PNLIPRP2

Summary

PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene), HGNC:9157) is a protein-coding gene on chromosome 10q25.3, encoding Pancreatic lipase-related protein 2 (P54317). Lipase that primarily hydrolyzes triglycerides and galactosylglycerides.

This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele.

Source: NCBI Gene 5408 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 14 total
• Druggable target: yes

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9157
Approved symbol	PNLIPRP2
Name	pancreatic lipase related protein 2 (gene/pseudogene)
Location	10q25.3
Locus type	gene with protein product
Status	Approved
Aliases	PLRP2
Ensembl gene	ENSG00000266200
Ensembl biotype	protein_coding
OMIM	604423
Entrez	5408

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding_CDS_not_defined, 1 protein_coding_LoF

ENST00000579578, ENST00000586762, ENST00000588823

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579578 — 13 exons

Exon	Start	End
ENSE00002703094	116627763	116627874
ENSE00002703320	116629943	116630062
ENSE00002722573	116645034	116645143
ENSE00002726850	116636785	116636914
ENSE00003566410	116631238	116631357
ENSE00003576757	116623945	116624099
ENSE00003632325	116638369	116638480
ENSE00003644864	116625946	116626071
ENSE00003685503	116634841	116634959
ENSE00003691483	116626864	116626998
ENSE00003741133	116621306	116621354
ENSE00003757402	116642115	116642282
ENSE00003757853	116620953	116620978

Expression profiles

Bgee: expression breadth ubiquitous, 149 present calls, max score 99.87.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 4.4907 / max 5662.6471, expressed in 16 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
107243	3.9765	15
107242	0.5143	7

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	99.87	gold quality
pancreas	UBERON:0001264	97.51	gold quality
jejunal mucosa	UBERON:0000399	96.90	gold quality
duodenum	UBERON:0002114	95.85	gold quality
islet of Langerhans	UBERON:0000006	94.10	gold quality
rectum	UBERON:0001052	87.63	gold quality
ileal mucosa	UBERON:0000331	84.12	gold quality
mucosa of sigmoid colon	UBERON:0004993	82.92	gold quality
epithelial cell of pancreas	CL:0000083	82.85	gold quality
small intestine	UBERON:0002108	82.50	gold quality
small intestine Peyer’s patch	UBERON:0003454	82.31	gold quality
colonic mucosa	UBERON:0000317	80.50	gold quality
jejunum	UBERON:0002115	77.37	gold quality
mucosa of transverse colon	UBERON:0004991	76.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.29	gold quality
body of stomach	UBERON:0001161	68.47	gold quality
intestine	UBERON:0000160	68.04	gold quality
transverse colon	UBERON:0001157	66.75	gold quality
stomach	UBERON:0000945	65.19	gold quality
large intestine	UBERON:0000059	63.51	gold quality
colon	UBERON:0001155	62.97	gold quality
right coronary artery	UBERON:0001625	62.49	gold quality
tibial nerve	UBERON:0001323	60.65	gold quality
fundus of stomach	UBERON:0001160	60.46	gold quality
ectocervix	UBERON:0012249	59.69	gold quality
metanephros cortex	UBERON:0010533	59.66	gold quality
right lobe of liver	UBERON:0001114	58.75	gold quality
left uterine tube	UBERON:0001303	58.31	gold quality
sigmoid colon	UBERON:0001159	57.87	gold quality
right uterine tube	UBERON:0001302	56.21	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-GEOD-81547	yes	5069.74
E-MTAB-5061	yes	3386.48
E-ENAD-27	yes	7.38
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• Investigation of the substrate specificity of purified recombinant pancreatic lipase-related protein 2 reveals that its physiological role is digestion of galactolipids, the main plant lipids present in the vegetables which are a part of the human diet. (PMID:15287741)
• Patients with chronic calcifying pancreatitis (CCP) had significantly lower levels of both pancreatic lipase and PLRP2 than the controls subjects. (PMID:16887271)
• finding that the inhibition of nonproteolyzed rHPLRP2 by tetrahydrolipstatin and diethyl-p-nitrophenyl phosphate does not involve any bile salt requirements suggests that the rHPLRP2 lid adopts an open conformation in aqueous media. (PMID:17401110)
• Most of the structural and kinetic properties of HPLRP2 were found to be different from those of rat PLRP2 (PMID:18702514)
• The pancreatic lipase related protein 2 is required for lipid-dependent cytotoxicity mediated by cytotoxic T lymphocytes. (PMID:19548271)
• localization of PLRP2 in endosomes of monocytes (PMID:21554982)
• Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns (PMID:21652702)
• BSSL and PLRP2 hydrolyzed triglycerides (TG) to free FA and glycerol. (PMID:21865348)
• Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. (PMID:23732775)
• The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PMID:26494624)
• findings show that endosomal lipases participate in lipid antigen presentation by processing lipid antigens and have a role in T cell immunity against mycobacteria (PMID:27662254)
• We analyzed mRNA expression in human pancreatic cDNA samples and found the variant allele markedly reduced. We conclude that the p.W358X truncation variant of PNLIPRP2 is expressed poorly and has no significant effect on the risk of chronic pancreatitis (PMID:30408063)
• Pancreatic lipase and its related proteins: where are we now? (PMID:38081381)

