823	0.0632	29
99818	0.0509	19

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
rectum	UBERON:0001052	95.34	gold quality
mucosa of transverse colon	UBERON:0004991	94.06	gold quality
colonic mucosa	UBERON:0000317	93.06	gold quality
mucosa of sigmoid colon	UBERON:0004993	92.94	gold quality
transverse colon	UBERON:0001157	91.32	gold quality
heart left ventricle	UBERON:0002084	91.29	gold quality
right atrium auricular region	UBERON:0006631	91.26	gold quality
muscle of leg	UBERON:0001383	91.07	gold quality
gastrocnemius	UBERON:0001388	91.03	gold quality
duodenum	UBERON:0002114	91.02	gold quality
cardiac ventricle	UBERON:0002082	91.00	gold quality
hindlimb stylopod muscle	UBERON:0004252	90.58	gold quality
jejunal mucosa	UBERON:0000399	90.27	gold quality
cardiac atrium	UBERON:0002081	90.24	gold quality
heart right ventricle	UBERON:0002080	90.21	gold quality
heart	UBERON:0000948	89.75	gold quality
ventricular zone	UBERON:0003053	89.69	gold quality
large intestine	UBERON:0000059	89.65	gold quality
muscle organ	UBERON:0001630	89.54	gold quality
colon	UBERON:0001155	89.45	gold quality
intestine	UBERON:0000160	89.42	gold quality
oocyte	CL:0000023	89.41	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.40	gold quality
metanephros cortex	UBERON:0010533	89.35	gold quality
small intestine Peyer’s patch	UBERON:0003454	89.30	gold quality
islet of Langerhans	UBERON:0000006	89.25	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.15	gold quality
apex of heart	UBERON:0002098	89.12	gold quality
small intestine	UBERON:0002108	88.80	gold quality
right adrenal gland	UBERON:0001233	88.58	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.63
E-MTAB-6524	no	161.78

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

43 targeting PLGRKT, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-636	99.80	69.58	1500
HSA-MIR-548A-3P	99.76	70.58	3524

Literature-anchored findings (GeneRIF, showing 6)

• Plg-R(KT) was highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 pheochromocytoma cells, and murine hippocampus. (PMID:21795689)
• Plg-R(KT) plays a key role in the plasminogen-dependent regulation of macrophage invasion, chemotactic migration, and recruitment in the inflammatory response. (PMID:21940822)
• Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes. (PMID:31316511)
• Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets. (PMID:32842150)
• The plasminogen receptor Plg-RKT regulates adipose function and metabolic homeostasis. (PMID:34897983)
• Plg-RKT Expression in Human Breast Cancer Tissues. (PMID:35454092)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	plgrkt	ENSDARG00000100789
mus_musculus	Plgrkt	ENSMUSG00000016495
rattus_norvegicus	Plgrkt	ENSRNOG00000015932
drosophila_melanogaster	CG13404	FBGN0030559
caenorhabditis_elegans		WBGENE00044322
caenorhabditis_elegans		WBGENE00044323

Protein

Protein identifiers

Plasminogen receptor (KT) — Q9HBL7 (reviewed: Q9HBL7)

All UniProt accessions (1): Q9HBL7

UniProt curated annotations — full annotation on UniProt →

Function. Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9.

Subunit / interactions. Interacts with PLAT and PLAUR.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla.

RefSeq proteins (1): NP_060935* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019319	Plg-R(KT)	Family

Pfam: PF10166

UniProt features (7 total): topological domain 3, transmembrane region 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HBL7-F1	89.60	0.68

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 173 (showing top): GOBP_POSITIVE_REGULATION_OF_PROTEIN_MATURATION, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GOBP_INFLAMMATORY_RESPONSE, GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP, GOBP_TAXIS, GOBP_PROTEIN_MATURATION, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, MARTINEZ_RB1_TARGETS_DN, MODULE_301, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP, GOBP_REGULATION_OF_PROTEIN_MATURATION, BROWN_MYELOID_CELL_DEVELOPMENT_UP, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP, GOBP_POSITIVE_REGULATION_OF_PROTEOLYSIS

GO Biological Process (3): chemotaxis (GO:0006935), inflammatory response (GO:0006954), positive regulation of plasminogen activation (GO:0010756)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): mitochondrion (GO:0005739), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
response to chemical	1
taxis	1
defense response	1
regulation of plasminogen activation	1
positive regulation of protein processing	1
plasminogen activation	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

