PLUT

Summary

PLUT (PDX1 associated lncRNA, upregulator of transcription, HGNC:43698) is a long non-coding RNA gene on chromosome 13q12.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product.
• GTEx eGene: eQTL in 1 tissue, sQTL in 1 (q < 0.05)

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43698
Approved symbol	PLUT
Name	PDX1 associated lncRNA, upregulator of transcription
Location	13q12.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	PLUTO, HI-LNC71
Ensembl gene	ENSG00000247381
Ensembl biotype	lncRNA
OMIM	621241
Entrez	100861550
RNAcentral	URS0000ABD8D4 — lncRNA, 2254 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 3: 1

ENST00000499662

RefSeq mRNA: 0

Canonical transcript exons

ENST00000499662 — 5 exons

Exon	Start	End
ENSE00001967059	27848008	27848536
ENSE00001972279	27834021	27834150
ENSE00003812294	27917150	27917298
ENSE00003812873	27822755	27823372
ENSE00003813606	27819376	27820467

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 79.69.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0564 / max 8.4987, expressed in 32 samples.

Highest expression (Bgee): islet of Langerhans, pancreas, duodenum, small intestine, gall bladder.

Genetic regulation across tissues (GTEx eQTL / sQTL)

PLUT is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 1 tissue and its splicing (sQTL) in 1 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

2 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Testis	eqtl	8.8e-06	+0.24	13:27858465:G:A
Testis	sqtl	1.2e-02	-0.44	13:27852767:C:T

FANTOM5 promoters

1 alternative TSS:

Promoter ID	TPM avg	Samples expressed
136502	0.0564	32

Top tissues by expression

15 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	79.69	gold quality
pancreas	UBERON:0001264	63.38	gold quality
duodenum	UBERON:0002114	53.65	gold quality
small intestine	UBERON:0002108	50.05	gold quality
gall bladder	UBERON:0002110	48.00	gold quality
intestine	UBERON:0000160	47.55	gold quality
stomach	UBERON:0000945	45.00	gold quality
transverse colon	UBERON:0001157	44.28	gold quality
colon	UBERON:0001155	44.25	silver quality
body of pancreas	UBERON:0001150	44.08	silver quality
body of stomach	UBERON:0001161	43.43	silver quality
small intestine Peyer’s patch	UBERON:0003454	38.87	silver quality
right testis	UBERON:0004534	33.73	silver quality
testis	UBERON:0000473	32.52	silver quality
left testis	UBERON:0004533	32.17	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.95

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
GSX1	protein-coding	219409
LNX2	protein-coding	222484
POLR1D	protein-coding	51082
PDX1	protein-coding	3651
LINC00543	ncRNA	100132234
CDX2	protein-coding	1045

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 2 curated MSigDB gene sets — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

DESCARTES_MAIN_FETAL_ISLET_ENDOCRINE_CELLS, chr13q12

ncRNA interactions

Experimentally supported non-coding-RNA interaction partners (NPInter).

showing 22 of 41 interaction partners:

Partner	Partner type	Level	Source
PDX1-AS1	lncRNA	RNA-Protein	High-throughput data
A1CF	protein	RNA-Protein	High-throughput data
DR1	protein	RNA-Protein	High-throughput data
EXOSC10	protein	RNA-Protein	High-throughput data
KHDRBS2	protein	RNA-Protein	High-throughput data
USF2	protein	RNA-Protein	High-throughput data
ZC3HAV1	protein	RNA-Protein	High-throughput data
ZMAT3	protein	RNA-Protein	High-throughput data
SP1	protein	RNA-Protein	High-throughput data
AGO1	protein	RNA-Protein	High-throughput data
FUS	protein	RNA-Protein	High-throughput data
EWSR1	protein	RNA-Protein	High-throughput data
IGF2BP3	protein	RNA-Protein	High-throughput data
RBMX	protein	RNA-Protein	High-throughput data
SOX2	protein	RNA-Protein	High-throughput data
CPSF7	protein	RNA-Protein	High-throughput data
KHSRP	protein	RNA-Protein	High-throughput data
IGF2BP1	protein	RNA-Protein	High-throughput data
AGO2	protein	RNA-Protein	High-throughput data
FTO	protein	RNA-Protein	High-throughput data
FUBP3	protein	RNA-Protein	High-throughput data
DHX36	protein	RNA-Protein	High-throughput data

Disease & clinical

ncRNA disease associations

Curated non-coding-RNA → disease associations (LncRNADisease, HMDD) — these are RNA-level associations for this gene, not the positional variant data omitted above.

1 ncRNA–disease associations:

Disease	Causal?	Validated by
Diabetes Mellitus	No	qRT-PCR

Drugs & pharmacology

ncRNA–drug associations

Curated non-coding-RNA → drug associations (drug response / resistance / target).

1 ncRNA–drug associations:

Drug	Relation	Effect	Condition
Panobinostat	drug_target	up-regulated	“cell line (SK-NEP-1, G401)”