Cross-species orthologs

17 orthologs

Organism	Symbol	Gene ID
mus_musculus	Pnliprp2	ENSMUSG00000025091
rattus_norvegicus	Pnliprp2	ENSRNOG00000017982
drosophila_melanogaster	CG5162	FBGN0030828
drosophila_melanogaster	CG6675	FBGN0032973
drosophila_melanogaster	CG6472	FBGN0034166
drosophila_melanogaster	CG5665	FBGN0036977
drosophila_melanogaster	sxe2	FBGN0038398
drosophila_melanogaster	CG4582	FBGN0039344
drosophila_melanogaster	CG6296	FBGN0039470
drosophila_melanogaster	CG6295	FBGN0039471
drosophila_melanogaster	CG17192	FBGN0039472
drosophila_melanogaster	CG17191	FBGN0039473
drosophila_melanogaster	CG6283	FBGN0039474
drosophila_melanogaster	CG6277	FBGN0039475
drosophila_melanogaster	CG6271	FBGN0039476
drosophila_melanogaster	CG4267	FBGN0264979
drosophila_melanogaster	CG18258	FBGN0265267

Paralogs (9): LIPG (ENSG00000101670), PLA1A (ENSG00000144837), LIPH (ENSG00000163898), LIPC (ENSG00000166035), LPL (ENSG00000175445), PNLIP (ENSG00000175535), PNLIPRP1 (ENSG00000187021), LIPI (ENSG00000188992), PNLIPRP3 (ENSG00000203837)

Protein

Protein identifiers

Pancreatic lipase-related protein 2 — P54317 (reviewed: P54317)

Alternative names: Cytotoxic T lymphocyte lipase, Galactolipase, Triacylglycerol lipase

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Function. Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane.

Subcellular location. Secreted. Zymogen granule membrane. Cell projection. Neuron projection.

Tissue specificity. Pancreas.

Activity regulation. Regulated by CLPS and bile salts levels ranging 1-5 mM in neonates and 2-30 mM in healthy adults. CLPS stimulates milk fat digestion in the presence of 4 mM bile salts. Triacylglycerol lipase activity toward short- and medium-chain triglycerides is inhibited by increasing concentrations of bile salts and weakly reactivated by CLPS. Optimal triacylglycerol lipase activity is reached at bile salts concentrations ranging from 0.1 to 0.5 mM and then decreases at concentrations higher than 1 mM. Lipase activity toward long-chain glycerolipids is stimulated by CLPS in the presence of 4 mM bile salts. Galactolipase activity is inhibited at high concentrations of bile salts. Triacylglycerol lipase activity is inhibited by anti-obesity drug tetrahydrolipstatin.