718 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PLGRKT	PLG	P00747	983
PLGRKT	PLAT	P00750	761
PLGRKT	ENO1	P06733	635
PLGRKT	H2BK1	A0A2R8Y619	585
PLGRKT	H2BW2	P0C1H6	585
PLGRKT	H2BC12L	P57053	585
PLGRKT	H2BW1	Q7Z2G1	585
PLGRKT	H2BC18	Q5QNW6	584
PLGRKT	H2BC26	Q8N257	584
PLGRKT	H2BC13	Q99880	584
PLGRKT	H2BC17	P23527	583
PLGRKT	H2BC9	Q93079	582
PLGRKT	H2BC14	Q99879	581
PLGRKT	H2BC11	P06899	565
PLGRKT	H2BC3	P33778	565
PLGRKT	H2BC15	Q99877	565

IntAct

24 interactions, top by confidence:

A	B	Type	Score
SEC23A	SEC24D	psi-mi:“MI:0914”(association)	0.690
PLGRKT	EEF1G	psi-mi:“MI:0915”(physical association)	0.560
EEF1G	PLGRKT	psi-mi:“MI:0915”(physical association)	0.560
PLGRKT	PLG	psi-mi:“MI:0407”(direct interaction)	0.440
ANKRD13A	PLGRKT	psi-mi:“MI:0915”(physical association)	0.400
Rmdn3	DERL1	psi-mi:“MI:0914”(association)	0.350
GOLT1B		psi-mi:“MI:0914”(association)	0.350
	NUP214	psi-mi:“MI:0914”(association)	0.350
TOMM20	TIMM44	psi-mi:“MI:0914”(association)	0.350
KRTAP19-4	ZMPSTE24	psi-mi:“MI:0914”(association)	0.350
COX7A1	GLS	psi-mi:“MI:0914”(association)	0.350
PLGRKT	VPS13C	psi-mi:“MI:0914”(association)	0.350
SAAL1	TMEM223	psi-mi:“MI:0914”(association)	0.350
CASP3	TMEM223	psi-mi:“MI:0914”(association)	0.350
FOS	TMEM223	psi-mi:“MI:0914”(association)	0.350
PLGRKT	HAX1	psi-mi:“MI:2364”(proximity)	0.270
PLGRKT	PGRMC1	psi-mi:“MI:2364”(proximity)	0.270
IMMP1L	NUDT19	psi-mi:“MI:2364”(proximity)	0.270
OMA1	HAX1	psi-mi:“MI:2364”(proximity)	0.270
PARL	HAX1	psi-mi:“MI:2364”(proximity)	0.270
PLGRKT	XRCC6	psi-mi:“MI:0915”(physical association)	0.000
SAT1	PLGRKT	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (89): PLGRKT (Two-hybrid), PLGRKT (Affinity Capture-MS), PLGRKT (Affinity Capture-MS), PLGRKT (Affinity Capture-MS), HAX1 (Proximity Label-MS), DNM1L (Proximity Label-MS), TRIAP1 (Proximity Label-MS), TIMM8A (Proximity Label-MS), OPA1 (Proximity Label-MS), MTX2 (Proximity Label-MS), SCO1 (Proximity Label-MS), TOMM70A (Proximity Label-MS), TOMM40 (Proximity Label-MS), COX4I1 (Proximity Label-MS), PDIA4 (Proximity Label-MS)

ESM2 similar proteins: A1L2P2, A1XQT2, A8MTT3, D4ACN8, D4ACP2, P04038, P09669, P0DO44, P0DO45, P11951, P46269, P80497, P80977, Q02827, Q0MQ88, Q0MQ89, Q0MQ90, Q0MQF7, Q0Q4Z0, Q1RMH3, Q28EM2, Q28GF4, Q4I8P5, Q5BKW8, Q5RK28, Q63ZZ0, Q68EV8, Q78RX3, Q7YRJ8, Q7YRJ9, Q7YRK0, Q7YRK1, Q7YRK2, Q7YRK3, Q7YRK7, Q810Q5, Q8BTC1, Q8BTE5, Q8SPI4, Q95KV7

Diamond homologs: D4ACN8, Q9D3P8, Q9HBL7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

39 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1352 predictions. Top by Δscore:

