POFUT2

Summary

POFUT2 (protein O-fucosyltransferase 2, HGNC:14683) is a protein-coding gene on chromosome 21q22.3, encoding GDP-fucose protein O-fucosyltransferase 2 (Q9Y2G5). GDP-fucose protein O-fucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological functions.

Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]).

Source: NCBI Gene 23275 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 72 total
• MANE Select transcript: NM_133635

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14683
Approved symbol	POFUT2
Name	protein O-fucosyltransferase 2
Location	21q22.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0958, FUT13
Ensembl gene	ENSG00000186866
Ensembl biotype	protein_coding
OMIM	610249
Entrez	23275

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 10 protein_coding, 8 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000331343, ENST00000334538, ENST00000349485, ENST00000451615, ENST00000460932, ENST00000463917, ENST00000468360, ENST00000471540, ENST00000476653, ENST00000485190, ENST00000493524, ENST00000493811, ENST00000612472, ENST00000615172, ENST00000898195, ENST00000898196, ENST00000898197, ENST00000898198, ENST00000937165

RefSeq mRNA: 2 — MANE Select: NM_133635 NM_015227, NM_133635

CCDS: CCDS13719, CCDS13721

Canonical transcript exons

ENST00000349485 — 9 exons

Exon	Start	End
ENSE00003462591	45269839	45270019
ENSE00003473928	45283383	45283527
ENSE00003489621	45263935	45265635
ENSE00003522310	45282349	45282459
ENSE00003530867	45277017	45277142
ENSE00003583701	45278103	45278169
ENSE00003614666	45285678	45285928
ENSE00003683659	45267590	45267713
ENSE00003906729	45287741	45287895

Expression profiles

Bgee: expression breadth ubiquitous, 269 present calls, max score 95.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.1903 / max 171.6274, expressed in 1809 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190832	17.1239	1802
190831	4.0483	1542
190830	0.0181	6

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	95.65	gold quality
stromal cell of endometrium	CL:0002255	95.01	gold quality
adenohypophysis	UBERON:0002196	93.38	gold quality
endocervix	UBERON:0000458	93.15	gold quality
right lobe of thyroid gland	UBERON:0001119	93.15	gold quality
left lobe of thyroid gland	UBERON:0001120	93.14	gold quality
left ovary	UBERON:0002119	93.09	gold quality
pituitary gland	UBERON:0000007	93.02	gold quality
sural nerve	UBERON:0015488	92.91	gold quality
pancreatic ductal cell	CL:0002079	92.44	gold quality
adrenal tissue	UBERON:0018303	92.43	gold quality
right ovary	UBERON:0002118	92.38	gold quality
metanephros cortex	UBERON:0010533	92.37	gold quality
left uterine tube	UBERON:0001303	92.36	gold quality
thyroid gland	UBERON:0002046	92.35	gold quality
gall bladder	UBERON:0002110	91.98	gold quality
ascending aorta	UBERON:0001496	91.72	gold quality
thoracic aorta	UBERON:0001515	91.66	gold quality
smooth muscle tissue	UBERON:0001135	91.32	gold quality
parotid gland	UBERON:0001831	91.32	gold quality
body of uterus	UBERON:0009853	91.25	gold quality
tibial nerve	UBERON:0001323	91.04	gold quality
aorta	UBERON:0000947	90.85	gold quality
descending thoracic aorta	UBERON:0002345	90.57	gold quality
body of pancreas	UBERON:0001150	90.50	gold quality
mucosa of stomach	UBERON:0001199	90.49	gold quality
popliteal artery	UBERON:0002250	90.33	gold quality
tibial artery	UBERON:0007610	90.33	gold quality
small intestine Peyer’s patch	UBERON:0003454	90.18	gold quality
left adrenal gland cortex	UBERON:0035825	90.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

84 targeting POFUT2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-4502	99.65	66.99	1021
HSA-MIR-4690-5P	99.65	66.24	813
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-4649-3P	99.56	66.90	1783
HSA-MIR-12122	99.56	69.33	1672
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-642A-5P	99.51	65.10	1152
HSA-MIR-4441	99.49	66.56	3216

Literature-anchored findings (GeneRIF, showing 4)

• Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation. (PMID:22588082)
• POFUT2 and B3GLCT mediate a noncanonical endoplasmic reticulum quality-control mechanism that recognizes folded thrombospondin type 1 repeats and stabilizes them by glycosylation. (PMID:25544610)
• This study demonstrated that the alteration of POFUT2 expression in the superior temporal gyrus of elderly patients with schizophrenia. (PMID:27773385)
• The Essential Role of Water Molecules in the Reaction Mechanism of Protein O-Fucosyltransferase 2. (PMID:36260536)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	pofut2	ENSDARG00000045175
mus_musculus	Pofut2	ENSMUSG00000020260
rattus_norvegicus	Pofut2	ENSRNOG00000001228
drosophila_melanogaster	O-fut2	FBGN0027791
caenorhabditis_elegans		WBGENE00010757

Protein

Protein identifiers

GDP-fucose protein O-fucosyltransferase 2 — Q9Y2G5 (reviewed: Q9Y2G5)

Alternative names: Peptide-O-fucosyltransferase 2

All UniProt accessions (4): A0A0C4DGX7, Q9Y2G5, H7C2T5, S6FW71

UniProt curated annotations — full annotation on UniProt →

Function. GDP-fucose protein O-fucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological functions. This pathway targets proteins with Thrombospondin type-1 (TSP1) repeats (TSR) in the endoplasmic reticulum. Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm.

Subcellular location. Endoplasmic reticulum. Golgi apparatus.

Tissue specificity. Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart.

Activity regulation. Inhibited by EDTA and by Zn(2+).

Pathway. Protein modification; protein glycosylation.

Similarity. Belongs to the glycosyltransferase 68 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9Y2G5-3	C	yes
Q9Y2G5-1	A
Q9Y2G5-2	B

RefSeq proteins (2): NP_056042, NP_598368* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019378	GDP-Fuc_O-FucTrfase	Family
IPR045130	OFUT2-like	Family

Pfam: PF10250

Enzyme classification (BRENDA):

• EC 2.4.1.221 — peptide-O-fucosyltransferase (BRENDA: 12 organisms, 68 substrates, 3 inhibitors, 15 Km, 2 kcat entries)

Substrate kinetics (BRENDA)

6 substrates with measured Km, best-characterized 6. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
GDP-BETA-L-FUCOSE	0.001–0.0368	6
FACTOR VII EGF	0.006–0.015	2
GDP-L-FUCOSE	0.013–0.015	2
GLCNACBETA(1-2)MANALPHA(1-6)[GLCNACBETA(1-2)MANA	0.15–0.154	2
GDP-FUCOSE	0.0098	1
TSR4	0.0295	1

Catalyzed reactions (Rhea), 2 shown:

• L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+) (RHEA:63644)
• L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+) (RHEA:70491)

UniProt features (55 total): helix 17, strand 12, mutagenesis site 8, binding site 4, glycosylation site 3, splice variant 3, disulfide bond 2, turn 2, signal peptide 1, chain 1, active site 1, site 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
4AP5	X-RAY DIFFRACTION	3
4AP6	X-RAY DIFFRACTION	3.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y2G5-F1	91.08	0.84

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (2): 54 (proton acceptor); 396 (essential for catalytic activity)

Ligand- & substrate-binding residues (4): 53–57; 292–294; 371; 388–389

Disulfide bonds (2): 161–192, 412–419

Glycosylation sites (3): 259, 189, 209

Mutagenesis-validated functional residues (8):

Position	Phenotype
54	abolishes enzyme activity.
92	abolishes enzyme activity.
152	reduces enzyme activity.
273	reduces enzyme activity.
294	abolishes enzyme activity.
297	reduces enzyme activity.
395	no enhanced secretion of adasmts13; when associated with a-396.
396	reduces enzyme activity. no enhanced secretion of adasmts13; when associated with a-396.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-5173214	O-glycosylation of TSR domain-containing proteins

MSigDB gene sets: 151 (showing top): YAGI_AML_WITH_INV_16_TRANSLOCATION, MORF_MSH3, GOBP_FORMATION_OF_PRIMARY_GERM_LAYER, MORF_BRCA1, MORF_RAD51L3, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_PROTEIN_MATURATION, GOBP_MESENCHYMAL_CELL_DIFFERENTIATION, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2, GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS, GOBP_CARBOHYDRATE_METABOLIC_PROCESS, GOBP_GASTRULATION, GOBP_SECRETION, GOBP_MESODERM_MORPHOGENESIS, GOBP_PROTEIN_FOLDING

GO Biological Process (9): mesoderm formation (GO:0001707), fucose metabolic process (GO:0006004), regulation of gene expression (GO:0010468), regulation of epithelial to mesenchymal transition (GO:0010717), protein O-linked glycosylation via fucose (GO:0036066), regulation of secretion (GO:0051046), positive regulation of protein folding (GO:1903334), obsolete protein glycosylation (GO:0006486), obsolete fucosylation (GO:0036065)