Pathway. Glycerolipid metabolism; triacylglycerol degradation. Glycolipid metabolism.

Similarity. Belongs to the AB hydrolase superfamily. Lipase family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000734	TAG_lipase	Family
IPR001024	PLAT/LH2_dom	Domain
IPR002331	Lipase_panc	Family
IPR013818	Lipase	Domain
IPR016272	Lipase_LIPH	Family
IPR029058	AB_hydrolase_fold	Homologous_superfamily
IPR033906	Lipase_N	Domain
IPR036392	PLAT/LH2_dom_sf	Homologous_superfamily

Pfam: PF00151, PF01477

Enzyme classification (BRENDA):

• EC 3.1.1.26 — galactolipase (BRENDA: 63 organisms, 125 substrates, 44 inhibitors, 15 Km, 2 kcat entries)

Substrate kinetics (BRENDA)

6 substrates with measured Km, best-characterized 6. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
MONOGALACTOSYLDIACYLGLYCEROL	0.119–0.65	6
PHOSPHATIDYLCHOLINE	0.53–1.7	3
1,2-DIACYL-3-O-ALPHA-D-GALACTOSYL-(1->6)-BETA-D-	0.54–1.05	2
DIGALACTOSYLDIACYLGLYCEROL	0.31	1
DIGALACTOSYLDILINOLENIN	7.8	1
MONOGALACTOSYLDILINOLENIN	1.5	1

Catalyzed reactions (Rhea), 12 shown:

• a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) (RHEA:12044)
• a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+) (RHEA:13189)
• 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+) (RHEA:38487)
• 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+) (RHEA:38575)
• (9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+) (RHEA:39955)
• 1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H(+) (RHEA:40475)
• a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) (RHEA:44664)
• 1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + octanoate + H(+) (RHEA:47864)
• di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) (RHEA:47868)
• 1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + propanoate + H(+) (RHEA:48024)
• a 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+) (RHEA:48372)
• 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + dodecanoate + H(+) (RHEA:48516)

UniProt features (74 total): strand 27, helix 13, turn 9, disulfide bond 6, binding site 4, active site 3, glycosylation site 2, sequence variant 2, sequence conflict 2, region of interest 2, signal peptide 1, chain 1, domain 1, mutagenesis site 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
2OXE	X-RAY DIFFRACTION	2.8
2PVS	X-RAY DIFFRACTION	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P54317-F1	93.19	0.87

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (3): 171 (nucleophile); 195 (charge relay system); 282 (charge relay system)

Ligand- & substrate-binding residues (4): 211; 214; 206; 209

Disulfide bonds (6): 21–27, 109–120, 256–280, 304–315, 318–323, 453–469

Glycosylation sites (2): 353, 428

Mutagenesis-validated functional residues (1):

Position	Phenotype
353	loss of n-glycosylation.

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-192456	Digestion of dietary lipid
R-HSA-9925561	Developmental Lineage of Pancreatic Acinar Cells

MSigDB gene sets: 125 (showing top): GOBP_DIGESTION, GOBP_PHOSPHOLIPID_METABOLIC_PROCESS, GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS, GOBP_STEROL_HOMEOSTASIS, GOCC_SECRETORY_GRANULE, GCANCTGNY_MYOD_Q6, GOBP_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, GOBP_MEMBRANE_LIPID_CATABOLIC_PROCESS, GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS, GOBP_LIPID_DIGESTION, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_LIPID_HOMEOSTASIS, GOBP_GLYCEROLIPID_METABOLIC_PROCESS

GO Biological Process (12): fatty acid biosynthetic process (GO:0006633), triglyceride metabolic process (GO:0006641), phospholipid catabolic process (GO:0009395), galactolipid catabolic process (GO:0019376), triglyceride catabolic process (GO:0019433), high-density lipoprotein particle remodeling (GO:0034375), phosphatidylcholine catabolic process (GO:0034638), cholesterol homeostasis (GO:0042632), lipid digestion (GO:0044241), cellular defense response (GO:0006968), response to bacterium (GO:0009617), intestinal lipid catabolic process (GO:0044258)

