PLS3-AS1

Summary

PLS3-AS1 (PLS3 antisense RNA 1, HGNC:50343) is a long non-coding RNA gene on chromosome Xq23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50343
Approved symbol	PLS3-AS1
Name	PLS3 antisense RNA 1
Location	Xq23
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000271826
Ensembl biotype	lncRNA
Entrez	101927352
RNAcentral	URS000075AAD5 — lncRNA, 2068 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000606397, ENST00000607680

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000606397 — 4 exons

Exon	Start	End
ENSE00003695706	115520484	115520653
ENSE00003695728	115562626	115562707
ENSE00003700774	115562404	115562530
ENSE00003702207	115527627	115527768

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 80.55.

FANTOM5 (CAGE): breadth broad, TPM avg 1.5078 / max 54.2742, expressed in 651 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
200242	1.5078	651

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.87	gold quality
calcaneal tendon	UBERON:0003701	76.02	gold quality
sural nerve	UBERON:0015488	70.86	gold quality
ventricular zone	UBERON:0003053	64.59	gold quality
descending thoracic aorta	UBERON:0002345	62.34	gold quality
skeletal muscle tissue	UBERON:0001134	62.29	gold quality
ascending aorta	UBERON:0001496	60.38	gold quality
thoracic aorta	UBERON:0001515	60.20	gold quality
popliteal artery	UBERON:0002250	60.19	gold quality
tibial artery	UBERON:0007610	60.11	gold quality
ganglionic eminence	UBERON:0004023	59.62	silver quality
bone marrow	UBERON:0002371	59.35	gold quality
liver	UBERON:0002107	58.92	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	58.86	gold quality
cortical plate	UBERON:0005343	58.76	silver quality
tonsil	UBERON:0002372	58.73	silver quality
right coronary artery	UBERON:0001625	58.35	gold quality
substantia nigra	UBERON:0002038	57.08	gold quality
right lobe of thyroid gland	UBERON:0001119	56.69	gold quality
prefrontal cortex	UBERON:0000451	56.54	gold quality
left coronary artery	UBERON:0001626	56.50	gold quality
apex of heart	UBERON:0002098	56.20	gold quality
myometrium	UBERON:0001296	56.05	gold quality
thyroid gland	UBERON:0002046	55.99	gold quality
adult mammalian kidney	UBERON:0000082	55.91	gold quality
right lobe of liver	UBERON:0001114	55.54	gold quality
stromal cell of endometrium	CL:0002255	55.35	silver quality
kidney	UBERON:0002113	55.34	gold quality
heart left ventricle	UBERON:0002084	55.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.91

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.