Variant	Effect	Δscore
9:5361073:CTTA:C	donor_loss	1.0000
9:5361074:TTA:T	donor_loss	1.0000
9:5361075:TA:T	donor_loss	1.0000
9:5361076:ACCTT:A	donor_loss	1.0000
9:5361077:C:CT	donor_loss	1.0000
9:5361077:CCTTT:C	donor_gain	1.0000
9:5361183:TCGCT:T	acceptor_gain	1.0000
9:5361184:CGCT:C	acceptor_gain	1.0000
9:5361184:CGCTC:C	acceptor_gain	1.0000
9:5361185:GCT:G	acceptor_gain	1.0000
9:5361186:CT:C	acceptor_gain	1.0000
9:5361186:CTC:C	acceptor_gain	1.0000
9:5361187:TC:T	acceptor_loss	1.0000
9:5361187:TCT:T	acceptor_gain	1.0000
9:5361188:C:CC	acceptor_gain	1.0000
9:5361194:C:CT	acceptor_gain	1.0000
9:5361195:A:T	acceptor_gain	1.0000
9:5361200:T:C	acceptor_gain	1.0000
9:5361200:T:TC	acceptor_gain	1.0000
9:5361754:ATAC:A	donor_loss	1.0000
9:5361755:TAC:T	donor_loss	1.0000
9:5361756:A:AC	donor_gain	1.0000
9:5361756:A:AG	donor_loss	1.0000
9:5361756:AC:A	donor_gain	1.0000
9:5361757:C:CC	donor_gain	1.0000
9:5361757:CC:C	donor_gain	1.0000
9:5361757:CCCAG:C	donor_gain	1.0000
9:5361761:G:C	donor_gain	1.0000
9:5361885:CCAG:C	acceptor_gain	1.0000
9:5361886:CAGC:C	acceptor_gain	1.0000

AlphaMissense

989 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:5361136:G:C	S88R	0.987
9:5361136:G:T	S88R	0.987
9:5361138:T:G	S88R	0.987
9:5361818:C:G	R51P	0.984
9:5358355:C:G	A110P	0.981
9:5361840:C:G	A44P	0.976
9:5361827:G:T	A48E	0.969
9:5361143:G:C	P86R	0.965
9:5361146:A:T	V85D	0.964
9:5361113:T:G	D96A	0.956
9:5361839:G:T	A44D	0.956
9:5361828:C:G	A48P	0.953
9:5361123:A:C	Y93D	0.949
9:5361875:A:G	L32P	0.949
9:5361113:T:A	D96V	0.948
9:5361143:G:T	P86Q	0.943
9:5361085:T:A	R105S	0.942
9:5361085:T:G	R105S	0.942
9:5361101:C:A	G100V	0.938
9:5358354:G:T	A110D	0.930
9:5361790:A:C	F60L	0.927
9:5361790:A:T	F60L	0.927
9:5361792:A:G	F60L	0.927
9:5361113:T:C	D96G	0.923
9:5361804:A:C	Y56D	0.923
9:5361107:C:T	G98D	0.919
9:5361152:G:C	P83R	0.915
9:5361101:C:T	G100E	0.914
9:5361887:A:G	L28P	0.912
9:5361108:C:G	G98R	0.909

dbSNP variants (sampled 300 via entrez): RS1000044167 (9:5418340 C>A,G), RS1000055243 (9:5432102 C>A), RS1000087609 (9:5413314 G>T), RS1000090392 (9:5387612 T>C), RS1000104879 (9:5384233 A>G), RS1000130761 (9:5399010 A>G), RS1000167711 (9:5371245 G>A), RS1000175626 (9:5401363 T>C), RS1000178648 (9:5370259 G>A), RS1000289106 (9:5422617 A>G), RS1000296651 (9:5366654 G>A), RS1000315773 (9:5408551 C>T), RS1000337579 (9:5426804 G>C), RS1000375833 (9:5388207 G>A), RS1000463594 (9:5370465 C>T)

Disease associations

OMIM: gene MIM:618444 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST001762_205	Obesity-related traits	3.000000e-06
GCST004955_4	Risky sexual behaviors in alcohol dependence	6.000000e-08
GCST007089_5	Polycystic ovary syndrome	3.000000e-08
GCST007932_85	Medication use (thyroid preparations)	9.000000e-10
GCST010571_46	Autoimmune thyroid disease	9.000000e-12
GCST011773_34	Type 1 diabetes (age at diagnosis)	5.000000e-06
GCST012319_10	LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder	6.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004530	triglyceride measurement
EFO:0009933	Thyroid preparation use measurement
EFO:0004918	age at diagnosis
EFO:0004611	low density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, decreases methylation	2
Rotenone	increases expression	2
dicrotophos	decreases expression	1
quercitrin	decreases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
cobaltous chloride	decreases expression	1
manganese chloride	increases abundance, increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Vorinostat	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, decreases expression	1
Cannabidiol	decreases expression	1
Estradiol	decreases expression	1
Lead	affects splicing	1
Manganese	increases abundance, increases expression	1
Methyl Methanesulfonate	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Sodium Dodecyl Sulfate	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	affects expression	1
Cyclosporine	increases expression	1
Asbestos, Crocidolite	increases expression	1
Copper Sulfate	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TE56	HAP1 PLGRKT (-) 1	Cancer cell line	Male
CVCL_TE57	HAP1 PLGRKT (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.