GO Molecular Function (7): lipoprotein lipase activity (GO:0004465), glycerophospholipase activity (GO:0004620), triacylglycerol lipase activity (GO:0004806), calcium ion binding (GO:0005509), glycerophospholipid phospholipase A1 activity (GO:0008970), monoacylglycerol lipase activity (GO:0047372), galactolipase activity (GO:0047714)

GO Cellular Component (4): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615), zymogen granule membrane (GO:0042589), neuron projection (GO:0043005)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Digestion	1
Developmental Cell Lineages of the Exocrine Pancreas	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
lipase activity	3
carboxylic ester hydrolase activity	3
lipid catabolic process	2
fatty acid metabolic process	1
lipid biosynthetic process	1
monocarboxylic acid biosynthetic process	1
acylglycerol metabolic process	1
phospholipid metabolic process	1
organophosphate catabolic process	1
galactolipid metabolic process	1
glycolipid catabolic process	1
triglyceride metabolic process	1
acylglycerol catabolic process	1
plasma lipoprotein particle remodeling	1
phosphatidylcholine metabolic process	1
glycerophospholipid catabolic process	1
sterol homeostasis	1
digestion	1
defense response	1
response to other organism	1
triacylglycerol lipase activity	1
phospholipase activity	1
metal ion binding	1
A1-type glycerophospholipase activity	1
cellular anatomical structure	1
secretory granule membrane	1
zymogen granule	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

10 interactions, top by confidence:

A	B	Type	Score
PNLIPRP2	EDC3	psi-mi:“MI:0915”(physical association)	0.620
PNLIP	LAMC1	psi-mi:“MI:0914”(association)	0.530
PNLIPRP2	TGFB1	psi-mi:“MI:0914”(association)	0.530
CYB5R4	PNLIPRP2	psi-mi:“MI:0915”(physical association)	0.400
SPRTN	SPOP	psi-mi:“MI:0914”(association)	0.350
ZNF436	PNLIPRP2	psi-mi:“MI:0914”(association)	0.350
GRK6	PNLIPRP2	psi-mi:“MI:0914”(association)	0.350

BioGRID (14): PNLIPRP2 (Affinity Capture-MS), PNLIPRP2 (Affinity Capture-MS), PNLIPRP2 (Affinity Capture-MS), DCP1B (Affinity Capture-MS), EDC3 (Affinity Capture-MS), PNLIPRP2 (Affinity Capture-MS), PNLIPRP2 (Affinity Capture-MS), TGFB1 (Affinity Capture-MS), PNLIPRP2 (Affinity Capture-MS), DDX6 (Affinity Capture-MS), PNLIPRP2 (Affinity Capture-MS), DCP1A (Affinity Capture-MS), PNLIPRP2 (Co-fractionation), PNLIPRP2 (Co-fractionation)

ESM2 similar proteins: A0A0M3KKW3, A2VBC4, A5PK46, A8PUY1, B2D0J5, C0HLL3, D7EZN2, O88354, P00591, P06857, P0CH47, P0CH86, P0CH87, P0DMB4, P0DMB5, P0DPT0, P0DSI2, P16233, P17892, P27657, P29183, P35501, P35502, P49369, P50903, P51528, P53357, P54315, P54316, P54317, P54318, P81139, P86100, P9WEM6, Q02157, Q04456, Q06478, Q17RR3, Q3ZU95, Q5BKQ4

Diamond homologs: A2VBC4, A5PK46, C0HLL3, D7EZN2, J3RZ81, O46559, O46647, O88354, P00591, P06857, P06858, P0CH47, P0CH86, P11150, P11151, P11152, P11153, P11602, P16233, P17892, P27656, P27657, P29183, P49060, P49923, P50903, P51528, P53357, P54315, P54316, P54317, P54318, P55031, P81139, P83629, P97535, Q02157, Q06000, Q06478, Q17RR3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