GO Molecular Function (4): peptide-O-fucosyltransferase activity (GO:0046922), fucosyltransferase activity (GO:0008417), transferase activity (GO:0016740), glycosyltransferase activity (GO:0016757)

GO Cellular Component (3): endoplasmic reticulum membrane (GO:0005789), Golgi apparatus (GO:0005794), endoplasmic reticulum (GO:0005783)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
O-linked glycosylation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
endomembrane system	2
intracellular membrane-bounded organelle	2
formation of primary germ layer	1
mesoderm morphogenesis	1
hexose metabolic process	1
gene expression	1
regulation of macromolecule biosynthetic process	1
epithelial to mesenchymal transition	1
regulation of cell differentiation	1
protein O-linked glycosylation	1
secretion	1
regulation of transport	1
protein folding	1
positive regulation of cellular process	1
regulation of protein folding	1
fucosyltransferase activity	1
catalytic activity, acting on a protein	1
hexosyltransferase activity	1
catalytic activity	1
transferase activity	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1

Protein interactions and networks

STRING

1068 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
POFUT2	B3GLCT	Q6Y288	959
POFUT2	POFUT1	Q9H488	868
POFUT2	ADARB1	P78555	802
POFUT2	PADI2	Q9Y2J8	777
POFUT2	THBS1	P07996	721
POFUT2	FUT8	Q9BYC5	703
POFUT2	TSR3	Q9UJK0	694
POFUT2	POFUT4	Q495W5	670
POFUT2	COL18A1	P39060	669
POFUT2	FUT1	P19526	650
POFUT2	SPON1	Q9HCB6	647
POFUT2	SLC35C1	Q96A29	594
POFUT2	EVA1C	P58658	587
POFUT2	YBEY	P58557	575
POFUT2	RWDD2B	P57060	572

IntAct

7 interactions, top by confidence:

A	B	Type	Score
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
USP22	CNOT1	psi-mi:“MI:0914”(association)	0.350
MAP1LC3A		psi-mi:“MI:0914”(association)	0.350
GABARAP		psi-mi:“MI:0914”(association)	0.350
C1orf54	QSOX1	psi-mi:“MI:0914”(association)	0.350
HBB	HNRNPH2	psi-mi:“MI:0914”(association)	0.350
INSR	BLTP3B	psi-mi:“MI:0914”(association)	0.350

BioGRID (19): POFUT2 (Proximity Label-MS), POFUT2 (Affinity Capture-MS), POFUT2 (Affinity Capture-RNA), POFUT2 (Proximity Label-MS), POFUT2 (Proximity Label-MS), POFUT2 (Proximity Label-MS), POFUT2 (Co-fractionation), POFUT2 (Co-fractionation), POFUT2 (Co-fractionation), POFUT2 (Affinity Capture-MS), POFUT2 (Affinity Capture-MS), POFUT2 (Proximity Label-MS), POFUT2 (Proximity Label-MS), POFUT2 (Affinity Capture-MS), POFUT2 (Proximity Label-MS)

ESM2 similar proteins: A4IID1, A5D7I4, A5PK45, A9X1C8, G5E897, O12971, O60568, O77783, O95803, P52848, P52849, P52850, P70428, P97464, Q02353, Q16394, Q3UHN9, Q5F407, Q5IGR6, Q5IGR7, Q5IGR8, Q5M854, Q5R6K5, Q5RBC3, Q5U367, Q5U4X8, Q6EV56, Q6GMK0, Q6GQI7, Q6GQK9, Q6IS24, Q6UW63, Q6ZQ11, Q7TT15, Q7Z4H8, Q812F8, Q86X52, Q8K297, Q8NBJ5, Q8VHI3

Diamond homologs: Q6EV56, Q8VHI3, Q8WR51, Q9W589, Q9Y2G5, Q501D6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	4
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

2809 predictions. Top by Δscore:

Variant	Effect	Δscore
21:45269837:AC:A	donor_gain	1.0000
21:45269838:CC:C	donor_gain	1.0000
21:45277019:T:A	donor_gain	1.0000
21:45277036:T:TA	donor_gain	1.0000
21:45278101:A:AC	donor_gain	1.0000
21:45278101:ACAT:A	donor_gain	1.0000
21:45278101:ACATC:A	donor_gain	1.0000
21:45278102:C:CC	donor_gain	1.0000
21:45278102:CAT:C	donor_gain	1.0000
21:45278102:CATC:C	donor_gain	1.0000
21:45278102:CATCC:C	donor_gain	1.0000
21:45282348:CCGGG:C	donor_gain	1.0000
21:45285929:C:CA	acceptor_loss	1.0000
21:45285930:T:A	acceptor_loss	1.0000
21:45287740:CCGT:C	donor_gain	1.0000
21:45267525:TGGG:T	donor_gain	0.9900
21:45267710:TATT:T	acceptor_gain	0.9900
21:45267712:TT:T	acceptor_gain	0.9900
21:45267714:C:CC	acceptor_gain	0.9900
21:45269836:TA:T	donor_loss	0.9900
21:45277138:CGGGT:C	acceptor_gain	0.9900
21:45277143:C:CC	acceptor_gain	0.9900
21:45278071:A:AC	donor_gain	0.9900
21:45278072:C:CC	donor_gain	0.9900
21:45278104:T:TA	donor_gain	0.9900
21:45278105:C:A	donor_gain	0.9900
21:45282340:GGCAC:G	donor_loss	0.9900
21:45282341:GCACT:G	donor_loss	0.9900
21:45282342:CACT:C	donor_loss	0.9900
21:45282343:ACT:A	donor_loss	0.9900

AlphaMissense

2801 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
21:45285889:G:C	N57K	1.000
21:45285889:G:T	N57K	1.000
21:45269957:G:C	F298L	0.999
21:45269957:G:T	F298L	0.999
21:45269959:A:G	F298L	0.999
21:45269970:C:G	R294T	0.999
21:45285750:A:G	W104R	0.999
21:45285750:A:T	W104R	0.999
21:45285786:A:G	W92R	0.999
21:45285786:A:T	W92R	0.999
21:45285815:A:T	V82D	0.999
21:45285879:C:G	D61H	0.999
21:45285887:A:G	L58P	0.999
21:45285892:G:C	F56L	0.999
21:45285892:G:T	F56L	0.999
21:45285894:A:G	F56L	0.999
21:45285897:C:G	G55R	0.999
21:45265605:A:C	F389L	0.998
21:45265605:A:T	F389L	0.998
21:45265607:A:G	F389L	0.998
21:45269962:C:G	D297H	0.998
21:45285784:C:A	W92C	0.998
21:45285784:C:G	W92C	0.998
21:45285789:G:C	H91D	0.998
21:45285804:A:G	W86R	0.998
21:45285804:A:T	W86R	0.998
21:45285878:T:A	D61V	0.998
21:45285878:T:G	D61A	0.998
21:45285885:G:T	R59S	0.998
21:45285897:C:A	G55C	0.998

dbSNP variants (sampled 300 via entrez): RS1000058421 (21:45275018 C>G), RS1000204260 (21:45279503 A>G), RS1000259810 (21:45266514 G>A), RS1000471690 (21:45281624 G>C), RS1000694497 (21:45270836 C>T), RS1000719586 (21:45282808 C>T), RS1000747148 (21:45270995 A>G), RS1000776128 (21:45286236 C>T), RS1000782514 (21:45281805 C>A,T), RS1001034887 (21:45277546 C>T), RS1001128530 (21:45268145 C>T), RS1001163892 (21:45276744 C>CT), RS1001173034 (21:45283097 G>A), RS1001302516 (21:45265488 G>A), RS1001378255 (21:45264594 G>A,T)

Disease associations

OMIM: gene MIM:610249 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST005175_68	Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes	8.000000e-06
GCST006999_5	Logical memory (immediate recall) in mild cognitive impairment	4.000000e-07
GCST012279_17	Suicide attempt severity in mood disorders	2.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004723	coronary artery calcification
EFO:0004874	memory performance
EFO:0006882	suicide behaviour measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, increases methylation	4
bisphenol F	increases expression, affects cotreatment, decreases expression	2
bisphenol A	decreases expression, decreases methylation	2
Smoke	decreases expression, increases abundance	2
2,4,6-tribromophenol	decreases expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
cobaltous chloride	increases expression	1
butyraldehyde	decreases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
bisphenol B	increases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
PCI 5002	increases expression, affects cotreatment	1
Temozolomide	decreases expression	1
Air Pollutants	increases abundance, decreases expression	1
Arsenic	affects methylation	1
Atrazine	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D8TG	Ubigene HCT 116 POFUT2 KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.