14 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	10
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1395 predictions. Top by Δscore:

Variant	Effect	Δscore
10:116624100:G:GG	donor_gain	1.0000
10:116625934:A:AG	acceptor_gain	1.0000
10:116625944:A:AG	acceptor_gain	1.0000
10:116625945:G:GG	acceptor_gain	1.0000
10:116625945:GCTA:G	acceptor_gain	1.0000
10:116626069:AAG:A	donor_loss	1.0000
10:116626859:CCCA:C	acceptor_loss	1.0000
10:116626861:CA:C	acceptor_loss	1.0000
10:116626862:A:AG	acceptor_gain	1.0000
10:116626863:G:GT	acceptor_gain	1.0000
10:116626863:GA:G	acceptor_gain	1.0000
10:116626863:GAA:G	acceptor_gain	1.0000
10:116626863:GAAA:G	acceptor_gain	1.0000
10:116626863:GAAAA:G	acceptor_gain	1.0000
10:116626990:GCACT:G	donor_gain	1.0000
10:116627368:G:T	donor_gain	1.0000
10:116627391:G:GT	donor_gain	1.0000
10:116629942:GGGCT:G	acceptor_gain	1.0000
10:116630061:AGGTG:A	donor_loss	1.0000
10:116630062:GGTG:G	donor_loss	1.0000
10:116630063:G:A	donor_loss	1.0000
10:116630064:T:G	donor_loss	1.0000
10:116634956:GGAG:G	donor_gain	1.0000
10:116634957:G:GT	donor_gain	1.0000
10:116634957:GAGGT:G	donor_loss	1.0000
10:116634960:G:GA	donor_loss	1.0000
10:116634961:T:A	donor_loss	1.0000
10:116638481:G:GG	donor_gain	1.0000
10:116642113:A:AG	acceptor_gain	1.0000
10:116642113:AGAG:A	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000288981 (10:116637116 T>C), RS1000364041 (10:116645638 G>A), RS1000798722 (10:116645256 C>A,T), RS1000997797 (10:116626534 G>A,C), RS1001051059 (10:116632570 T>C), RS1001103316 (10:116632349 C>G,T), RS1001709532 (10:116638214 A>C), RS1001914954 (10:116632909 G>A), RS1002072651 (10:116639423 A>T), RS1002163239 (10:116637925 G>C), RS1002228219 (10:116621484 C>T), RS1002275931 (10:116621212 C>A,G), RS1002444850 (10:116639894 C>A,T), RS1002563951 (10:116622741 A>G,T), RS1002766241 (10:116628199 C>A)

Disease associations

OMIM: gene MIM:604423 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST001414_24	Phospholipid levels (plasma)	8.000000e-09
GCST003771_4	Loneliness	1.000000e-06
GCST003772_15	Loneliness (linear analysis)	8.000000e-07
GCST003773_9	Loneliness (multivariate analysis)	4.000000e-06
GCST005951_66	Body mass index	4.000000e-08
GCST006585_461	Blood protein levels	0.000000e+00
GCST010204_154	Low density lipoprotein cholesterol levels	4.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007865	loneliness measurement
EFO:0004340	body mass index
EFO:0004611	low density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2169728 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects cotreatment, increases expression, affects expression	6
propionaldehyde	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	increases expression	1
pentanal	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
belinostat	decreases expression	1
dorsomorphin	increases expression, affects cotreatment	1
Orlistat	decreases activity	1
Aldehydes	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Paraoxon	decreases activity	1
Aflatoxin B1	increases methylation	1
Copper Sulfate	decreases expression	1
Galactolipids	increases metabolic processing	1
Monoglycerides	increases metabolic processing	1

ChEMBL screening assays

5 unique, capped per target: 5 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL2174360	Binding	Inhibition of recombinant HPLRP2 expressed in Pichia pastoris assessed as residual activity at 40 molar excess after 30 mins by mass spectrophotometric analysis in presence of NaTDC	Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones. — Eur J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.